Ðe míaƒo nu tso ʋumenugbagbeviɣidɔ sesẽ sia, si nye Acute Myeloid Leukemia (AML) ŋua?

Ðe vuvɔ le ŋuwò si medzona le ŋkeke ʋɛ aɖewo megbe oa? Alo ɖe ɖeko nèsena le ɖokuiwò me be ɖeɖi te ye ŋu eye yeƒe lãme gbɔdzɔa? Ɣeaɖewoɣi la, nu suesuesuewo abe esia ene ate ŋu anɔ nu gã aɖe ɣlam. Egbea míele nu ƒom tso dɔléle aɖe si nu sẽ vie ŋu, gake ele vevie ŋutɔ be míanɔ ŋudzɔ. Emae nye ʋumenugbagbeviɣidɔ sesẽ, alo AML kpuie.

Nukae nye AML?

Kpuie ko la, Acute Myeloid Leukemia (AML) nye kansa ƒomevi aɖe si gblẽa nu le wò ƒumeŋuɖui kple ʋu ŋu. Enye dɔléle si mebɔ o gake nu sẽ ŋutɔ. Zi geɖe la, wò domenyiŋusẽfianu alo domenyiŋusẽfianu ƒe tɔtrɔ aɖe gbɔe wòtsona. Ebɔ ɖe amesiwo xɔ wu ƒe 60. Gake ate ŋu adze sɔhɛwo kple ɖeviwo hã dzi. AML nye kansa si le kakam kabakaba, si dea ame ƒe agbe afɔku me. Dzɔgbenyuietɔe la, dɔdamɔnu yeyewo na ame geɖe te ŋu nɔa agbe didi wu kple dɔlélea.

Ðe AML ƒomevi vovovowo lia?

Ẽ, AML ƒe hatsotso sue vovovo geɖe li. Nu siawo ƒomevi ɖesiaɖe kpɔa ŋusẽ ɖe lãmenugbagbevi siwo le wò ʋu me ƒe xexlẽme dzi. Gake ƒomevi ɖesiaɖe ate ŋu ahe dzesi vovovowo vɛ eye wòawɔ nu ɖe ​​atikewɔwɔ ŋu le mɔ vovovowo nu.

Ðɔktawo dea dzesi AML ƒe hatsotso sue siawo to kansa lãmenugbagbeviwo me dzodzro le nusuekpɔmɔ̃ me. Wodia tɔtrɔ siwo va le wò domenyiŋusẽfianu me kple domenyiŋusẽfianu aɖewo siwo kpɔa lãmenugbagbeviwo ƒe tsitsi dzi ƒe tɔtrɔwo hã.

AML ƒe hatsotso sue vevi aɖewoe nye esi:

• Myeloid leukemia: Esiae nye AML ƒomevi si bɔ wu. Edzɔna abe lãmenugbagbevi siwo wɔa neutrophils, si nye ʋumenugbagbevi ɣi ƒomevi aɖe, ƒe kansa ene.
• Acute monocytic leukemia (AML-M5): Esia dzɔna le lãmenugbagbevi siwo wɔa ʋumenugbagbevi ɣi ƒomevi aɖe si woyɔna be monocytes me.
• Acute megakaryocytic leukemia (AMLK): Esia nye lãmenugbagbevi siwo wɔa ʋumenugbagbevi dzĩwo alo ʋumenugbagbevi dzĩwo ƒe kansa.
• Acute promyelocytic leukemia (APL): Le esia me la, ʋumenugbagbevi ɣi ƒomevi aɖe si metsi o si woyɔna be promyelocytes metsina nyuie o eye wòzua kansa lãmenugbagbeviwo.

Aleke gbegbee AML bɔe?

Le nyateƒe me la, AML nye dɔléle si mebɔ kura o. Le mama dedie nu la, ame tsitsi siwo ade 4 le 100,000 ɖesiaɖe me xɔa dɔlélea ƒe sia ƒe. Azɔ hã, woka nya ta be wokpɔa AML le ɖevi siwo ade 1,160 ŋu ƒe sia ƒe.

Nukawoe nye AML ƒe dzesiwo?

