Ðe dzesi wɔnuku siawo le ŋuwòa? Mina míaƒo nu tso Carcinoid Syndrome ŋu!

Ɣeaɖewoɣi la, míenya nusi tututu le edzi yim le míaƒe ŋutilã me o, alo? Ðe wò ʋu biã kpata, gbɔgbɔ sesẽ, ƒodo veve, kple aɖuɖɔtoe kpɔa? Menye nusiwo dzɔna le vome koe esiawo nye o. Ɣeaɖewoɣi la, esiawo ate ŋu anye dɔléle aɖe si mebɔ o si woyɔna be Carcinoid Syndrome ƒe dzesiwo. Mina míaƒo nu tso esia ŋu tsitotsito egbea.

Nukae nye Carcinoid Dɔléle?

Kpuie ko la, carcinoid syndrome nye dzesi siwo kansa ƒomevi aɖe ƒe tsitsi le wò ŋutilã me si woyɔna be neuroendocrine tumors (NETs) hena vɛ ƒe ƒuƒoƒo . Ahɔhɔ̃mekawo ƒe lãmenugbagbevi siawo nye lãmenugbagbevi tɔxɛ aɖe si kpɔa gome le míaƒe lãmekawo kple lãmetsiŋusẽ ƒe dɔwɔwɔ me. NETwo dzɔna ne lãmenugbagbevi siawo ma zi ɖeka eye wodzina kabakaba, eye wowɔa dɔdzẽ.

Fifia ɖewohĩ ànɔ ɖokuiwò biam be ɖe esia nye dɔléle si dzea amesiame dzi hã. Ao, le nyateƒe me la, enye nɔnɔme si mebɔ o . Numekukuwo ɖee fia be amesiwo ŋu ahɔhɔ̃mekawo ƒe dɔdzẽ (NET) le la ade ame ɖeka le atɔ̃ ɖesiaɖe me xɔa kansadɔ. NET-wo hã mebɔ nenema gbegbe o, eye wobu akɔnta be wo dometɔ 5 le 100,000 ɖesiaɖe me le United States.

NET siawo, vevietɔ esiwo le wò dɔgbo alo lãkusi me, ɖea lãmetsiŋusẽ gbogbo aɖewo abe serotonin kple atike bubuwo ene ɖea ŋutilãa me zi ɖeka. Ɣemaɣie carcinoid syndrome ƒe dzesiwo dzena. Ɣeaɖewoɣi la, ènya gbã be NET le ye ŋu ne dɔléle sia ƒe dzesiwo dze.

Ƒã ŋutɔ ne womekpɔ kansadɔ sia nyuie hedae o la, ate ŋu ahe nɔnɔme kpata si ate ŋu ade ame ƒe agbe afɔku me si woyɔna be ‘kansa ƒe kuxi’ vɛ. Eyata ele vevie ŋutɔ be míanya esia.

Nukae nye Carcinoid Syndrome ƒe dzesiwo?

Mina míalé ŋku ɖe nɔnɔme sia ƒe dzesi siwo bɔ wu ŋu. Kpɔe ɖa be dzesi siawo dometɔ aɖe le ŋuwò hã, ɖekaɖeka:

• Tsilele: Esia ate ŋu ana ame naɖe dzi ɖi vie. Ðeko wòle abe wò mobiãna ne ŋu kpe wò ene, gake ne edzɔna enuenu le susu aɖeke manɔmee la, ele be nàtsi dzi.
• Gbɔgbɔtsixetsixe kple gbɔgbɔtsixetsixe (gbɔgbɔtsixetsixe): Ate ŋu ase le eɖokui me abe gbɔgbɔ sesẽe ene, alo abe kpẽkuku ƒe gbeɖiɖi si tso akɔta ene.
• Ƒodo ƒe ʋuʋu kple aɖuɖɔtoe si wóna, si dzɔna enuenu: Dɔgbo ƒe vevesese si me aɖuɖɔtoe si nu sẽ, si yia edzi le. Ɣeaɖewoɣi la, esesẽna be woaɖu edzi.
• Aɖuɖɔ si me ami le si ʋẽna lilili: Aɖuɖɔ ate ŋu adze abe ami le eme ene eye ʋeʋẽ si mebɔ o anɔ eme.
• Wò afɔwo kple afɔwo ƒe ʋuʋu alo vuvu:Esia ate ŋu anye dzidɔ ƒe dzesi ɣeaɖewoɣi, eyata ele vevie be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo kaba.
• Gbɔdɔdɔ ƒe dzodzro dzi ɖena kpɔtɔna alo ŋutsuwo ƒe tsitretsitsi ƒe dɔmawɔmawɔ nyuie: Nɔnɔme siawo ate ŋu ato ame aɖewo me.
• Ŋutilã ƒe ɣie kple ŋku ƒe ɣie (Jaundice): Esiae míeyɔna be ‘jaundice’. Ate ŋu anye aklã ƒe kuxi.
• Taɖuame alo sese le eɖokui me be yeƒe tagbɔ gblẽ: Esia ate ŋu anye ʋu ƒe sisi ƒe dzesi.
• Sese le ɖokuiwò me be yeƒe dzi le ƒoƒom: Ðeko nàse le ɖokuiwò me be yeƒe akɔta le ƒoƒom kabakaba.

