Mina míasrɔ̃ nu tso enzyme ƒe dzesi siwo le wò ʋu me ŋu.

Ne ɖɔkta gblɔ na wò be nàlé ŋku ɖe wò "Enzyme Markers" ŋu la, ɖewohĩ nyabiase ʋɛ aɖewo le susu me na wò, alo? "Nukae nye enzyme siawo?", "Nukatae wole wo me dzrom?" Nyabiase mawo tɔgbe. Mègatsi dzi o, ele bɔbɔe ŋutɔ. Mina míasrɔ̃ nu geɖe tso esia ŋu egbea, abe ale si ko míele nu ƒom na mía xɔlɔ̃ ene.

Eyata nukawoe nye enzyme ƒe dzesi siawo?

Kpuie ko la, Enzyme Markers nye ʋudodokpɔ si dzidzea enzyme aɖewo ƒe agbɔsɔsɔ le wò ʋu me. Zi geɖe la, enzyme siawo nɔa míaƒe ŋutilã ƒe lãmenugbagbeviwo me. Gake ne míaƒe ŋutilã ƒe ŋutinu aɖe, abe aklã, dzi, alo lãmeka ene, gblẽ, dɔléle le eŋu, alo xɔ abi la, enzyme siawo dometɔ aɖewo dona tso lãmenugbagbevi mawo siwo gblẽ la me yia ʋua me. Ele abe tsi si le dodom tso aŋetu si gbã me ene.

Emegbe to ʋudodokpɔ sia dzi la, ɖɔkta ate ŋu akpɔe ɖa be enzyme sia ƒe agbɔsɔsɔ le wò ʋu me sɔ gbɔ alo le ʋɛ wu alesi wòle dzɔdzɔmee hã. Ðɔktawo yɔa esiawo ɣeaɖewoɣi be "nu gbagbewo ƒe dzesiwo." Eyae nye dɔléle aɖe ƒe dzesi si tso nugbagbewo me. Esia ate ŋu ana ɖɔktaa nanya ne nane gblẽ le wò ŋutilã me.

Enyo, eyata nukae nye "enzyme" siawo?

Ðeko míeƒo nu tso "enzyme markers" ŋu. Eyata nukae nye "enzyme" siawo? Bu enzymewo be wonye protein siwo le abe dɔwɔla sue siwo le míaƒe ŋutilã me ene. Wokpena ɖe atike bubuwo ƒe dɔwɔwɔ le míaƒe ŋutilã me ŋu, eye wonaa míaƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kabakaba. Ele abe ame aɖe si kpena ɖe mía ŋu míeɖua nuɖuɖu kabakaba ene.

Enzyme vovovo akpe geɖe le míaƒe ŋutilã me, eye wo dometɔ ɖesiaɖe wɔa dɔ aɖe koŋ. Kpɔɖeŋu ʋɛ aɖewoe nye esi:

• Le ʋu ƒe sisi me: Ekpena ɖe ʋu ƒe sisi ŋu.
• Nuɖuɖumeŋusẽ: Ekpena ɖe mía ŋu míeɖua nuɖuɖu siwo míeɖuna.
• Lãmetsiwo ƒe dɔwɔwɔ: Lãmetsiwo kpena ɖe ame ŋu le dɔwɔwɔ kple ʋuʋu me.
• Lãmetsiŋusẽ: Ekpena ɖe ahɔhɔ̃, aklã, kple lãmekawo ƒe dɔwɔwɔ ŋu.
• Yagbɔgbɔ ƒe ɖoɖo: Ekpena ɖe ame ŋu le gbɔgbɔ ƒe ɖoɖoa me.
• Aɖuɖɔtoe: Ekpena ɖe ame ŋu wòɖea gbeɖuɖɔ ɖa le ŋutilãa me.

Èkpɔa, enzymewo wɔa akpa vevi aɖe ale gbegbe le míaƒe ŋutilã me!

Amekae hiã enzyme marker dodokpɔ sia?

