Ðe kuxi sia si nye ‘ɖoɖoezizi’ ate ŋu anɔ wò ʋu mea? Mina míasrɔ̃ nu tso Smoldering Multiple Myeloma (SMM) ŋu!

Ɣeaɖewoɣi la, kuxi gãwo ate ŋu ado mo ɖa le míaƒe ŋutilã me gotagome dzesi aɖeke manɔmee. Àte ŋu asusu be, "Oo, aleke wòate ŋu adzɔe nenema?" Enyo, ẽ, ate ŋui. Egbea míele nu ƒom tso nɔnɔme aɖe koŋ si ate ŋu ado mo ɖa le ɖoɖoezizi me, evɔ maɖe dzesi aɖeke afia o, gake ate ŋu azu kansa sesẽ le etsɔme ŋu. Ðɔktawo yɔa esia be (Smoldering Multiple Myeloma - SMM) . Kpuie ko la, esia le abe dɔléle aɖe si woyɔna be "chronic multiple myeloma" ƒe gɔmedzedze ene.

Nukae Nye Smoldering Multiple Myeloma (SMM) ƒe dɔléle?

Kpuie ko la, Smoldering Multiple Myeloma nye dɔléle si gblẽa nu le wò ʋu kple ƒumeŋuɖui ŋu. Esia ate ŋu ava zu ʋumenugbagbeviɣidɔ si mebɔ o si woyɔna be active Multiple Myeloma (MM) . Fifia ɖewohĩ ànɔ ɖokuiwò biam be, "Nukae nye multiple myeloma sia?" Plasma cells nye ʋumenugbagbevi ɣi ƒomevi aɖe si le míaƒe dɔlélenutsiŋutete me. Esiawoe wɔa dɔlékuiwutike siwo kpena ɖe míaƒe ŋutilã ŋu wòwɔa avu kple dɔléle. Gake ɣeaɖewoɣi la, ʋumenugbagbevi siawo te ŋu trɔna eye wozua lãmenugbagbevi siwo mesɔ o. Ɣemaɣie nɔnɔme aɖe si woyɔna be multiple myeloma dzɔna.

Eyata, SMM nye "ɖoɖoezizi" ƒe afɔɖeɖe hafi wòzua kansa si woyɔna be multiple myeloma, dzesi aɖeke manɔmee. Ɣeaɖewoɣi la, ate ŋu axɔ ƒe geɖe hafi SMM nava zu dɔléle si nye multiple myeloma si le dɔ wɔm. Nukutɔe la, ame aɖewo siwo ŋu SMM le la mexɔa active multiple myeloma gbeɖe o. Esia tae ɖɔktawo léa ŋku ɖe amesiwo ŋu SMM le ŋu edziedzi be dzesi siwo fia be ate ŋu atrɔ azu kansa si le dɔ wɔm hã.

Ðe (SMM) nye kansa?

Esia nye nyabiase si me ayedzedze le vie. Womewɔa atike na SMM abe kansa ŋutɔŋutɔ ene o. Gake esi wònye be ate ŋu ava zu kansa si woyɔna be active multiple myeloma ta la, wobua eŋu be enye kansa ƒe ŋgɔdonya . Tsɔe be teƒe aɖe si mebɔ o le wò ŋutigbalẽ ŋu, si nye dzigbedzesi. Ema ate ŋu anye ŋutigbalẽ me kansa ƒe dzesi gbãtɔ, alo? Emae nye nusi SMM nye. Efia be mɔnukpɔkpɔ aɖe li be nàxɔ multiple myeloma. Esia tae ɖɔktawo léa ŋku ɖe amesiwo ŋu dɔléle sia le ŋu nyuie ŋutɔ ɖo .

Ðe nɔnɔme bubu aɖewo li siwo ate ŋu ana ame nate ŋu adze ame dzi si gblẽa nu le multiple myeloma ŋua?

Ẽ, bubu aɖe hã li. Woyɔe be Monoclonal Gammopathy of Undetermined Significance (MGUS) . Abe SMM ene la, esia nye nɔnɔme si ate ŋu adzɔ hafi multiple myeloma nadze egɔme. Ðɔktawo bua MGUS (si woyɔna be "M-gus") be enye nusi doa ŋgɔ na myeloma geɖe.

Aleke (SMM) kpɔa ŋusẽ ɖe nye ŋutilã dzii? Nukawoe nye dzesiawo?