Ne èyi edzi le dzesi siawo dometɔ ɖeka alo esi wu nenema kpɔm la, kpɔ egbɔ be yeyi ɖɔkta gbɔ be yeadzro wo me. Esiawo ate ŋu anye nɔnɔme bubuwo hã ƒe dzesiwo, gake ele vevie be nàɖo kpe edzi be carcinoid syndrome le ŋuwò.

Nukatae kansadɔ sia dzɔna?

Abe alesi megblɔe va yi ene la, carcinoid syndrome dzɔna ne neuroendocrine tumors (NETs) le ŋuwò. NET siawo nye dɔdzẽ siwo dona tso lãmenugbagbevi tɔxɛ siwo le wò ahɔhɔ̃mekawo ƒe dɔwɔwɔ me. Lãmenugbagbevi siawo wɔa lãmetsiŋusẽwo heɖea wo ɖe go ɖe ŋutilãa me.

Zi geɖe la, NET siawo ate ŋu adze le teƒewo abe wò dɔgbo, lãkusi, kple dɔgbo ene. Gake zi geɖe la, NET siwo le dɔgboa alo lãkusi me siwo ɖea lãmetsiŋusẽ gbogbo aɖewo (vevietɔ serotonin) ɖe ʋukawo me zi geɖe gbɔe carcinoid ƒe dɔlélea tsona .

Bu eŋu abe pɔmpi si le tsia ʋuʋum vivivi ene, zi geɖe la, lãmenugbagbevi siawo ɖea lãmetsiwo ɖe go le agbɔsɔsɔ sue aɖe me. Gake ne NET dzɔ la, ɖeko wòle abe ɖe woʋu pɔmpia zi ɖeka wòʋu, eye lãmetsi geɖe dona zi ɖeka ene. Ɣemaɣie dɔléle sia ƒe dzesiwo dzena.

Amekawoe le afɔku gã me be woaxɔ kansadɔ?

Afɔku vevitɔ si ate ŋu ahe esia vɛ enye be ahɔhɔ̃mekawo ƒe dɔdzẽ (NET) nanɔ wò dɔgbo alo lãkusi me . Ne míagblɔe bubui la, zi geɖe la, carcinoid ƒe dɔlélea medzɔna ne womewɔ NET o.

Ema fia be ne wokpɔe be NET le ŋuwò la, ele be nàtsi dzi ɖe dɔléle sia hã ŋu. Ɣeaɖewoɣi la, ne NET le ƒomea me kpɔ la, ema hã ate ŋu anye afɔku vaseɖe afi aɖe, gake ƒã ŋutɔ.

Nukawoe nye kuxi siwo ate ŋu ado tso Carcinoid Syndrome me?

Menye dzesi aɖewo koe carcinoid ƒe dɔlélea nye o, ate ŋu ahe kuxi sesẽ geɖewo vɛ. Nɔnɔme mawo dometɔ ɖekae nye nɔnɔme si ate ŋu ade ame ƒe agbe afɔku me si woyɔna be ‘carcinoid crisis’ si megblɔ va yi.

