Mina míasrɔ̃ nu tso kalẽtɔ sue eve siwo tua míaƒe ƒunukpeƒe ŋu ko: Osteoblasts kple Osteoclasts!

Èbu wò ƒuwo ŋu kpɔa? Zi geɖe la, míebua wo be wonye nu sesẽ siwo metrɔna o. Gake menye nenemae o. Míaƒe ƒuwo nye lãmenugbagbevi gbagbewo , abe míaƒe ŋutilã mamlɛawo ene. Ðewohĩ màsusui nenema o, gake wole tsitsim ɣesiaɣi, le gbagbãm, eye wole wo ɖɔlim, menye tso ɖevime va se ɖe tsitsime ko o, ke le míaƒe agbemeŋkekewo katã me! Lãmenugbagbevi ƒomevi vevi eve siwo kpena ɖe dɔ wɔnuku sia ŋu la woyɔna be `Osteoblasts` kple `Osteoclasts`. Mina míaƒo nu tso ame eve siawo ŋu vie egbea, alo?

Amekawoe nye `Osteoblasts`? Nukae wowɔna?

Kpuie ko la, `Osteoblasts` nye "Mason Jars" siwo tua míaƒe ƒuwo. Ɣeaɖewoɣi la, wogayɔa wo be `osteogenic cells`. Woawoe doa ŋusẽ míaƒe ƒuwo, eye woawoe wɔa ƒu yeyewo. Dɔ vevi etɔ̃ le `Osteoblasts` si:

• Ƒu yeyewo tutu ( ƒu ƒe wɔwɔme).
• Ne míele tsitsim, si fia be ne míele tsitsim tso ɖevime va ɖo tsitsime la, míaƒe ƒuwo trɔna be woasɔ ɖe míaƒe ŋutilã ƒe nɔnɔme nu, si nye nuwɔna si woyɔna be `remodeling`.
• Ƒuwo ƒe dɔyɔyɔ ne wogbã, wogbã, alo woxɔ abi .

Bu eŋu kpɔ, ne ehiã be míaƒe ƒu ɖeka natsi, atrɔ le mɔ aɖe nu, alo ahaya le eƒe gbagbã megbe la, atike vovovo siwo le míaƒe ŋutilã me, alo `lãmetsiŋusẽwo` ʋãa `Osteoblasts` lãmenugbagbevi siawo. Emegbe `Osteoblasts` lãmenugbagbevi siawo va ƒoa ƒu eye wowɔa tsakatsaka tɔxɛ aɖe si woyɔna be `bone matrix` eye woɖea wo ɖe go. `Ƒe ƒe ƒuƒoƒo` sia nye `proteins` abe `collagen` kple `calcium` kple `phosphate`, siwo nye mineral vevi ŋutɔ na míaƒe ƒuwo. Dɔ sia le abe amesi kɔa `kɔnkrit` ne ele mɔ tum ene. Ate ŋu atu mɔ yeye aɖe ŋutɔ. Alo ate ŋu azã `kɔnkrit` ma ke atsɔ akɔ mɔ xoxo aɖe ƒe gbagbãƒewo kple gbagbãƒewo. Nenema ke `Osteoblasts`, `Masons`, zãa `bone matrix` `concrete` sia tsɔ tua ƒu yeyewo, doa ŋusẽ xoxowo, eye wodaa gbe le esiwo gbã ŋu. Ne wotu ƒu ƒe lãkusi yeyea alea vɔ la, `Osteoblasts` lãmenugbagbevi aɖewo va zua ƒu yeye ma ƒe akpa aɖe. Emegbe woyɔa wo be `Osteocytes` . Ne menye nenema o la, ne woƒe subɔsubɔdɔwo megahiã o la, lãmenugbagbevi mawo kuna.

Mina míasrɔ̃ nu vi aɖe tso esiwo woyɔna be `Osteocytes` ŋua?