Le gɔmedzedzea me la, AML ƒe dzesiwo ate ŋu ase le ɖokuiwò me abe dzamezã vɔ̃ɖi alo dzamezã si le edzi yim ŋkeke ʋɛ aɖewoe nye esia ene. Gake AML nye kansa si nu sẽ ŋutɔ. Ema fia be, .Eteƒe madidi o àdze dzesi yeye siwo dzena wu la kpɔkpɔ gɔme. Emegbe la, àte ŋu ade dzesi dzesiwo abe:

• Taɖuame ƒe seselelãme ɣesiaɣi.
• Nuwo abe aɖuɖɔɖɔɖɔ bɔbɔe, ʋu si dona le ŋɔti me enuenu, kple ʋu si dona le aɖuwo me ne èle aɖu tutum ene.
• Ðeɖiteameŋu si womate ŋu ado dzi atsɔ o ƒe seselelãme.
• Vuvɔ ƒe seselelãme.
• Asrã.
• Zã me fifia.
• Dɔlékuiwo xɔa ame enuenu, alo dɔlékui siwo dzɔna xɔa ɣeyiɣi didi hafi wohayana.
• Taɖuame.
• Nuɖuɖua mevivina o.
• Be woanye ame tsɛ le susu aɖeke manɔmee.
• Ŋutilã si ƒe ŋutigbalẽ le ɣie.
• Yagbɔgbɔ sesẽ (gbɔgbɔtsixetsixe).
• Lãmetsiŋusẽ ƒe ʋuka siwo vuvu.
• Gbɔdzɔgbɔdzɔ ƒe seselelãme.
• Vevesese le ƒuwo, akɔta, alo dɔgbo me.
• Teƒe dzĩ suesuesue siwo le ŋutigbalẽa ŋu (petechiae).
• Abi xɔa ɣeyiɣi hafi wohaya.

Nukawoe hea AML vɛ?

Eŋutinunyalawo menya nusi tututu hea AML vɛ haɖe o. Gake wonyae be nɔnɔmea dzɔna ne domenyiŋusẽfianu alo domenyiŋusẽfianu aɖewo siwo le míaƒe ŋutilã me trɔ (trɔ, si na ʋumenugbagbevi siwo mesɔ o va dzɔ. Domenyiŋusẽfianu ƒe tɔtrɔ siawo ate ŋu anye:

• Nane kpɔ ŋusẽ ɖe wò DNA dzi le wò agbenɔɣi.
• Ne domenyiŋusẽfianu ƒe dɔléle aɖe le ŋuwò si toa dzidzimewo me eye wònaa afɔku si le asiwò be nàxɔ AML dzina ɖe edzi.
• Le tɔtrɔ si va le domenyiŋusẽfianu aɖewo me le dziwòlawo ƒe tsinyenye alo aziwo me ta.

Aleke domenyiŋusẽfianu ƒe tɔtrɔwo hea AML vɛ?

Be nàse alesi domenyiŋusẽfianu ƒe tɔtrɔ siawo ate ŋu ana nàxɔ AML gɔme la, anyo be nànya nu vi aɖe tso wò ƒumeŋuɖui kple ʋumenugbagbevi dzĩwo ŋu. Wò ƒumeŋuɖui nye lãkusi falɛfalɛ si le abe ƒumeŋuɖui ene si le wò ƒu akpa gãtɔ titina. Wowɔe tso:

• Wowɔa lãmenugbagbeviwo. Esiawoe nye lãmenugbagbevi siwo va zua ʋumenugbagbevi dzĩwo emegbe siwo tsɔa ɔksidzin, ʋumenugbagbevi ɣi siwo kpɔa ame ta tso dɔlékuiwo xɔxɔ me, kple ʋumenugbagbevi dzĩ siwo kpena ɖe ʋu ƒe sisi ŋu.

Zi geɖe la, wò ƒumeŋuɖui wɔa dɔ abe nusi wɔa dɔ nyuie ene, si wɔnɛ be ʋumenugbagbevi dzĩwo kple ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ si sɔ pɛpɛpɛ na wò ŋutilã. Gake le amesi ŋu AML le gome la, ƒumeŋuɖui dzea lãmenugbagbevi siwo mesɔ o siwo woyɔna be myeloid blasts alo myeloblasts wɔwɔ gɔme.

Myeloid blast cell siawo mewɔa nu abe ʋumenugbagbevi siwo sɔ ene o. Lãmenugbagbevi siwo sɔ la xɔa mɔfiame tso woƒe domenyiŋusẽfianuwo gbɔ ku ɖe ɣeyiɣi kple alesi wòle be woama ahatsi kabakabae ŋu. Ne lãmenugbagbeviawo tsi la, wokuna be woaɖe teƒe na lãmenugbagbevi yeyewo le ƒumeŋuɖui me. Gake myeloid blast cells mewɔna ɖe mɔfiame siawo dzi o. Womãna le wo ɖokui si womate ŋu aɖu wo dzi o eye womekunana o. Esi myeloid blast cells yi edzi le ƒumeŋuɖui me yɔm ta la, teƒe aɖeke megali na ʋumenugbagbevi siwo le lãmesẽ me o. Esi teƒe aɖeke meli o ta la, ƒumeŋuɖui la dzudzɔa ʋumenugbagbevi siwo le lãmesẽ me wɔwɔ. Ne ʋumenugbagbevi yeye siwo le lãmesẽ me meli o la, ŋutilãa mekpɔa nusiwo wòhiã be wòate ŋu awɔ dɔ nyuie o.

