Nukae le dzɔdzɔm ɖe wò ŋkuɖodzinyawo dzi? Mina míasrɔ̃ nu tso Creutzfeldt-Jakob Dɔléle (CJD) ŋua?

Ðe nèsusuna ɣeaɖewoɣi be, "Oo, nye hã meŋlɔ esia be!"? Nu suesuesuewo ŋɔŋlɔ be eye ɣeaɖewoɣi la, tɔtɔ ate ŋu anye nusi sɔ. Gake nuwo abe ŋkuɖoɖonudzi vivivi kple agbenɔnɔ ƒe tɔtrɔ ene hã ate ŋu anye dɔléle sesẽ aɖe ƒe dzesiwo. Egbea míele nu ƒom tso dɔléle aɖe si mebɔ o, gake wòsẽa ŋu ŋutɔ, si gblẽa nu le ahɔhɔ̃a ŋu la ŋu. Emae nye Creutzfeldt-Jakob ƒe dɔléle, alo CJD abe alesi míeyɔnae kpuie ene.

Nukae nye CJD sia? Kpuie ko la,...

Bu eŋu kpɔ, míaƒe ahɔhɔ̃ nye mɔ̃ si gɔme sese sesẽ ŋutɔ. Be mɔ̃ sia nate ŋu awɔ dɔ nyuie la, ele be eƒe akpa suesuesue siwo woyɔna be lãmenugbagbeviwo nanɔ lãmesẽ me. CJD nye dɔléle sesẽ aɖe si mebɔ o, si gblẽa míaƒe ahɔhɔ̃menugbagbeviwo vivivi. Nusi koŋ gbɔ esia tsona enye protein ƒomevi aɖe si mesɔ o si woyɔna be ``prions`` .

Fifia ɖewohĩ ànɔ ɖokuiwò biam be nukae nye ‘prion’ siawo hã. Le míaƒe ŋutilã me, vevietɔ le ahɔhɔ̃a me la, nanewo li siwo woyɔna be protein. Esiawo le abe mɔ̃ suewo ene, woƒe nɔnɔme aɖe koŋ le wo si, eye ne wole nɔnɔme ma me ko hafi woate ŋu awɔ woƒe dɔ nyuie. Bu eŋu abe origami ene. Ne èblae nyuie la, àte ŋu awɔ lã alo seƒoƒo dzeani aɖe. Gake ne èxatsae vodadatɔea? Mewɔa dɔ o. Aleae protein siawo le. Ɣeaɖewoɣi la, protein siawo ƒoa ƒu nyuie o. Míeyɔa protein mawo siwo womebla nyuie o be ‘prions’.

‘Prion’ siawo siwo womebla nyuie o la dzea ƒoƒo ƒu ɖe ahɔhɔ̃menugbagbeviwo me. Woƒoa lãmenugbagbevi mawo nu ƒu hegblẽa wo. Ele abe gbeɖuɖɔ gbogbo aɖe si ƒoa ƒu gbesiagbe ene. Esia tae tagbɔdɔléle ƒe dzesiwo dzena le CJD dɔnɔwo ŋu , abe ŋkuɖoɖonudzi ƒe dɔmawɔmawɔ nyuie kple tɔtɔ ene. Woate ŋu akpɔ tɔtrɔ le woƒe agbenɔnɔ me eye azɔlizɔzɔ sesẽ na wo hã.

Nu vevitɔ kekeakee nye be CJD wua ame ɣesiaɣi. Womekpɔ atike aɖeke haɖe o, eye mɔ aɖeke meli si dzi woato ahe dɔlélea ƒe ŋgɔyiyi dzi akpɔtɔ o. Gake atikewɔwɔ kple belélename aɖewo li siwo ate ŋu akpe ɖe dɔnɔa ŋu wòanɔ agbe nyuie wu eye wòaɖe vevesese dzi akpɔtɔ.

Esia nye dɔléle si mebɔ kura o. Le xexeame katã la, dɔlélea dzea ame abe ame ɖeka va ɖo eve ene le miliɔn ɖeka me ƒe sia ƒe. Le dukɔ abe United States ene gɔ̃ hã me la, CJD dɔléle siwo ade 350 koe wogblɔna ƒe sia ƒe.