Ƒumeŋuɖuiwo le abe "dedienɔnɔdzikpɔlawo" siwo le míaƒe ƒuwo me ene.Di. Míaƒe ƒuwo ƒe akpa gãtɔ nye `Osteocytes` lãmenugbagbevi siawo. Wole ŋku lém ɖe nyaƒoɖeamenu alo nyaƒoɖeamenu si ƒomevi wole wɔwɔm ɖe míaƒe ƒuwo ŋu la ŋu ɣesiaɣi. Ne míezɔ, ƒu du, alo kɔ nane ɖe dzi la, ne ŋusẽkpɔɖeamedzi gã aɖe le eŋu abe ƒu ƒe gbagbã ene hã la, `Osteocytes` siawo senɛ le wo ɖokui me. Ɣemaɣi la, woawoe ɖoa dzesiwo ɖe `Osteoblasts` (amesiwo tua) kple `Osteoclasts` (amesiwo gbãna - míaƒo nu tso eŋu emegbe) siaa gblɔna be, "Kuxi aɖee nye esi, va ɖɔe ɖo." Le kpɔɖeŋu me, ne ƒu aɖe gbã alo gbã la, `Osteocytes` ye nye esiwo hea lãmenugbagbevi bubuwo vaa teƒea kabakaba, ɖea kakɛ siwo gbã la ɖa, eye wokpena ɖe ƒu yeye tutu ŋu eye wòdaa gbe le eŋu.

Eyata lãmenugbagbevi ka ƒomevie nye `Osteoclasts`?

Osteoclasts nye "klɔƒedɔwɔla" si tsɔa lãmenugbagbevi xoxo siwo gblẽ le míaƒe ƒuwo me heɖea wo ɖa . Ele abe xɔgbagbã ƒe dɔwɔlawo ene. Woawoe ʋua mɔ na ƒumeŋuɖuiwo be woatu ƒu yeyewo.

Mɔ bɔbɔe aɖe si dzi nàto aɖo ŋku edzi enye: `Blasts` le abe `Builders`, `Clasts` le abe `Cleaners` ene.

Ƒumeŋuɖuiwo ɖea enzyme tɔxɛwo ɖe go. Enzyme siawo lɔ̃a ƒu xoxo eye wogbãnɛ. Wonana atikewo wɔa dɔ ɖe ƒu ƒe lãkusi xoxowo ƒe anyime, si wɔnɛ be kakɛ mawo ʋẽna eye wònaa mɔnukpɔkpɔ lãmenugbagbevi yeye siwo ŋu ŋusẽ le wu be woawɔ. Gake ne ƒumeŋuɖuiwo ƒo ƒuwo la, mele abe acid ɖua ga kakɛ aɖe abe alesi wòle le nutata me ene o. Wokpɔa ɖoɖo sia dzi ŋutɔ eye wòwɔa nu pɛpɛpɛ . Teƒe siwo ƒumeŋuɖui siwo míeyɔ va yi (dedienɔnɔdzikpɔlawo) de dzesii be "afisiae wòle be míaɖee le" koe ƒumeŋuɖuiwo lɔ̃na. Enzyme siwo ƒumeŋuɖuiwo ɖena ɖe go la gbãa ƒu sesẽa eye wogaxɔa emenuwo ake. Emegbe, do suesuesuewo dona ɖe ƒua tame. Ne do mawo nya do ko la, ``Osteoblasts`` (xɔtulawo) gena ɖe eme eye wotsɔa ƒu yeye yɔa doawo me. Ele abe ƒuƒoƒo ƒe agbagbadzedze ene!

Aleke `Osteoblasts` kple `Osteoclasts` lãmenugbagbevi siawo le?

Lãmenugbagbevi siawo evea siaa le sue ŋutɔ eye wole míaƒe ƒuwo ƒe gotagome nutsyɔnu (`ƒu ƒe ƒuƒoƒo`) kple ƒuawo ŋutɔ me.