Susu geɖewo li siwo tae ɖɔkta ate ŋu aɖe gbe be woawɔ dodokpɔ sia ɖo. Wo dometɔ vevitɔwoe nye:

• Dodokpɔwo: Ɣeaɖewoɣi la, ne èyi ɖado wò ŋutilã kpɔ edziedzi la, woate ŋu awɔ dodokpɔ sia atsɔ akpɔe ɖa be ememe kuxi aɖeke le ŋuwò, ŋutinuwo ƒe gbegblẽ, alo lãmekawo ƒe ɖeɖiteameŋu hã, ne dzesi aɖeke mele ŋuwò o gɔ̃ hã.
• Be woakpɔ dɔlélea (Diagnosis):Ne dzesi aɖewo le ŋuwò la, dodokpɔ sia ate ŋu akpe ɖe ŋuwò nànya nenye be dɔléle aɖe koŋ gbɔe wòtso alo dzidɔ.
• Lé ŋku ɖe atikewɔwɔ ƒe dzidzedzekpɔkpɔ ŋu: Ne èle atike nom na dɔléle aɖe la, wowɔa enzyme dodokpɔ siawo hã be woakpɔe ɖa be atike la le dɔ wɔm nyuie alo le nu gblẽm le ŋutinu bubu ŋu hã.

Enzyme marker dodokpɔ ƒomevi kawoe li?

Ðɔktawo zãa enzyme marker dodokpɔ vovovowo tsɔ dea dzesi dɔléle vovovowo kple woƒe nɔnɔme. Wo dometɔ vevi aɖewoe nye esi:

• Dzitodzito me enzyme dodokpɔ: Esia léa ŋku ɖe dzitodzito me lãmeka ŋu be nu gblẽ le eŋu hã.
• Creatinine phosphokinase (CPK) isoenzymes dodokpɔ: Esia doa enzymewo abe `(CK-MB)` kple `(CK-MM)` kpɔna. Esia ate ŋu ade dzesi nusiwo gblẽ le lãmekawo ŋu, vevietɔ dzi kple lãmeka bubuwo hã.
• Aklã me enzyme dodokpɔ: Dodokpɔ sia dzidzea enzymewo abe `(ALT)`, `(AST)`, `(Alkaline phosphatase)`, `(GGT)`, kple `(5'-NT)` be woakpɔ aklã ƒe nɔnɔme ƒe susu.

Azɔ mina míalé ŋku ɖe ƒomevi siawo dometɔ ɖesiaɖe ŋu tsitotsito vie.

Nukae Nye Dzitodzito me Enzyme Dodokpɔ?

Zi geɖe la, wowɔa esia ne wosusu be dzidɔ le ame ŋu, alo be woatsɔ akpɔe ɖa be dzidɔ bubu aɖe gblẽ nu le dzitodzitoa ŋu hã. Wowɔa esia hã be woatsɔ akpɔ alesi dzia le dɔ wɔm le dzitodzito me dɔwɔwɔ aɖewo, abe dzitodzito me ʋuka siwo me ʋu sina tona (CABG) alo ʋukawo ƒe dɔwɔwɔ ene megbe.

Ne nane gblẽ le dzia me la, dzia ɖea protein si woyɔna be troponin (cTn) kple enzyme aɖe si woyɔna be creatine phosphokinase (CPK) ɖe ʋua me. Tsã la, creatine phosphokinase (CPK) ƒe agbɔsɔsɔe nye dodokpɔ vevitɔ si wozãna tsɔ dea dzesi dzidɔ. Gake fifia, ne èsusu be ɖewohĩ dzidɔ le ye ŋu la, zi geɖe la, ɖɔktawo wɔa troponin dodokpɔ tsɔ ɖoa ​​kpe dɔlélea dzi. Esia le alea elabena dzi me koe troponin enzyme la le. Esia tae wògblɔ nya aɖe koŋ ŋutɔ ɖo.

Troponin ƒe agbɔsɔsɔ si le ʋua me ate ŋu adze dzidziɖedzi gɔme le gaƒoƒo 12 me tso esime dzidɔ dze ame dzi. CPK ƒe agbɔsɔsɔ si dzi ɖe edzi hã ate ŋu afia nɔnɔme aɖe si woyɔna be dzitodzito me dɔléle, si nye ʋuka siwo naa ʋu yia dzia me ƒe xexe.

