Nukae nye G6PD ƒe Gbɔdzɔgbɔdzɔ? Mina míasrɔ̃ nu vɔvɔ̃manɔmee!

Èse G6PD ƒe Dɔmawɔmawɔ nyuie kpɔa? Ðewohĩ ŋkɔa ɖi nusi wɔ nuku vie. Gake le nyateƒe me la, enye domenyiŋusẽfianu si le ame geɖe si le xexeame, gake zi geɖe la, mehea kuxi gã aɖeke vɛ o. Eyata, egbea míaƒo nu tso nusi G6PD ƒe gbɔdzɔgbɔdzɔ sia nye, nusita wòdzɔna, kple nusiwo wòle be míanya ŋu. Mehiã be míavɔ̃ o, mina míaɖe nusianu me bɔbɔe.

Nuka tututue nye G6PD ƒe Gbɔdzɔgbɔdzɔ?

Kpuie ko la, G6PD ƒe anyimanɔmanɔ nye domenyiŋusẽfianu ƒe nɔnɔme si me G6PD ƒe agbɔsɔsɔ si le wò ŋutilã me le sue ŋutɔ. Enyo, fifia èle biabiam be nukae nye G6PD. G6PD (Glucose-6-Phosphate Dehydrogenase) nye dɔlékui vevi aɖe ŋutɔ le míaƒe ŋutilã me. Dɔ vevitɔ si enzyme sia wɔnae nye be wòakpɔ míaƒe ʋumenugbagbevi dzĩwo ta tso nu vovovo siwo agblẽ nu le wo ŋu me.

Gbɔdzɔgbɔdzɔ sia dzɔna ne wodzi ame aɖe kple tɔtrɔ, alo tɔtrɔ, le domenyiŋusẽfianu si wɔa G6PD enzyme la me. Esia wɔnɛ be wò ʋumenugbagbevi dzĩwo mewɔa G6PD enzyme la wòdea edeƒe o.

Gake nya lae nye esi. Ame geɖe siwo ŋu G6PD ƒe anyimanɔmanɔ le la mekpɔa dzesi aɖeke o . Wonɔa agbe si sɔ. Ke hã, ɣeaɖewoɣi la, kuxiwo ateŋu atso "nu siwo ʋãa ame" abe atike aɖewo, dɔlékuiwo, alo nuɖuɖu aɖewo (míaƒo nu tso esiawo ŋu emegbe). Le nɔnɔme mawo me la, nɔnɔme aɖe si woyɔna be hemolytic anemia ate ŋu ado mo ɖa. Esia fia be ʋumenugbagbevi dzĩwo gbãna kabakaba hegblẽa wo. Ɣeaɖewoɣi la, vidzĩ siwo wodzi yeyee ate ŋu axɔ ʋuʋudedi sesẽ le G6PD ƒe anyimanɔmanɔ ta.

G6PD ƒe anyimanɔmanɔ nye nɔnɔme si bɔ wu alesi nàsusui. Wobu akɔnta be ame miliɔn 400 va ɖo 500 ye ŋu dɔlélea le le xexeame katã. Eyata ne ele ŋuwò la, wò ɖɔkta ate ŋu akpe ɖe ŋuwò be wò ʋumenugbagbevi dzĩwo nanɔ dedie.

Nukae nye G6PD ƒe anyimanɔmanɔ ƒe dzesiwo?

