Ðe nègblɔ Glioma si nye High-Grade Glioma ŋu nya na viwòa? Na míaƒo nu tso eŋu.

Esesẽ be nàgblɔ alesi wòsena le eɖokui me abe dzila ene be nàse be ahɔhɔ̃mekansa le viwò ŋu. Nyabiase geɖewo vaa susu me nam le ɣeyiɣi sia tɔgbe me. Eyata, egbea míele nu ƒom tso High-Grade Glioma, si nye ahɔhɔ̃ me dɔdzẽ ƒomevi sesẽ aɖe si kaka kabakaba ŋu. Míele mɔ kpɔm be nyatakaka siawo ana gɔmesese kple ŋusẽ aɖe mi le mɔzɔzɔ sesẽ sia me.

Nukae Nye Glioma si ƒe Dzesidede Kɔkɔe? Mina míase egɔme bɔbɔe ŋutɔ.

Kpuie ko la, glioma si ƒe dzesi deŋgɔ nye kansa ƒomevi aɖe si tsina kabakaba ŋutɔ le viwò ƒe ahɔhɔ̃ alo aklã me. "Glioma" gɔmee nye dɔdzẽ. Dɔdzẽ siawo dzɔna ne lãmenugbagbevi ƒomevi aɖe si woyɔna be "glial cells" dze mama gɔme eye wòtsi kabakaba eye womekpɔ ŋusẽ ɖe edzi o. Glial lãmenugbagbevi siawo nye lãmenugbagbevi ƒomevi aɖe si doa alɔ ahɔhɔ̃mekawo, alo lãmeka siwo le míaƒe lãmeka siwo le titina eye wonaa nunyiame wo.

"High-grade" fia be glioma sia ƒomevi tsina kabakaba ŋutɔ eye wòwɔa adã . Le nyateƒe me la, ɖewohĩ menye ɣesiaɣie woate ŋu ada glioma siwo ƒe nyonyome de ŋgɔ keŋkeŋ o. Esia le alea elabena wo dada sesẽna wu. Esia le alea elabena kansa lãmenugbagbevi siawo kaka kabakaba ŋutɔ ɖe ahɔhɔ̃ alo aklã me. Wotsina hã to lãmenugbagbevi siwo le lãmesẽ me dzi dzedze kple woƒe kadodo kple wo nɔewo me. Bu alesi wòsesẽna be woaɖe kansa la ɖeɖeko ɖa evɔ womagblẽ nu le lãmenugbagbevi siwo le lãmesẽ me ŋu o ne lãmenugbagbevi siwo le lãmesẽ me kple kansa lãmenugbagbeviwo do ƒome kple wo nɔewo ŋu kpɔ. Esia tae esesẽna ɣeaɖewoɣi be woaɖe wo ɖa keŋkeŋ to amekoko me ɖo.

Nukae nye "grade" si le gliomas siwo ƒe dzesi deŋgɔ ŋu?

Xexeame ƒe Lãmesẽ Habɔbɔ (WHO) da gliomas ɖe hatsotsowo me le woƒe tsitsi kple woƒe sesẽ nu. Le esia nu la, ƒomevi eve li: "low-grade" (si mesẽ boo o, grade 1 kple 2) kple "high-grade" (si nu sẽ wu, grade 3 kple 4). Gliomas siwo ƒe dzesi deŋgɔ nye dɔdzẽ siwo tsina kabakaba eye woƒe hatsotso 3 alo 4.

Glioma aɖewo siwo le ame tsitsiwo me ate ŋu adze egɔme abe esiwo mebɔ o ene eye emegbe woava zu esiwo ƒe dzesi deŋgɔ. Gake nukutɔe la, zi geɖe la, gliomas siwo ƒe dzesi deŋgɔ le ɖeviwo me dzea egɔme tso glioma siwo ƒe dzesi deŋgɔ gbɔ. Gake woate ŋu ada glioma siwo ƒe dzesi mede o le ɖeviwo me ƒe akpa gãtɔ eye ƒã hafi wozua esiwo ƒe dzesi deŋgɔ.

Afikae glioma siwo ƒe dzesi deŋgɔ dzɔna le wu le ahɔhɔ̃a me?

Gliomas deŋgɔwo dona zi geɖe le ahɔhɔ̃a ƒe "supratentorial compartment" me, alo ahɔhɔ̃mekawo.