Gakpe ɖe eŋu la, ne myeloid blast cell siawo yi edzi le mamam la, wodona le ƒumeŋuɖui me yia ʋukawo me. Ne lãmenugbagbevi siawo nya ge ɖe ʋua me ko la, wozɔa mɔ yia ŋutilãa ƒe akpa bubuwo, siwo dometɔ aɖewoe nye wò lãmekawo, ahɔhɔ̃, kple aklã.

Nukawoe nye afɔku siwo ate ŋu ana ame naxɔ AML?

Togbɔ be eŋutinunyalawo menya nusi tututu hea domenyiŋusẽfianu ƒe tɔtrɔ siwo hea AML vɛ o hã la, wonya nu aɖewo (afɔku siwo nana dɔlélea xɔxɔ ƒe afɔkua dzina ɖe edzi. (Ne míebu afɔkuwo ŋu la, ele vevie be míaɖo ŋku edzi be ne afɔku aɖe le asiwò la, mefia be dɔlélea axɔ wò o. ) Nusiwo ate ŋu ana nàxɔ AML dometɔ aɖewoe nye:

• Ƒe si woxɔ: Ame siwo xɔ AML la dometɔ siwo ade afã xɔ ƒe 65 alo esi wu nenema ne wokpɔ dɔlélea. Gake abe alesi míegblɔe va yi ene la, AML dzɔna zi geɖe le ame tsitsiwo me, gake ate ŋu adzɔ le ɖeviwo hã gome.
• Sigaretnono: Esia lɔ dzudzɔ si wozãna tsã la gbɔgbɔ ɖe eme.
• Kansa dada: Nuwo abe atikewɔmɔnu kple keklẽŋusẽdɔdamɔnu ene.
• Atike aɖewo siwo hea kansa vɛ zazã ɣeyiɣi didi: Kpɔɖeŋu aɖewoe nye nusiwo le abe benzene kple formaldehyde ene.
• Kekeli gbogbo siwo dona tso nukliaʋawɔnu ƒe afɔku alo atɔm bɔmb me.
• Domenyiŋusẽ ƒe dɔléle aɖewo siwo ƒe dome wonyi.
• Ƒumeŋuɖui ƒe dɔléle bubuwo.

Domenyiŋusẽfianu kawoe dzia AML xɔxɔ ƒe afɔkua ɖe edzi?

Numekulawo kpɔe be domenyiŋusẽfianu ƒe tɔtrɔ aɖewo siwo ƒe dome míenyi la dzia afɔku si le AML xɔxɔ me ɖe edzi. Esiawo dometɔ aɖewoe nye:

• Down ƒe dɔléle si nye Down syndrome
• Ataxia telangiectasia ƒe dɔléle
• Li-Fraumeni ƒe dɔlélea
• Klinefelter ƒe dɔlélea
• Fanconi ʋusɔgbɔdɔ
• Wiskott-Aldrich ƒe dɔléle - Esia gblẽa nu le ʋumenugbagbevi dzĩwo ƒe wɔwɔme ŋu.
• Bloom ƒe dɔléle si woyɔna be Bloom syndrome
• Ƒome ƒe Ʋumenugbagbeviɣidɔ - Esia hã nye dɔléle si do ƒome kple ʋumenugbagbeviɣidɔ.

Ƒumeŋuɖui ƒe dɔléle kawoe dzia AML xɔxɔ ƒe afɔkua ɖe edzi?

Ame aɖewo siwo ŋu myeloproliferative neoplasms, alo myeloproliferative disorders le ate ŋu axɔ ʋumenugbagbeviɣidɔ sesẽ aɖe. (Myelo gɔmee nye ƒumeŋuɖui. Proliferative fia be woatsi akpa.) Amesiwo ŋu dɔléle siawo le hã le afɔku gã aɖe me be woaxɔ AML:

• Polycythemia vera ƒe ʋumenugbagbeviɣidɔ
• Myelofibrosis ƒe dɔléle
• Ʋumenugbagbeviɣidɔ
• Myelodysplastic ƒe dɔléle si nye myelodysplastic ƒe dɔléle
• Aplastic ʋusɔgbɔdɔ

Nukawoe nye kuxi siwo ate ŋu ado tso AML me?

