Nin ye kɔnɔbara kansɛri suguya kɛrɛnkɛrɛnnen ye: An ka MSI-H dɔn dɔrɔn! (Microsatellite basigibaliya-Kɔnɔbara kansɛri min ka bon)

Yala aw ye fɛn dɔ yeli ye aw ka banakɔtaa la, kɔnɔdimi, walima joli min bɛ aw ka banakɔtaa la kɔsa in na wa? Aw kana aw ɲɛmajɔ nin taamasiɲɛ ninnu na, k’a miiri ko u tɛ kojugu ye. U bɛ se ka kɛ kɔnɔbara kansɛri taamasiɲɛw ye. Bi, an bɛ kuma kɔnɔbara kansɛri suguya dɔ kan min ka bon dɔɔnin, nka a fana ka bon dɔɔnin. A bɛ Weele ko MSI-H.

N’an y’a fɔ cogo nɔgɔman na, nin MSI-H kɔnɔbara kansɛri in ye mun ye?

Walasa k’o faamu, an ka fɔlɔ ka ADN lajɛ an farikolo yɔrɔw kɔnɔ. Miiri an ka ADN la iko cakɛda jan. O cakɛda in na, biɲɛ suguya kelenw bɛ nɔrɔ a la siɲɛ caman. O ADN yɔrɔ minnu bɛ segin-ka-bɔ, olu bɛ wele ko mikrosatelitiw.

Sisan, ni an farikolo yɔrɔw tilalen don ani ni farikolokisɛ kuraw dabɔra, o ADN cakɛda kopiw bɛ dilan. Tuma dɔw la, filiw (mutations) bɛ se ka kɛ ni o kopiw kɛra. Nka aw kana aw hakili ɲagami, an farikolo bɛ ni sigida ye i n’a fɔ ‘polisi min bɛ filiw sɔrɔ’. A bɛ fɔ a ma ko Mismatch Repair (MMR) sitɛmu. A bɛ filiw lajɛ o ADN kopiw kɔnɔ, ka u latilen o yɔrɔnin bɛɛ.

Nka, kansɛribana dɔw la, o MMR kɛcogo tɛ baara kɛ ka ɲɛ. An b’a wele ko dMMR (ADN Mismatch Repair dɛsɛlen). O kɔfɛ, ikomi mɔgɔ si tɛ yen min bɛ filiw labɛn o ADN kopiw kɔnɔ, filiw bɛ dalajɛ ani ADN bɛ kɛ fɛn ye min tɛ sabati kosɛbɛ. O de ye cogoya ye ni mikrosatelitiw ye minnu tɛ sabati kosɛbɛ, an b’o wele ko MSI-H (Microsatellite Instability-High) .

Kabako don, nin ADN "basigibaliya" in ye tiɲɛ na tuma dɔw la ko ɲuman ye. MSI-H kansɛriw bɛ furakɛli dɔ jaabi ka ɲɛ min bɛ wele ko immunotherapy ka tɛmɛ kansɛri suguya wɛrɛw kan. Ka fara o kan, u ka jateminɛ kɛcogo ka ɲi kosɛbɛ.

MSI-H kansɛri taamasiɲɛ minnu bɛ se ka kɛ, olu ye jumɛnw ye?

A bɛ se ka kɛ a taamasiɲɛw tɛ ye tuma bɛɛ, nka ni a taamasiɲɛw bɛ ye, u ni kɔnɔbara basigilen kansɛri taamasiɲɛw bɛ tali kɛ ɲɔgɔn na.

Nafama: Nin taamasiɲɛ ninnu bɛ mɔgɔ o mɔgɔ la, kansɛri tɛ olu bɛɛ la. Nka , ni joli bɛ aw ka banakɔtaa la walima ni kɔnɔdimi jugumanba don aw la, aw bɛ taa dɔgɔtɔrɔso la joona. Ni taamasiɲɛ wɛrɛw tora senna ka tɛmɛ dɔgɔkun fila kan, aw ka kan ka dɔgɔtɔrɔ ka ladilikan ɲini sisan.

Tuma dɔw la, kansɛri in taamasiɲɛ fɔlɔ ye joli sɛgɛsɛgɛli ye min b’a jira ko joli kuru bilenmanw hakɛ dɔgɔyara (jolidɛsɛ). O bɛ sɔrɔ joli bɔli fɛ banakɔtaa la.

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MSI-H kansɛri sɔrɔli sababuw ni farati minnu bɛ a la

MSI-H kansɛri sababu fɔlɔ ye MMR jamu nafamafɛnw ye an ye minnu kofɔ ka tɛmɛ. Olu ka teli ka kɛ mɔgɔ ka ɲɛnamaya kɔnɔ, kun kɛrɛnkɛrɛnnen tɛ.

Nka kɔnɔbara kansɛri bɛ mɔgɔ minnu na, olu 5% ɲɔgɔn na, o jamu nafama in bɛ tɛmɛ mɔgɔw fɛ mɔgɔw fɛ. an bɛ nin wele ko Lynch syndrome . Ni nin bana in bɛ aw ka denbaya kɔnɔ mɔgɔ dɔ la, aw fana ka kan ka kɔnɔbara kansɛri sɔrɔ.