• Supratentorial compartment: Esia nye ahɔhɔ̃a ƒe akpa si ahɔhɔ̃meka, thalamus, kple hypothalamus le. Dɔdzẽ siawo ate ŋu ado tso glial lãmenugbagbevi siwo le afisia me.
• Ahɔhɔ̃ ƒe lãkusi:Gliomas siawo siwo le ɖoƒe kɔkɔ la ateŋu adzɔ le ahɔhɔ̃a ƒe akpa si woyɔna be ``pons`` hã me. Woyɔa esia be ``Diffuse Intrinsic Pontine Gliomas'' (DIPG) ƒomevi tɔxɛ aɖe. DIPG sia ƒomevi wɔa adã ŋutɔ eye edada sesẽ.

Afisi dɔdzẽa le le vevie ŋutɔ, elabena eyae afia atikewɔmɔnu siwo li na viwòa. Le kpɔɖeŋu me, zi geɖe la, womate ŋu aɖe dɔdzẽ siwo le ahɔhɔ̃mekawo me la ɖa dedie to amekoko me o.

Ameka dzie nɔnɔme sia gblẽa nu le wu?

Glioma si ƒe dzesi deŋgɔ ate ŋu adzɔ le vidzĩwo, ɖevi tsitsiwo, sɔhɛ tsitsiwo, kple ame tsitsiwo gɔ̃ hã me. Gake glioma si ƒe dzesi deŋgɔ le vidzĩwo kple ɖevi suewo me to vovo na glioma si ƒe dzesi deŋgɔ le ƒewuiviwo kple ame tsitsiwo me. Le vovototo siawo ta la, alesi woawɔ nu ɖe ​​vidzĩwo kple ɖevi suewo ŋu ate ŋu ato vovo.

Aleke gbegbee glioma si ƒe dzesi deŋgɔ bɔe?

Gliomas siwo ƒe dzesi deŋgɔe nye ahɔhɔ̃meka vɔ̃ɖi ƒomevi evelia si bɔ ɖe ɖeviwo me. Woawoe nyea 10% va ɖo 20% le dɔdzẽ siwo katã gblẽa nu le ɖeviwo ƒe lãmekawo ƒe dɔwɔwɔ ŋu la me.

Nukae nye glioma si ƒe dzesi deŋgɔ ƒe dzesiwo?

Dzesiawo ate ŋu ato vovo tso ɖevi ɖesiaɖe gbɔ. Wonɔ te ɖe ahɔhɔ̃a ƒe akpa (alo aklã) ƒe akpa si dɔdzẽa gblẽ nu le, ƒe si ɖevia xɔ, kple alesi dɔdzẽa le tsitsim kabakabae dzi. Dzesi siawo tsoa dɔdzẽa ƒe nyaƒoɖeamenu ɖe ​​ahɔhɔ̃a dzi eye wònana wòvuvu gbɔ koŋ.

Dzesi si bɔ wue nye taɖuame. Esia nye nyateƒe vevietɔ ne taɖuamea kpe ɖe taɖuame alo ʋuʋudedi ŋu. Taɖuame sia nu sẽna wu le ŋdi me. Ɣeaɖewoɣi la, ate ŋu asẽ ale gbegbe be wòanyɔ wò le zã me. Kpɔe ɖa le susu me be ɖevi sue aɖe le nɔnɔme sesẽ sia me tom.

Dzesi bubu siwo woate ŋu akpɔ dometɔ aɖewoe nye:

• Nukpɔkpɔ, nusese, alo nuƒoƒo sesẽ (nukpɔkpɔ si me mekɔ o, tosese, nuƒoƒo si me mekɔ o).
• Dadasɔ ƒe bu alo lãmekawo ƒe gbɔdzɔgbɔdzɔ (ataxia), abe azɔlizɔzɔ alo nuwo léle sesẽ ene.
• Tɔtɔ alo ŋkuɖoɖonudzi ƒe dɔmawɔmawɔ nyuie.
• Alɔ̃dɔdɔ ɣesiaɣi, kuviawɔwɔ ƒe seselelãme.
• Alɔ̃madɔmadɔ (abe alɔ̃madɔmadɔ ene) .

