Ðe wò ŋutilã mele dɔ wɔm nyuie ɖe Parathyroid Hormone ŋu oa? Mina míaƒo nu tso nɔnɔme wɔnuku sia (Pseudohypoparathyroidism) ŋu!

Ðe nèsena le ɖokuiwò me ɣeaɖewoɣi be nane le yeƒe ŋutilã me mele dɔ wɔm nyuie oa? Dɔléle wɔnuku aɖewo li, siwo ƒe ŋkɔwo ate ŋu ado vɔvɔ̃ na ame vie. Dɔléle mawo dometɔ ɖeka si ŋu womesea nu tsoe boo o, gake wòle vevie be woanya nu tso eŋue nye Pseudohypoparathyroidism (PHP). Togbɔ be ŋkɔa adze abe ɖe wòdidi vie ene hã la, mina míana wòanɔ bɔbɔe.

Nukae nye pseudohypoparathyroidism ƒe dɔléle?

Kpuie ko la, domenyiŋusẽfianu ƒe nɔnɔme si mebɔ o nye esia . Lãmetsi suesuesuewo le míaƒe ŋutilã me siwo woyɔna be parathyroid glands. Esiawo wɔa lãmetsi aɖe si woyɔna be Parathyroid Hormone (PTH). PTH lãmetsi sia le vevie ŋutɔ na míaƒe ŋutilã. Elabena, lãmetsi sia kpena ɖe mía ŋu be Calcium, Phosphorus, kple Vitamin D ƒe agbɔsɔsɔ si sɔ nanɔ míaƒe ʋu me.

Fifia, ènya nusi dzɔna ɖe amesi ŋu pseudohypoparathyroidism (PHP) le dzia? Togbɔ be woƒe parathyroid glands wɔa PTH hormone le mɔ nyuitɔ nu hã la, lãmenugbagbevi siwo le woƒe ŋutilã me mewɔa nu ɖe ​​eŋu nyuie o, si fia be womate ŋu "ade dzesii" o. Ðeko wòle abe ame aɖe le nu ƒom na wò gake màte ŋu ase wo o ene. Míeyɔa esia be Parathyroid Lãmetsiŋusẽ ƒe Tsitretsitsi .

Nukae dzɔna le esia ta? Calcium ƒe agbɔsɔsɔ le ʋu me dzi ɖena kpɔtɔna, gake phosphorus ya dzina ɖe edzi. Dadasɔ sia ate ŋu ana lãmekawo naʋuʋu, woƒe lãme nasẽ, woƒe lãme nasẽ, eye aɖu ƒe kuxiwo nadze wo dzi.

Vevietɔ la, nɔnɔme sia si woyɔna be PHP to vovo na nɔnɔme si woyɔna be Hypoparathyroidism. Ame siwo ŋu hypoparathyroidism le la mewɔa PTH lãmetsi si sɔ le gɔmedzedzea me o. Gake le PHP me la, lãmetsiŋusẽa dona, gake ŋutilãa mezãnɛ o.

Nukawoe nye PHP ƒomevi veviwo?

PHP ƒe nɔnɔme sia ƒe ƒomevi vevi geɖewo li. Na míakpɔ nusiwo wonye ɖa.

PHP-1 ƒomevi

Esiae nye PHP ƒomevi si bɔ wu . Tsɔ kpe ɖe PTH lãmetsiŋusẽ ƒe tsitretsitsi si míeyɔ va yi ŋu la, woate ŋu akpɔ tɔtrɔ aɖewo le ƒunukpeƒewo ŋu. Le kpɔɖeŋu me:

• Mo ƒe gogloƒe
• Kɔkɔme dzi ɖe kpɔtɔ (gbɔgbɔ kpuie) .
• Kɔ ƒe vevesese
• Asiwo kple afɔwo ƒe gbagbã

Ðɔktawo yɔa dzesi siawo ƒe ƒuƒoƒo be Albright Hereditary Osteodystrophy (AHO) . Ame siwo ŋu PHP-1 le la xɔa nɔnɔmea le domenyiŋusẽfianu ƒe tɔtrɔ aɖe si woyɔna be `GNAS` si ƒe dome wonyi tso wo dzilawo dometɔ ɖeka gbɔ ta.

PPHP (Pseudopseudohypoparathyroidism ƒe dɔléle si nye alakpatɔ) .

Esia nye PHP-1 ƒe nɔnɔme si seɖoƒe li na. Amesiwo ŋu PPHP (Pseudopseudohypoparathyroidism) le ate ŋu akpɔ ŋutilã ƒe nɔnɔme siwo wokpɔna le AHO me (abe mo goglo kple kɔkɔme kpui ene), gake PTH lãmetsiŋusẽ ƒe dɔlélenutsiŋutete mele wo ŋu o . Esia fia be woƒe calcium kple phosphorus ƒe agbɔsɔsɔ sɔ.