Esia ƒe tɔtrɔ ɖeka li si woyɔna be ``trɔtrɔ CJD`` (alo ``vCJD``) . Ƒã ŋutɔ hã. Etsoa nyilã si ŋu dɔléle si nye ``bovine spongiform encephalopathy`` (BSE) le ɖuɖu me, si nye dɔléle si dzea nyiwo dzi.

Nukawoe nye CJD ƒe dzesiwo? Na míalé ŋku ɖe eŋu tso gɔmedzedzea me ke.

Zi geɖe la, CJD ƒe dzesiwo dzena vivivi. Gake ne dɔlélea le sesẽm ɖe edzi la, dzesi siawo ate ŋu adzi ɖe edzi kabakaba. Mina míalé ŋku ɖe dzesi veviawo ŋu, tso dɔlélea ƒe gɔmedzedze va ɖo eƒe nuwuwu:

• Nuŋlɔɖi be kple ŋkuɖoɖonudzi ƒe kuxiwo:Edzea egɔme tso nu suesuesuewo ŋɔŋlɔ be dzi. Nuwo abe xɔ̃wò aɖe ƒe ŋkɔ, ablɔ aɖe, alo dɔ si wɔm nènɔ ene. Vivivi la, esia va le gbegblẽm ɖe edzi.
• Tɔtɔ kple susu ƒe tɔtɔ: Màte ŋu aɖo ŋku afisi nèle, gaƒoƒo si me wòle, alo amesiwo le gbɔwò dzi o.
• Tɔtrɔ le nuwɔna kple amenyenye me: Ðewohĩ mànye ame si nènye tsã o. Àte ŋu ado dziku bɔbɔe, alé blanui, alo seselelãmewo katã maganɔ ŋuwò o.
• Nukpɔkpɔ ƒe kuxiwo, nusi nèkpɔna gɔmesese sesẽna: Wò ŋku ƒe nukpɔkpɔ gbɔdzɔna, eye màte ŋu ade dzesi nusi nèkpɔna o.
• Susumesusu alo susumenuwo: Nusiwo mele afima o kpɔkpɔ alo wo sese, alo alakpadzixɔsewo ƒe amesinɔnɔ be ame aɖe le agbagba dzem be yeagblẽ nu le ŋuwò.
• Kuxi siwo le nuwɔwɔ ɖekae (ataxia): Ðewohĩ màte ŋu azɔ nyuie o, asesẽ na wò be nàɖu wò abɔwo kple afɔwo dzi, eye àte ŋu aʋuʋu abe ahatsunola ene.
• Kuxi siwo le ŋutilã ƒe dadasɔ ŋu: Anyidzedze ne èle tsitrenu alo le zɔzɔm.
• Lãmetsiwo ƒe tete si dzi womeɖu o (`myoclonus`) kple lãmekawo ƒe sesẽ (`dystonia`): Abɔ alo afɔ ƒe ʋuʋu kpata, alo ŋutilã ƒe lãmekawo ƒe ʋuʋu ƒe seselelãme.
• Alɔ̃madɔmadɔ: Ate ŋu ava abe alɔ̃madɔmadɔ ene.
• Lãmetsiŋusẽ: Ŋutilã ƒe akpa aɖewo zua lãmetutudɔ.
• Lãmetsiwo ƒe gbagbã: Ŋutilãa ƒe lãmekawo ƒe lolome buna.

Dzesi siawo ate ŋu adze ɖekaɖeka, alo wo dometɔ geɖe ate ŋu adze ɖekae. Nu vevitɔe nye be nàyi ɖɔkta gbɔ kaba ne dzesi siawo dometɔ aɖe le ŋuwò.

Nukae hea CJD vɛ? Mina míagaɖo ŋku ‘prion’ mawo dzi ake

Abe alesi míeƒo nu tso eŋu va yi ene la, nusi koŋ gbɔ CJD tsona enye protein siwo womebla nyuie o si woyɔna be ``prions.'' Nusi me afɔku le wu le ``prion'' siawo ŋu enye be woateŋu abla protein siwo sɔ, siwo le lãmesẽ me gɔ̃ hã vodadatɔe. Abe alesi ko akɔɖu gbegblẽ ɖeka ate ŋu ana akɔɖu bubuawo katã nagblẽ ene.