Abe alesi míegblɔe va yi ene la, zi geɖe la, dzesi aɖeke menɔa ame akpa gãtɔ siwo ŋu G6PD ƒe anyimanɔmanɔ le ŋu o. Gake ne nusi hea dɔlélea vɛ na nuteɖeamedzi va wò ʋumenugbagbevi dzĩwo dzi eye wòna wogbã (hemolysis) ko hafi dzesiawo dzena. Ne edzɔ alea la, nu siawo tɔgbe ate ŋu adzɔ:

• Sese le eɖokui me be ɖeɖi te ye ŋu vevie
• Dzi ƒe tsotso kabakaba ( tachycardia ) .
• Yagbɔgbɔ sesẽ ( Dyspnea ) .
• Ŋutilã ƒe ɣie alo ŋku ƒe ɣie (esiawo nye dzesi siwo fia be ʋumenugbagbeviɣidɔ ) .
• Ŋutilã si le ɣie (nuyiwo kple aɖe ate ŋu anye ɣie gɔ̃ hã) .
• Aɖuɖɔ si ƒe amadede nye ɣie viviti, aŋutiɖiɖi, alo tii
• Aɖuɖɔtoe si lolo

Ne dzesi siawo do mo ɖa kpata eye wòsẽ ŋu la, woyɔnɛ be ʋumenugbagbeviɣidɔ . Ne èto esia me la , ele vevie ŋutɔ be nàdi atikewɔƒe enumake.

G6PD ƒe anyimanɔmanɔ ƒe dzesiwo le vidzĩ yeyewo me

G6PD ƒe anyimanɔmanɔ ƒe dzesi siwo dze ƒã mebɔ ɖe vidzĩ yeyewo ŋu o. Dzesi si bɔ wue nye ʋumenugbagbeviɣidɔ . Zi geɖe la, esia dzena le ŋkeke ʋɛ aɖewo megbe tso esime wodzii. Ne womedae nyuie o la, aɖuɖɔtoe sesẽ ate ŋu agblẽ nu le vidzĩa ƒe ahɔhɔ̃ ŋu. Woyɔa esia be kernicterus . Esia tae ɖɔktawo doa vidzĩ yeyewo kpɔna be G6PD ƒe anyimanɔmanɔ le wo ŋu ne wosusui be ele nenema hã.

Nukae hea G6PD ƒe anyimanɔmanɔ vɛ?

G6PD ƒe anyimanɔmanɔ tso tɔtrɔ (tɔtrɔ) si le wò G6PD domenyiŋusẽfianu me gbɔ. Tɔtrɔ sia xea mɔ na wò ŋutilã be wòafia mɔ wò nyuie be nàwɔ G6PD enzyme la o. Ènyia domenyiŋusẽfianu ƒe tɔtrɔ sia ƒe dome tso dziwòlawo gbɔ, to X domenyiŋusẽfianu dzi .

Domenyiŋusẽfianu ƒe tɔtrɔ sia ƒe amesinɔnɔ fia be G6PD mesɔ gbɔ ɖe wò ʋumenugbagbevi dzĩwo me o. G6PD enzyme le vevie ŋutɔ elabena exea mɔ na ʋumenugbagbevi dzĩwo be woagaƒo "free radicals " geɖe nu ƒu o. Zi geɖe la, free radicals nyea nusiwo megblẽa nu le ame ŋu o. Woate ŋu akpɔ wo le nutoa me, le nuɖuɖu aɖewo me (le kpɔɖeŋu me, fava-ku), kple le atikewo me.

Gake ne G6PD mesɔ gbɔ na wò o la, nu aɖewo siwo ʋãa ame (e.g. fava beans ɖuɖu) ate ŋu ana free radical siawo dometɔ geɖe naƒo ƒu ɖe wò lãmenugbagbeviwo me akpa. Esia hea nɔnɔme aɖe si woyɔna be oxidative stress , si hea nuteɖeamedzi vɛ na wò ʋumenugbagbevi dzĩwo. Mlɔeba la, lãmenugbagbevi siawo gbãna eye wotsrɔ̃na. Esia ɖea ʋumenugbagbevi dzĩwo ƒe xexlẽme dzi kpɔtɔna, si wɔnɛ be ʋusɔgbɔdɔ si me ʋu sina tona .

Nukawoe hea ʋusɔgbɔdɔ si do ƒome kple nɔnɔme sia vɛ?