• Zi geɖe la, ƒumeŋuɖui nyea lãmenugbagbevi sue siwo ƒe nɔnɔme le abe kubi ene.
• Ƒumeŋuɖuiwo lolo vie wu ƒumelãmenugbagbeviwo. Woƒe nɔnɔme le abe dome ene, eye woƒe nɔnɔme le abe dome ene.

Dɔléle kawoe bɔ siwo gblẽa nu le lãmenugbagbevi siawo ƒe dɔwɔwɔ ŋu?

Osteoblasts kple osteoclasts nye míaƒe ƒuwo ƒe akpa vevi eve ŋutɔ. Eyata, dɔléle ɖesiaɖe si adze míaƒe ƒuwo dzi ate ŋu agblẽ nu le lãmenugbagbevi siawo ƒe dɔwɔwɔ hã ŋu. Kuxi vevi siwo xea mɔ na míaƒe ƒuwo be womegatu ŋusẽ ɖo helé wo me ɖe asi o dometɔ aɖewoe nye esi:

• Ƒumeŋuɖui - Esia nye ne ƒuwo va le tsɛ, wogbɔdzɔ, eye wogbãna bɔbɔe.
• Ƒumeŋuɖui - Esia nye ƒumeŋuɖui ƒe ŋgɔdonya. Ƒuawo ƒe kpekpeme dzea egɔme nɔa ɖeɖem kpɔtɔ.
• Hyperparathyroidism - Lãmetsiŋusẽwo wɔwɔ fũu akpa to parathyroid glands dzi, si wɔnɛ be calcium buna le ƒuwo me.
• `Paget ƒe ƒu ƒe dɔléle (osteitis deformans)` - Le esia me la, ƒu ɖɔɖɔɖo ƒe ɖoɖoa me gblẽna, eye ƒuawo ateŋu agbɔdzɔ eye woazu nuwɔametɔwo.

Ðe dodokpɔ tɔxɛ aɖewo li woatsɔ anya nu tso lãmenugbagbevi siawo ŋua?

Zi geɖe la, womewɔa dodokpɔ aɖeke koŋ be woatsɔ akpɔ alesi wò ƒumeŋuɖui alo ƒumeŋuɖui le dɔ wɔm nyuie o. Zi geɖe la, ɖɔktawo doa ƒu bliboa ƒe lãmesẽ kpɔna, tsɔ wu be woalé ŋku ɖe lãmenugbagbevi aɖewo koŋ ŋu. Gake ɣeaɖewoɣi la, woate ŋu awɔ ʋudodokpɔwo (dɔdaƒewo) atsɔ akpɔ alesi wò ƒumeŋuɖuiwo le dɔ wɔm nyuie alo akpe ɖe ŋuwò nànya dɔléle aɖe abe ƒumeŋuɖui ene. Dodokpɔ siwo bɔ tsɔ léa ŋku ɖe wò ƒuwo ƒe lãmesẽ ŋu dometɔ aɖewoe nye esi:

• Ƒu ƒe kpekpeme dodokpɔ (DXA scan) : Esia zãa X-ray siwo mebɔ o tsɔ dzidzea alesi wò ƒuwo sesẽe. Ate ŋu akpe ɖe ŋuwò nànya ne wò ƒuwo le ƒuƒum ne èle tsitsim, alo ne ƒumeŋuɖui alo ƒumeŋuɖui ƒe dzesiwo le ŋuwò.
• Vitamin D dodokpɔ (` Vitamin D 25-hydroxy dodokpɔ`) : Ekpɔnɛ ɖa be èle `Vitamin D` xɔm wòsɔ gbɔ hã.
• Calcium dodokpɔ : Esia léa ŋku ɖe calcium ƒe agbɔsɔsɔ si le wò ʋu me ŋu, eye ate ŋu akpɔ calcium agbɔsɔsɔme si le wò aɖuɖɔ si nèzãna gaƒoƒo 24 me hã.
• `Intact parathyroid hormone (IPTH)` dodokpɔ : Eléa ŋku ɖe parathyroid lãmetsi ƒe agbɔsɔsɔ ŋu.
• Creatinine dodokpɔ : Esia léa ŋku ɖe wò ayikuwo le dɔ wɔm nyuie hã.