Ahɔhɔ̃ me lãmenugbagbeviwo mate ŋu aɖe ‘prion’ siawo siwo womebla nyuie o la ɖa o. Eyata woƒoa ƒu, eye wogblẽa ahɔhɔ̃menugbagbeviwo dome mlɔeba. Ne ‘prion’ siawo le kakam ɖe ahɔhɔ̃a katã me la, dɔlélea yia edzi kabakaba ŋutɔ.

Ðe CJD ƒomevi vovovowo lia?

Ẽ, CJD ƒomevi vevi geɖewo li:

• CJD si dzɔna ɣeaɖewoɣi: Esiae nye CJD ƒomevi si bɔ wu. Womenya nusi tututu gbɔ wòtso haɖe o. Edzɔna zi ɖeka, eye susu aɖeke si dze ƒã manɔmee.
• Domenyiŋusẽfianu ƒe CJD: Esia nye domenyinu. Domenyiŋusẽfianu si gblẽ si ƒe dome wonyi tso dzila ɖeka alo wo ame evea siaa gbɔ gbɔe wòtsona. Esia ƒe ƒomevi sue evee li: Gerstmann-Sträussler-Scheinker (GSS) ƒe dɔlélea kple ƒomea ƒe alɔ̃madɔmadɔ si wua ame . Esiawo nye ayemɔ vie, gake wonye nɔnɔme siwo le tẽ ŋutɔ.
• CJD si woxɔ (`CJD si woxɔ`):Esia ate ŋu adzɔ le gotagome nusiwo gbɔ wòtso ta. Le kpɔɖeŋu me, ate ŋu adzɔ to ŋutinuwo dodo na ame aɖe si ŋu CJD le gbɔ, lãmekawo dodo na ame, alo amekokodɔwɔnu siwo me dɔlékuiwo le zazã me. Gake esia mebɔ kura o. Fifia la, amewo tsia dzi ɖe esia ŋu ŋutɔ.
• Variant CJD (vCJD): Míeƒo nu tso esia ŋu do ŋgɔ. nyilã si ŋu nyitsu ƒe dɔléle si nye mad cow disease (BSE) le ɖuɖu gbɔe wòtsona. Prion siwo hea BSE vɛ ate ŋu axɔ amegbetɔwo kpakple lã bubuwo hã.

Amekawoe le afɔku gã me be woaxɔ CJD?

Ame sia ame ate ŋu axɔ CJD. Ɣeaɖewoɣi la, ‘prion’ siwo le wò ŋutilã me ate ŋu anɔ anyi ƒe geɖe evɔ womaɖe dzesi aɖeke afia o. Gake ne dzesiawo nya dze ko la, dɔlélea ate ŋu asẽ kaba ne ahɔhɔ̃a le gbegblẽm.

Zi geɖe la, dɔléle sia dzea amesiwo xɔ tso ƒe 50 va ɖo ƒe 80. Gake zi geɖe la, domenyiŋusẽfianu ƒe CJD ƒomevi ate ŋu adze le ƒe 30 va ɖo 50 dome.

Ðe CJD nye dɔléle si xɔa ame mea?

Esia nye kuxi na ame geɖe. Menye kadodo dzro aɖe koe CJD kaka , abe asikpekpe, nuƒoƒo, alo nuɖuɖu ɖekae ene o. Mɔ ɖeka kolia si dzi woato akaka CJD tso ame ɖeka gbɔ ayi ame bubu gbɔe nye to ŋutinu alo lãkusi aɖe dodo na ame aɖe si ŋu CJD le gbɔ, alo to lãmetsiŋusẽ aɖewo zazã tso amesi ŋu CJD le gbɔ me.

Wogblɔna be woate ŋu axɔ ƒomevi si woyɔna be `vCJD` to ʋudodo me, gake ema ƒã ŋutɔ, ƒã ŋutɔ. Dɔléle si woyɔna be `vCJD` ŋutɔ mebɔ kura o.

Aleke ɖɔktawo wɔa dea dzesi CJD?