Le eƒe gɔmedzedze la, ʋumenugbagbeviɣidɔ sesẽ kpɔa ŋusẽ ɖe ʋumenugbagbevi dzĩwo, ʋumenugbagbevi ɣiwo, kple ʋumenugbagbevi dzĩ siwo le lãmesẽ me ƒe xexlẽme dzi le wò ŋutilã me. Ne ʋumenugbagbevi dzĩwo kple ʋumenugbagbevi dzĩwo mesɔ gbɔ na wò o la, àte ŋu ato nɔnɔme aɖewo abe:

• Ʋusɔgbɔdɔ - ema fia ʋu ƒe anyimanɔmanɔ.
• Thrombocytopenia - Esia fia be ʋumenugbagbevi dzĩwo ƒe anyimanɔmanɔ.
• Pancytopenia - Esia fia be ʋumenugbagbevi dzĩwo kple ʋumenugbagbevi dzĩwo ƒomevi ɖesiaɖe dzi ɖena kpɔtɔna.

Aleke wowɔna dea dzesi AML? (Dɔléle ƒe dzesi) .

Ðɔktawo zãa dodokpɔ geɖe tsɔ dea dzesi AML, siwo dometɔ aɖewoe nye domenyiŋusẽfianu dodokpɔ tsɔ nyaa AML ƒomevi si tututu. Zi geɖe la, afɔɖeɖe gbãtɔ nyea ŋutilãmedɔdada. Esia lɔ ŋkuléle ɖe abi, ʋu le dodom, kple dɔlékuiwo ŋu hã ɖe eme. Woléa ŋku ɖe ŋutinuwo abe aklã, dɔgbo, kple ʋuka siwo me ʋu sina tona ene hã me vuvu hã.

Dodokpɔ kawoe wozãna tsɔ dea dzesi AML?

Ðewohĩ ahiã be nàwɔ dodokpɔ siawo dometɔ ɖeka alo esi wu nenema:

• Ʋu ƒe xexlẽme bliboa (CBC) .
• Ʋu si le gota - Esia bia be woaɖe ʋu eye woakpɔe le nusuekpɔmɔ̃ me.
• Bone marrow biopsy - Le esia me la, woɖea ƒumeŋuɖui ƒe kpɔɖeŋu sue aɖe hedonɛ kpɔna.
• Spinal tap - Wowɔa esia ɣeaɖewoɣi tsɔ léa ŋku ɖe kansa lãmenugbagbeviwo ŋu le tsi si ƒo xlã aklãa me hã.

Nukae nye domenyiŋusẽfianu ƒe dodokpɔ siwo wozãna tsɔ dea dzesi AML?

Atikewɔlawo ƒe dɔléleŋutinunyalawo wɔa domenyiŋusẽfianu dodokpɔwo tsɔ nyaa AML ƒomevi si tututu. Wodia tɔtrɔ (nu gbagbewo ƒe tɔtrɔ) le domenyiŋusẽfianu alo domenyiŋusẽfianu aɖewo me. Ne wonya nya AML ƒomevi ko la, enɔa bɔbɔe na ɖɔktawo be woatso nya me le atikewɔmɔnu siwo ate ŋu ada AML la ŋu wu. Dodokpɔ tɔxɛ siwo wowɔna ɖe esia ta dometɔ aɖewoe nye:

• Dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ: Le esia me la, wodea ama lãmenugbagbeviwo eye wodoa wo kpɔ le nusuekpɔmɔ̃ me. Mɔnu si wozãna tsɔ dea amae la toa vovo le atike siwo le lãmenugbagbeviawo me nu.
• Sisi ƒe lãmenugbagbeviwo ƒe dodokpɔ.
• Karyotype dodokpɔ.
• Fluorescence-in-situ-hybridization (FISH): Esia ate ŋu ade dzesi tɔtrɔ siwo va le domenyiŋusẽfianuwo me.

Nukawoe nye atike siwo wozãna na AML?

