Ènya nu tso kansa si mebɔ o si woyɔna be Sarcomatoid Carcinoma ŋua? Mina míaƒo nu tsitotsito!

Kansa doa vɔvɔ̃ na mí katã vie, alo? Gake menye kansawo katãe sɔ o. Egbea míele nu ƒom tso kansa ƒomevi aɖe si mebɔ o eye wòsesẽ ŋutɔ ŋu. Woyɔa esia be Sarcomatoid Carcinoma. Ŋkɔa aɖi nusi wɔ nuku na wò, gake mina míadze agbagba aɖe eme bɔbɔe. Ðɔktawo yɔa esia be kansa ƒomevi si le dzidzim ɖe edzi kabakaba ŋutɔ, si nu sẽ ŋutɔ .

Nukae nye Sarcomatoid Carcinoma?

Kpuie ko la, Sarcomatoid Carcinoma nye kansa ƒomevi eve ƒe ƒuƒoƒo. Eyae nye be kansa kple sarcoma siaa ƒe nɔnɔmewo le esi. Azɔ mina míakpɔ nusi carcinoma kple sarcoma nye ɖa.

• Kansa: Esiae nye kansa ƒomevi si bɔ wu. Edzea egɔme tso lãkusi siwo tsyɔa míaƒe ŋutinuwo alo ŋutigbalẽ ƒe gowo dzi. Míeyɔa lãkusi siawo be lãmenugbagbevi siwo le lãkusi me elabena lãmenugbagbevi siwo le lãkusi me ye wɔ wo.
• Sarcoma: Esia mebɔ abe kansa ene o. Sarcomas dzea egɔme tso teƒewo abe ƒu, kadodoŋusẽ (e.g., ƒunukpeƒetetedɔ, lãkusiwo), kple lãkusi falɛfalɛwo (e.g., lãmeka, ami, lãmekawo). Lãmenugbagbevi ƒomevi aɖe si woyɔna be mesenchymal cells ye wotsɔ wɔ woe.

Eyata le sarcomatoid carcinoma gome la, dɔdzẽ si me lãmenugbagbeviwo kple lãkusi siwo do ƒome kple kansa kple sarcoma siaa le la dzɔna. Dɔdzẽ siawo tsina kabakaba ŋutɔ eye woate ŋu akaka (akaka) ayi ŋutilã ƒe akpa vovovowo. Ne esia kaka la, lãmenugbagbevi siwo le lãmesẽ me le ŋutilãa me gblẽna.

Afikae esia dzɔna le le ŋutilãa dzi zi geɖe wu?

Ne èse ŋkɔ sarcomatoid carcinoma la, anɔ eme godoo be ètsɔe do ƒome kple wò lãkusiwo . Gake kansa sia ƒomevi, si ƒe nɔnɔmewo nye carcinoma kple sarcoma siaa, ate ŋu adzɔ le ŋutilã ƒe akpa bubuwo hã. Le kpɔɖeŋu me:

• Ŋutigbalẽ
• Ƒu
• Nu
• Thyroid ƒe lãkusi
• Nowo
• Ƒodo
• Dɔgbo sue aɖe
• Aklã
• Dɔgbo ƒe dɔléle
• Vidzidɔ
• Prostate ƒe ʋuka
• Tsinyegoe
• Ayikuwo
• Teƒe si le akɔta titina (woyɔa esia be ``Mediastinum''. Nuwo abe dzi, yaƒoƒo, kple thymus gland ene le afisia)

Wogblɔ be sarcomatoid carcinoma, si dzea egɔme tso lãkusi me la kakana kabakaba ŋutɔ. To mɔ sia dzi la, ate ŋu akaka ɖe teƒe geɖe zi ɖeka, abe adrenal glands, ahɔhɔ̃, ƒuwo, aklã, ayiku, peritoneum, dɔgbo, ŋutigbalẽ, kple dzi ene.

Ðe esia hã ƒomevi vovovowo lia?

