Nukawoe nye mast cell siawo? Ðe esia gbɔe wò nulɔdɔa tsoa?

Ðe nèdzea aɖuɖɔɖɔɖɔ hã gɔme ne èka asi ke sue aɖe ŋua? Alo ne anyidi alo nudzodzoe aɖe ɖu wò la, teƒea biãna, vuvuna, eye wòvuvuna ale gbegbe? Nuteƒekpɔkpɔ mawo tɔgbe to mía dometɔ geɖe me kpɔ. Eyata, egbea míele nu ƒom tso akpa vevi aɖe si gbɔ nuwɔna sia si dzɔna le míaƒe ŋutilã me le ɣeyiɣi siawo tɔgbe me tsona ŋu. Emae nye "Mast Cells ".

Kpuie ko la, amekawoe nye mast cell siawo?

Mast cells nye asrafo tɔxɛwo le wò dɔlélenutsiŋutete me. Abe alesi aʋakɔ le míaƒe dukɔa si be woakpɔ eta ene la, dɔlélenutsiŋutete hã le míaƒe ŋutilã si be wòakpɔ eta. Lãmenugbagbevi siawoe nye dzɔlawo le ɖoɖo ma me, eye wonɔa ŋudzɔ ɣesiaɣi.

Wowɔa lãmenugbagbevi siawo le míaƒe ƒumeŋuɖui me. Emegbe wotoa ʋua me henɔa míaƒe ŋutilã ƒe lãkusi vovovowo me. Afi mae woƒe dɔa dzea egɔme tsoe. Woƒe dɔ vevitɔe nye be woakpɔ mía ta tso ŋɔdzinu vovovo siwo ate ŋu adzɔ ɖe ŋutilãa dzi la me.

Gake ɣeaɖewoɣi la, mast cell siawo va wɔa dɔ akpa. Ɣemaɣie kuxiawo dzea egɔme. Woate ŋu ana amewo nawɔ nu gã aɖe ɖe nusiwo megblẽa nu le ame ŋu o abe ke alo nuɖuɖu ene gɔ̃ hã ŋu. Míeyɔa nɔnɔme siawo be ‘nulɔdɔ’ alo ‘nulɔdɔ ƒe asrã’. Le nɔnɔme sesẽ aɖewo me la, lãmenugbagbevi siawo ƒe dɔwɔwɔ ate ŋu ana nulɔdɔ sesẽ aɖe si woyɔna be anaphylaxis, si ate ŋu ade ame ƒe agbe afɔku me.

Aleke lãmenugbagbevi siawo wɔa dɔe? Mina míase ‘alarm system’ sia gɔme!

Bu wò ŋutilã be enye mɔ̃ sesẽ gã aɖe. Mast cells le abe nuxlɔ̃ameɖoɖo si woda ɖe mɔ̃ sesẽ ma ƒe gliwo ŋu le afisiafi ene. Ʋuʋudedi sia nɔa klalo ɣesiaɣi be yeakpɔ ŋutilãa ta tso gotagome futɔwo si me, si nye dɔlékuiwo abe dɔlékuiwo kple dɔlékuiwo, kple aɖinuwo abe da ƒe aɖi kple ʋetsuviwo ƒe aɖi ene.

Mina míalé ŋku ɖe alesi nuwɔna sia dzɔnae ŋu tsitotsito vie:

1. De dzesi futɔa: Gbã la, ne dɔlékui alo nulɔdɔ yeye aɖe ge ɖe wò ŋutilã me la, dɔlélenutsiŋutete ƒe akpa aɖe si woyɔna be B-cells dea dzesii.

2. Aʋawɔnu tɔxɛwo wɔwɔ: Ne B-lãmenugbagbeviwo de dzesi futɔa vɔ la, wodzea dɔlékuiwutike ƒomevi aɖe si sɔ na futɔ ma koŋ wɔwɔ gɔme. Woyɔa dɔlékuiwutike siawo be immunoglobulin E (IgE) .

3. Aʋawɔnuwo dzadzraɖo na dzɔlawo:IgE dɔlékuiwutike siawo siwo wowɔ la yia ɖaléna ɖe mast cells, siwo nye míaƒe ŋutinyaa me kalẽtɔwo, ƒe anyime. Ðeko wòle abe aʋawɔnu nana dzɔla ene.

4. Alarm la ɖina: Fifia mast cells la le ŋudzɔ vevie kple woƒe IgE aʋawɔnuwo. Ɣebubuɣi si futɔ ma ke (i.e. dɔlékui alo nulɔdɔ ma ke) gage ɖe ŋutilãa me ake la, IgE si kpe ɖe mast cells ŋu la alée. Emae nye esime mast cells la ``wɔa dɔ''.

5. Histamine ƒe amedzidzedze: Ne wowɔ dɔ la, mast cells ɖea atike gbogbo aɖewo siwo wodzra ɖo ɖe wo me la dona zi ɖeka. Atike siawo dometɔ vevitɔe nye histamine .

