Ðe wò ŋkuɖoɖonudzi kple wò ʋuʋu le gbegblẽm vivivia? Mina míasrɔ̃ nu tso (Corticobasal Degeneration) sia ŋu!

Ðe nèŋlɔa nuwo be ɣeaɖewoɣia? Alo ɖe wòsesẽna na wò be nàʋuʋu wò abɔwo kple afɔwoa? Ðe nèdoa vlo wò nyawo ne èle nu ƒoma? Ne edze abe nusiawo le dzidzim ɖe edzi ene la, ɖewohĩ ele vevie be nànya nɔnɔme sia si ŋu míele nu ƒom tsoe egbea si woyɔna be `(Corticobasal Degeneration)`. Mègatsi dzi o, mina míaƒo nu tso esia ŋu bɔbɔe.

Nukae nye ``Corticobasal Degeneration''?

Kpuie ko la, `(Corticobasal Degeneration)` nye ahɔhɔ̃mekawo ƒe dɔléle si gblẽa nu le míaƒe ahɔhɔ̃ ŋu. Ame aɖewo hã yɔnɛ be `(Corticobasal Syndrome).` Nusi dzɔna le esia me enye be lãmenugbagbevi aɖewo siwo le míaƒe ahɔhɔ̃ me gblẽna eye wogblẽna vivivi. Abe alesi dɔwɔnu aɖewo gblẽna le ɣeyiɣi aɖe megbe ene. Le esia ta la, míaƒe nuƒoƒo, mimi nuɖuɖu, míaƒe ŋutilã ʋuʋu, kple ŋkuɖoɖo nuwo dzi ate ŋu aɖe akpɔtɔ vivivi. Nublanuinya lae nye be dzesi siawo dzina ɖe edzi vivivi (ŋgɔyiyi) le ɣeyiɣi aɖe megbe.

Nya "corticobasal" le ŋkɔa me fia ahɔhɔ̃a ƒe akpa eve siwo koŋ dɔlélea gblẽna:

• Ahɔhɔ̃meka: Esiae nye lãmeka siwo le gota wu le míaƒe ahɔhɔ̃ me. Akpa sia le vevie ŋutɔ na míaƒe ŋkuɖoɖonudzi, nusɔsrɔ̃, lɔlɔ̃nu faa ʋuʋu, kple seselelãmewo.
• Basal ganglia: Esia nye lãmenugbagbevi siwo le ahɔhɔ̃a me goglo la ƒe ƒuƒoƒo. Ele vevie na nusɔsrɔ̃ kple lãmekawo ƒe dɔwɔwɔ.

Nya "gbegblẽ" gɔmee nye "gbegblẽ" alo "dɔwɔwɔ ƒe bu." Eyata nusi dzɔna le dɔléle sia mee nye be ahɔhɔ̃a ƒe akpa eve siawo ƒe dɔwɔwɔ dzi ɖena kpɔtɔna vivivi.

Nɔnɔme sia, ``Corticobasal Degeneration``, ateŋu ana ame ƒe agbenɔƒe nadidi eye wòahe kuxi siwo ate ŋu ade eƒe agbe afɔku me vɛ. Ne dzesiawo le kakam ɖe ŋutilã bliboa me la, ate ŋu asesẽ be woawɔ dɔ le wo ɖokui si.

Nukae nye `(Corticobasal Degeneration)` ƒe dzesiwo?

Nɔnɔme sia ƒe dzesiwo ate ŋu ato vovo tso ame ɖeka gbɔ yi bubu gbɔ, gake ŋutete siwo dzi wòate ŋu akpɔ ŋusẽ ɖo le goawo katã me enye:

• Ʋuʋu ƒe kuxiwo (`Apraxia`): Esia fia be nuwo abe abɔta ƒoƒo alo gaku léle ɖe asi be woaɖu nu ene va sesẽna. Togbɔ be ahɔhɔ̃a ɖoa gbedasiwo ɖe asiwo hã la, womate ŋu awɔ wo nyuie o.
• Ŋkuɖodzinu ƒe dɔmawɔmawɔ nyuie: Eva sesẽna be woaɖo ŋku nu yeyewo dzi, eye vivivi la, woŋlɔa nu xoxowo be.
• Nukpɔkpɔ ƒe dɔmawɔmawɔ nyuie: Ame aɖewo hã ate ŋu akpɔ kuxiwo.
• Nuƒoƒo ƒe kuxiwo (`Aphasia`): Nyawo didi sesẽ, nya si nèdi be yeagblɔ la tsɔtsɔ ƒu gbe, eye ɣeaɖewoɣi la, nuƒoƒo ƒe bu keŋkeŋ.
• Nu mimi sesẽ: Ðewohĩ àse le ɖokuiwò me be yeƒe lãme le ƒoƒom ne èle nuɖuɖu kple nunono mimim.

Tsɔ kpe ɖe esia ŋu la, woate ŋu akpɔ dzesi bubuwo abe esiawo ene hã:

• Lãmetsiwo ƒe ʋuʋu, ʋuʋu, lãmekawo ƒe sesẽ, alo ʋuʋu.
• Dɔ sue siwo me kɔ nyuie wɔwɔ sesẽ (e.g., awudziwui ƒe abɔta, nuŋɔŋlɔ kple nuŋlɔti).
• Alien hand syndrome: Ŋutete si mele ame si be wòaɖu alɔ alo afɔ ɖeka dzi abe alesi nèdi ene (`Alien hand syndrome`). Tsɔe be wò abɔ ɖeka le nu siwo mèdi be wòawɔ o wɔm, eye nèse le ɖokuiwò me be yemate ŋu aɖu edzi o.
• Seselelãme si nye be ŋutilã ƒe akpa ɖeka le ʋuʋum.
• Ʋuʋu blewu ŋutɔ (`Bradykinesia`) alo ŋutetemanɔamesi be woaʋuʋu abɔ kple afɔwo (`Akinesia`).
• Susu ƒe dɔwɔwɔ dzi ɖe kpɔtɔ, si fia be nunya dzi ɖe kpɔtɔ (Dementia).
• Azɔlizɔzɔ sesẽe kpekpeɖeŋu manɔmee.
• Seselelãme kple nuwɔna ƒe tɔtrɔ (ame ƒe susumanɔamesi, dzikudodo kpata, ɖekematsɔleme).

Dɔléle sia medzea amesiame dzi le mɔ ɖeka nu o. Zi geɖe la, eyia ŋgɔ vivivi. Ɣeaɖewoɣi la, dzesiawo dzea egɔme tso alɔ ɖeka dzi, emegbe wokakana ɖe alɔ kple afɔ kemɛ dzi. Ðewohĩ àva nɔ sesem le ɖokuiwò me abe ɖe nèle kpo klim ne èle zɔzɔm ene, eye emegbe màgate ŋu azɔ kpekpeɖeŋu manɔmee o. Àte ŋu adze wò nyawo ƒoƒo ƒuƒlu gɔme ne èle nu ƒom, eye le ɣeyiɣi aɖe megbe la, màte ŋu agblɔ nyagbe ɖeka pɛ hã si ŋu gɔmesese le o.

Esi dɔlélea le nu gblẽm le ahɔhɔ̃a ƒe akpa geɖe wu ŋu la, dzesiawo va le sesẽm ɖe edzi vivivi. Esia dzɔna vivivi.

Ɣekaɣie `(Corticobasal Degeneration)` ƒe dzesiwo dzea egɔme?

Zi geɖe la, dzesiawo dzea egɔme tso ƒe 50 va ɖo 70. Ame akpa gãtɔ dzea egɔme tso ƒe 64. Togbɔ be ƒã hafi wòate ŋu adze egɔme tso ƒe 40 xɔxɔ me hã la, womegblɔ nya aɖeke be dɔlélea doa mo ɖa le ƒe tsitsi me o.

Nukae nye nusiwo gbɔ `(Corticobasal Degeneration)` tsona?

Susu vevitɔ si tae nye be ahɔhɔ̃mekawo kple lãkusiwo gblẽna vivivi hekuna. Zi geɖe la, nugbegblẽ sia dzea egɔme tso teƒe siwo míeƒo nu tsoe va yi siwo woyɔna be ahɔhɔ̃mekawo kple basal ganglia. Ne dɔlélea le sesẽm ɖe edzi la, ate ŋu adze ahɔhɔ̃a ƒe akpa bubuwo hã dzi.

