Esesẽna be míagblɔ vɔvɔ̃ kple dzimaɖitsitsi si ame sena ne wokpɔ kansa le eŋu la ɖe nyagbewo me. Gake esi atikewɔwɔ ŋuti dzɔdzɔmeŋutinunya le ŋgɔ yim ta la, egbea mɔnu deŋgɔwo kple dzidzedzekpɔkpɔ ŋutɔ li siwo dzi woato ada kansa. To vovo na tsã la, fifia atikewɔmɔnu tɔxɛ aɖewo li siwo tɔa ŋku kansa lãmenugbagbeviwo ko dzi hedzea wo dzi. Egbea la, míele nu ƒom tso atikewɔwɔmɔnu vevi aɖe ŋutɔ si wozãna na dɔdzẽ si le dɔgboa me ŋu. Emae nye Monoclonal Antibody Therapy.
Nukae nye Monoclonal Antibodies siawo?
Hafi míase esia gɔme la, mina míalé ŋku ɖe mía ŋutɔwo míaƒe ŋutilã ƒe dzɔdzɔme ametakpɔnu ŋu. Ne gotagome amedzidzela aɖe, abe dɔlékui alo dɔlékui ene, ge ɖe míaƒe ŋutilã me la, míaƒe dɔlélenutsiŋutete wɔa protein tɔxɛwo be woake ɖe wo ŋu ahatsrɔ̃ wo. Míeyɔa dɔlékuiwutike siawo be dɔlékuiwutikewo. Ele abe aʋakɔ aɖe si le dukɔ aɖe ta kpɔm ene.
Azɔ bu eŋu kpɔ be "asrafoha tɔxɛ aɖe" le asrafoha sia si si wona hehee etɔxɛe eye wònya alesi woadze taɖodzinu ɖeka ko dzii. Monoclonal Antibodies nye nane si le abe ema ene. Esiawo nye dɔlékuiwutike tɔxɛ siwo wowɔ le nudokpɔƒe. Wotrɔ asi le wo ŋu be woadi taɖodzinu ɖeka, alé ɖe eŋu, eye woatsrɔ̃e. Le go sia me la, taɖodzinu ma nye kansa lãmenugbagbevi.
Viɖe gãtɔ kekeake si le atikewɔwɔ sia ŋue nye alesi wòwɔa nu pɛpɛpɛ . Atikewɔmɔnu si wozãna le blema la le abe bɔmb ene. Togbɔ be ewua kansa lãmenugbagbeviwo hã la, ate ŋu agblẽ nu le lãmenugbagbevi siwo le lãmesẽ me le míaƒe ŋutilã me hã ŋu. Esia tae atikewɔmɔnu hea nugbegblẽ le ame ŋu abe ɖa ƒe ŋeŋe kple ɖeɖiteameŋu ene vɛ ɖo. Gake Monoclonal Antibody ƒe atikewɔwɔ le abe "tu si wofia mɔe" ene. Eyina ɖe kansa ƒe lãmenugbagbevi la gbɔ tẽ. Eyata àte ŋu akpɔ mɔ be nugbegblẽ le ame ŋu ʋɛ aɖewo koe ado tso eme.
Atike siwo xea mɔ na kansa ƒe "agbemɔ"
Menye lãmenugbagbevi gbogbo aɖewo koe kansa nye o. Ele abe dɔwɔƒe sue aɖe ene. Ehiã nunyiame hafi wòatsi, be wòalolo. Be kansa lãmenugbagbeviwo nakpɔ nunyiame sia la, wowɔa ʋuka yeyewo na wo ɖokui. Le atikewɔwɔ me la, míeyɔa nuwɔna sia be ʋukawo ƒe dzɔdzɔ . Ʋuka siawo mee kansa la kpɔa nunyiame si wòhiã be wòatsi agbe.
Eyata nusi dɔlékuiwutike siwo nye monoclonal aɖewo wɔnae nye be wodzudzɔa ʋuka mawo ƒe wɔwɔme. Ele abe ami ƒe "nana" si wotsɔna naa kansa la ɖeɖeɖa ene. Atike vevi aɖe si le hatsotso sia mee nye Bevacizumab (Avastin) .
Aleke Avastin wɔa dɔe?