Zi geɖe la, troponin ƒe agbɔsɔsɔ le ʋu me nɔa ʋɛ ŋutɔ – anɔ abe 0.02 nanograms le mililita ɖeka me (0.02 ng/mL). Dzitodzito me dɔlékui sia ƒe agbɔsɔsɔ si dzi ɖe edzi le ʋu me fia be dzidɔ ate ŋu adzɔ. Zi alesi asixɔxɔa loloe la, zi nenemae nu gblẽ le dzia ŋui.

Esi wònye be enzyme ƒe agbɔsɔsɔ trɔna le dzidɔ me ta la, wò ɖɔkta ate ŋu aɖe gbe be woawɔ dodokpɔ geɖe atsɔ adzidze wò CPK kple troponin ƒe agbɔsɔsɔ le gaƒoƒo ʋɛ aɖewo ɖesiaɖe me.

Wò ɖɔkta ate ŋu adɔ be woado dzitodzito me dɔlékuiwo kpɔ ne dzesi siawo dometɔ aɖe le ŋuwò:

• Akɔtave
• Taɖuame
• Xeɖeɖe
• Fifia si gbɔ eme (Fifia geɖe / Hyperhidrosis) .
• Gbɔgbɔ kpui aɖe / Dyspnea

Nukae nye CPK Isoenzymes Dodokpɔ?

Dodokpɔ sia dia `(CPK)` ƒe agbɔsɔsɔ si kɔ. Esia fia be lãmekawo ƒe gbegblẽ dzɔ. Ne dɔléle alo abi gblẽ míaƒe lãmekawo (siwo dome dzi ƒe lãmeka hã le), ahɔhɔ̃, kple lãkusiwo me la, `(CPK)` isoenzyme siawo dona ɖe ʋua me. Isoenzymes nye enzyme ƒomevi siwo le ŋutinu alo lãkusi aɖewo koŋ ŋu.

Le kpɔɖeŋu me:

• Dzime-koŋ ƒe `(CK)` enye `CK-MB` .
• `(CK)` tɔxɛ si wozãna na ƒunukpeƒeŋusẽwo (abe abɔta ƒe lãmekawo ene) enye `CK-MM` .
• `(CK)` gbɔgblɔ dzro ko nye `(CK)` ƒe agbɔsɔsɔ bliboa si tso teƒe siawo katã.

Le wò dzesiwo, dɔléle si wokpɔ, alo afɔku siwo le ŋuwò nu la, wò ɖɔkta ate ŋu aɖe gbe na isoenzyme dodokpɔ sia (CPK) be wòalé ŋku ɖe nɔnɔme aɖewo abe:

• Dzidɔ
• Gbagbãdᴐ
• Ahɔhɔ̃ me dɔdzẽ
• Muscular dystrophy (dɔléle si nana lãmekawo gbɔdzɔna) .
• Dermatomyositis (dɔléle si le ŋutigbalẽ kple lãmekawo ŋu) .
• Inclusion body myositis (dɔléle si nana lãmekawo gbɔdzɔna) .
• Polymyositis (lãmekawo ƒe dɔléle) .
• Malignant hyperthermia (nɔnɔme si me ame xɔa asrã sesẽ le le atike si wua alɔ̃dɔdɔ ta le amekoko me) .

Nukae Nye Aklã me Enzyme Dodokpɔ?

Ne dɔléle alo abi aɖe gblẽ nu le míaƒe aklã ŋu la, aklãa ɖea enzyme vovovowo ɖe ʋua me. Enzyme siawo dometɔ eve siwo wonya nyuie wue nye alanine aminotransferase (ALT) kple aspartate aminotransferase (AST). Aklã me koŋue wowɔa enzyme si nye ALT. Wowɔa aspartate aminotransferase (AST) le aklã, dzi, ayiku, ahɔhɔ̃, kple lãmekawo me.