Le numekula aɖewo ƒe nya nu la, fava-ku ɖuɖue nye nusi gbɔ wòtsona wu . Ne ʋusɔgbɔdɔ dze amesi ŋu G6PD mele o dzi le fava-ku ɖuɖu vɔ megbe la, woyɔnɛ be favism . Nu bubu siwo gbɔ wòtsona zi geɖee nye:

• Dɔlékuiwo: Dɔlékuiwo abe Aklãdɔléle A kple Aklãdɔléle B , Typhoid Fever , kple Aklãdɔ .
• Atike aɖewo siwo wozãna na asrãdɔ: Le kpɔɖeŋu me , Primaquine .
• Dɔlékuiwutike aɖewo : abe nitrofurantoin , dapsone, kple sulfa atikewo ene .
• NSAID (vevesesenutsitikewo): Abe aspirin kple ibuprofen ene .
• Sigaretnono kple ahanono fũu akpa.
• Susu me nuteɖeamedzi sesẽ.
• Kamedede sesẽ.

Nukawoe nye afɔku siwo le eme?

Nu geɖe li siwo nana afɔku si le G6PD ƒe anyimanɔmanɔ ƒe domenyinyi me dzina ɖe edzi:

• Na:Ŋutsuwo ate ŋu axɔ G6PD ƒe anyimanɔmanɔ wu. Esia le alea elabena X domenyiŋusẽfianu ɖeka koe le ŋutsuwo si si tsɔa domenyiŋusẽfianu ƒe tɔtrɔ sia. (Esi X domenyiŋusẽfianu eve le nyɔnuwo si ta la, ɣeyiɣi aɖewo li siwo me kuxi aɖe si le ɖeka ŋu ate ŋu axe fe na evelia.)
• Anyigba ƒe nɔnɔme: Nɔnɔme sia bɔ ɖe amesiwo le Afrika ƒe anyiehe Sahara, Mediterranea-nutowo, kple Anyieheɣedzeƒe Asia dome.
• Ameƒomevinyenye: Numekulawo bu akɔnta be ŋutsu siwo tso Afrika le United States dometɔ siwo wu 10% ƒe G6PD ƒe dɔmawɔmawɔ nyuie le wo ŋu.

Aleke wowɔa dea dzesi G6PD ƒe anyimanɔmanɔ?

Zi geɖe la, ɖɔktawo abia wò atikewɔwɔ ŋutinya bliboa gbã eye woado wò ŋutilã kpɔ. Woate ŋu abia hã nenye be ètrɔ atikewo nyitsɔ laa alo dɔlékui aɖewo va dze ŋuwò. Woalé ŋku ɖe eŋu hã be G6PD ƒe dɔmawɔmawɔ nyuie le wò ƒomea me hã.

Dodokpɔ siwo wozãna tsɔ dea dzesi G6PD ƒe anyimanɔmanɔe nye:

• Ʋu Xexlẽme Blibo (CBC): Eléa ŋku ɖe wò ʋumenugbagbevi dzĩwo ƒe xexlẽme ŋu.
• Ʋu ƒe Ʋuʋudedi: Eléa ŋku ɖe ʋusɔgbɔdɔ ƒe dzesiwo ŋu le ʋumenugbagbeviɣidɔ me, si fia be ʋumenugbagbevi dzĩ siwo ƒe nɔnɔme mesɔ o alo woƒe lolome mesɔ o hã.
• Bilirubin Dodokpɔ: Kpɔ bilirubin, si nye gbeɖuɖɔ si wowɔ tso ʋumenugbagbevi dzĩ siwo gbã me la ƒe agbɔsɔsɔ ɖa.
• G6PD Dodokpɔ: Kpɔ wò G6PD enzyme ƒe agbɔsɔsɔ ɖa.

Aleke wokpɔa G6PD ƒe anyimanɔmanɔ gbɔe?

