A ka ca a la mɔgɔ o mɔgɔ bɛ siran ni kabakoba sɔrɔ ni a ye "kolo kansɛri" daɲɛw mɛn. Nka, ɲɛtaa minnu kɛra furakɛli la bi, furakɛli kura ni ɲɛtaa caman bɛ yen minnu bɛ se k’an dɛmɛ ka o bana suguw kunbɛn. Bi, an bɛna kuma "furakɛli laɲinilen" fɛɛrɛ dɔ kan min ni laadala chimiothérapie tɛ kelen ye, wa a bɛ kansɛribanakisɛw laɲini kɛrɛnkɛrɛnnenya la ani ka bin u kan.
N’an y’a fɔ cogo nɔgɔman na, nin Banakisɛfagalan Monoclonal ninnu ye mun ye?
Sani an ka nin faamuya, an ka an farikolo lafasalicogo kabakoma lajɛ. Ni banakisɛ dɔ, i n’a fɔ banakisɛ walima banakisɛ, donna an fari la, an farikolo tangalanw bɛ farikolojɔlifɛn kɛrɛnkɛrɛnnenw dilan minnu bɛ se ka o binkannikɛlaw dɔn, ka nɔrɔ u la, ka u tiɲɛ. An bɛ ninnu wele ko "bodyguards", walima anticorps (banakisɛfagalanw) walasa ka ɲɛfɔli kɛ ka ɲɛ.
Sisan, nin ``Monoclonal Antibodies`` ninnu ye banakisɛfagalan dilannen suguya dɔ ye min dilannen don laboratuwari kɔnɔ ni fɛɛrɛ kɛrɛnkɛrɛnnenw ye. Olu bɛ Kɛ ka bin laɲini kɛrɛnkɛrɛnnen kelen dɔrɔn kan. Walasa k’a fɔ tigitigi, u dabɔra walasa ka farikolojɔli dumuni kɛrɛnkɛrɛnnen dɔ dɔn kansɛribanakisɛ dɔ sanfɛ, ka nɔrɔ a la, ka o kansɛribanakisɛ tiɲɛ .
O bɛ i n’a fɔ komando min dege kɛrɛnkɛrɛnnenya la, n’a bɛ se ka jugu sɔrɔ yɔrɔ la, yɔrɔ min falen bɛ mɔgɔw la, ka bin o jugu dɔrɔn kan, k’a sɔrɔ a ma kojugu kɛ mɔgɔ wɛrɛ la. O la, sanni a ka farikolokisɛ ɲumanw tiɲɛ i n’a fɔ chimiothérapie basigilen, a bɛ se ka jira ko nin furakɛli fɛɛrɛ in kɔlɔlɔ ka dɔgɔn barisa a kɛrɛnkɛrɛnnen don.
Fura minnu bɛ joli siraw falenni bali kansɛri la (Angiogenesis Inhibitors) .
Kansɛri tɛ fɛn ye min bɛ bonya dɔrɔn. A bɛ iko jiri dɔ. A mago bɛ balo la walasa ka ɲɛnamaya, ka bonya ani ka bonya. Walasa ka o balo sɔrɔ, kansɛribanakisɛw bɛ joli sira kura falen u lamini na. An b'o wale in wele ko ``angiogenesis.`` O la, n'an ye joli siraw jɔ minnu bɛ nin "dumuni ni minfɛn" ninnu di kansɛri ma, an bɛ se ka kansɛri bonya dabila, ɔnhɔn? An b’o de wele ko dɔrɔgu suguya min bɛ o kɛ.
Bevacizumab (Avastin) bɛ baara kɛ nin cogo in na:
Bevacizumab (a tɔgɔ: Avastin) ye fura jɔnjɔn ye nin suguya in na. Kansɛribanakisɛw bɛ taamasiɲɛ dɔ ci min b’a fɔ u ye ko u ka “joli siraw jɔ.” O taamasiɲɛ in bɛ wele ko joli-sira-funu-kɔnɔ-fɛnw falen-falen, walima VEGF. Avastin bɛ min Kɛ o ye k’o taamaʃyɛn bali a ka Se yɔrɔ laɲininen na. Kuma nɔgɔman na, a bɛ kansɛri ye "sɛbɛn min ci ka joli siraw jɔ" o minɛ k'a tiɲɛ.
O bɛ kansɛri bali ka joli sira kura dilan, o bɛ kansɛri bonya sumaya. Nin fura in dagalen don kolotuguda kansɛri la min jɛnsɛnna (a bɛ taa yɔrɔ wɛrɛw la) farikolo yɔrɔ wɛrɛw la. Hali ni a tɛ se ka kansɛri furakɛ pewu, sɛgɛsɛgɛliw y’a jira ko Avastin, ni a kɛra ni chimiothérapie ye, a bɛ se ka banabagatɔw ka ɲɛnamaya waati janya ni kalo 5 ɲɔgɔn ye .
`Fruquintinib (Fruzaqla)`, `ramucirumab (Cyramza)`, ani `ziv-aflibercept (Zaltrap)` ye fura kura dɔw ye minnu fana bɛ `VEGF` laɲini.