Mina míalé ŋku ɖe kuxi ʋɛ bubu siwo do mo ɖa ŋu:

• Dzidɔ si me kansa le:Esia hã mebɔ o, gake ate ŋu ade ame ƒe agbe afɔku me. Lãmetsiŋusẽ siwo NETwo ɖena dona la kpɔa ŋusẽ ɖe wò dzitodzito ƒe xɔwo, ʋukawo, kple ʋukawo ƒe akpa si le eme dzi. Esia ate ŋu ana dzi nawɔ dɔ gɔ̃ hã.
• Mesenteric fibrosis: NET ate ŋu ana mesentery, si nye lãkusi si doa ka kple wò dɔgbowo kple wò ƒodo ƒe gli la, naxɔ abi eye wòaxɔ abi. Esia ate ŋu ado kplamatse dɔgboa ƒe dɔwɔwɔ.
• Blanuiléle: Carcinoid ƒe dɔléle ate ŋu akpɔ ŋusẽ ɖe wò ŋutilã ƒe ŋutete be wòazã amino acid vevi aɖe si woyɔna be tryptophan dzi. Tryptophan kpena ɖe ame ŋu wòwɔa serotonin. Serotonin nye ahɔhɔ̃meka aɖe si kpɔa nuwo abe míaƒe seselelãme, nuwɔna, kple alɔ̃dɔdɔ ene dzi. Eyata serotonin ƒe agbɔsɔsɔ si bɔbɔ ate ŋu ana ame nalé blanui.

Nɔnɔme si me afɔku le si woyɔna be carcinoid crisis

Kansa ƒe kuxi nye nudzɔdzɔ kpata si mebɔ kura o gake ate ŋu ade ame ƒe agbe afɔku me . Ate ŋu adzɔ le amekoko, atikewɔmɔnu bubuwo, alo abi si wòxɔ le afɔku aɖe ta.

Esia ƒe nɔnɔmewoe nye:

• Tɔtrɔ gãwo le ʋu ƒe sisi me: Ʋu ƒe sisi ate ŋu aɖiɖi akpa (ʋusɔgbɔdɔ) alo akɔ ɖe dzi akpa zi ɖeka.
• Ʋuʋudedi sesẽ: Kasia ametia katã biãna eye ate ŋu ase le eɖokui me be dzoxɔxɔ le ye ŋu.
• Yagbɔgbɔ sesẽ (Dyspnea): Gbɔgbɔtsixe sesẽ ate ŋu adzɔ.
• Tɔtɔ: Ðewohĩ àse le ɖokuiwò me abe ɖe wole fu ɖem na wò susu ene.

Ele vevie ŋutɔ be amesi ŋu carcinoid syndrome alo neuroendocrine tumor (NET) le natsɔ agbalẽvi si dzi woŋlɔ woƒe nɔnɔmea ɖo ɖe asi. Esia ate ŋu akpe ɖe wo ŋu ŋutɔ ne wohiã atikewɔla kpata. Azɔ hã, ne woawɔ dɔ na wò la, ele vevie be nàgblɔ nɔnɔme sia na wò ɖɔktawo. Emegbe woate ŋu ana atike wò do ŋgɔ na amekokoa kple le amekokoa wɔɣi be woaɖe ‘kansa ƒe kuxi’ ƒe afɔkua dzi akpɔtɔ.

Aleke wowɔa dea dzesi Carcinoid Syndrome ƒe dɔlélea?

Ðɔktawo zãa dodokpɔ geɖe tsɔ dea dzesi dɔléle sia. Mina míalé ŋku ɖe nusiwo wonye ŋu:

• Aɖuɖɔ dodokpɔ: Esia léa ŋku ɖe lãmetsi aɖewo ƒe agbɔsɔsɔ le wò aɖuɖɔ me ŋu, vevietɔ serotonin ƒe akpa aɖe si woyɔna be 5-HIAA (5-hydroxyindoleacetic acid) .
• Lãmesẽdodokpɔ kple atikewɔwɔ ŋutinya: Carcinoid syndrome ƒe dzesiwo ate ŋu asɔ kple dɔléle bubu siwo mesẽ boo o ƒe dzesiwo, eyata wò ɖɔkta abia wò tsitotsito tso wò dzesiwo, ɣeyiɣi didi si wòxɔ, kple nenye be wole sesẽm ɖe edzi hã ŋu.
• Ʋudodokpɔ:Esiawo léa ŋku ɖe nusiwo dona le ʋua me tso wò ŋutinuwo kple lãkusiwo me ƒe agbɔsɔsɔ ŋu. Ne nu aɖewo ƒe agbɔsɔsɔ dzi ɖe edzi alo ɖiɖi zi ɖeka la, ate ŋu anye dɔléle ƒe dzesi. Le kpɔɖeŋu me, woléa ŋku ɖe dzesi aɖe si woyɔna be Chromogranin A ŋu.
• Neuroendocrine Positron Emission Tomography (PET) scan: Esia nye scan tɔxɛ aɖe si zãa amadede si woyɔna be gallium 68 dotatate tsɔ dia afisi ahɔhɔ̃mekawo ƒe dɔdzẽ (NETs) le.
• CT scan: CT scan zãa X-ray kple kɔmpiuta tsɔ wɔa wò ŋutinuwo kple ƒuwo ƒe nɔnɔmetata siwo le akpa etɔ̃ (3D). Esia ate ŋu akpe ɖe ame ŋu hã be woanya afi si ƒunukpeƒetetedɔ ɖesiaɖe anɔ kple eƒe lolome.
• Ultrasound scan: Esia zãa gbeɖiɖi ƒe ƒutsotsoewo tsɔ wɔa ŋutinuwo ƒe nɔnɔmetatawo.
• MRI scan (Magnetic Resonance Imaging (MRI): Esia zãa magnet gã aɖe, radio ƒutsotsoewo, kple kɔmpiuta tsɔ wɔa ŋutilãa ƒe akpa si le eme ƒe nɔnɔmetata tsitotsito.
• Endoscopy: Le dodokpɔ sia me la, ɖɔkta tsɔa mɔ̃ didi aɖe si le sue si me fotoɖemɔ̃ kple akaɖi le dea wò ŋutilã me be yeadoe kpɔ. Le kpɔɖeŋu me, woate ŋu azã mɔnu sia atsɔ ado dɔgboa alo dɔgbowo kpɔ.

Nukawoe nye Carcinoid Syndrome ƒe atikewo?

Ahɔhɔ̃mekawo me dɔdzẽ (NETs) gbɔe carcinoid ƒe dɔlélea tsona. Eyata ne woda dɔdzẽ mawo la, wodaa dɔlélea hã.

Atikewɔwɔmɔnu vevi geɖewo li:

• Amekoko: Woate ŋu aɖe ahɔhɔ̃mekawo ƒe dɔdzẽwo ɖa keŋkeŋ alo woaɖe woƒe lolome dzi akpɔtɔ. Amekoko ƒe ƒomevi nɔ te ɖe afisi dɔdzẽa le kple eƒe lolome dzi.
• Somatostatin analogs: Esiawo nye atike tɔxɛ aɖe. Atike siawo ate ŋu ana wò ŋutilã nagawɔ lãmetsiŋusẽ fũ o. Woate ŋu akpe ɖe ame ŋu hã be woaɖu dɔdzẽ ƒe tsitsi dzi ne kansa lãmenugbagbeviwo kaka ɖe ŋutilã ƒe akpa bubuwo (metastasis). Kpɔɖeŋu aɖewoe nye atike siwo woyɔna be Octreotide kple Lanreotide .
• Atikewɔwɔ si woɖo taɖodzinu na: Esia hã nye atikewɔwɔmɔnu tɔxɛ aɖe si wozãna tsɔ wua kansa lãmenugbagbeviwo. Le esia me la, wonaa atikewo be woatsɔ aɖo domenyiŋusẽfianu alo protein aɖewo koŋ siwo le kansa lãmenugbagbeviwo me.
• Atikewo zazã: Esia zãa atikewo tsɔ wua kansa lãmenugbagbeviwo. Chemotherapy mewɔa dɔ ɖekae na NET ƒomevi ɖesiaɖe o.
• Embolization: Le mɔnu sia me la, ʋuka si naa ʋu yia dɔdzẽa me la xea mɔ, si gblẽa dɔdzẽa. Esia nye atike si wozãna koŋ na NET siwo le aklã me.

Ðe woate ŋu axe mɔ ɖe Carcinoid Syndrome nua?