Atikewɔwɔ ƒe tiatia aɖewoe nye atikewɔmɔnu, atikewɔwɔ si woɖo taɖodzinu na (si me monoclonal antibody therapy hã le), alo allogeneic stem cell transplantation. Atikewɔwɔmɔnu mawo ke li na ame tsitsiwo kple ɖeviwo siaa. Taɖodzinu vevitɔ si le atikewɔwɔ ŋue nye be woaɖe AML ɖa keŋkeŋ.Le AML me la, ‘dɔyɔyɔ blibo’ fia be wò ʋu ƒe xexlẽme sɔ le dodokpɔwo me. Efia hã be ɖɔktawo mate ŋu akpɔ kansa lãmenugbagbevi aɖeke ne wole ŋku lém ɖe wò ƒumeŋuɖui ƒe kpɔɖeŋu aɖe ŋu le nusuekpɔmɔ̃ me o.

Atikewɔwɔ na AML

Atikewɔwɔ ƒe akpa vevi etɔ̃ li na AML - eƒe dɔwɔwɔ, eƒe ŋusẽdodo, kple edzikpɔkpɔ.

Remission induction ƒe atikewɔwɔ

Esiae nye afɔɖeɖe gbãtɔ si ana woaɖe AML ɖa keŋkeŋ. Zi geɖe la, atikewɔwɔa xɔa ŋkeke ʋɛ aɖewo. Ame aɖewo ate ŋu ahiã be woawɔ atike gbãtɔ sia zi eve alo esi wu nenema be woaɖe AML ɖa keŋkeŋ. Ðɔktawo ate ŋu azã atike siwo gbɔna siwo wotsɔ daa dɔe le atikewɔwɔ gbãtɔ sia me:

• Cytarabine (Cytosar-U®) ƒe dɔlékuiwutike .
• Daunorubicin (Cerubidine®) ƒe dɔlékuiwutike .
• Idarubicin (Idamycin®) ƒe dɔlékuiwutike .
• Azasitidine (Vidaza®) ƒe atike .
• Decitabine (Dacogen®) ƒe dɔlékuiwutike .
• Glasdegib (Daurismo®) ƒe lãmesẽnyawo gbɔ kpɔkpɔ .
• Venetoclax (Venclexta®, Venclyxto®) ƒe ʋumenugbagbeviɣidɔlékuiwo.

Le eŋutinunyalawo ƒe nya nu la, atikewɔwɔ gbãtɔ siawo:

• Ðeviwo kple sɔhɛwo ƒe 60% kple edzivɔ hayana.
• Ame tsitsi siwo xɔ ƒe 60 kple esiwo mexɔ nenema haɖe o dometɔ siwo ade 75% hayana.
• Ame siwo xɔ wu ƒe 60 la dometɔ siwo ade 50% hayana.

Atikewɔwɔ si wotsɔ doa ŋusẽ nu

Wozãa atike si wotsɔ ƒoa ƒui tsɔ wua kansadɔlékui ɖesiaɖe si susɔ. Esia ɖea afɔku si le kansa la ƒe tɔtrɔgbɔ (gbugbɔgadzɔ) me dzi kpɔtɔna. Wonaa cytarabine (Ara-C) alo HiDAC si ƒe agbɔsɔsɔme sɔ gbɔ na ame akpa gãtɔ ŋkeke atɔ̃ ɣleti sia ɣleti hena ɣleti etɔ̃ va ɖo ene.

Beléle na wo ƒe atikewɔwɔ

Zi geɖe la, wotsɔa atike si wotsɔna ƒoa ƒui daa AML. Gake le go aɖewo me la, ɖɔktawo ate ŋu aɖo aɖaŋu be woayi atikewɔmɔnu dzi le agbɔsɔsɔ si bɔbɔ wu me. Beléle na dɔdamɔnu ate ŋu ayi edzi ɣleti alo ƒe geɖe. Atike siwo wozãna tsɔ daa dɔlékuiwoe ate ŋu anye:

• Azasitidine (Vidaza®) ƒe atike .
• Decitabine (Dacogen®) ƒe dɔlékuiwutike .
• Midostaurin (Rydapt®) ƒe ʋuƒoƒo .

Atikewɔwɔ si ŋu woɖo taɖodzinu ɖo

Abe alesi ŋkɔa ɖee fia ene la, atikewɔwɔ sia tɔa ŋku domenyiŋusẽfianu ƒe tɔtrɔ tɔxɛ siwo le kansa lãmenugbagbeviwo me. Ne kansadɔlékuiawo ɖoa taɖodzinu na nugbagbeviwo ƒe tɔtrɔ siawo la, wodzudzɔa tsitsi. Monoclonal antibody therapy hã nye atikewɔwɔ ƒomevi aɖe si woɖo taɖodzinu na. Ðɔktawo ate ŋu azã atikewɔmɔnu siwo woɖo taɖodzinu na atsɔ ada AML si mewɔ nu ɖe ​​atikewɔmɔnu ŋu o alo esi gatrɔ gbɔ:

• Ðɔktawo ate ŋu azã atike siwo nye Midostaurin (Rydapt®) alo Gilteritinib (Xospata®) atsɔ ada AML dɔnɔ siwo ŋu FTL3 domenyiŋusẽfianu ƒe tɔtrɔ le. Wokpɔa tɔtrɔ sia le amesiwo ŋu AML le ƒe 25% va ɖo 30% me.
• Woate ŋu azã enasidenib (IDHIFA®) alo Ivosidenib (Tibsovo®) atsɔ ada dɔ na amesiwo ŋu AML le le woƒe X domenyiŋusẽfianu ƒe tɔtrɔ ta.

Allogeneic stem cell ƒe dodo na ame

Allogeneic stem cell transplant zãa lãmenugbagbevi siwo tso nunala si do ƒome kplii alo esi medo ƒome kplii o gbɔ. Ðɔktawo ate ŋu axɔ lãmenugbagbevi siawo tso ƒumeŋuɖui, ʋu si le gota, alo ka me ʋu (ʋu si woxɔna tso vidzidɔ me le vidzidzi megbe) me.

Dɔdamɔnu ƒe kuxiwo alo eƒe nugbegblẽ le ame ŋu

Kansa dadawo katã kloe ƒe nugbegblẽ le ame ŋu. Le AML me la, lãmenugbagbeviwo dodo na ame ƒe nugbegblẽ le ame ŋu wu. Atikewo zazã ate ŋu ahe nɔnɔme aɖe si woyɔna be myelosuppression vɛ, si fia be ʋumenugbagbevi dzĩwo kple ʋumenugbagbevi dzĩwo ƒe xexlẽme si sɔ la bu le wò ŋutilã me. Dɔdamɔnu siwo woɖo taɖodzinu na ƒe nugbegblẽ le ame ŋu toa vovo le atike si wozãna nu.

Nusiwo dona tso eme gɔmesese le vevie be nànya alesi kansa dada akpɔ ŋusẽ ɖe wò gbesiagbegbenɔnɔ dzii. Wò ɖɔktae nye ame nyuitɔ kekeake si anya nu tso wò atikewɔwɔ ƒe nugbegblẽ le ame ŋu koŋ ŋu. Ame aɖewo ate ŋu akpɔ viɖe tso beléle si naa ame ƒe dziɖeɖi me be wòakpe ɖe ame ŋu woakpɔ eƒe nugbegblẽ le ame ŋu gbɔ.

Ðe woate ŋu ada AML keŋkeŋa?

Fifia la, allogeneic stem cell transplantation koe nye mɔ si dzi woato ada acute myeloid leukemia keŋkeŋ. Le wò nɔnɔmea nu la, wò ɖɔkta ate ŋu aɖo aɖaŋu be nàdo lãmenugbagbeviwo na ame bubuwo be wòanye wò AML dɔdamɔnu gbãtɔ. Alo, ne wò AML trɔ gbɔ le ɣleti 12 me la, woate ŋu ado atike sia ɖa. Nublanuitɔe la, menye amesiamee dze na lãmenugbagbeviwo dodo na ame o.

Nukae nye AML ƒe ŋgɔdonya?

Ne míele nu ƒom tso ʋumenugbagbeviɣidɔ sesẽ ƒe ŋgɔdonya ŋu la, akpa evee li. Ðekae nye be woatsɔe ake keŋkeŋ. Bubue nye gbugbɔgadzɔ, si nye ne AML gadze egɔme ake.

• Le blibo me la, wobu akɔnta be amesiwo ŋu ʋumenugbagbeviɣidɔ sesẽ le ƒe 50% va ɖo 80% ahaya bliboe le atikewɔwɔ vɔ megbe. Ðeviwo kple amesiwo mexɔ ƒe 60 haɖe o ate ŋu ahaya bliboe. Hayahaya sia ate ŋu anɔ anyi ɣleti alo ƒe geɖe.
• Ame siwo haya keŋkeŋ la dometɔ siwo ade 50% agaxɔ AML ake. Ne edzɔ alea la, ɖɔktawo ate ŋu aɖo aɖaŋu be woagazã atike bubuwo alo ado lãmenugbagbeviwo na ame bubuwo. Woate ŋu aɖo aɖaŋu hã be woakpɔ gome le dɔdamɔnu dodokpɔ aɖe me.

Ne AML le wò alo viwòa ŋu la, bia wò ɖɔkta tso nusi nàte ŋu akpɔ mɔ na ŋu.