Ðɔktawo nɔa te ɖe nɔnɔmea dzi daa dɔlélea. Le kpɔɖeŋu me, ne ʋusɔgbɔdɔ si nu mesẽ o le ŋuwò eye nènya be G6PD ƒe dɔmawɔmawɔ nyuie le ye ŋu la, woada ʋusɔgbɔdɔ ƒe dzesiwo gbã. Emegbe, woagblɔ nusiwo aʋã wò wòle be nàƒo asa na wò.

Gake ne dzesiawo nu sẽ la, atikewɔwɔa to vovo. Ne ʋusɔgbɔdɔ sesẽ aɖe le ŋuwò la, ate ŋu ahiã be woado ʋu na wò .

Ne jaundice le viwò si wodzi yeyee ŋu la, wò ɖɔkta ate ŋu atsɔ fotoɖemɔ̃ (si nye atike si zãa dzɔdzɔmekekeli alo esi wotsɔ asi wɔe) adae. Le nɔnɔme siwo nu sẽ wu me la, ahiã be woado ʋu na viwòa . Esia bia be woaɖe vidzĩa ƒe ʋu si mele lãmesẽ me o la ɖa eye woatsɔ ʋu si le lãmesẽ me, si wotsɔ na la aɖo eteƒe.

Ðe woate ŋu axe mɔ ɖe G6PD ƒe anyimanɔmanɔ nua?

Esi wònye domenyiŋusẽfianu ƒe nɔnɔme sia nye ta la, manya wɔ be woaxe mɔ nɛ be wòagadzɔ o. Ke hã, mɔ aɖewo li siwo dzi woato ade dzesii hafi wòahe lãmesẽkuxi gãwo vɛ. Esiawo dometɔ aɖewoe nye:

• Dodokpɔ na vidzĩ yeyewo: Le dukɔ geɖe siwo me nɔnɔme sia bɔ ɖo me la, wole dodokpɔ ƒe ɖoɖowo wɔm be woatsɔ ade dzesi G6PD ƒe anyimanɔmanɔ le vidzĩ yeyewo me.
• Domenyiŋusẽfianu dodokpɔ: Ne G6PD ƒe anyimanɔmanɔ le wò ƒomea me la, ahiã be woado wò DNA hã kpɔ.Ðewohĩ wò ɖɔkta aɖo aɖaŋu na wò be nàwɔe nenema.

Nukae mate ŋu akpɔ mɔ na ne nɔnɔme sia le ŋunye?

G6PD ƒe anyimanɔmanɔ ƒe atike aɖeke meli si anɔ anyi ɖaa o . Gake ame akpa gãtɔ ate ŋu anɔ agbe kuxi aɖeke manɔmee ne woƒo asa na nusiwo aʋã wo. Eye mekpɔa ŋusẽ ɖe agbenɔƒe dzi o.

Gake nɔnɔme sia mekpɔa ŋusẽ ɖe amesiame dzi sɔsɔe o. Ðewohĩ ame geɖe siwo ŋu G6PD ƒe dɔmawɔmawɔ nyuie le la menya gɔ̃ hã be ele yewo ŋu o elabena dzesi aɖeke mele yewo ŋu o. Ame akpa gãtɔ siwo ƒe dzesiwo dzena la mesẽna kura o. Gake le ame aɖewo gome la, ne wodo go nusi aʋã wo la, woate ŋu adze ʋumenugbagbeviɣidɔ aɖe gɔme, si ate ŋu ade woƒe agbe afɔku me.

Wò ɖɔkta ate ŋu anɔ te ɖe dɔléle si nèkpɔ dzi aɖe nusi nàte ŋu akpɔ mɔ na me nyuie wu.

Aleke mawɔ alé be na ɖokuinye?

