Yala aw delila ka ‘Anticorps monoclonal’ tɔgɔ mɛn wa? N’a sɔrɔ aw ye nin tɔgɔ in mɛn ka kɛ kansɛri fura ye, walima banaw i n’a fɔ Covid-19. Hali n’a y’a sɔrɔ daɲɛ kabakoma ni belebeleba don dɔɔnin, tiɲɛ na, nin ye fura sugu dɔ ye min ye fɛn kabakoma caman wuli an ka furakɛli la. Aw kana aw hakili ɲagami, nin faamuyali man gɛlɛn. Bi, an ka kuma dɔrɔn ninnu ye fɛn minnu ye, u bɛ baara kɛ cogo min na, ani u bɛ kɛ bana minnu na.
N’an y’a fɔ cogo nɔgɔman na, farikolo tangalan kelen-kelenw ye mun ye?
Walasa k’o faamuya, an ka fɔlɔ ka fɛn dɔ dɔn an farikolo la: ‘Kan farikolo tangalanw’.
Miiri k’a filɛ, an farikolo ye jamana ye. O tuma na fɛ, an ka farikolo tangalanw ye o jamana ka kɛlɛbolo ye. Sɔrɔdasi kɛrɛnkɛrɛnnen minnu bɛ o kɛlɛbolo in na, olu bɛ Weele ko ‘Anticorps’. Ni jugu dɔ bɔra kɛnɛma, o kɔrɔ ye ko fɛn dɔ i n’a fɔ tumu walima kansɛribana (furakɛli la an b’o wele ko antigènes ) donna farikolo la, o sɔrɔdasiw bɛ taa o jugu minɛ ka taamasiyɛn di selilu wɛrɛw ma walasa u k’a tiɲɛ.
Sisan, ‘banakisɛfagalan kelen-kelenw’ ye banakisɛfagalan suguya kɛrɛnkɛrɛnnen ye an bɛ min dilan laboratuwari kɔnɔ. Olu bɛ i n’a fɔ farikolo tangalan minnu bɛ an farikolo la, olu kopiw tigitigi.
- ‘Mono’ kɔrɔ ye ‘kelen’ ye.
- ‘Klon’ kɔrɔ ye ‘klon’ ye.
O kɔrɔ ye ko u bɛ i n’a fɔ banakisɛfagalan kelen ka ‘fotokopi’ caman. U bɛ Kɛ ka binkanni Kɛ jugu kɛrɛnkɛrɛnnen kelen dɔrɔn de kan (antigène). Misali la, farikolo tangalanw bɛ dilan walasa ka bin farikolojɔlifɛn kɛrɛnkɛrɛnnen dɔ dɔrɔn kan min bɛ kansɛribanakisɛ dɔ sanfɛ. N’a sɔrɔ aw y’a ye ko fura ninnu tɔgɔw bɛ laban ni "mab" ye (misali la, Trastuzumab, Rituximab).
N’an y’a fɔ cogo nɔgɔman na, farikolo tangalanw ye ‘misilɛw’ ye minnu dilannen don laboratuwari kɔnɔ walasa ka jugu kɛrɛnkɛrɛnnen dɔ tiɲɛ, wa u tɛ tɛmɛ u laɲini kan abada.
Ninnu bɛ bana sugu jumɛnw furakɛ?
O fɛɛrɛ in bɛ kɛ ka bana suguya caman furakɛ sisan. Kabini banakisɛfagalan fɔlɔ min bɛ wele ko monoclonal anticorps, o dabɔra san 1986, fura suguya caman dilanna.
| Bana suguya | Ɲɛfɔli ni misaliw |
|---|---|
| Kansɛri | Ka kansɛribanakisɛw laɲini ani k’u tiɲɛ i n’a fɔ sinji kansɛri, sɔgɔsɔgɔninjɛ, ani jolidɛsɛ. |
| farikolo tangalanw ka banaw | Walasa ka farikolo tangalanw ka baara caya kojugu kunbɛn cogoyaw la i n’a fɔ sɔgɔsɔgɔninjɛ ni Crohn ka bana. |
| Banakisɛw | Ka banakisɛw kunbɛn ani k’u kɛlɛ i n’a fɔ COVID-19 banakisɛ. |
| Farikolo yɔrɔw cili banna | Walasa farikolo kana ban farikolo yɔrɔ dɔ la, i n’a fɔ sugunɛ, a jiginni kɔfɛ. |
| Bana wɛrɛw | A bɛ kɛ fana koloci, kunkolodimi, kolosinsinnan caman, ɲɛnabana dɔw, ani farikolojidɛsɛbanaw fana na. |
Nin furakɛli in bɛ kɛ cogo di?