Kansa lãmenugbagbeviwo ɖea dzesi tɔxɛ aɖe si woyɔna be Vascular Endothelial Growth Factor (VEGF) . Ne woxɔ dzesi sia la, ŋutilãa dzea ʋuka yeyewo wɔwɔ gɔme. Atike si nye Avastin wɔa dɔ to mɔxexe ɖe VEGF ƒe dzesi ma nu me. Esia wɔnɛ be kansa la megawɔa ʋuka yeyewo o. Emegbe ne nunyiame aɖeke meli o la, kansa ƒe tsitsi dzi ɖena kpɔtɔna alo nu tsona.
Avastin nye atike si dzi woda asi ɖo na dɔgbo me kansa si kaka (si kaka) ɖe ŋutilã ƒe akpa bubuwo. Togbɔ be medaa kansa la keŋkeŋ o hã la, numekukuwo ɖee fia be ne wona Avastin kple atikewɔmɔnu la, edzia dɔnɔwo ƒe agbenɔƒe ɖe edzi abe ɣleti atɔ̃ ene.
Atike yeye siwo le hatsotso sia me dometɔ aɖewoe nye `Fruquintinib (Fruzaqla), `ramucirumab (Cyramza)` kple `ziv-aflibercept (Zaltrap).` Esiawo hã wɔa dɔ to nudede VEGF ƒe dzesiɖoɖoa me.
Alesi wonaa Avastin kple eƒe nugbegblẽ le ame ŋu
Avastin nye atike si wodona ɖe ʋuka me alo wodona ɖe ʋuka me. Zi geɖe la, wonaae kwasiɖa eve va ɖo etɔ̃ ɖesiaɖe tsɔ kpe ɖe atikewɔmɔnu ŋu. Nu vevi si dzi wòle be míaɖo ŋkui enye be atike sia doa ŋusẽ atikewɔmɔnu ƒe ŋusẽkpɔɖeamedzi, gake womekpɔe be ewɔa dɔ nenema gbegbe ne wozãe ɖeɖeko na dɔnɔ siwo ŋu dɔdzẽ le dɔgboa me o.
Ele vevie ŋutɔ be nàƒo nu faa kple wò ɖɔkta tso vevesese ɖesiaɖe si ate ŋu ado mo ɖa ŋu hafi nàdze atikewɔwɔ sia gɔme kple le ewɔɣi.
| Bevacizumab (Avastin) ƒe nugbegblẽ le ame ŋu siwo ate ŋu ado tso eme . | |
|---|---|
| Nusiwo dona tso eme zi geɖe siwo wokpɔna zi geɖe | |
| Sese le eɖokui me be ɖeɖi te ye ŋu eye agbe mele ye si o | Taɖuame |
| Ʋusɔgbɔdɔ | Nudzroame |
| Aɖuɖɔtoe (dɔgbo ƒe vevesese) . | |
| Nu gbegblẽ sesẽ siwo wòle be woagblɔ na ɖɔkta enumake | |
| Dodo le dɔgboa me (ate ŋu abia be woawɔ dɔ nɛ) . | Ayikuwo ƒe gbegblẽ kple protein ƒe dzidziɖedzi le aɖuɖɔ me |
| Dzidɔ alo akɔtave | Abi ƒe dɔyɔyɔ dzi ɖe kpɔtɔ (eyata mele be woazãe le amekoko vɔ megbe teti o) . |
| Ʋu ƒe dodo fũ alo ʋu ƒe sisi ƒe kuxiwo | |
Atike siwo tsia "tsitsi ƒe ʋuƒo" le kansa lãmenugbagbeviwo me
Mina míaƒo nu tso dɔlékuiwutike si woyɔna be monoclonal antibody ƒomevi bubu ŋu. Esiawo mewɔa dɔ abe alesi míegblɔe va yi ene o. Atike siawo tɔa ŋku protein aɖe koŋ si le kansa lãmenugbagbeviwo ƒe anyime tẽ. Woyɔe be Epidermal Growth Factor Receptor (EGFR) .
Kpuie ko la, EGFR sia le abe "switch" si gblɔna na kansa lãmenugbagbevi la be "wòatsi, atsi." EGFR protein sia le dɔgbo me kansa siwo ade 75% me.