Vidzĩ sue ŋutɔwo (vidzĩwo) ate ŋu ade dzesi avifafa si mebɔ o, dzikudodo, tɔtrɔ le nuɖuɖu nana me (abe notsi manɔmanɔ ene). Woateŋu ade dzesii hã ɣeaɖewoɣi be yewoƒe ta le lolom vie, eye teƒe falɛfalɛ (fontanelles) alo "agado" siwo le woƒe ta tame ate ŋu adze ƒã wu.

Nukatae glioma siawo siwo ƒe dzesi deŋgɔ la va dona? Nukawoe gbɔ wòtsona?

Ne míagblɔe tututu la, numekulawo menya nusi tututu tae wòle alea ɖo haɖe o.Le ame tsitsiwo gome la, wokpɔe be keklẽŋusẽdɔdada do ŋgɔ nye afɔku si ate ŋu ana woaxɔ dɔdzẽ siawo. Ate ŋu adzɔ be gotagome alo nutome ƒe afɔku mawo tɔgbe ate ŋu akpɔ ŋusẽ ɖe ɖeviwo hã dzi, gake numekuku bubuwo hiã.

Gake domenyiŋusẽfianu ƒe dɔléle aɖewo siwo ƒe dome mebɔ kura o ate ŋu ana glioma si ƒe dzesi deŋgɔ ƒe afɔkua nadzi ɖe edzi le ɖeviwo me. Domenyiŋusẽfianu ƒe nɔnɔme nye domenyiŋusẽfianu ƒe gbɔdzɔgbɔdzɔ alo nusi mesɔ o, siwo nye "kɔda" si gblɔa lãmenugbagbeviwo alesi woawɔ dɔe.

Nɔnɔme mawo dometɔ aɖewoe nye esi:

• Ahɔhɔ̃mekawo ƒe dɔléle ƒomevi-1 (`Ahɔhɔ̃mekawo ƒe dɔléle ƒomevi-1 - NF1`)
• Turcot ƒe dɔlélea
• Li-Fraumeni ƒe dɔlélea

Gake ele vevie be míaɖo ŋku edzi be ɖevi geɖe siwo ŋu glioma si ƒe dzesi deŋgɔ le la mekpɔ dɔléle sia le ƒomea me o.

Aleke wowɔa dea dzesi glioma si ƒe dzesi deŋgɔ?

Viwòa ƒe ɖɔkta alé ŋku ɖe viwòa ƒe dzesiwo kple eƒe atikewɔwɔ ŋutinya ŋu nyuie gbã. Emegbe, woateŋu awɔ ahɔhɔ̃mekadodo, alo `nɔnɔmetata`, akpɔe ɖa be dɔdzẽ aɖe le eme eye nenye be eyae le dzesiawo hem vɛ hã. Ne dɔdzẽ aɖe le eme la, woawɔ `biopsy` atsɔ anyae kple kakaɖedzi nenye be kansa (vɔ̃ɖi) alo dɔléle (benign) ye.

• Nɔnɔmetatawo ɖeɖe: MRI (Magnetic Resonance Imaging) scan kple CT scan (Computed Tomography scan) ate ŋu akpe ɖe ɖɔktawo ŋu woakpɔ dɔdzẽ siwo le viwò ƒe ahɔhɔ̃ alo aklã me. MRI, vevietɔ MRI si me woɖea vovototodedeameme le, ate ŋu ana nɔnɔmetata siwo me kɔ, siwo me kɔ wu CT-dɔdamɔnu. MRI zãa magnet kple radio ƒutsotsoewo tsɔ wɔa nusiwo le ŋutilãa me ƒe nɔnɔmetatawo le kɔmpiuta dzi. Le MRI si to vovo na ema me la, wodoa amadede si megblẽa nu le ame ŋu o ɖe viwòa ƒe alɔnu. Esia wɔnɛ be teƒe siwo dɔdzẽ le la dzena nyuie wu le screen la dzi.