Mina míalé ŋku ɖe nusi dzɔna le míaƒe ŋutilã me ne atike aɖe si woyɔna be histamine do.

Fifia èse nusi dzɔna ɖe ŋutilãa dzi ne nulɔdɔ aɖe le mía ŋu gɔme, alo? Togbɔ be wowɔa esiawo katã be woatsɔ akpɔ mía ta hã la, ɣeaɖewoɣi la, ŋuɖoɖo sia nu sẽna akpa.

Afikae lãmenugbagbevi siawo bɔ ɖo wu le ŋutilãa me?

Dzɔla siawo ƒe akpa gãtɔ nɔa mɔ gã siwo dzi dɔlékuiwo kple nusiwo nana ŋutilã melɔ̃a nu le o siwo tso gota gome gena ɖe mía me la dzi. Ema nye:

• Yagbɔgbɔmɔ̃ kple lãkusi: Takpɔ ɖokuiwò ta tso nusiwo va kpe ɖe ya si míegbɔna ŋu la si me.
• Nuɖuɖumeŋusẽ (GI tract): Takpɔ ɖokuiwò ta tso dɔlékui siwo va kpe ɖe nusiwo míeɖuna kple nunono ŋu la si me.
• Ŋutilã: Takpɔ ɖokuiwò ta tso nusiwo gena ɖe ŋutigbalẽa me la me.
• Lãmenugbagbevi siawo le ʋukawo kple lãmekawo hã ŋu .

Dɔléle kawoe ate ŋu ado ƒome kple mast cells?

Ne mast cells mewɔa dɔ nyuie o la, dɔléle vovovowo ate ŋu ado mo ɖa. Wo dometɔ aɖewo bɔ eye wonya wo nyuie.

Nya nu tso dzesi siawo ŋu.

Mast cell dɔléle ƒe dzesiwo ate ŋu anye:

• Ŋutilã ƒe biã, ʋuʋudedi, dzoxɔxɔ ƒe seselelãme.
• Vuvu (edema) le ŋutilã ƒe akpa vovovowo.
• Yagbɔgbɔ sesẽ.
• Nulɔdɔ sesẽwo (anaphylaxis).

Ne èkpɔa dzesi siawo enuenu la, ele vevie ŋutɔ be nàyi ɖɔkta gbɔ aɖaɖo aɖaŋu na wò tsɔ wu be nàda atike na ɖokuiwò.

Aleke ɖɔkta awɔ anya dɔléle siawo? Nukawoe nye atikewɔmɔnuawo?

Ne wò ɖɔkta susui be mast cell dɔléle aɖe le ŋuwò le wò dzesiwo nu la, ate ŋu abia be woawɔ dodokpɔ vovovowo.

• Ʋudodokpɔwo
• Aɖuɖɔtoe dodokpɔwo
• Nulɔdɔ ŋuti ŋutigbalẽ dodokpɔ
• Ɣeaɖewoɣi la, woxɔa ƒumeŋuɖui alo ŋutigbalẽ sue aɖe hena dodokpɔ (`biopsy`).

Atikewɔwɔ ƒe tiatia vovovowo toa vovo tso dɔnɔ ɖesiaɖe gbɔ eye wònɔa te ɖe nɔnɔmea ƒe nɔnɔme nu. Atikewɔwɔ siwo bɔ ate ŋu anye:

• Ƒo asa na nusiwo nana wò nulɔdɔ: De dzesi nusiwo ŋu wò nulɔdɔ le eye nànɔ adzɔge tso wo gbɔ.
• Atikewo: Atike siwo wonana be woatsɔ aɖu dzesiwo dzi. Kpɔɖeŋu aɖewoe nye atike siwo wua histamine kple montelukast.
• Mast cell stabilizers: Atike siawo wɔa dɔ to atikewo abe histamine ene ƒe dodo tso mast cells me nutsitsi me.
• Atike siwo wozãna kpata: Atikewo abe epinephrine ene na anaphylaxis sesẽ.

Mlɔeba la, ɖe mast cells nyo loo alo menyo oa?

Ne nɔnɔme aɖe si ɖea fu na ame abe nulɔdɔ ene le wo ŋu ko hafi ame akpa gãtɔ sea nu tso mast cells ŋu, eyata woate ŋu abui be wonye nu gbegblẽ. Gake le nyateƒe me la, mast cells nye míaƒe ŋutilã ƒe ametakpɔnu ƒe akpa vevi aɖe si le vevie ŋutɔ.

Zi geɖe la, wokpɔa mía ta tso dɔlélewo kple dɔlékuiwo si me. Ne dzo le wo me vie akpa ye míexɔa nulɔdɔ. Abe dzɔla siwo doa vevie nu akpa ƒe ha aɖe si tɔ dzo kɔƒea katã be yewoalé fiafitɔ sue aɖe ene.

Eyata ɣebubuɣi si nàɖe aɖuɖɔ alo aƒo ɖokuiwò la, da akpe na mast cell sue siawo tso dzi me. Elabena wodzea agbagba vevie be yewoakpɔ tawò!