PHP-2 ƒomevi

Ame siwo ŋu PHP-2 le la te ŋu nɔa te ɖe PTH lãmetsiŋusẽ nu, si fia be calcium kple phosphorus sɔ gbɔ ɖe wo me. Gake ŋutilã ƒe nɔnɔme (abe mo goglo kple kɔkɔme kpui ene) si wokpɔna le AHO me mele wo si o. Numekulawo mekpɔ nya domenyiŋusẽfianu ƒe gbɔdzɔgbɔdzɔ si tututu hea PHP-2 ƒomevi sia vɛ haɖe o.

Nukae nye PHP ƒe dzesiwo?

PHP ƒe dzesiwo ate ŋu ato vovo tso ame ɖeka gbɔ yi bubu gbɔ . Esia fia be menye amesiamee akpɔ dzesi ɖeka ma ke o. Dzesi siwo bɔ dometɔ aɖewoe nye:

• Lãmetsiwo ƒe ʋuʋu
• Lãmetsiwo ƒe tete enuenu : Seselelãme si le abe afɔ aɖe hem ene.
• Afɔ kple afɔwo ƒe ʋuʋu alo ʋuʋudedi
• Alɔ̃madɔmadɔ
• Aɖuɖɔtoe si tsi megbe
• Aɖu ƒe ʋuʋudedi ƒe gbɔdzɔgbɔdzɔ
• Ʋu ƒe sisi ƒe ɖiɖi
• Taɖa kple ɖa siwo le gbagbãm
• Dzitsitsi
• Teteɖeanyi

Amesiwo ŋu PHP-1 le ate ŋu akpɔ dzesi bubu siwo kpe ɖe Albright domenyinyi ƒe ƒumeŋuɖui (AHO) ƒe nɔnɔme si míeyɔ va yi ŋu. Ame aɖewo siwo ŋu PHP le hã ate ŋu akpɔ dzesi siawo:

• Mo ƒe gogloƒe
• Kpuie ƒe kɔkɔme (kɔkɔme kpui) .
• Kɔ ƒe vevesese
• Ƒu siwo le asiwo kple afɔwo me : Ate ŋu adze abe abɔta, vevietɔ asibidɛ enelia kple atɔ̃lia tɔ, trɔ ɖe eme ene.
• Lolo akpa : Efia be woalolo akpa.
• Nukpɔkpɔ ƒe dɔmawɔmawɔ nyuie : nuwo abe ŋku ƒe ʋuʋu, ŋku ƒe ʋuʋu, kple kekeli ƒe seselelãme.
• Ƒu ƒe ʋuʋudedi le wò ŋutigbalẽ te
• Tsitsi ƒe megbetsitsi : Ðevi aɖewo ate ŋu akpɔ tsitsi ƒe megbetsitsi aɖewo.

Nukae nye nusiwo gbɔ PHP tsona?

Nusi koŋ gbɔ dɔléle sia tsonae nye tɔtrɔ le míaƒe domenyiŋusẽfianuwo me, vevietɔ le domenyiŋusẽfianu si woyɔna be `GNAS` me . Ame aɖewo nyia dome tso wo dzilawo gbɔ . Ema fia be enye domenyiŋusẽfianu. Gake ɣeaɖewoɣi la, nɔnɔme sia ate ŋu adzɔ ƒome ŋutinya aɖeke manɔmee eye womate ŋu akpɔ nusi gbɔ wòtso o.

Zi geɖe la, wokpɔa PHP le vidzĩme alo ɖevimenɔɣi , gake ate ŋu adze ɣeaɖewoɣi le ame tsitsi me.

Nukawoe nye kuxi siwo ate ŋu ado tso PHP me?

Ne PHP le ŋuwò la, anɔ eme be lãmenugbagbeviwo ƒe dɔmawɔmawɔ nyuie bubuwo anɔ ŋuwò . Kuxi siawo siwo do ƒome kple lãmetsiŋusẽ ate ŋu ahe dzesiwo abe ŋusẽ si mede ame dzi o kple gbɔdɔdɔ ƒe dzodzro si mebɔ o ene vɛ.

Ame aɖewo siwo ŋu PHP le la le afɔku gã aɖe me be woaxɔ nɔnɔmewo abe:

• Parkinson ƒe dɔléle: Dzesi siwo ɖi Parkinson ƒe dɔlélea ɖeɖefia.
• Difficulty with fine motor skills : Esia fia be dɔ nyuiwo abe buttoning alo nuŋɔŋlɔ ene sesẽ.
• Carpal Tunnel Syndrome : Vevietɔ na amesiwo ŋu PHP-1 le. Esia nye nɔnɔme si me lãmeka aɖe si le asibidɛa me la tea ɖe edzi, si wɔnɛ be asia tsia dzodzodzoe eye wòsea veve.
• Aklã ƒe ʋuʋu
• Alɔ̃dɔdɔ ƒe gbɔgbɔtsixetsixe : Vevietɔ le ɖeviwo gome.