Ka fara o kan, fɛn dɔw bɛ an ka ɲɛnamaya kɛcogo la minnu bɛ dɔ fara kansɛri sɔrɔli kan.

Bana in bɛ se ka sɛgɛsɛgɛ cogo di?

Ni aw ka dɔgɔtɔrɔ bɛ sigasiga kansɛri la ka da aw ka bana taamasiɲɛw kan, a bɛna aw bila ka taa sɛgɛsɛgɛli caman kɛ.

1. Kɔnɔbara lajɛ : Tubabufura min bɛ se ka wuli, kamera sirilen bɛ min na, o bɛ don kɔnɔbara fɛ walasa ka kolotuguda bɛɛ sɛgɛsɛgɛ. O waati la, farikolo yɔrɔ fitinin dɔ bɛ bɔ yɔrɔ la min bɛ siga la walasa ka a sɛgɛsɛgɛ. o bɛ wele ko biyɔpisi .

2. Molecules sɛgɛsɛgɛliw : Sɛgɛsɛgɛli kɛrɛnkɛrɛnnenw bɛ kɛ walasa ka jamu caman yeli dɔn, i n’a fɔ MSI-H cogoya, farikolo yɔrɔw la minnu bɔra biyɔpisi la. Fɛɛrɛ minnu bɛ Kɛ i n’a fɔ IHC , PCR , ani NGS , olu bɛ Kɛ o la.

3. Jala sɛgɛsɛgɛliw : Scanw i n’a fɔ CT ani MRI bɛ kɛ walasa ka a dɔn ni kansɛri jɛnsɛnna farikolo yɔrɔ wɛrɛw la.

MSI-H kansɛri furakɛcogo jumɛnw bɛ yen?

Furakɛli bɛ bɔ kansɛri taabolo la ani a jɛnsɛnna fo yɔrɔ min na. Furakɛli fɛɛrɛba fila bɛ yen.

Operelikɛyɔrɔ

Ni kansɛri ma jɛnsɛn yɔrɔ wɛrɛw la, a fɔlɔ ye ka kuru bɔ opereli fɛ. Opereli suguya bɛ se ka ɲɔgɔn ta ka kɛɲɛ ni kansɛri hakɛ ye.

Furakɛcogo

O yɔrɔ de la MSI-H kansɛri kɛrɛnkɛrɛnnenya bɛ na ni a ye.

• Banakisɛfagalanw furakɛli : Nin ye MSI-H kansɛri furakɛli ye min nafa ka bon kosɛbɛ ani min bɛ ɲɛ .. Aw ye miiri an ka farikolo tangalanw na i n’a fɔ ‘on’/‘off’ switch bɛ u la. Tuma dɔw la, kansɛribanakisɛw bɛ o switch in faga ni hakilitigiya ye ani ka dogo an farikolo lafasalifɛnw na. Banakisɛfagalanw (checkpoint inhibiteurs) bɛ o ‘off’ switch in daminɛ kokura, ka farikolo tangalanw dɛmɛ ka kansɛribanakisɛw sɔrɔ ani ka u tiɲɛ.
• Chimiothérapie : Fura barikamaw dili walasa ka kansɛribanakisɛw faga. Tuma dɔw la, a bɛ kɛ ka kɔn opereli ɲɛ walima opereli kɔfɛ.
• Furakɛcogo laɲininen : Fura minnu bɛ farikolojɔli dumuni kɛrɛnkɛrɛnnenw walima wale kɛrɛnkɛrɛnnenw laɲini ani k’u jɔ minnu bɛ kansɛribanakisɛw dɛmɛ u ka bonya.

Ka ɲɛnamaya kɛ ni MSI-H kansɛri ye

A nafa ka bon kosɛbɛ ka farikolo ni hakili kɛnɛya sabati kansɛri furakɛli waati.

• Dumuni duncogo : Opereli kɔfɛ, aw bɛ dɔgɔtɔrɔ ka laadilikanw labato ani ka dumuni dun min bɛ se ka dun nɔgɔya la, wa farikolojɔli dumuniw ka ca. A ka fisa ka dɔ bɔ gazi bɔ dumuniw dunni na (misali la, kaba, shɛfan) ani sogo dilannenw.
• Farikoloɲɛnajɛ: Degeli nɔgɔmanw i n’a fɔ taama i seko la, olu bɛ se ka nafa caman lase i farikolo ni i hakili ma. Nka aw bɛ a lajɛ dɔgɔtɔrɔ fɛ sani aw ka farikoloɲɛnajɛ kɛcogo bɛɛ daminɛ.
• Hakilila kɛnɛya: A ka ɲi ka jɔrɔ ani ka siran nin waati suguw la. Aw kana aw dusukunnataw to buteli kɔnɔ aw kɔnɔ. Aw bɛ kuma mɔgɔ dɔ fɛ aw dalen bɛ min na, aw ka denbaya, ani ka dɛmɛ ɲini hakili kɛnɛya ladilikɛla dɔ fɛ ni a mago bɛ o la.

MSI-H kansɛri furakɛli hakɛ ka ca ni a bɛ tali kɛ kɔnɔbara kansɛri suguya wɛrɛw la, kɛrɛnkɛrɛnnenya la ni a sɔrɔla joona, wa furakɛli i n’a fɔ farikolo tangacogo bɛ se ka nɔ ɲumanba lase mɔgɔ ma.