Numekulawo xɔe se be protein aɖe si woyɔna be "Tau" ye kpɔa gome le dɔléle sia me. Zi geɖe la, ahɔhɔ̃menugbagbeviwo mee protein sia le. Gake le dɔléle sia me la, protein sia ƒoa ƒu ɖekae le mɔ si mesɔ o nu eye wòwɔa ƒuƒoƒo. Woyɔa ƒuƒoƒo siawo be "neurofibrillar tangles." Ƒuƒoƒo siawo nana ahɔhɔ̃menugbagbeviwo gblẽna hekuna. Esia wɔnɛ be kuxiwo doa mo ɖa le ʋuʋu, nuƒoƒo, kple ŋkuɖoɖonudzi ŋu.

Womenya susu si tututu tae Tau protein la ƒoa ƒu ɖo haɖe o. Wokpɔe be domenyiŋusẽfianu ƒe tɔtrɔ (trɔtrɔ) aɖe le ame geɖe siwo ŋu Corticobasal Degeneration le si woyɔna be H1 haplotype le chromosome 17. Domenyiŋusẽ ƒe tɔtrɔ sia ate ŋu ana Tau protein la nagbɔ eme eye wòaƒo ƒu ɖekae, alo ate ŋu anye be methyl ƒuƒoƒo aɖe kpe ɖe Tau domenyiŋusẽfianu ŋu, si akpɔ ŋusẽ ɖe eƒe dɔwɔwɔ dzi.

Gake numekulawo nya be menye domenyiŋusẽfianu sia koe hea esia vɛ o. Esi wònye be domenyiŋusẽfianu sia le ame geɖe siwo le amehawo dome ta la, womekpɔa ``Corticobasal Degeneration.`` ƒe dzesiwo o. Eyata wogale numekuku wɔm be woake ɖe nusi tututu gbɔ nɔnɔme sia tso ŋu.

Ðe `(Corticobasal Degeneration)` nye domenyiŋusẽfianua?

Atikeŋutinunyalawo menya nusita ame aɖewo xɔa Corticobasal Degeneration haɖe o. Ƒã ŋutɔ be ƒome ɖeka me tɔwo naxɔ dɔlélea. Ema fia be esesẽ be woagblɔ be domenyiŋusẽfianu ƒe dɔlélee.

Nukawoe nye kuxi siwo ate ŋu ado tso eme?

Ne dɔlélea le sesẽm ɖe edzi la, afɔku si le eme be kuxi siwo ate ŋu ade ame ƒe agbe afɔku me abe:

• Dɔlékuiwo ƒe dɔlélewo
• Ʋu ƒe sisi kple aklã me ʋu ƒe sisi
• Ŋutilãmefɔkuwo (abe anyidzedze ene) .
• Aklãdɔléle
• Sepsis (dɔlékui sesẽ aɖe si dɔlékui siwo gena ɖe ʋukawo me hena vɛ) .

Aleke ɖɔktawo wɔa dea dzesi dɔléle siae? (`Dɔléle ƒe dzesi`) .

Nu tɔxɛ si le `(Corticobasal Degeneration)` didi me enye be ne woado ahɔhɔ̃a kpɔ le ku megbe ko hafi woate ŋu aɖo kpe edzi bliboe. Ema ko hafi ɖɔkta alo dɔléleŋutinunyala ate ŋu anya alesi gbegbe ahɔhɔ̃a gblẽe nyuie.

Ke hã, le wò agbenɔɣi la, wò ɖɔkta ate ŋu ayɔ nɔnɔme sia be "Corticobasal Syndrome" le wò dzesiwo nu.

Be nànya dɔlélea la, wò ɖɔkta awɔ ŋutilãmedɔdada gbã. Woalé ŋku ɖe wò dzesiwo ŋu nyuie ŋutɔ.