Nukae nye AML dɔnɔwo ƒe agbetsitsi?

Acute myeloid leukemia nye dɔléle sesẽ aɖe. Esi wònye be AML ƒe ƒomevi sue geɖe li ta la, esesẽna be woagblɔ etsɔme ɖi tututu.

Le kpɔɖeŋu me, ƒe atɔ̃ ƒe agbetsitsi ƒe agbɔsɔsɔme na ɖevi siwo mexɔ ƒe 15 haɖe o nye 67%. Gake numekuku aɖewo ɖee fia be ƒe atɔ̃ ƒe agbetsitsi ƒe agbɔsɔsɔme na ɖevi siwo ŋu APL ƒe hatsotso suea le wu 80%. Ƒe hã wɔa akpa aɖe. Le mama dedie nu la, ame tsitsi siwo ŋu AML le ƒe 30% nɔa agbe ƒe atɔ̃ le dɔlélea kpɔkpɔ vɔ megbe. Ðo ŋku edzi be zi geɖe la, AML dzea ame siwo xɔ ƒe 60 kple edzivɔ, eye lãmesẽkuxi bubuwo hã ate ŋu anɔ wo ŋu.

Ele vevie be míaɖo ŋku edzi be agbetsitsi ƒe agbɔsɔsɔ siawo ɖea amesiwo ŋu AML le ƒe ƒuƒoƒo gã aɖewo ƒe nuteƒekpɔkpɔ fiana. Nyatakaka sia lɔ agbetsitsi tso ƒe 2012 va ɖo ƒe 2018 me ɖe eme, eye fifia atike yeye siwo wɔa dɔ nyuie wu li na AML.

Nu geɖe kpɔa ŋusẽ ɖe ɣeyiɣi didi si nànɔ agbe kple ʋumenugbagbeviɣidɔ sesẽ si woyɔna be myeloid leukemia. Esia fia be wò ɖɔkta siwo nya wò atikewɔwɔ ŋutinya kple wò lãmesẽ bliboae nye ame nyuitɔ kekeake siwo nya nu tso esia ŋu.

Ðe woate ŋu axe mɔ ɖe AML nua?

Ao, womate ŋu axe mɔ ɖe ʋumenugbagbeviɣidɔ sesẽ nu o. Togbɔ be eŋutinunyalawo nya be domenyiŋusẽfianu ƒe tɔtrɔ gbɔe AML tsona hã la, womenya nusi gbɔ wòtsona o. Gake wonya nu tso afɔku siwo ate ŋu ana woaxɔ AML ŋu. Afɔku siwo nàte ŋu atrɔ dometɔ aɖewoe nye esi:

• Sigaretnono: Esia lɔ dzudzɔ si wozãna tsã ɖe eme. Ne ènoa atama la, dze agbagba nàdzudzɔ. Ne ame aɖe si noa atama le gbɔwò alo nèle dɔ wɔm kplii la, dze agbagba nàɖe ɣeyiɣi si nèzãna kplii ne ele atama nom la dzi akpɔtɔ.
• Atike aɖewo siwo hea kansa vɛ zazã ɣeyiɣi didi: vevietɔ benzene kple formaldehyde. Ne èwɔa dɔ kple kansadɔlékui siawo la, wɔ dedienɔnɔ ƒe afɔɖeɖewo katã, abe ametakpɔnu dodo ene.

Aleke malé be na ɖokuinye? (Ðokuidzikpɔkpɔ) .

Agbenɔnɔ kple kansa si ate ŋu atrɔ gbɔ mele bɔbɔe o. Kansa ƒe agbetsitsi ƒe ɖoɖowo me nɔnɔ nye mɔ siwo dzi nàto akpɔ ɖokuiwò dzi la dometɔ ɖeka. Ðewohĩ màte ŋu axe mɔ na ʋumenugbagbeviɣidɔ sesẽ ƒe tɔtrɔgbɔ o. Gake àte ŋu aɖe afɔ aɖewo be nànɔ lãmesẽ me alesi nàte ŋui, eɖanye nuka kee dzɔ o. Aɖaŋuɖoɖo aɖewoe nye esi:

• Acute myeloid leukemia dada ate ŋu akpɔ ŋusẽ ɖe wò nuɖuɖu dzi.Ele be nàɖu nu nyuie hafi ŋusẽ nanɔ ŋuwò. Ne nuɖuɖu sesẽ na wò la, ƒo nu kple nuɖuɖuŋutinunyala.
• AML dada ƒe nugbegblẽ le ame ŋu dzi ɖuɖu ate ŋu asesẽ. Ne ehiã la, ƒo nu kple wò ɖɔkta tso atikewɔwɔ si naa ame ƒe dzi dzea eme ŋu.
• Kansa nye nɔnɔme si tea ɖeɖi ame ŋu ŋutɔ. Kamedede ate ŋu akpe ɖe ŋuwò nàɖu nuteɖeamedzi dzi. Gake ƒo nu kple wò ɖɔkta hafi nàdze kamedede ƒe ɖoɖo yeye si me nuteɖeamedzi le gɔme.
• Kansa ate ŋu ana nàse le ɖokuiwò me be yetsi akogo. AML nye dɔléle si mebɔ o. Ðewohĩ àtsi dzodzodzoe ne èle nu ƒom tso wò nɔnɔmea ŋu. Ne nenemae la, bu eŋu kpɔ be yeage ɖe kpekpeɖeŋunaha aɖe me.
• Ʋumenugbagbeviɣidɔ sesẽ ate ŋu ana ɖeɖi te ŋuwò ŋutɔ. Dɔdamɔnuawo ate ŋu ana ŋusẽ nanɔ ŋuwò. Ðo ŋku edzi nàdɔ alɔ̃ alesi nèhiãe.

Ɣekaɣie wòle be makpɔ ɖɔkta?

Àkpɔ wò ɖɔkta edziedzi le wò hayahaya katã me, vevietɔ ne èle atike si woatsɔ alé be na wòe zãm. Wò ɖɔkta agblɔ dzesi siwo ate ŋu anye dzesi siwo fia be wò AML le tɔtrɔm gbɔ na wò. Esia akpe ɖe ŋuwò nànya ɣeyiɣi si nàte ɖe wo ŋu hena atikewɔwɔ yeyewo alo bubuwo.

Nya kawoe wòle be mabia nye ɖɔkta?

Ne AML le ŋuwò la, àte ŋu abia nya siawo ɖokuiwò:

• AML ƒomevi ka ƒomevie le asinye?
• Nukawoe nye nye atikewɔwɔ ƒe tiatia?
• Afɔku kple nugbegblẽ kawoe le atikewɔwɔ me?
• Aleke mawɔ akpɔ atikewɔwɔ ƒe nugbegblẽ le ame ŋu gbɔe?
• Beléle si akplɔm ɖo kae mehiã le atikewɔwɔ vɔ megbe?
• Ðe wòle be malé ŋku ɖe kuxiwo ƒe dzesiwo ŋua?
• Ðe dɔdamɔnu dodokpɔ aɖewo li siwo ŋu wòle be mabua?

Mlɔeba la, nu siwo dzi wòle be woaɖo ŋkui

Acute Myeloid Leukemia (AML) nye kansa si mebɔ o si gblẽa nu le wò ƒumeŋuɖui kple ʋu ŋu. Zi geɖe la, AML dzea amesiwo xɔ wu ƒe 65 dzi, gake ate ŋu adze ɖeviwo kple sɔhɛ tsitsiwo hã dzi. Le atikewɔwɔ yeyewo ta la, ame geɖe wu va le agbe kple AML fifia le atikewɔwɔ vɔ megbe. Togbɔ be kansa ate ŋu atrɔ ava hã la, atikewɔwɔ ŋuti numekulawo yi edzi le numekuku wɔm le mɔ siwo dzi woato ada AML si gatrɔna la ŋu.

Ne ʋumenugbagbeviɣidɔ sesẽ aɖe le ŋuwò alo viwòa ŋu la, àte ŋu ase le ɖokuiwò me abe ɖe wotsɔ ye ƒu gbe tso anyigba sesẽ dzi yi atsiaƒu si ŋu kakaɖedzi mele o me ene. Ðewohĩ àbia ɖokuiwò be ɖe atikewɔwɔ ana gbɔdzɔe ye hã. Ne nenemae la, àte ŋu atsi dzi ɖe ɣeyiɣi didi si gbɔdzɔe ma anɔ anyi ŋu. Wò ɖɔktawo se ale si nèsena le ɖokuiwò me gɔme. Woanɔ gbɔwò esi nèle AML ƒe kuxiwo gbɔ kpɔm. Eya ta sẽ ŋu eye mègahe ɖe megbe le kpekpeɖeŋu si nèhiã la xɔxɔ me o.

` Acute myeloid leukemia, AML, ʋumenugbagbeviɣidɔ, ƒumeŋuɖui, dzesiwo, atikewɔmɔnu, lãmenugbagbeviwo dodo na ame