Bia wò ɖɔkta be nuɖuɖu kple atike kawoe wòle be nàƒo asa na. Aɖaŋuɖoɖo bubu aɖewoe nye esi:

• Ðe ahanono dzi kpɔtɔ: Ahanono fũ ate ŋu ana wò ʋumenugbagbevi dzĩwo nate ŋu aƒoe ɖe enu.
• Ƒo asa na atamanono: Atamanono ate ŋu ana free radicals naƒo ƒu ɖe wò ʋumenugbagbevi dzĩwo me.
• Kamedede le ɖoɖo nu: Kamedede sesẽ akpa ate ŋu ana oxidative stress nadzi ɖe edzi.
• Dze agbagba nàgbɔ ɖe eme nyuie: Alɔ̃dɔdɔ doa ŋusẽ wò dɔlélenutsiŋutete, si kpena ɖe ŋuwò nèwɔa avu kple dɔlékui siwo ate ŋu ahe ʋusɔgbɔdɔ vɛ le ʋudodo me.
• Dzra nuteɖeamedzi dzi: Ne èle nuteɖeamedzi geɖe sem la, bia wò ɖɔkta be wòakpe ɖe ŋuwò nàɖu wò nuteɖeamedzi dzi.

Vevietɔ: Ne G6PD ƒe dɔmawɔmawɔ nyuie le viwò yeyea ŋu la, ele be nàƒo asa na fava-ku ɖuɖu ne èle no nam . Atike siwo ate ŋu ahe ʋusɔgbɔdɔ si gblẽa nu le ame ŋu vɛ ate ŋu ato no me no me ayi vidzĩa gbɔ.

Ɣekaɣie wòle be makpɔ nye ɖɔkta?

Kpɔ wò ɖɔkta ɣesiaɣi ne G6PD ƒe anyimanɔmanɔ ƒe dzesiwo dze le ŋuwò. Ne dzesiawo nu sẽ eye wodona kabakaba (ʋudodo ƒe kuxi ƒe dzesiwo) la, yi atikewɔƒe enumake .

Nya kawoe wòle be mabia nye ɖɔkta?

Nyabiase aɖewo siwo wòle be nàbia ne G6PD ƒe dɔmawɔmawɔ nyuie le ŋuwòe nye esi:

• Aleke gbegbee nye nɔnɔmea nu sẽe?
• Nuɖuɖu kple atike kawoe wòle be matsri?
• Ðe nutome ƒe nuwɔna aɖewo li siwo wòle be maƒo asa na?
• Mɔnukpɔkpɔ kawoe li be vinye nanyi G6PD ƒe anyimanɔmanɔ ƒe dome?

Mlɔeba la, nusi dzi nàɖo ŋkui (Take-Home Message) .

G6PD ƒe anyimanɔmanɔ ƒe dzesi ate ŋu akpɔ ŋusẽ ɖe amesiame dzi le mɔ vovovowo nu. Togbɔ be womate ŋu adae o hã la, zi geɖe la, enyea dɔléle si dzi woate ŋu aɖu. Nu vevitɔe nye be woade dzesi nusiwo nana ʋusɔgbɔdɔ si gblẽa nu le ame ŋu ƒe afɔkua dzina ɖe edzi ahaƒo asa na wo.Ema ate ŋu afia be woaƒo asa na fava-ku kple nu bubu siwo hea dɔlélea vɛ. Ele vevie hã be nàwɔ numame siwo naa lãmesẽ, abe ɖiɖiɖeme geɖe kple atamanono ene. Bia wò ɖɔkta be wòana nyatakaka wò be wòakpe ɖe ŋuwò nàkpɔ alesi G6PD ƒe anyimanɔmanɔ kpɔa ŋusẽ ɖe wò agbe dzii gbɔ. Mègatsi dzodzodzoe o, nyanyananae nye ametakpɔnu nyuitɔ kekeake!

` G6PD ƒe anyimanɔmanɔ, ʋusɔgbɔdɔ si nana ʋu sina tona, ʋusɔgbɔdɔ, domenyiŋusẽfianu ƒe dɔlélewo, ʋumenugbagbevi dzĩwo, fava beans, enzymes