• Biopsy: Dɔdamɔnu tɔxɛ aɖe si woyɔna be "stereotactic biopsy" ateŋu ade dzesi afisi tututu dɔdzẽa le eye wòaxɔ lãkusi sue aɖe tso afima aɖoe ɖe dodokpɔxɔ. Emegbe la, eŋutinunyala bibi aɖe si woyɔna be "dɔléleŋutinunyala" doa lãmenugbagbeviawo kpɔna be wonye glioma lãmenugbagbevi siwo le ɖoƒe kɔkɔ hã. Dodokpɔ siawo ate ŋu ade dzesi kansa lãmenugbagbeviwo ƒe nɔnɔme aɖewo hã. Wozãa nɔnɔme siawo ɣeaɖewoɣi tsɔ nyaa atikewɔwɔ. Le kpɔɖeŋu me, wotrɔ asi le kansadɔdamɔnu yeye aɖewo ŋu be woawɔ dɔ le kansadɔlékui ƒomevi aɖewo ko ŋu. Eyata dodokpɔ siawo ate ŋu akpe ɖe ŋuwò hã be nànya ne viwòa nye ame nyui aɖe si woate ŋu awɔ atike ma na.

Ɣeaɖewoɣi la, ne anya wɔ la, ɖɔktawo ɖea dɔdzẽ bliboa ɖa le esi teƒe be woaxɔ kakɛ sue aɖe ko hena lãmenugbagbeviwo ƒe dɔwɔwɔ.Emegbe, tsɔ kpe ɖe dɔlélea didi ŋu la, atikewɔwɔ (amekoko) hã dzɔna.

Gake ɖewohĩ manya wɔ ɣesiaɣi be woaɖe ŋutilã ƒe akpa aɖewo le glioma siwo ƒe dzesi deŋgɔ me o. Le afisi dɔdzẽa le (le kpɔɖeŋu me, le ahɔhɔ̃meka me) nu la, lãmeka aɖe xɔxɔ ate ŋu agblẽ nu le ahɔhɔ̃a ƒe akpa veviwo ŋu. Le nɔnɔme mawo me la, ɖɔktawo ɖoa ŋu ɖe nɔnɔmetatawo dodokpɔ ŋu be woatsɔ anya dɔlélea.

Ðe woate ŋu ada glioma si ƒe dzesi deŋgɔ keŋkeŋa?

Esiae nye nyabiase gãtɔ kekeake si le amesiame ƒe susu me. Esesẽ be woaɖo eŋu tẽ. Nu geɖe li siwo kpɔa ŋusẽ ɖe esia dzi, abe ƒe si ɖevia xɔ, domenyiŋusẽfianu ƒe tɔtrɔ siwo le kansa lãmenugbagbeviwo me, kple alesi woɖe dɔdzẽa ƒe akpa si woɖe le amekokoa me ene.

Nukawoe nye glioma si ƒe dzesi deŋgɔ ƒe atikewo?

Taɖodzinu vevi siwo le atikewɔwɔ ŋue nye be woaɖe dɔdzẽa ɖa, atɔ te dɔdzẽa ƒe tsitsi alo aɖu edzi, eye wòana gbɔdzɔe ɖevia to dzesiwo dzi ɖeɖe kpɔtɔ me.

Le dɔdzẽ ƒomevi, afisi wòle, kple nu bubuwo nu la, eŋutinunyala bibi geɖewo ate ŋu akpɔ gome le viwòa dzi kpɔkpɔ me. Ðewohĩ ahɔhɔ̃ŋutinunyala, ahɔhɔ̃mekawo ƒe dɔdzẽŋutinunyala, keklẽŋusẽdɔdala, lãmenugbagbeviwo ƒe dɔwɔwɔ ŋuti nunyala, dɔnɔdzikpɔla, kple hadomekpekpeɖeŋudɔwɔla ate ŋu anɔ ƒuƒoƒoa me.

Woate ŋu azã nusiwo gbɔna dometɔ ɖeka alo esi wu nenema atsɔ awɔ atike:

• Amekoko: Amekokoe nye atike vevitɔ na gliomas siwo ƒe nyonyome deŋgɔ siwo woate ŋu aɖe dedie. Le afisia la, ɖɔkta la dzea agbagba be yeaɖe dɔdzẽa ƒe akpa gãtɔ ɖa alesi yeate ŋui evɔ magblẽ nu le lãmenugbagbevi siwo le lãmesẽ me si ƒo xlãe ŋu o.
• Kekeli ƒe atikewɔwɔ: Kekeli ƒe dɔdamɔnu si wozãna le teƒe ɖeka nye atikewɔwɔ si wozãna ɖaa na ɖevi siwo xɔ wu ƒe 3. Zi geɖe la, wometsɔa keklẽŋusẽtike naa ɖevi sue ŋutɔwo o elabena ate ŋu akpɔ ŋusẽ ɖe woƒe ahɔhɔ̃ ƒe tsitsi dzi. Dɔdamɔnu sia lɔ mɔ̃ aɖe si zãa X-ray si ƒe agbɔsɔsɔme sɔ gbɔ tsɔ tɔa ŋku dɔdzẽa, eye wòkpɔa egbɔ be yemagblẽ nu le lãmenugbagbevi siwo le lãmesẽ me siwo ƒo xlãe ŋu o. Kekelidɔdamɔnu ɖea dɔdzẽwo dzi kpɔtɔna, ewua kansa lãmenugbagbeviwo, eye wòɖea dzesiwo dzi kpɔtɔna.
• Atikewɔmɔnu: Esi ɖevi sue ŋutɔwo mate ŋu axɔ keklẽŋusẽdɔdamɔnu o ta la, wozãa atikewɔmɔnu tsɔ léa dɔdzẽ ƒe tsitsi nu. Atikewɔmɔnu zãa atikewo tsɔ wua kansadɔlékuiwo. Gake wogale nya hem le alesi atikewɔmɔnu wɔa dɔe na glioma siwo ƒe dzesi deŋgɔ ŋu. Togbɔ be atike aɖewo abe temozolomide ene wɔa dɔ nyuie na glioma ƒomevi aɖewo le ame tsitsiwo gome hã la, atike mawo ke mewɔa dɔ le ɖeviwo ŋu nenema gbegbe o.
• Beléle na ame ƒe dziɖeɖi:Dɔwɔla siwo kpɔa viwòa dzi kpɔtɔna ate ŋu akpe ɖe ŋuwò nàwɔ nyametsotso siwo akpe ɖe viwòa ƒe agbenɔnɔ ƒe nyonyome ŋu le atikewɔwɔ me. Woate ŋu aɖo aɖaŋu le mɔ siwo dzi nàto akpe ɖe viwòa ŋu wòanɔ te ɖe dɔlélea nu eye wòakpɔ gbɔdzɔe tso dzesiawo me hã.

Glioma si ƒe dzesi deŋgɔ ate ŋu agadzɔ le atikewɔwɔ vɔ megbe. Ne esia dzɔ la, wò ɖɔkta ate ŋu ado susu ɖa be "dɔdamɔnu siwo ŋu woɖo taɖodzinu ɖo." Esiawo nye atikewɔwɔ siwo me wotsia dzi ɖe molecule siwo mesɔ o (siwo tso domenyiŋusẽfianu ƒe tɔtrɔ gbɔ) siwo le viwò ƒe dɔdzẽa me ko ŋu. "Dɔdamɔnu siwo woɖo ɖe molecule dzi" siawo ate ŋu anɔ anyi to "dɔdamɔnu dodokpɔwo" me. Dɔdamɔnu dodokpɔwo nye numekuku siwo doa atike yeyewo ƒe dedienɔnɔ kple woƒe dɔwɔwɔ kpɔna.

Ɣeaɖewoɣi la, ne atike siawo siwo woɖo taɖodzinu na le asi me le asi me, alo ne numekuku siwo wowɔ va yi ɖee fia be wowɔa dɔ nyuie na viwòa ƒe glioma ƒomevi la, wò ɖɔkta ate ŋu ana wo le dɔdamɔnu dodokpɔ aɖe godo.

Nukawoe nye atike siawo ƒe nugbegblẽ le ame ŋu?

Ðo dze kple wò ɖɔkta tso atike vovovowo ƒe nugbegblẽ le ame ŋu si ate ŋu ado tso eme ŋu. Togbɔ be ɖɔktawo dzea agbagba ɖesiaɖe be yewoaƒo asa na nugbegblẽ le lãmeka siwo le lãmesẽ me ŋu le keklẽŋusẽdɔdamɔnu me hã la, ate ŋu agblẽ nu le lãmeka siwo le lãmesẽ me dometɔ aɖewo ŋu kokoko. Le ahɔhɔ̃a ƒe akpa siwo ŋu wògblẽ nu le nu la, keklẽŋusẽdɔdamɔnu ate ŋu akpɔ ŋusẽ ɖe ahɔhɔ̃a ƒe dɔwɔwɔ, vidzĩa ƒe tsitsi dzi, eye wòagblẽ lãmetsiŋusẽ ƒe dɔwɔwɔ me.