Atike siwo nye cetuximab (Erbitux) kple panitumumab (Vectibix) wɔa dɔ to wo tsɔtsɔ kpe ɖe "switch" ma si woyɔna be EGFR ŋu kple etsitsi me. Esia xea mɔ na dzɔdzɔmedzesi si gblɔna na lãmenugbagbeviwo be woatsi be wòagava ka ɖe switch la dzi o. Esia wɔe be kansadɔlékuiawo dzudzɔa tsitsi.
Amekawoe wozãna na Erbitux kple Vectibix?
Woda asi ɖe atike siawo evea siaa dzi na dɔgbo me kansa si kaka (si kaka) ɖe ŋutilã ƒe akpa bubuwo. Gake nu ɖeka aɖe li si le vevie ŋutɔ . Hafi nàdze atikewɔwɔ sia gɔme la, ele be nàwɔ domenyiŋusẽfianu ƒe dodokpɔ tɔxɛ aɖe (`domenyiŋusẽfianu ƒe tɔtrɔ dodokpɔ`) na wò kansa lãmenugbagbeviwo. Dodokpɔ mae ɖenɛ fiana nenye be atike siawo awɔ dɔ na wò kansa alo mawɔ dɔ o. Esia mesɔ na amesiame o.
Wodoa Erbitux ɖe ʋuka me zi ɖeka le kwasiɖa me. Wonanɛ ɖeɖeko alo wotsɔa atike si wozãna tsɔ daa dɔe si nye irinotecan (Camptosar) kpena ɖe eŋu. Wonaa vectibix kwasiɖa eve ɖesiaɖe, zi geɖe la, wotsɔa atike bubu geɖe siwo wozãna tsɔ daa dɔe kpena ɖe eŋu.
| Erbitux kple Vectibix ƒe nugbegblẽ le ame ŋu siwo ate ŋu ado tso eme | |
|---|---|
| Ŋutilã ƒe kuxiwo: ʋuʋudedi siwo le abe aklã ene, ŋutigbalẽ ƒe ʋuʋudedi, ŋutigbalẽ si ƒu. (Ðo ŋku edzi be ɣeaɖewoɣi la, ŋutigbalẽ ƒe nuwɔna siawo ate ŋu anye dzesi be atike la le dɔ wɔm ɖe kansa la ŋu!) | Asrã |
| Sese le eɖokui me be ɖeɖi te ye ŋu eye agbe mele ye si o | Miléle |
| Dɔgbo ƒe vevesese | Nulɔdɔwo abe gbɔgbɔ sesẽ kple ʋu ƒe sisi ene |
| Nuwɔna siwo dzɔna ne wodo atike la ɖe ŋutilãa me | |
Dɔdamɔnu siawo katã nye esiwo ku ɖe ame ŋu koŋ ŋutɔ. Wò ɖɔkta koe ate ŋu anɔ te ɖe kansa ƒomevi kple wò lãmesẽ dzi anya atike nyuitɔ kekeake na wò. Mèganɔ te ɖe nya siwo nèxlẽ le internet dzi alo nya siwo ame bubu gblɔ dzi awɔ nyametsotsowo o.
Gbedasi si Wotsɔ Yi Aƒeme
- Monoclonal Antibody nye atike tɔxɛ aɖe si woto vɛ le nudokpɔƒe aɖe si tɔa ŋku kansa lãmenugbagbeviwo ko hedzea wo dzi.
- Mɔ vovovowoe li siwo dzi esiawo wɔa dɔ le. Atike aɖewo xea mɔ na ʋu ƒe sisi na kansa la, eye bubuwo xea mɔ na dzesi siwo kansa lãmenugbagbeviwo nana be woatsi.
- Dɔdamɔnu siawo mesɔ na amesiame o. Hafi woana atike aɖewo la, ahiã be nàwɔ domenyiŋusẽfianu ƒe dodokpɔ tɔxɛwo akpɔe ɖa be atike la awɔ dɔ na wò kansa hã.
- Abe atikewo katã ene la, esia hã ƒe nugbegblẽ le ame ŋu. Mègavɔ̃ wo o, gake ƒo nu tso wo ŋu na wò ɖɔkta nyuie hafi nàdze atikewɔwɔ gɔme.
- Wò ɖɔkta si le dɔ wɔm na wò koe ate ŋu ana aɖaŋuɖoɖo kple mɔfiame nyuitɔ kekeake wò ku ɖe wò kansa dada ŋu, eyata ele vevie ŋutɔ be nàwɔ ɖe woƒe mɔfiamewo dzi.
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