Nu vevitɔe nye esi: Ame akpa gãtɔ siwo ŋu (SMM) le la meɖea dzesi aɖeke fiana o.. Ema fia be ɖewohĩ màse veve alo vevesese aɖeke o. Ame akpa gãtɔ va nya be SMM le yewo ŋu ne wowɔ ʋudodokpɔ na yewo edziedzi le susu bubu aɖe ta. Ʋudodokpɔ mawo ate ŋu aɖee afia be protein ƒomevi aɖe si mesɔ o si woyɔna be M proteins , si ʋumenugbagbevi dzĩ siwo mesɔ o wɔ le wò ŋutilã me la le asiwò.

Ʋudodokpɔwo ɖee fia be ʋumenugbagbevi dzĩ siawo siwo mesɔ o le dɔlélenutsiŋutete ƒe protein (M proteins) siwo mesɔ o wɔm. Azɔ hã, ne èwɔ ƒumeŋuɖui ŋuti numekuku la, ɖɔktawo ate ŋu akpɔ ʋumenugbagbevi dzĩ siawo siwo mesɔ o le ƒumeŋuɖui me. Ke hã, le "dzudzɔ" ƒe akpa sia me la, myeloma mele kuxi aɖeke hem vɛ le wò ŋutilã me o, eyata zi geɖe la, dzesi aɖeke menɔa amesiwo ŋu SMM le ŋu o.

Amekae ate ŋu axɔ (SMM)? Ðe esia nye dɔléle si bɔa?

Zi geɖe la, dɔléle sia dzea amesiwo xɔ wu ƒe 60. Ƒe si woxɔna le mamã dedie nu esime wokpɔ dɔlélea tso ƒe 62 va ɖo ƒe 67.

(SMM) menye dɔléle si bɔ o. Numekulawo bu akɔnta be ame ɖeka le 100,000 ɖesiaɖe me koe wòdzena le. Gake ame siwo ade adre le 100,000 ɖesiaɖe me koe dɔléle si nye multiple myeloma dzea edzi. Eyata, (SMM) nye nɔnɔme si mebɔ o wu gɔ̃ hã.

Nukae nye afɔku si le amedzidzedze (SMM) me be wòazu active multiple myeloma?

Esia hã le vevie be míanya. Le ƒe atɔ̃ gbãtɔ siwo me wokpɔ SMM le wo ŋu vɔ megbe la, amesiwo ŋu SMM le dometɔ siwo ade 10% xɔa active multiple myeloma ƒe sia ƒe. Le ƒe atɔ̃ siwo gbɔna me la, alafa memamã ma ɖiɖi va ɖo 3% ƒe sia ƒe. Le ƒe 10 gbãtɔwo megbe la, afɔku sia ɖiɖina ɖe edzi va ɖoa 1% ƒe sia ƒe.

Esia fia be menye amesiame si ŋu (SMM) le lae axɔ multiple myeloma o. Gake afɔku aɖe li, eyata atikewɔlawo ƒe ŋkuléle ɖe wo ŋu edziedzi le vevie ŋutɔ.

Ðe dodokpɔ aɖewo li siwo ate ŋu agblɔe ɖi pɛpɛpɛ nenye be ame aɖe axɔ multiple myeloma?

Nublanuitɔe la, dodokpɔ aɖeke meli fifia si ate ŋu agblɔe ɖi pɛpɛpɛ nenye be ame aɖe axɔ multiple myeloma o. Ðɔktawo kple numekulawo yi edzi le domenyiŋusẽfianu ƒe tɔtrɔ siwo do ƒome kple myeloma geɖe me dzrom eye wole didim be yewoakpɔe ɖa be yewoate ŋu ade dzesii nenye be ame aɖe si ŋu SMM le la axɔ multiple myeloma hã.

Nukae nye susu siwo ta (SMM) do?