Nukae wòle be míawɔ be míaƒe ƒuwo nanɔ lãmesẽ me?

Nu geɖe li nàte ŋu awɔ be wò ƒuwo nanɔ lãmesẽ me ahasẽ ŋu. Nu siwo nàte ŋu awɔ dometɔ aɖewoe nye esi:

• Ƒo nuɖuɖu nyui si me nunyiame le , vevietɔ nuɖuɖu siwo me calcium kple vitamin D sɔ gbɔ ɖo.
• Wɔ kamedede si tsɔa kpekpeme . Eyae nye kamedede si naa agba na wò ƒuwo, abe azɔlizɔzɔ , duƒuƒu, kple atrakpuiwo lialia ene.
• Ƒo asa na atamanono keŋkeŋ . Sigaretnono gblẽa nu le ƒuwo ŋu ŋutɔ.
• Na calcium kple vitamin D nasu asiwò.Kpɔ nyuie nenye be èle nu ɖum. Ne ehiã la, no atike siwo kpena ɖe ame ŋu le atikewɔlawo ƒe aɖaŋuɖoɖo te.
• Di atikewɔlawo ƒe dodokpɔ edziedzi . Ne èse le ɖokuiwò me be dɔléle alo tɔtrɔ aɖe le ye ŋu la, yi ɖɔkta gbɔ enumake.

Vovototo kae le `Osteoblasts` kple `Osteocytes` dome?

`Osteoblasts` kple `Osteocytes` siaa nye lãmenugbagbevi siwo kpena ɖe míaƒe ƒuwo tutuɖo kple wo dzi kpɔkpɔ ŋu. Gake vovototo sue aɖe le wo dome.

• Ƒumeŋuɖuiwoe nye lãmenugbagbevi siwo tua ƒu yeye, tsia ƒu si li xoxo, eye wodzranɛ ɖo. Woawoe ɖea asi le ƒu ƒe ƒuƒoƒo ŋu eye wotua lãkusi yeyewo ɖo.
• Ƒumeŋuɖui nye lãmenugbagbevi siwo le ƒu ƒe lãkusi tsitsiwo me . Woawoe dea dzesi nyaƒoɖeamenu kple nuteɖeamedzi si le ƒuwo dzi eye woɖoa dzesiwo ɖe ƒumeŋuɖuiwo kple ƒumeŋuɖuiwo, gblɔna be, "Kuxi aɖe le afisia, ehiã be woaɖɔe ɖo."

Mlɔeba la, nusi dzi nàɖo ŋkui (Take-Home Message) .

Fifia èse alesi lãmenugbagbevi sue eve siawo siwo woyɔna be `Osteoblasts` kple `Osteoclasts` kpɔa ŋusẽ gã aɖe ɖe míaƒe ƒuwo ƒe lãmesẽ dzii gɔme. Wowɔa dɔ ɖekae ɣesiaɣi, wokpena ɖe míaƒe ƒuwo ŋu wotsina, wozua yeye, eye wosẽna. Abe kalẽtɔ siwo womedzi ha na o ene.

Ele vevie ŋutɔ na amesiwo xɔ wu ƒe 65, nyɔnu siwo to dzinukpɔkpɔ me, kple amesiwo ŋu atikewɔwɔ me dɔléle siwo nɔa anyi didi le be woadi atikewɔlawo ƒe aɖaŋuɖoɖo ahado wo kpɔ le atikewɔƒe edziedzi. Esia wɔnɛ be ɖɔktawo te ŋu léa ŋku ɖe wò ƒu ƒe lãmesẽ ŋu eye wokpɔa ƒu ƒe gbagbã alo ƒumeŋuɖui ƒe dzesiwo kaba.

Eyata, lé be na wò ƒuwo hã. Nuɖuɖu nyuie, kamedede, kple agbenɔnɔ si me lãmesẽ le ye nye nu vevitɔwo kekeake!