Ẽ, Xexeame ƒe Lãmesẽ Habɔbɔ (WHO) da sarcomatoid carcinoma ɖe hatsotso vevi atɔ̃ me le ƒe 2015. Woyɔ ƒomevi siawo dometɔ ɖesiaɖe be "poorly differentiated non-small cell lung carcinoma." "Womede vovototo wo dome nyuie o" fia be lãmenugbagbeviawo ƒe vovototo le mɔ si mesɔ o nu ale gbegbe be esesẽna be woagblɔ ƒomevi si tututu wonye. Aɖuɖɔtoedɔdzẽ si menye lãmenugbagbevi suewo o nye lãkusi me dɔdzẽ ƒomevi aɖe si bɔ si tsina eye wòkakana kabakaba.

Ƒomevi atɔ̃ siawoe nye:

• Pleomorphic carcinomas: Kansa ƒe dzesiwo koŋue le esiawo me. Gake zi geɖe la, sarcoma ƒe dzesiwo nɔa wo dometɔ 10% ya teti ŋu. Esiae nye sarcomatoid carcinoma ƒomevi si bɔ wu.
• Spindle-cell carcinoma: Kansa sia ƒomevi xɔ ŋkɔ tso alesi eƒe lãmenugbagbeviwo dzena le nusuekpɔmɔ̃ me gbɔ. Wodidi, wole tsɛ, eye woɖi tasiaɖamfɔ si le tsatsam ƒe aŋenuwo.
• Lãmenugbagbevi gãwo ƒe kansa: Lãmenugbagbevi gã siwo woɖo ɖe ɖoɖo nu abe sarcomas ene le esia me. Zi geɖe la, esiawo dzɔna le lãkusi ƒe akpa si le etame.
• Carcinosarcoma: Esia lɔ lãkusi siwo tso kansa ƒomevi aɖewo me, abe adenocarcinoma kple squamous cell carcinoma ene me ɖe eme. Sarcoma ƒe lãkusi si mesɔ o, si metsi nyuie o hã le eme.
• Aklã me ʋu ƒe sisi: Esia nye adenocarcinoma ƒomevi aɖe si ɖi fugboe ƒe lãkusi. Woate ŋu akpɔ mesenchymal cells (abe sarcomas ene) hã.

Amekae ate ŋu axɔ nusia wu?

Sarcomatoid Carcinoma bɔ ɖe ŋutsuwo me wu . Ebɔ ɖe amesiwo zãa atama fifia alo zã wo va yi la koŋ me . Ƒe si woxɔ hafi wokpɔ dɔlélea le mama dedie nu anɔ abe ƒe 65 ene.

Aleke gbegbee esia bɔe?

Esia nye kansa ƒomevi aɖe si mebɔ kura o . Sarcomatoid Carcinoma nye aɖuɖɔtoedɔdzẽwo katã ƒe alafa memamã sue aɖe ŋutɔ, si le 0.1% va ɖo 0.4% dome.

Nukae nye esia ƒe dzesiwo?

Dzesi siwo nèkpɔna la nɔ te ɖe afisi kansa la kaka ɖo le wò ŋutilã me dzi. Ne sarcomatoid carcinoma le lãkusi me le ŋuwò la, àte ŋu akpɔ dzesiwo abe:

• Kɔdzidede (si nɔa anyi ɖaa) .
• Yagbɔgbɔ sesẽ (gbɔgbɔtsixetsixe) .
• Akɔtave
• Ʋu si le dodom kple ʋuʋudedi
• Lolo dzi ɖeɖe kpɔtɔ susu aɖeke manɔmee

Nukatae nane si le abe esia ene dzɔna?

Ðɔktawo xɔe se be nu vevitɔ si hea sarcomatoid carcinoma vɛ enye nuwɔna aɖe si woyɔna be "Epithelial-Mesenchymal Transition (EMT)." Kpuie ko la, ɣeyiɣi sia mee kansa ƒe lãmenugbagbevi siwo le lãkusi me dɔdzẽ si menye lãmenugbagbevi suewo o me trɔna, eye wo dometɔ aɖewo trɔna zua mesenchymal lãmenugbagbeviwo. Kansa lãmenugbagbevi siwo trɔ alea la kaka kabakaba ŋutɔ le ŋutilã bliboa me.