Ðɔkta dea dzesi CJD to wò dzesiwo kple dzesiwo me dzodzro nyuie me. Tsɔ kpe ɖe ŋutilãmedɔdada ŋu la, woawɔ ahɔhɔ̃mekawo ƒe dodokpɔ hã. Woabia tso asiwò be nàwɔ dɔ bɔbɔe aɖewo atsɔ adze agbagba ade dzesi kuxi siwo le wò ahɔhɔ̃ ƒe dɔwɔwɔ ŋu.

Eŋutinunyalawo bu CJD be enye ‘tagbɔdɔ si woyɔna be spongiform encephalopathy si woate ŋu akaka’ . Togbɔ be ŋkɔa aɖi nya sesẽ vie hã la, efia alesi ahɔhɔ̃ si ‘prion’ gblẽ nu le la dzena le nusuekpɔmɔ̃ me. Eyae nye be edze abe ƒumebɔbɔ si ŋu ʋuʋudedi le ene.

Be woaɖo kpe CJD ƒe dzesi dzi la, wowɔa dodokpɔwo abe MRI scan alo spinal tap (akɔta ƒe ʋuʋu) ene.

Tsɔ kpe ɖe eŋu la, ɖɔktawo ate ŋu azã dodokpɔwo abe esiawo ene atsɔ aɖe nɔnɔme bubu siwo ƒe dzesiwo sɔ kple CJD tɔ ɖa eye woagaku nu me le CJD ŋu geɖe wu:

• Ʋudodokpɔwo
• Domenyiŋusẽfianu dodokpɔ - vevietɔ be woakpɔe ɖa be ƒomevi aɖe nye domenyiŋusẽfianu hã
• Elektrikŋusẽ ƒe ahɔhɔ̃mekawo ƒe dɔwɔwɔ (EEG) .
• Aɖuɖɔtoe me dzodzro
• Brain biopsy - Ƒã ŋutɔ hafi wowɔa esia, ne dodokpɔ bubuawo katã mete ŋu kpɔ dɔléle si ŋu kakaɖedzi le o ko.

Ðe atike aɖe li na CJD?

Nublanuitɔe la, atike aɖeke meli na CJD o, atike aɖeke meli si woatsɔ axe mɔ ɖe dɔlélea ƒe kaka nu o, alo atike aɖeke meli si ana eƒe ŋgɔyiyi nagbɔdzɔ o. Nu ɖeka si ɖɔktawo ate ŋu awɔe nye be woakpe asi ɖe ame ŋu be woaɖe vevesese si dzesiawo hena vɛ dzi akpɔtɔ. Woyɔa esia be beléle si naa ame ƒe dzi dzea eme .

Le kpɔɖeŋu me, woate ŋu ana atikewo atsɔ ada alɔ̃madɔmadɔ, agbenɔnɔ ƒe tɔtrɔ, alo lãmekawo ƒe ʋuʋu si dzi womate ŋu aɖu o. Gake viɖe siwo dona tso atikewɔmɔnu siawo me la mesɔ gbɔ o.

Nɔnɔme sia ate ŋu agblẽ ɖe edzi kaba ŋutɔ. Eyata belélename ƒe tiatia siwo akpe ɖe ŋuwò na wò kple wò lɔlɔ̃tɔwo le vevie ŋutɔ. Le dɔlélea ƒe akpa mamlɛawo me la, ame tsitsiwo dzikpɔƒe ƒe dɔwɔƒewo ate ŋu akpe ɖe ame ŋu ŋutɔ.

Ɣeaɖewoɣi la, ne èdze la, wò atikewɔlawo ƒe ƒuƒoƒoa ate ŋu ado susua ɖa be nàkpɔ gome le dɔdamɔnu dodokpɔ aɖe si me wole numekuku wɔm le le atikewɔwɔ yeyewo ŋu me.

Etsɔme ka ƒomevie amesi ŋu CJD le ate ŋu akpɔ mɔ na?

Esi wònye be womate ŋu ada CJD o eye atike aɖeke mele eŋu o ta la, mɔkpɔkpɔ si le amesi ŋu dɔlélea le ŋu me mekɔ tututu o. Ne dzesiawo nya dze egɔme ko la, eteƒe medidina hafi ŋutete si le ame si be wòawɔ dɔ le eɖokui si, aʋuʋu, ahaƒo nu la nu yina o.