Ele vevie ŋutɔ be woadzro viɖe kple afɔku siwo ate ŋu ado tso atikewɔwɔ me kple atikewɔlawo ƒe ƒuƒoƒo si le ɖevia dam la me nyuie ahada wo kpɔ.

Nukae wòle be makpɔ mɔ na ne glioma si ƒe dzesi deŋgɔ le vinye ŋu?

Viwò ƒe ŋgɔdonya nɔ te ɖe nu geɖe dzi, siwo me viwòa ate ŋu adzro kpli wò. Lãmenugbagbevi ƒomevi si ŋu wògblẽ nu le, lãmenugbagbeviawo ƒe nɔnɔme, kple alesi woɖe dɔdzẽa le amekokoa me katãe afia nusi ado tso eme.

Bia wò ɖɔkta nusi nàkpɔ mɔ na le viwòa ƒe nɔnɔme tɔxɛa nu.

Nukae nye agbetsitsi ƒe agbɔsɔsɔme le glioma si ƒe dzesi deŋgɔ me?

Anɔ eme be dɔdzẽ sia ƒomevi atrɔ ava le atikewɔwɔ vɔ megbe. Ƒe atɔ̃ ƒe agbetsitsi ƒe agbɔsɔsɔme na gliomas siwo ƒe dzesi deŋgɔ le ɖeviwo me mede 20% o. Gake ele vevie be míade dzesii be dɔdzẽ siawo to vovo kura tso wo nɔewo gbɔ. Wotsina le teƒe vovovowo, eye lãmenugbagbevi siwo le wo me ƒe nɔnɔmewo to vovo. Vovototo siawo ate ŋu akpɔ ŋusẽ ɖe viwòa ƒe etsɔme dzi.

Nya kawoe wòle be mabia ɖɔktaa?

Nyabiase gbogbo aɖewo li siwo vaa susu me nam le ɣeyiɣi sia tɔgbe me. Gake mègaŋlɔ be be yeabia nya siawo wò ɖɔkta o:

• Atikewɔwɔmɔnu kawoe li na vinyea?
• Aleke afisi dɔdzẽa le kpɔa ŋusẽ ɖe atikewɔmɔnu siwo woate ŋu azã dzii?
• Afɔku kawoe le atikewɔwɔ me?
• Nukawoe wòle be míakpɔ mɔ na tso atikewɔwɔ me?
• Aleke wòle be malé be na vinye le atikewɔwɔ me?
• Zi nenie wòahiã be vinye nava be woawɔ atike nɛ ahakplɔe ɖo?

Mlɔeba la, nu siwo dzi wòle be woaɖo ŋkui

Glioma si ƒe dzesi deŋgɔ ƒe dzesi xɔxɔ ate ŋu anye nusi sesẽ ŋutɔ. Kansa sia kaka kabakaba, eye dɔdzẽawo ate ŋu atrɔ ava le atikewɔwɔ vɔ megbe gɔ̃ hã. Zi geɖe la, ahiã be nàda viɖe siwo le atikewɔwɔ me akpɔ kple nugbegblẽ siwo mèdi be viwòa nakpɔ o.

Zã nunɔamesi siwo katã li nàtsɔ akpe ɖe wò, viwò, kple wò ƒomea me tɔ mamlɛawo ŋu le ɣeyiɣi sia me. Ƒo nu kple wò ɖɔkta tso atikewɔmɔnu siwo nàte ŋu azã kple dɔdamɔnu dodokpɔwo ŋu. Ne dɔlélenutsiŋutete ƒe dɔwɔƒe aɖewo li la, ke do asi ɖe wo gbɔ. Ka ɖe edzi na viwòa be yeado alɔ wo ɣesiaɣi ne miele dɔléle sia me tom ɖekae. Esia anye ŋusẽtsoƒe gã aɖe na wo.

` Glioma, Ahɔhɔ̃mekansa, Ðeviwo ƒe Kansa, Glioma si ƒe Dzeside Deŋgɔ, Ahɔhɔ̃mekawo ƒe Dɔléle, Kekeli ƒe Dɔdamɔnu, Atikewɔwɔ