Zi geɖe la , lãmenugbagbeviwo ƒe tɔtrɔ kple tsitsi kabakaba siawo do ƒome kple domenyiŋusẽfianu ƒe tɔtrɔ le lãmenugbagbeviwo me . Ènyaa, míaƒe domenyiŋusẽfianuwoe nye mɔfiame siwo gblɔa alesi lãmenugbagbeviwo nawɔ nui. Domenyiŋusẽfianu ƒe tɔtrɔ nye tɔtrɔ alo vodada le mɔfiame mawo me. Dzɔdzɔmeŋutinunyalawo ke ɖe domenyiŋusẽfianu ƒe tɔtrɔ geɖe siwo do ƒome kple sarcomatoid carcinoma ŋu.

Nukawoe nye afɔku siwo gblẽa nu le esia ŋu?

Afɔku nye nane si dzia mɔnukpɔkpɔ si li be woaxɔ dɔléle aɖe ɖe edzi. Le sarcomatoid carcinoma gome la, atamanonoe nye afɔku vevitɔ eye wonya nyuie wu. Enyo be míade dzesii be amesiwo xɔa aɖuɖɔtoedɔdzẽ sia ƒe 80% va ɖo 90% nye atamanolawo fifia alo tsã.

Mègaŋlɔ be o be ne èdzudzɔ atamanono ate ŋu akpɔ tawò tso lãkusidɔ geɖe me, eye kansa abe esia ene hã le eme.

Aleke ɖɔkta wɔna dea dzesi esia?

Wò ɖɔkta ado wò kpɔ gbã eye ne ehiã la, awɔ nɔnɔmetatawo ɖeɖe ƒe dɔ aɖewo. Gake be woaka ɖe edzi be sarcomatoid carcinoma ye nye esia la, ehiã be woaɖe lãmenugbagbevi siwo me kansa le la akpɔ.

• Nɔnɔmetatawo ɖeɖe: Ðɔkta ate ŋu awɔ CT-dɔdamɔnu aɖe atsɔ akpɔ afisi kansa la le. Be woate ŋu akpɔ ŋutilãa ƒe akpa si le eme nyuie la, woate ŋu awɔ CT/PET scan alo F-fluorodeoxyglucose (FDG)-PET scan. CT/PET scan ƒoa dodokpɔ eve (CT kple PET) nu ƒu le ɣeyiɣi ɖeka me. Fluorodeoxyglucose nye atike si wodona ɖe ŋutilãa me le PET scan wɔwɔ me. Eƒoa ƒu ɖe kansa lãmenugbagbeviwo ŋu, si wɔnɛ be wodzena nyuie wu le fotoɖeɖea me.

• Lãmetsiŋusẽŋutinunya: Lãmetsiŋusẽŋutinunya nye kansa ƒe lãkusi ƒe kpɔɖeŋu si woɖe tso lãmenugbagbeviwo ƒe dɔwɔwɔ me ƒe nusuekpɔmɔ̃ me dzodzro. Lãmenugbagbeviawo ƒe dzedzeme ate ŋu akpe ɖe ɖɔkta ŋu wòanya nenye be sarcomatoid carcinoma ye eye ne ele nenema la, eƒe ƒomevi sue kae wònye (e.g., pleomorphic carcinoma, spindle cell carcinoma).

• Dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ:Dodokpɔ sia dia nusiwo woyɔna be antigens siwo do ƒome kple lãmenugbagbevi ƒomevi aɖewo. Dɔlékuiwutike aɖewo ate ŋu ade dzesi lãmenugbagbevi aɖe be mesɔ o alo be enye dɔléle vɔ̃ɖi.

Aleke wowɔa atike nɛ?

Kansa sia dada nyuitɔ kekeakee nye amekoko be woaɖe dɔdzẽ bliboa ɖa. Atikewɔwɔ ate ŋu akpe ɖe ame ŋu wòawu kansa lãmenugbagbevi ɖesiaɖe si susɔ le amekoko vɔ megbe. Gake zi geɖe la, kansa la kakana hafi wokpɔnɛ, eyata amekoko mate ŋu adzɔ o. Ne kuxiwo abe vevesese, ʋudodo, alo gbɔgbɔ sesẽ ene li la, woate ŋu ana keklẽŋusẽdɔdamɔnu hã.