Aleke ɖɔktawo wɔa dea dzesi PHP?

Ne èsusu be PHP le ye ŋu la, wò ɖɔkta awɔ ŋutilãmedɔdada gbã . Woabia nya tso wò ƒomea ƒe ŋutinya hã ŋu . Emegbe woate ŋu awɔ dodokpɔ bubu geɖe atsɔ aɖo kpe dɔlélea dzi. Esiawo dometɔ aɖewoe nye:

• Ʋudodokpɔ : Dzidze lãmetsiŋusẽ ƒe agbɔsɔsɔ, vevietɔ calcium, phosphorus, kple PTH ƒe agbɔsɔsɔ.
• Aɖuɖɔtoe dodokpɔ : Kpɔ calcium kple phosphorus ƒe agbɔsɔsɔ le aɖuɖɔ me ɖa.
• Domenyiŋusẽfianu dodokpɔ : Kpɔ tɔtrɔ siwo le `GNAS` domenyiŋusẽfianu me ɖa.
• Electrocardiogram (EKG) : Eléa ŋku ɖe dzi ƒe tsotso ƒe nɔnɔme siwo mesɔ o ŋu.
• Asi ƒe X-ray : Kpɔe ɖa be ƒuwo gbã kple tɔtrɔ bubuwo hã.
• CT Scan (CT - Computed Tomography scan) : Be woakpɔe ɖa be tɔtrɔ aɖewo le ahɔhɔ̃a me hã.

Nyatakaka siwo woxɔ tso dodokpɔ siawo me dzie ɖɔktaa ate ŋu aɖo kpe PHP ƒe nɔnɔmea dzi pɛpɛpɛ.

Aleke wowɔa nu ɖe ​​PHP ŋui?

Womekpɔ atike aɖeke na dɔléle sia haɖe o . Gake mègatsi dzi o. Ne èda dɔ nyuie hekpɔ egbɔ nyuie la, àte ŋu aɖu wò dzesiwo dzi ahanɔ agbe si sɔ.

Taɖodzinu vevitɔ si le atikewɔwɔ ŋue nye be nàna calcium kple phosphorus ƒe agbɔsɔsɔ si sɔ nanɔ wò ʋu me . Ne wolé agbɔsɔsɔ siawo me ɖe asi ate ŋu aɖe dzesiawo dzi akpɔtɔ ŋutɔ. Esia nye atikewɔwɔ si woawɔ le eƒe agbemeŋkekewo katã me .

Atikewɔwɔ ƒe tiatia ate ŋu anye:

• Calcium kple vitamin D kpeɖeŋutɔ : le atikekui alo tsi ƒe nɔnɔme me.
• Calcitriol capsules : Esia nye atike si dzia calcium ƒe agbɔsɔsɔ ɖe ŋutilã me ɖe edzi.
• Calcitriol dodo ɖe lãme na ame
• Tsitsi ƒe lãmetsi alo thyroid lãmetsi ɖɔliɖɔli ƒe atikewɔwɔ : ne ehiã.
• Nuɖuɖu si me calcium sɔ gbɔ ɖo, si me phosphorus mesɔ gbɔ ɖo o : Abe alesi nuɖuɖuŋutinunyala ɖo aɖaŋue ene.

Nu vevitɔe nye be nàwɔ ɖe atikewɔlawo ƒe aɖaŋuɖoɖowo dzi nyuie eye nàdoe kpɔ ɖe game dzi.

Ɣekaɣie wòle be makpɔ ɖɔkta?

Ne PHP le ŋuwò la, ele vevie be nàyi ɖɔkta gbɔ edziedzi be woado wò calcium kple phosphorus ƒe agbɔsɔsɔ kpɔ . Lé ŋku ɖe nusianu ŋu edziedzi sia akpe ɖe ŋuwò be woakpɔ nusianu dzi.

Ne èkpɔ dzesi sesẽwo abe gbɔgbɔ sesẽ kpata, lãmekawo ƒe ʋuʋu vevie, alo alɔ̃madɔmadɔ ene la , yi kɔdzi ƒe xɔ si te ɖe ŋuwò kpata me enumake alo nàƒo ka na 1990.

Nukae nàte ŋu akpɔ mɔ na ne èle agbe kple PHP ƒe nɔnɔmea?