Esi dɔléle geɖe ƒe dzesiwo sɔ ta la, wò ɖɔkta ate ŋu awɔ dodokpɔ vovovowo atsɔ anya nusi tututu gbɔ wòtso. Esiawo ate ŋu anye:

• Ʋudodokpɔwo
• Ahɔhɔ̃ ƒe nɔnɔmetata dodokpɔwo (`Nɔnɔmetata ƒe dodokpɔwo`) - le kpɔɖeŋu me `(MRI)` alo `(CT scan`) .
• Ahɔhɔ̃mekawo ƒe susuŋutinunya dodokpɔ be woatsɔ akpɔ ahɔhɔ̃a ƒe dɔwɔwɔ kple ŋkuɖoɖonudzi

Tsɔ kpe ɖe eŋu la, ɖɔkta ate ŋu adɔ nukliatike ƒe fotowo abe `(FDG-PET (Fluorodeoxyglucose Positron Emission Tomography))` kple `(DAT (Dopamine Transporter))` hã. Ɣeaɖewoɣi la, `skin biopsy` hã ateŋu akpeɖeŋu le dɔlélea didi me.

Nukae nye atikewɔwɔ na `(Corticobasal Degeneration)`?

Wò ɖɔkta ate ŋu aŋlɔ atike vovovowo na wò be wòatsɔ aɖu dɔléle sia ƒe dzesi vovovoawo dzi.

Ðo ŋku edzi be fifia la, atike aɖeke meli na dɔléle sia alo atike aɖeke meli si ana dzesiawo natsi o. Gake nanewo li siwo ate ŋu akpe ɖe ame ŋu be woaɖe vevesese si dzesiawo hena vɛ dzi akpɔtɔ.

Atike siwo woatsɔ akpɔ dzesi siwo do ƒome kple lãmekawo ate ŋu anye:

• Ʋuʋu blewu alo lãmekawo ƒe sesẽ: `(Levodopa)`
• Le lãmekawo ƒe ʋuʋu gome la: Clonazepam (Benzodiazepines) .
• Le lãmekawo ƒe sesẽ alo ʋuʋu dzi ɖuɖu gome la: `(Botulinum toxin)` (Botox injections) .
• Le lãmekawo ƒe sesẽ gome la: `(Cyclobenzaprine)`, `(Levetiracetam)` alo `(Baclofen)`

Le ŋkuɖoɖonudzi ƒe kuxiwo gome la, wò ɖɔkta ateŋu aŋlɔ atike siawo dometɔ ɖeka si woyɔna be ``Cholinesterase inhibitors'':

• `(Donepezil)`
• `(Rivastigmine)`
• `(Galantamine)`

Atike aɖewo mewɔa dɔ nyuie na amesiame ƒe dzesiwo sɔsɔe o, eyata wò ɖɔkta ate ŋu ate ƒomevi vovovowo kpɔ be yeake ɖe esi awɔ dɔ na wò wu ŋu.

Azɔ hã, abe atikewo katã ene la, nugbegblẽ le ame ŋu ate ŋu ado tso eme. Wò ɖɔkta aƒo nu tso esia ŋu na wò. Woalé ŋku ɖe ŋuwò edziedzi be atikeawo le dɔ wɔm nyuie eye ne kuxi aɖewo li hã. Ne èkpɔ nugbegblẽ aɖewo la, ele be nàgblɔe na wò ɖɔkta enumake.

Vevietɔ wu la, atike aɖeke meli fifia si ana dzesi siawo ƒe ŋgɔyiyi alo ada dɔlélea keŋkeŋ o.

Aleke woawɔ akpɔ dzesiawo gbɔe?

Ne èle agbe kple ``Corticobasal Syndrome'' ƒe dzesiwo la, atikewɔmɔnu siwo gbɔna ate ŋu akpe ɖe ŋuwò nàkpɔ wo gbɔ:

• Dɔwɔwɔ ƒe atikewɔwɔ: Esia ate ŋu akpe ɖe ŋuwò nàsrɔ̃ mɔ yeye siwo dzi nàto awɔ gbesiagbedɔwo eye nàlé wò ɖokuisinɔnɔ me ɖe asi ɣeyiɣi didi si nàte ŋui. Ne ehiã la, àte ŋu asrɔ̃ alesi nàzã mɔ̃ siwo kpena ɖe ame ŋu le ʋuʋum hã.
• Lãmesẽfefewɔwɔ: Esia kpena ɖe ame ŋu wòléa ŋutilã ƒe ʋuʋu ɖe te eye wòɖea vevesese si lãmekawo ƒe dzesiwo hena vɛ dzi kpɔtɔna. Kamedede ate ŋu akpe ɖe ame ŋu wòado ŋusẽ lãmekawo eye wòana woate ŋu atrɔ ɖe nɔnɔmewo ŋu.
• Nuƒoƒo ƒe atikewɔwɔ: Esia kpena ɖe ame ŋu le nuƒoƒo kple nu mimi ƒe kuxiwo me. Ate ŋu akpe ɖe ame ŋu le nuwo abe alesi woaɖe susuwo agblɔ, alesi woayɔ nyawo, kple alesi woami nuɖuɖu dedie ene me.

Wò ɖɔkta awɔ dɔ kpli wò be nàdi mɔnu nyuitɔ siwo dzi nàto akpɔ wò dzesiwo gbɔ. Mɔnu siawo ate ŋu ato vovo tso ame ɖeka gbɔ yi bubu gbɔ, eye ahiã be nàtrɔ asi le wo ŋu ne wò nɔnɔmea le tɔtrɔm le ɣeyiɣi aɖe megbe.

Ɣekaɣie wòle be nàkpɔ ɖɔkta?

Ne `(Corticobasal Degeneration)` ƒe dzesi siawo dometɔ aɖe le ŋuwò alo wò lɔlɔ̃tɔ aɖe ŋu la, yi ɖɔkta gbɔ enumake:

• Ne esesẽ na wò be nàzɔ alo aɖu wò abɔwo kple afɔwo dzi.
• Ne ŋkuɖoɖonudzi ƒe kuxiwo alo tagbɔdɔléle ƒe dzesiwo le fu ɖem na wò.
• Ne nuƒoƒo, nu mimi, alo gbɔgbɔ sesẽ na wò.
• Ne ʋuʋudediwo li.

Nukae nye `(Corticobasal Degeneration)` ƒe ŋgɔdonya?

Ne míagblɔe tututu la, mɔkpɔkpɔ si le Corticobasal Degeneration ŋu medo ŋugbe boo o. Enye dɔléle si yia edzi ɖaa, si fia be dzesiawo nu sẽna ɖe edzi le ɣeyiɣi aɖe megbe.Gake zi geɖe la, esia dzɔna vivivi, le ƒe geɖe megbe. Wò ɖɔkta ana atike siwo akpe ɖe ŋuwò nànɔ te ɖe wò dzesiwo nu ahakpɔ wo gbɔ. Togbɔ be atikewɔmɔnu siawo ate ŋu aɖe wò dzesiawo ƒe sesẽ dzi akpɔtɔ hã la, womate ŋu axe mɔ na wo be woagagblẽ ɖe edzi o. Ne wò dzesiawo le sesẽm ɖe edzi la, ate ŋu asesẽ wu be nàkpɔ wo gbɔ le ɖokuiwò si.

Esi dɔléle sia le ŋgɔ yim vivivi ta la, ɣeyiɣi le asiwò nàwɔ ɖoɖo ɖe wò etsɔme ŋu. Mehiã be nàwɔ nusiawo enumake ne wokpɔ dɔlélea le ŋuwò o. Ele be nàdi ɣeyiɣi ade ŋugble le nusi anyo na wò ŋu. Ele be nàwɔ dɔ kple wò ɖɔktawo kple amesiwo dzi nèka ɖo be woawɔ ɖoɖo ɖe wò didiwo kple beléle si nèhiã ŋu.

Nukae nye ame si ŋu `(Corticobasal Degeneration)` le ƒe agbenɔƒe?

Le mamã dedie nu la, ame akpa gãtɔ nɔa agbe abe ƒe ade va ɖo enyi ene le Corticobasal Degeneration ƒe dzesi gbãtɔwo dzedze vɔ megbe. Ke hã, esia mesɔ na amesiame o, eye ame aɖewo nɔa agbe didi wu sã. Ðewohĩ wò nɔnɔmea masɔ kple akɔntabubuwo o, eyata ame nyuitɔ si nàƒo nu tso esia ŋu nae nye wò ɖɔkta.