Le sarcomatoid carcinoma gome la, dɔdamɔnu dodokpɔ ate ŋu anye atike nyuitɔ kekeake. Dɔdamɔnu dodokpɔ nye numekuku si doa atike yeyewo ƒe dedienɔnɔ kple woƒe dɔwɔwɔ kpɔna. Dzɔdzɔmeŋutinunyalawo le numekuku wɔm tso atikewɔwɔ siwo ate ŋu akpe ɖe ŋuwò nàdidi ɣeyiɣi si nàte ŋu anɔ agbe kple kansa sia ɖe edzi ŋu fifia. Wo dometɔ evee nye:

• Atikewɔwɔ si woɖo taɖodzinu na: Esia bia be woaɖo taɖodzinu tɔxɛ siwo nana kansa lãmenugbagbeviwo dzina ɖe edzi le mɔ si dzi womate ŋu aɖu o nu.
• Dɔlélenutsiŋutete ƒe atikewɔwɔ: Esia doa ŋusẽ wò dɔlélenutsiŋutete, si kpena ɖe eŋu wòkpɔa kansa lãmenugbagbeviwo hegblẽa wo.

Nukae míate ŋu awɔ atsɔ aɖe afɔkua dzi akpɔtɔ?

Ne ètiae be yemazã atamanuwo o la, àte ŋu aɖe afɔku si le sarcomatoid carcinoma, kpakple lãkusi me dɔdzẽ bubu geɖewo xɔxɔ me dzi akpɔtɔ. Esiae nye afɔɖeɖe vevitɔ kekeake si nàte ŋu aɖe.

Ðe woate ŋu ada esia keŋkeŋa?

Le nyateƒe me la, sarcomatoid carcinoma nye kansa ƒomevi aɖe si zi geɖe la, esesẽna be woadae keŋkeŋ. Gake esi dzɔdzɔmeŋutinunyalawo le nu geɖe srɔ̃m tso lãmenugbagbeviwo ƒe nɔnɔme siwo le dɔdzẽ siawo me, abe domenyiŋusẽfianu ƒe tɔtrɔ ene ŋu la, wote ŋu toa atikewɔmɔnu yeye siwo woɖo ɖe wo ŋu vɛ. Ne wokpɔ dɔléle sia le ŋuwò la, àte ŋu adze akpɔ gome le dɔdamɔnu dodokpɔ aɖe si me wodoa atike yeyewo kpɔna me. Bia wò ɖɔkta tso esia ŋu.

Ɣeyiɣi didi kae wòle be nànɔ agbe kple dɔléle sia?

Esesẽ be nàgblɔ ɣeyiɣi didi si nànɔ agbe le nɔnɔme sia me, gake ele vevie be nànya. Le mamã dedie nu la, agbetsitsi ƒe agbɔsɔsɔme le mama dedie nu anɔ abe ɣleti 10 ene. Ƒe atɔ̃ ƒe agbetsitsi ƒe agbɔsɔsɔme anɔ abe 15% ene. Gake akɔntabubu siawo meku ɖe amesiame ŋu sɔsɔe o. Nu geɖewo ate ŋu akpɔ ŋusẽ ɖe wò nɔnɔmea dzi:

• Lãmenugbagbevi ƒomevi si koŋ le kansa me.
• Nukawoe nye domenyiŋusẽfianu ƒe tɔtrɔ siwo dzɔ?
• Ɣeyiɣi didi kae wòxɔ tso esime dzesiawo dze egɔme vaseɖe esime wokpɔ dɔlélea.
• Afisi kansa la tsi ɖo eye wògblẽ lãmeka siwo le lãmesẽ me.
• Aleke gbegbee kansa la kaka ɖoe.
• Ne ɖɔktaa ate ŋu aɖe kansa ƒe dɔdzẽa ɖa keŋkeŋ.