Ne PHP le asiwò la, ele be nàyi edzi awɔ dɔ kple wò Dɔnɔdzikpɔla Gbãtɔ . Esi wònye be PHP ate ŋu akpɔ ŋusẽ ɖe ŋutilã ƒe akpa vovovo geɖe dzi ta la, ahiã be nàkpɔ eŋutinunyala bibi geɖe be woakpɔ wò dzesi tɔxɛwo gbɔ. Wò atikewɔlawo ƒe ƒuƒoƒoa ate ŋu anye:

• Endocrinologists : Lãmetsiŋusẽŋutinunyala bibiwo.
• Ƒumeŋutinunyalawo : Na kuxi siwo do ƒome kple ƒuwo.
• Ðeviwo ƒe dɔdalawo : Ne ɖevie.
• Ahɔhɔ̃ŋutinunyalawo : Na kuxi siwo ku ɖe lãmekawo ƒe dɔwɔwɔ ŋu.
• Lãmesẽdɔwɔlawo
• Dɔwɔɖui ŋuti dɔdamɔnufialawo
• Nuɖuɖuŋutinunyalawo
• Aɖudɔdalawo
• Domenyiŋusẽfianuŋutinunyalawo
• Vevesesenutsitike ŋuti nunyala bibiwo

Anɔ eme godoo be ahiã be nàno kpeɖeŋutɔ mawo le wò agbemeŋkekewo katã me .

Tsitsi kple susuŋutete ate ŋu ato vovo ŋutɔ le dɔlélea ƒomevi kple eƒe sesẽ nu. Gake zi geɖe la, amesiwo ŋu PHP le ƒe agbenɔƒe sɔ ne wotsɔe sɔ kple amesiwo ŋu PHP mele o . Wò ɖɔkta ate ŋu agblɔ nusi nàkpɔ mɔ na na wò le wò nɔnɔmea nu.

Esi wònye be PHP nye nɔnɔme si mebɔ o ta la, ate ŋu asesẽ be nàkpɔ ame bubu siwo ƒe nɔnɔme sɔ kple wò . Ate ŋu ase le eɖokui me hã be yetsi akogo ɣeaɖewoɣi. Ne wokpɔe be PHP le ŋuwò alo viwòa ŋu la, ƒo nu kple wò ɖɔkta tso kpekpeɖeŋunahawo kple hehenana ƒe dɔwɔnuwo ŋu . Esiawo ate ŋu akpe ɖe ŋuwò nàkpɔ mɔ siwo dzi nàto ana wò dzesiwo kple agbenɔnɔ bliboa nanyo ɖe edzi.

Gbedasi si Wotsɔ Yi Aƒeme

Enyo, eyata mina míalé ŋku ɖe nu aɖewo siwo dzi míaɖo ŋkui tso pseudohypoparathyroidism (PHP) si ŋu míeƒo nu tsoe ŋu.

• PHP nye domenyiŋusẽfianu ƒe nɔnɔme si mebɔ o si me ŋutilãa mewɔa nu nyuie ɖe parathyroid hormone (PTH) ŋu o.
• Esia wɔnɛ be calcium si le ʋua me dzi ɖena kpɔtɔna eye phosphorus hã dzina ɖe edzi.
• Wole ƒomevi vevi geɖewo : PHP-1, PHP-2, kple PHP-3.Ɛ̃. PHP-1 ate ŋu ana tɔtrɔwo nava ƒu siwo woyɔna be AHO me.
• Dzesi vovovowo ate ŋu ado mo ɖa, abe lãmekawo ƒe ʋuʋu, lãmetutudɔ, alɔ̃madɔmadɔ, aɖu ƒe kuxiwo, ame ƒe kɔkɔme kpui, kple mo si le goglo ene .
• Nusi koŋ gbɔ wòtsoe nye domenyiŋusẽfianu ƒe tɔtrɔ le `GNAS` domenyiŋusẽfianu me .
• Togbɔ be womate ŋu adae bliboe o hã la, woate ŋu aɖu dzesiawo dzi ne wozã atike na wo le woƒe agbemeŋkekewo katã me (calcium, vitamin D, si nye nuɖuɖu tɔxɛ aɖe).
• Atikewɔlawo ƒe dodokpɔ edziedzi kple ɖɔkta bibiwo ƒe kpekpeɖeŋu le vevie ŋutɔ.
• Ame akpa gãtɔ ate ŋu anɔ agbe si sɔ .
• Kpekpeɖeŋu si tso kpekpeɖeŋunahawo gbɔ le vevie ŋutɔ be susu nasẽ.

Mègaŋlɔ be o, menye wò ɖeka koe o. Togbɔ be esia nye dɔléle si mebɔ o hã la, woate ŋu akpɔ egbɔ nyuie ne woɖo aɖaŋu na wo nyuie eye wodo alɔe. Ðo ŋku edzi be ɖɔktawo, ƒometɔwo, kple xɔlɔ̃wo nɔa anyi na wò ne èhiã ŋusẽ.

` Pseudohypoparathyroidism, PHP, parathyroid lãmetsi, calcium, phosphorus, domenyiŋusẽfianu ƒe dɔlélewo, AHO