Nyateƒea,Mɔ aɖeke meli si dzi woato axe mɔ ɖe kansadɔléle nu o elabena edo ƒome kple ahɔhɔ̃mekawo ƒe dɔdzẽ (NETs). Esi wonya mɔ aɖeke meli si dzi woato axe mɔ ɖe NET ƒe dzɔdzɔ nu o ta la, mɔ aɖeke meli si dzi woato axe mɔ ɖe dzesi siwo dona tso eme nu o.

Gake ne ènya be NET le ye ŋu la, ne ède dzesi carcinoid syndrome ƒe dzesiwo kaba eye nèdze atikewɔwɔ gɔme la, ate ŋu aɖe kuxi siwo ate ŋu ado mo ɖa dzi akpɔtɔ.

Aleke malé be na ɖokuinye? / Aleke mawɔ akpɔ dzesiawo gbɔe?

Ne carcinoid syndrome le ŋuwò la, ke ahɔhɔ̃mekawo ƒe dɔdzẽ (NET) hã ate ŋu anɔ ŋuwò. Eyata ne carcinoid syndrome ƒe dzesiwo le ŋuwò la, gblɔe na wò ɖɔkta enumake. Woate ŋu ada wò nɔnɔmea kpɔ eye woakafu dodokpɔ siwo hiã be woakpɔe ɖa be NET le asiwò hã.

Dzesi vevi etɔ̃ siwo dzena le carcinoid syndrome ŋue nye ʋu ƒe sisi, ʋuʋudedi, kple aɖuɖɔtoe. Nu ʋɛ aɖewo siwo nàte ŋu awɔ atsɔ akpe asi ɖe nusiawo dzi kpɔkpɔ ŋue nye esi:

• Flushing: Esiae nye alesi wò lãmekawo wɔa nu ɖe ​​ŋutilã alo susu me nuteɖeamedzi ŋu. Be nàɖe esia dzi akpɔtɔ la, gbɔ ya sesĩe, tsɔ avɔ si me tsi le tutu mo kple akɔta, alo nàdo ya nyui aɖe ɖe gota. Ƒo asa na ahanono hã ate ŋu akpe ɖe ŋuwò.
• Gbɔgbɔtsixetsixe: Ne gbɔgbɔtsixe tsi ƒowò la, dze agbagba nàno gbetikewo ƒe tii alo nàzã atike si wotsɔna gbɔa ya alo ya si wotsɔna ƒoa yae . Ne ènoa atama la, dze agbagba nàdzudzɔ. Sigaretnono ate ŋu ana wò yaƒoƒomɔ̃wo nagado dzo ɖe edzi.
• Aɖuɖɔtoe: Ne aɖuɖɔtoe nye kuxi na wò la, ƒo nu kple wò ɖɔkta tso mɔ siwo dzi nàto aɖe eƒe dzɔdzɔ zi geɖe kple eƒe sesẽ dzi akpɔtɔ ŋu. Atike tɔxɛ aɖewo li siwo ŋu wotrɔ asi le be woatsɔ axe mɔ ɖe aɖuɖɔtoe si carcinoid syndrome hena vɛ nu. Azɔ hã, nuɖuɖu siwo me ami le, siwo me nu ʋeʋĩwo le, kple nyinotsi nuɖuɖuwo ate ŋu ana nɔnɔme sia nagagblẽ ɖe edzi na ame aɖewo. Eyata kpɔ nyuie le nusi nèɖuna ŋu.

Ɣekaɣie wòle be makpɔ ɖɔkta? / Ɣekaɣie wòle be mayi xɔ si me wowɔa dɔ kpata le?

Ne wò carcinoid syndrome ƒe dzesiwo nu sẽ ɖe edzi la, kpɔ egbɔ be yeyi ɖɔkta gbɔ. Ne wole NET dam na wò la, gblɔe na wò ɖɔkta ne ède dzesi tɔtrɔ yeye aɖewo le wò ŋutilã me si ate ŋu ase le ɖokuiwò me abe NET ƒe dzesiwo ene. Ðewohĩ tɔtrɔ siawo medo ƒome kple wò NET dɔlélea o, gake mɔ nyuitɔ si dzi nàto anyae kple kakaɖedzie nye be nàƒo nu kple wò ɖɔkta. Azɔ hã, ne wò dzesiwo alo wò dɔdamɔnua ƒe nugbegblẽ le ame ŋu va gblẽ ɖe edzi la, gblɔe na wò ɖɔkta.