Avastin bɛ di cogo di? A kɔlɔlɔw ye mun ye?
Avastin ye pikiri ye min bɛ kɛ jolisira fɛ (IV). A ka ca a la a bɛ di dɔgɔkun fila fo dɔgɔkun saba o dɔgɔkun saba ka fara chimiothérapie kan.
A nafa ka bon kosɛbɛ ka aw janto fura in kɔlɔlɔw la minnu bɛ se ka kɛ.
| Kɔnɔnatumu suguya | Cogojirali |
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| Kɔnɔnatumuw kɔlɔlɔ minnu ka teli ka sɔrɔ |
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| Kɔnɔnatumu jugumanba minnu bɛ sɔrɔ a la |
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Fura minnu bɛ nɔ bila kansɛribanakisɛw falenni na k’a ɲɛsin u yɛrɛ ma
Setuximab (Erbitux) ani panitumumab (Vectibix) ye banakisɛfagalan suguya fila wɛrɛw ye minnu bɛ kɛ ni farikolo kelen ye. Olu bɛ baara kɛ cogo wɛrɛ la. U bɛ farikolojɔlifɛn dɔ laɲini min bɛ wele ko epidermal growth factor receptor (EGFR) kansɛribanakisɛw sanfɛ.
Aw ye miiri nin `EGFR` in na i n’a fɔ `On` switch min b’a fɔ kansɛribana ye ko a ka `tila joona ka bonya ka taa a fɛ.` Fura `Erbitux` ni `Vectibix` bɛ min kɛ, o ye ka sigi switch in kan k’a `block`. O kɔfɛ, taamasiɲɛ dafalen min b’a fɔ selilɛri ye ko a ka bonya, o tɛ se ka switch (switch) da. O cogo la, kansɛribanakisɛw falenni bɛ kɔlɔsi.
Nin fura in bɛ di jɔn ma?
Erbitux ni Vectibix fila bɛɛ dagalen don ka kɔnɔbara kansɛri furakɛ min jɛnsɛnna farikolo yɔrɔ wɛrɛw la.
Erbitux boloci bɛ kɛ siɲɛ kelen dɔgɔkun kɔnɔ, a kelen walima ni chimiothérapie fura ye min tɔgɔ ye ko irinotecan (Camptosar). Vectibix boloci bɛ kɛ dɔgɔkun fila o dɔgɔkun fila ka fara chimiothérapie fura wɛrɛw kan.
A nafa ka bon kosɛbɛ sani aw ka fura in di, aw ka sɛgɛsɛgɛli kɛrɛnkɛrɛnnen kɛ aw ka kansɛribanakisɛw kan walasa ka a dɔn ni fura in bɛna baara kɛ o kansɛri la. Ninnu man ɲi kansɛri bɛɛ ma. O la, nin kɔrɔbɔli in bɛ Kɛ sisan.
Erbitux ni Vectibix kɔlɔlɔ jumɛnw ye?
Nin fura ninnu kɔlɔlɔ kɛrɛnkɛrɛnnenw fana bɛ u la.
| Erbitux ni Vectibix kɔlɔlɔ minnu ka teli ka sɔrɔ | |
|---|---|
| Fari gɛlɛyaw | Kurukuru minnu bɛ i n’a fɔ kunfilanitu, fari kurukuruw, ani fari jalen. Nka kabako ye, tuma dɔw la, o faritanabanaw kɔrɔ ye ko fura in bɛ baara kɛ ka ɲɛ kansɛri kɛlɛli la. |
| Kɔnɔnatumu wɛrɛw |
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Take-Home cikan
- Banakisɛfagalanw (Monoclonal Anticorps) ye furakɛli kɔrɔlen ye min bɛ kansɛribanakisɛw laɲini kɛrɛnkɛrɛnnenya la ani ka bin u kan. U ni chimiothérapie furakɛli basigilenw tɛ kelen ye.
- Fura dɔw bɛ joli sira tigɛ ka taa kansɛri la, dɔw bɛ taamasiɲɛw bali minnu bɛ kansɛribanakisɛw falen.
- Nin fura ninnu bɛɛ kɔlɔlɔw bɛ u yɛrɛ la. Aw bɛ baro kɛ o kow kan kɛnɛ kan ni aw ka dɔgɔtɔrɔ ye sani aw ka furakɛli daminɛ.
- Nin furakɛli ninnu man ɲi bɛɛ ma. Aw ka dɔgɔtɔrɔ bɛna a latigɛ furakɛli min ka fisa aw ma ka kɛɲɛ ni kansɛri suguya ye min bɛ aw la, a jɛnsɛnna yɔrɔ min na, ani jamu sɛgɛsɛgɛli kɛrɛnkɛrɛnnenw jaabiw.
- Ni kansɛri bɛ aw walima aw ka denbaya kɔnɔmɔgɔ dɔ la, aw kana siran. Aw bɛ kuma aw ka kansɛri dɔgɔtɔrɔ fɛ furakɛli suguya bɛɛ kan, u nafa n’u dɛsɛ, ani ka aw jagɛlɛya ka furakɛli kunbɛn.
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