Nɔnɔme bubu kawoe ƒe dzesi mawo tɔgbe dzena le wo ŋu?

`(Corticobasal Degeneration)` ƒe dzesi aɖewo ateŋu asɔ kple dɔléle bubuwo ƒe dzesiwo, abe:

• Ahɔhɔ̃ me kansa (`Ahɔhɔ̃ me kansa / ahɔhɔ̃ me dɔdzẽ`)
• `(Frontotemporal tagbɔdɔléle)`
• Alzheimer ƒe dɔlélea
• `(Nuɖoanyi geɖe ƒe atrophy)`
• Parkinson ƒe dɔlélea
• `(Progressive supranuclear palsy)`
• Gbagbãdᴐ

Eyata ele vevie ŋutɔ be nàyi ɖɔkta gbɔ enumake ne èkpɔ dzesi aɖewo, elabena atikewɔwɔ kaba ate ŋu axɔ ame ɖe agbe, vevietɔ le nɔnɔmewo abe lãmetutudɔ ene me.

Ateŋu asesẽ be woakpɔ seselelãme siwo vaa dɔléle abe `(Corticobasal Degeneration)` ene gbɔ. Ðewohĩ àse le ɖokuiwò me be vɔvɔ̃ le ye ƒo eye yeatsi dzimaɖi ɖe etsɔme ŋu. Ne dzesiawo le tsitsim le ƒeawo me la, ɖewohĩ ànɔ alesi nàwɔ awɔ ɣeyiɣi ɖesiaɖe ŋudɔ nyuie wu ŋu bum. Ate ŋu asesẽ be woakpɔ nusiawo katã gbɔ zi ɖeka. Àte ŋu aƒo nu kple susumedɔdala aɖe hã be wòakpe ɖe ŋuwò le ɣeyiɣi sesẽ sia me.

Ðo ŋku edzi be menye wò ɖeka koe le nusiawo katã me o. Ne èhiã kpekpeɖeŋu la, mègahe ɖe megbe gbeɖe le wò atikewɔlawo ƒe ƒuƒoƒoa gbɔ yiyi me o.

Mlɔeba la, nu siwo dzi wòle be woaɖo ŋkui

Enyo, eyata nu aɖewo siwo ŋu míeƒo nu tsoe tso `(Corticobasal Degeneration)` ŋu siwo mesusu be anɔ vevie na wò lae nye esi:

• Esia nye nɔnɔme si gblẽa nu le ahɔhɔ̃a ŋu eye dzesiawo dzina ɖe edzi vivivi le ɣeyiɣi aɖe megbe.
• Womekpɔ nusi tututu gbɔ esia tso haɖe o, gake wosusu be edo ƒome kple protein aɖe si woyɔna be `(Tau)`.
• Fifia la, atike aɖeke meli si woatsɔ ada dɔlélea keŋkeŋ o.
• Gake atikewɔmɔnu aɖewo li siwo dzi woato akpɔ dzesiawo gbɔ eye woana agbea nanɔ bɔbɔe.(Abe atike, kamedede, dɔwɔwɔ ƒe atikewɔwɔ, nuƒoƒo ƒe atikewɔwɔ ene).
• Ele vevie be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo kaba.
• Wɔ ɖoɖo ɖe etsɔme ŋu eye nàxɔ kpekpeɖeŋu si nèhiã.
• Menye wò ɖeka koe o. Ele vevie ŋutɔ hã be wò susu nasẽ. Di kpekpeɖeŋu tso ɖɔktawo, ƒometɔwo, kple xɔlɔ̃wo gbɔ.

Mele mɔ kpɔm be nyatakaka sia akpe ɖe ŋuwò. Ne nya aɖe le asiwò la, mègahe ɖe megbe le nuƒoƒo kple wò ɖɔkta me o.

` Corticobasal Degeneration, Ahɔhɔ̃medɔlélewo, Ahɔhɔ̃mekawo ƒe Dɔlélewo, Ʋuʋu ƒe Dɔlélewo, Ŋkuɖodzi ƒe Dɔmawɔmawɔ nyuie, Nuƒoƒo ƒe kuxiwo, Tau Protein, CBS, Brain Atrophy, Apraxia, Aphasia, Dementia