A ka ca a la fura in bɛ di i n’a fɔ kɔgɔji bɛ kɛ jolisira dɔ kɔnɔ (jolisira fɛ - IV) . O fana bɛ Weele ko ‘infusion’. A ka c’a la, aw bɛna don dɔgɔtɔrɔso walima dɔgɔtɔrɔso ‘pikirikɛyɔrɔ’ la tile kelen kɔnɔ, ka nin furakɛli in kɛ lɛri damadɔ kɔnɔ.
- Furakɛli fɔlɔ: Ni nin ye aw siɲɛ fɔlɔ ye ka nin furakɛli in kɛ, aw bɛ se ka a ɲini aw somɔgɔw dɔ fɛ a ka na ni aw ye. O bɛ kɛ barisa dɔgɔtɔrɔso baarakɛlaw bɛna u janto kɛrɛnkɛrɛnnenya la aw la walasa ka furakɛli ɲɛfɔ ani ka a lajɛ ni faritanabana si bɛ aw la.
- Pikiri min bɛ kɛ fari jukɔrɔ : Tuma dɔw la, fura in bɛ kɛ fana pikiri ye fari jukɔrɔ (farikolo jukɔrɔ) . O cogo la, aw ka dɔgɔtɔrɔ walima dɔgɔtɔrɔso baarakɛla bɛna a pikiri kɛcogo jira aw yɛrɛ la. A ka ca a la, olu bɛ di kɔnɔbara walima cɛya la.
Furakɛli fɛɛrɛ suguyaw
Nin banakisɛfagalanw bɛ kɛ cogo caman na:
1. Banakisɛfagalan farilankolonw: Ninnu ye furakɛli ye min bɛ kɛ a kelen na. U bɛ taa fɛnw na k’u nɔrɔ ɲɔgɔn na i n’a fɔ kansɛribanakisɛw, k’u falenni jɔ walima ka taamasiɲɛ di farikolo tangalanw ma walasa u k’u tiɲɛ.
2. Banakisɛfagalan kelen-kelenw (conjugués) :Olu bɛ i n’a fɔ ‘parsela’. Simifura walima fɛnɲɛnamafagalan dɔ bɛ nɔrɔ banakisɛfagalan na ka ci. Banakisɛfagalan bɛ kansɛribanakisɛ tigitigi sɔrɔ ka o ‘parsela’ in ‘lase’ yen. O tɛ tiɲɛni dɔɔnin dɔrɔn de lase farikolokisɛ kɛnɛmanw ma.
3. Banakisɛfagalan kelen-kelen fila : Olu bɛ se ka bin laɲini fila kan siɲɛ kelen. A bɛ iko bolo fila bɛ baara fila kɛ. Misali la, k’a sɔrɔ a bɛ kansɛribanakisɛ minɛ ni bolo kelen ye, bolo tɔ kelen bɛ farikolo tangalan dɔ minɛ, ka o fila siri ɲɔgɔn na ani ka dɛmɛ don ka kansɛribana tiɲɛ.
Nin furakɛli in nafa ni a farati jumɛnw bɛ a la?
Nafa minnu b’a la
- Laɲini kɛrɛnkɛrɛnnen don: Laadala furakɛli i n’a fɔ chimiothérapie bɛ farikolokisɛw bɛɛ tiɲɛ minnu bɛ tila joona (kansɛribanakisɛw ani kunsigi ni farikisɛ kɛnɛmanw). Nka ikomi ninnu bɛ bin farikolokisɛw dɔrɔn de kan minnu sen bɛ bana in na, a kɔlɔlɔw ka dɔgɔn.
- Nafa ka bon kosɛbɛ: Ninnu ye ɲɛtaa sɔrɔ kosɛbɛ bana dɔw furakɛli la, kɛrɛnkɛrɛnnenya la kansɛriw.