Ɣekaɣie nàyi Atikewɔwɔ Kpata ƒe Dɔwɔƒe (ETU) .

Ne womeda dɔdzẽ ƒe dɔlélea o la, dzesiawo ate ŋu agblẽ ɖe edzi le ɣeyiɣi aɖe megbe eye woava zu nɔnɔme si ate ŋu ade ame ƒe agbe afɔku me si woyɔna be ‘kansa ƒe kuxi.’ Eyata yi kɔdzi ƒe dɔwɔƒe si kpɔa nudzɔdzɔ kpatawo gbɔ enumake ne:

• Ne dzi ƒe tsotso alo akɔta le veve sem na wò.
• Ne aɖuɖɔtoe sesẽ aɖe le ŋuwò ŋkeke geɖe.
• Ne ƒodo le veve sem vevie.
• Ne èse le ɖokuiwò me be yegbɔdzɔ.
• Ne wò mo, kɔ, kple akɔta biã kpata vevie (ʋuʋudedi sesẽ).

Nya kawoe wòle be mabia nye ɖɔkta?

Carcinoid syndrome ate ŋu anye dzesi be ahɔhɔ̃mekawo ƒe dɔdzẽ (NET) le ŋuwò. Eyata ne nyabiase aɖewo le asiwò ku ɖe carcinoid syndrome ŋu la, ɖewohĩ nyabiase geɖe anɔ asiwò ku ɖe NETwo ŋu. Nya aɖewo siwo nàte ŋu abia wò ɖɔktae nye esi:

• Ne carcinoid syndrome le ŋunye la, aleke mawɔ anya ne ahɔhɔ̃mekawo ƒe dɔdzẽ le ŋunye?
• Ne dɔdzẽ le ŋunye la, afikae wòle le nye ŋutilã me?
• Nukawoe nye atike siwo wozãna na nye dɔdzẽ?
• Nukawoe nye atikewɔwɔa ƒe nugbegblẽ le ame ŋu?
• Ðe woate ŋu ada ahɔhɔ̃mekawo ƒe dɔdzẽ si na nye carcinoid syndrome la keŋkeŋa?
• Ðe carcinoid ƒe dɔlélea ate ŋu atrɔ ava ne woda nye ahɔhɔ̃mekawo ƒe dɔdzẽa?

Gbedasi Mamlɛtɔ si Wotsɔ Yi Aƒeme

Carcinoid Syndrome nye dɔléle si mebɔ o si ate ŋu adzɔ le amesi ŋu ahɔhɔ̃mekawo ƒe dɔdzẽ (NET) le ŋu. Zi geɖe la, amesiwo ŋu carcinoid syndrome le nya xoxo be NET le yewo ŋu. Ɣeaɖewoɣi la, amewo nya gbã be NET le yewo ŋu ne wokpɔe be carcinoid syndrome le yewo ŋu vɔ.

Akpa nyuitɔ kekeakee nye be woate ŋu ada NET-wo. Nyanya be kansa ƒe dɔléle le ŋuwòe nye afɔɖeɖe gbãtɔ si nàwɔ be nànya ne kansa le ŋuwò eye ne ele nenema la, alesi nàdae. Eyata, ne wokpɔe be carcinoid syndrome le ŋuwò la, mègavɔ̃ be yeaƒo nu kple wò ɖɔkta ahabia afɔɖeɖe siwo kplɔe ɖo be nàɖo kpe edzi be NET le ŋuwò hã o. Nu vevitɔe nye be woakpɔ dɔlélea ahadae kaba.

Ðo ŋku edzi be menye wò ɖeka koe o. Le nɔnɔme sia tɔgbe me la, ele vevie ŋutɔ be nàwɔ ɖe atikewɔlawo ƒe aɖaŋuɖoɖo dzi eye nàdi kpekpeɖeŋu tso wò ƒomea gbɔ.

` Carcinoid syndrome, ahɔhɔ̃mekawo ƒe dɔdzẽ, NETs, ​​serotonin, dzesiwo, kansa, lãmetsiwo