Aklã me enzyme dodokpɔ dia enzyme siawo ƒe agbɔsɔsɔ si dzi ɖe edzi. Ne wodo wo ɖe dzi la, ate ŋu atso nɔnɔme aɖe abe:

• Ʋuka si me ʋu sina tona si xe
• Celiac dɔléle (si nye gluten ƒe nulɔdɔ) .
• Aklã ƒe ʋuka me dɔléle
• Aklãdɔ si me ami le alo aklãdɔ si do ƒome kple ahanono
• Hemochromatosis (iron si sɔ gbɔ ɖe ʋu me) .
• Aklãdɔléle A, aklãdɔléle B kple aklãdɔléle C
• Aklã me dɔdzẽ
• Mononucleosis (dɔléle si nana lãkusiwo vuvu) .
• Wilson ƒe dɔléle (akɔbli si sɔ gbɔ ɖe ƒu me) .

Ðo ŋku edzi be enzyme ƒe agbɔsɔsɔ si dzi ɖe edzi ɖeɖe mefia kokoko be dɔléle aɖe le ŋuwò o. Wò ɖɔkta atsɔ esiawo asɔ kple wò dzesiwo kple dodokpɔ bubuwo me tsonu be wòaƒo nya ta.

Aleke wòle be madzra ɖo ɖe enzyme marker dodokpɔ ŋu?

Ne èle ʋudodokpɔ ge la, nu ʋɛ siawo léle ɖe susu me ate ŋu ana dɔa nanɔ bɔbɔe wu:

• No tsi geɖe: No tsi geɖe hafi nàna ʋu. Esia akpe ɖe ʋua ŋu be wòato ʋukaawo me nyuie wu, si ana wòanɔ bɔbɔe be woaƒo ʋu nu ƒu.
• Ƒo asa na nicotine: Ne ènoa atama (si me vaping hã le) la, ƒo asa nɛ hafi nàdo ʋu. Nicotine nana ʋukawo xana, si wɔnɛ be esesẽna be woaɖe ʋu tso ʋuka si xaxa me.
• Gblɔe na mí ne èle vɔvɔ̃m: Ne vɔvɔ̃ le ŋuwò na aŋe (Trypanophobia) alo vɔvɔ̃ na ʋukpɔkpɔ (Hemophobia) la, gblɔe na wò ɖɔkta alo amesi le wò ʋu hem do ŋgɔ. Woate ŋu akpe ɖe ŋuwò be wò ʋuɖeɖe ƒe ɖoɖoa naɖe dzi ɖi wu.

Ðe wòhiã be matsi nu adɔ hafi woawɔ enzyme marker dodokpɔa?

Wò ɖɔkta agblɔ na wò nenye be ehiã be nàtsi nu adɔ (negbe tsi koe mele eme o). Zi geɖe la, mehiã be nàwɔe o. Vevietɔ esi wònye be wowɔa dzitodzito me enzyme dodokpɔwo le nɔnɔme kpata aɖe me, abe dzidɔ ene ta la, womakpɔ mɔ be nàtsi nu adɔ le ɣeyiɣi ma me o.

Nukae dzɔna ne wowɔ enzyme marker dodokpɔ?

Ʋudodokpɔ bɔbɔe aɖe ŋutɔ koe nye esia. Le wò nɔnɔmea nu la, woate ŋu awɔ dodokpɔ sia le ɖɔkta ƒe dɔwɔƒe, ʋudodokpɔƒe, alo kɔdzi. Phlebotomist (ame si wona hehee etɔxɛe be wòaɖe ʋu) alo lãmesẽdɔwɔla bubu aɖe wò ʋu. Aɖabaƒoƒo ʋɛ aɖewo koe dɔ sia xɔa.

Nukae wòle be makpɔ mɔ na le enzyme marker dodokpɔ vɔ megbe?

Anyo wu be nàna aŋɔa nanɔ teƒe si woɖe ʋua le abe gaƒoƒo eve va ɖo ene ene be dɔlékuiwo xɔxɔ ƒe afɔkua dzi naɖe akpɔtɔ. Teƒe si wotsɔ aŋea de la ate ŋu avuvu vie eye wòaƒoe. Esia nu ayi le ŋkeke ʋee aɖewo megbe.