- Sariya kelen : Ikomi a dilannen don laboratuwari kɔnɔ, fura suguya bɛɛ suguya bɛɛ ye kelen ye.
Farati minnu bɛ a la
I n’a fɔ fura tɔw bɛɛ, o furakɛli bɛ se ka farati dɔw lase mɔgɔ ma. Nka aw kana aw hakili ɲagami, aw ka dɔgɔtɔrɔ bɛna aw kalan nin bɛɛ la ani ka aw ladon ka ɲɛ.
- Pikiri kɛcogo : Ninnu ye faritanabanaw ye minnu ka teli ka kɛ pikiri kɛtuma na walima dɔɔni o kɔfɛ. Olu bɛ se ka kɛ farikolodimi, sumaya, farigan, ninakili gɛlɛya, sumaya, ani tansiyɔn jiginni ye. A ka ca a la, olu bɛ se ka kunbɛn ni pikiri kɛcogo sumaya ye.
- Fali jugumanw (a man teli): A man teli kosɛbɛ, nka faritanabana jugumanw bɛ se ka kɛ.
- Anaphylaxie acute (Anaphylaxie acute): faritanabana jugumanba min bɛ kɛ yɔrɔnin kelen.
- Sitokini bɔli (CRS): Banakisɛfagalanw bɛ se ka baara kɛ kojugu ani ka farikolo yɔrɔw tiɲɛ.
- Serum Sickness: Farikolo farikolo tangalanw ka binkanni fura in kan.
O ye ko nin ɲɔgɔnna kow bɛ se ka kɛ, o de kama dɔgɔtɔrɔw ni furakɛlikɛlaw bɛ u janto aw la kosɛbɛ, kɛrɛnkɛrɛnnenya la ni aw bɛ furakɛli kɛ siɲɛ fɔlɔ.
Yala aw b’a fɛ ka kuma dɔgɔtɔrɔ fɛ wa?
Ɔwɔ, tiɲɛ yɛrɛ la. Ni ɲininkali dɔw bɛ aw fɛ furakɛli in kan, walima ni aw b’a fɛ k’a dɔn ni nin furakɛli in bɛnnen don aw ma, aw bɛ kuma aw ka dɔgɔtɔrɔ fɛ kɛnɛ kan. A bɛna laadilikan ɲumanw di aw ma ka kɛɲɛ ni aw ka furakɛli cogoya ye ani aw ka kɛnɛya cogoya ye.
Nafama: Ni aw ye faritanabana dɔ sɔrɔ aw ma deli ka min kɛ furakɛli kɔfɛ, kɛrɛnkɛrɛnnenya laNi ninakili gɛlɛya, disidimi, kurukuru jugumanba, kuma gɛlɛya, walima hakili caman yeli, aw bɛ dɔgɔtɔrɔ wele joona, walima aw bɛ taa dɔgɔtɔrɔso la min ka surun aw la, o ka kɔrɔtɔko ɲɛmɔgɔso (ETU).
Take-Home cikan
- Banakisɛfagalan monoklɔni ye farikolojɔli dumuni suguya kɛrɛnkɛrɛnnen ye min dilannen don laboratuwari kɔnɔ min bɛ baara kɛ i n’a fɔ an yɛrɛ ka farikolo tangalanw yɔrɔ dɔw.
- Ninnu ye bi fɛɛrɛ ye min bɛ se ka kɛ ka bana suguya caman furakɛ, i n’a fɔ kansɛri, jolidɛsɛ, ani COVID-19.
- Ikomi nin furakɛli in bɛ baara kɛ a laɲininen na, a kɔlɔlɔw bɛ se ka dɔgɔya ka tɛmɛ tubabufura kan.
- Farikoloɲɛnajɛw i n’a fɔ farigan ni kurukuruw bɛ se ka kɛ ni fura in dira. Nka, kɔlɔlɔ jugumanw man ca kosɛbɛ.
- Aw bɛ baro kɛ ni aw ka dɔgɔtɔrɔ ye tuma bɛɛ ni nin furakɛli in bɛnnen don aw ma ani a nafa ni a dɛsɛ ye min ye.
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