Eyata ele vevie ŋutɔ be nàƒo nu tso nusiawo katã ŋu gaglãa kple wò ɖɔkta be nàse wò nɔnɔmea gɔme nyuie wu.

Nya vevi kawoe wòle be míabia ɖɔktaa?

Ne èva nya be sarcomatoid carcinoma le ye ŋu la, àte ŋu atsi dzimaɖi vevie eye àtɔtɔ elabena kansa siawo to vovo eye woƒe dɔwɔwɔ sesẽ ŋutɔ. Ele vevie be nàƒo nu kple wò ɖɔkta gaglãa tso atikewɔmɔnu siwo nàte ŋu azã kple alesi dɔlélea azɔ le etsɔme ŋu. Wò ɖɔkta ate ŋu anɔ te ɖe wò kansa lãmenugbagbeviwo ƒe nɔnɔme kple afisi kansa le le wò ŋutilã me dzi aɖe nusi nàkpɔ mɔ na me na wò.

Nya aɖewo siwo nàte ŋu abia wò ɖɔktae nye esi:

• Ðe nye kansa kakaa?
• Aleke gbegbee nye kansa nu sẽe?
• Atikewɔwɔ ka ƒomevie nèkafu?
• Nugbegblẽ kawoe wòle be woakpɔ mɔ na tso atikewɔwɔa me?
• Èsusu be anyo nam be maxɔ atikewɔlawo ƒe nukpɔsusu eveliaa?
• Ðe wòle be mawɔ dɔ kple dɔlélenutsiŋutete ŋuti nunyala bibiwoa?
• Ðe medze akpɔ gome le dɔdamɔnu dodokpɔ aɖe mea?

Wò ɖɔkta ate ŋu ana nyatakaka siwo nèhiã la wò, aɖo wò ɖe dɔdamɔnu dodokpɔwo me ne èdze, eye wòakpe ɖe ŋuwò nàxɔ beléle si naa ame ƒe dzi dzea eme.

Nu siwo dzi wòle be míaɖo ŋkui

Enyo, eyata, le nusi ŋu míeƒo nu tsoe tso Sarcomatoid Carcinoma ŋu nu la, nu vevi siwo dzi wòle be míaɖo ŋkui ye nye esi:

• Esia nye kansa ƒomevi si mebɔ kura o, si wɔa adã, si kakana kabakaba ŋutɔ.
• Esia ɖea kansa kple sarcoma siaa ƒe nɔnɔmewo fiana.
• Sigaretnonoe nye nusi koŋ ate ŋu ana esia nate ŋu adzɔ.
• Dzesiawo nɔ te ɖe afisi kansa la le dzi. Le lãkusi me la, dzesiawo ate ŋu anye kɔdzi kple gbɔgbɔ sesẽ.
• Dodokpɔ tɔxɛwo (biopsy, imaging) hiã be woatsɔ anya dɔlélea.
• Atikewɔwɔ ƒe tiatiawɔblɔɖewo sesẽ. Tsɔ kpe ɖe amekoko, atikewɔmɔnu, kple keklẽŋusẽdɔdamɔnu ŋu la, wole dɔdamɔnu yeyewo (dɔdamɔnu siwo woɖo taɖodzinu na, dɔlélenutsiŋutete ƒe dɔdamɔnu) hã ŋu bum.
• Togbɔ be mɔnukpɔkpɔ si li be wòahaya keŋkeŋ le sue hã la, numekuku yeyewo na mɔkpɔkpɔ.
• Ele vevie ŋutɔ be nàƒo nu kple wò ɖɔkta faa tso wò nɔnɔmea ŋu eye nànya nusianu nyuie.

Mele mɔ kpɔm be nyatakaka sia akpe ɖe ŋuwò. Ne nyabiase bubu aɖewo gale asiwò ku ɖe esia ŋu la, taflatse yi ɖɔkta gbɔ faa.

` Sarcomatoid carcinoma, kansa, lãkusi me kansa, atamanono, kansa ƒe dzesiwo, kansa dada, kansa