Àte ŋu aɖe abi alo vevesese dzi akpɔtɔ ne èwɔ nusiawo:

• Xatsa tsikpegoe aɖe ɖe avɔ kakɛ aɖe me eye nàtsɔe aɖo aŋɔa tame.
• No vevesesenutsitike si womeƒlena o.
• Mègakɔ kpekpemewo alo awɔ kamedede sesẽ gaƒoƒo 24 le ʋudodo vɔ megbe o.

Afɔku kawoe le enzyme marker dodokpɔ me?

Ʋudodokpɔ nye dɔ siwo me afɔku mele boo o. Ame aɖewo ate ŋu akpɔ ʋu ƒe sisi (hypotension) ne woɖe ʋu le wo me. Esia ate ŋu ana nàse le ɖokuiwò me be yeƒe ta natsi alo yeƒe lãme nasẽ. Ne èse le ɖokuiwò me be yeƒe lãme mekɔ o alo yeƒe lãme gbã la, gblɔe na wò ɖɔkta alo amesi le ʋua nom enumake. Woate ŋu akpe ɖe ŋuwò to nana be nàmlɔ anyi alo awɔ nu bubuwo me.

Ɣekaɣie maxɔ dodokpɔa me tsonu?

Le kpɔɖeŋu me, le nɔnɔme kpata aɖe me ne wosusu be dzidɔ le ame ŋu la, emetsonuwo dzena kaba ŋutɔ. Ne menye nenema o la, ate ŋu axɔ ŋkeke geɖe hafi ɖɔktaa naxɔ dodokpɔa me tsonuawo tso dodokpɔxɔa me.

Wò ɖɔkta adzro emetsonuwo me kpli wò. Ðewohĩ ahiã be nàwɔ dodokpɔ geɖe wu be nànya kuxi aɖe koŋ alo akpɔ egbɔ be kuxi aɖeke mele eŋu o. Le kuxia ƒe nɔnɔme nu la, àte ŋu awɔ enzyme marker dodokpɔ geɖe le gaƒoƒo alo ŋkeke aɖewo me.

Nukae wòle be mabia nye ɖɔkta?

Àte ŋu abia ɖɔktaa nya siawo abe esiawo ene:

• Nukatae wòhiã be mawɔ enzyme marker dodokpɔ sia?
• Ðe wòhiã be matsi nu adɔ, adzudzɔ atamanono, alo adzudzɔ atikewo nono hafi woawɔ dodokpɔa?
• Ɣekaɣie maxɔ dodokpɔa me tsonu?
• Ðe wòle be matsi dzi ɖe dodokpɔa me tsonu ŋua?
• Ðe wòahiã be mawɔ dodokpɔ bubuwoa?
• Zi nenie wòahiã be woawɔ enzyme marker dodokpɔ sia?

Mlɔeba la, nusi dzi nàɖo ŋkui (Take-Home Message) .

Enzyme marker dodokpɔ nye dodokpɔ si naa nyatakaka veviwo ku ɖe míaƒe ŋutinuwo ƒe dɔwɔwɔ, dɔlélewo ƒe nɔnɔme, kple atikewɔwɔ ŋu. Ne dzesi aɖewo le ŋuwò la, ɖɔkta ate ŋu aɖe gbe na dodokpɔ sia be woatsɔ anya dɔléle aɖe alo atsɔ aɖo kpe edzi be dɔléle ma tɔgbe aɖeke meli o.

Dzitodzito me dɔlékuiwo dodokpɔ tsɔ daa nusiwo gblẽ le dzia ŋu le dzidɔ megbe ŋu. Phosphokinase (CPK) dodokpɔ aɖe dia dɔléle siwo do ƒome kple lãmekawo. Aklã me enzyme dodokpɔ aɖe daa aklã ƒe dɔwɔwɔ kpɔna. Bia wò ɖɔkta nya alo dzimaɖitsitsi ɖe sia ɖe si ate ŋu anɔ ŋuwò ku ɖe dodokpɔ sia alo eƒe emetsonuwo ŋu. Mègatsi dzi o, wò ɖɔkta le afima be yeakpe ɖe ŋuwò.

` Enzymes, enzyme dodokpɔ, ʋu dodokpɔ, dzidɔ, aklãdɔ, lãmekawo ƒe dɔléle, dɔléle didi