Esi wònye be tɔtrɔwo ate ŋu adzɔ kabakaba ta la, ele vevie be nàwɔ dɔ kple wò atikewɔlawo ƒe ƒuƒoƒoa awɔ ɖoɖo do ŋgɔ akpɔ egbɔ be wokpɔ wò didiwo kple nuhiahiãwo gbɔ. Le nyateƒe me la, eɖanye atikewɔwɔ ƒe nɔnɔme aɖe le ŋuwò alo mele asiwò o, enyo be `mɔfiame do ŋgɔ` nanɔ amesiame si. Esia fia be èŋlɔ atikewɔwɔ si dim nèle la ɖi do ŋgɔ ne mète ŋu gblɔa wò didiwo o. Ele vevie ŋutɔ be ɖoɖo sia nanɔ anyi kaba le dɔléle si le kakam kabakaba abe CJD ene me.

Esi wònye be nɔnɔme sia nu sẽe ta la, anyo be nàdi aɖaŋuɖoɖo tso tagbɔdɔdala gbɔ be wòakpe ɖe ŋuwò kple wò ƒomea mianɔ te ɖe tɔtrɔ siawo nu eye mianɔ ŋusẽ kpɔm le susu me.

Nukae nye CJD dɔnɔ ƒe agbenɔƒe?

CJD dɔnɔ akpa gãtɔ kuna le ɣleti ʋɛ aɖewo alo ƒe ɖeka me tso esime wokpɔ dɔlélea. Nusi to vovo koe nye CJD ƒe domenyiŋusẽfianu, si me amewo ate ŋu anɔ agbe tso ƒe ɖeka va ɖo ƒe ewo le dzesiawo ƒe gɔmedzedze megbe.

Wò ɖɔkta ate ŋu ana nyatakaka tɔxɛ siwo sɔ ɖe ɣeyiɣia nu tso wò nɔnɔmea ŋu. Ðo ŋku edzi be akɔntabubuwo mekpɔa ŋusẽ ɖe amesiame dzi sɔsɔe o.

Ðe woate ŋu axe mɔ ɖe CJD nua?

Womate ŋu axe mɔ ɖe CJD ƒomevi akpa gãtɔ nu o. Nusi to vovo koe nye ƒomevi si woyɔna be `vCJD`. Etsoa nyilã si ŋu `BSE` (nyitsu ƒe dɔléle si ƒe tagbɔ gblẽ) le ɖuɖu me.

Lãwo dodokpɔ kpena ɖe nyi siwo ŋu BSE le ŋu be woagage ɖe nuɖuɖu ƒe ɖoɖoa me o. Gake lã si womedo kpɔ o eye womeɖae nyuie o ate ŋu anye afɔku kokoko. Be nànɔ dedie la, ƒo asa na lã siwo womedo kpɔ o kple esiwo ŋu womewɔ ɖoɖo ɖo o ɖuɖu, vevietɔ ahɔhɔ̃ ƒe akpa aɖewo alo ƒumeŋuɖui.

Mlɔeba la, nu siwo dzi wòle be woaɖo ŋkui

CJD dɔléle ƒe dzesi nye nuteƒekpɔkpɔ si trɔa ame ƒe agbenɔnɔ. Ate ŋu ase le eɖokui me abe ɖe wò kple xexe si ƒo xlã wò la nu yi le ŋkuʋuʋu me ene. Tɔtrɔ sia tɔgbe ate ŋu asesẽ na wò ŋutɔ kple wò ame veviwo be nànɔ te ɖe enu.

Ne mèka ɖe nusi nàkpɔ mɔ na alo alesi nàwɔ anɔ te ɖe enu dzi o la, wò atikewɔlawo ƒe ƒuƒoƒoa le afisia be yewoakpe ɖe ŋuwò. Woate ŋu akpe ɖe ŋuwò nàwɔ ɖoɖo do ŋgɔ ahadzra ɖo ɖe nusiwo gbɔna ŋu. Ðo ŋku edzi be menye wò ɖeka koe o.

` CJD, Creutzfeldt-Jakob Dɔléle, prion, ahɔhɔ̃medɔ, ahɔhɔ̃medɔ, ŋkuɖoɖonudzi ƒe dɔmawɔmawɔ nyuie, tagbɔdɔ, nyitsu ƒe tagbɔdɔléle