Numekulawo nya be ʋumenugbagbevi dzĩ siwo mesɔ o kple nusiwo woyɔna be M proteins nye dzesi na multiple myeloma (MM) kple multiple myeloma (MM). Gake womenya nusi tututu nana ʋumenugbagbevi dzĩ siwo le lãmesẽ me zua esiwo mesɔ o haɖe o. Wole numekuku wɔm tso nusiwo ate ŋu ahe wo vɛ dometɔ aɖewo ŋu:

• Domenyiŋusẽfianu ƒe tɔtrɔ: Numekulawo le ŋku lém ɖe eŋu be kadodo aɖe le domenyiŋusẽfianu aɖewo ƒe tɔtrɔ (oncogenes - domenyiŋusẽfianu siwo doa lãmenugbagbeviwo ƒe tsitsi ɖe ŋgɔ) kple multiple myeloma (MM) dome hã.
• Lolo akpa: Ðikeke aɖe li be ami si sɔ gbɔ ɖe ŋutilã me hã ate ŋu anye nusi gbɔ wòtso.

Aleke woawɔ ade dzesi (SMM)? Dodokpɔ ka ƒomevie wowɔna?

Ðɔktawo ate ŋu awɔ dodokpɔ geɖe atsɔ akpɔe ɖa be dɔléle sia le ŋuwò hã. Ðo ŋku edzi be ne ʋu kple/alo aɖuɖɔ dodokpɔ si wowɔna edziedzi ɖe M protein ƒe dzesiwo fia la, ema ate ŋu anye nu gbãtɔ si afia be multiple myeloma le ŋuwò. Emegbe ɖɔktawo awɔ dodokpɔ aɖewo le gɔmedzedzea me akpɔe ɖa be wò dɔlélea le ŋgɔ yim va ɖo multiple myeloma hã. Dodokpɔ siawo ate ŋu anye:

• Ʋu Xexlẽme Blibo (CBC): Esia dzidzea ʋumenugbagbevi dzĩwo, ʋumenugbagbevi ɣiwo, kple ʋumenugbagbevi dzĩ siwo wò ƒumeŋuɖui wɔ.
• Ʋu ƒe dɔwɔwɔ dodokpɔ: Esia léa ŋku ɖe wò creatinine ƒe agbɔsɔsɔ (be woatsɔ akpɔ alesi wò ayikuwo le dɔ wɔm nyuie), albumin ƒe agbɔsɔsɔ (be woakpɔ alesi wò ayiku kple aklã le dɔ wɔm nyuie), kple calcium ƒe agbɔsɔsɔ (be woatsɔ akpɔe ɖa be ƒuwo le gbagbãm hã).
• Dɔlélenutsiŋutete ƒe agbɔsɔsɔme dodokpɔ: Ʋudodokpɔ sia dzidzea M protein (dɔlélenutsiŋutete ƒe protein) ƒe agbɔsɔsɔ le wò ʋu me.
• Electrophoresis kple serum immunofixation: Dodokpɔ siawo dia M protein siwo le wò ʋu me.
• Aɖuɖɔ dodokpɔ: Ðɔktawo ate ŋu abia tso asiwò be nàƒo aɖuɖɔ nu ƒu le aƒeme gaƒoƒo 24 be nàlé ŋku ɖe M proteinwo ŋu.
• X-ray: Wozãa X-ray tsɔ kpɔae ɖa be ƒu aɖewo gblẽ le multiple myeloma ta hã.
• Computed Tomography (CT) scan: Esia nye mɔ bubu si dzi woato akpɔ ƒu ƒe gbagbã.
• Magnetic Resonance Imaging (MRI): Dodokpɔ sia zãa radio ƒutsotsoewo kple magnet sesẽwo tsɔ wɔa wò ƒuwo kple akɔta ƒe nɔnɔmetata tsitotsito. Woate ŋu azã dodokpɔ sia atsɔ adi kpeɖodzi be ƒuwo gblẽ kaba.
• Ƒumeŋuɖui ƒe lãmenugbagbeviwo ɖeɖe: Ðɔktawo ate ŋu atsɔ wò ƒumeŋuɖui ƒe kpɔɖeŋu aɖe adzro eme akpɔ alesi ʋumenugbagbevi dzĩ siwo sɔ kple esiwo mesɔ o ƒe alafa memamã le eme. Woate ŋu alé ŋku ɖe ƒumeŋuɖui ƒe kpɔɖeŋua hã ŋu be tɔtrɔ aɖewo le wò DNA me si ate ŋu ana nàxɔ kansa hã.

Nukae nye dzidzenu siwo woatsɔ awɔ (SMM)?

Ne ɖɔktawo ƒo nu tso "dzidzenuwo" ŋu la, wofia dodokpɔ me tsonu siwo ɖo atikewɔwɔ ƒe dzidzenu siwo hiã be woatsɔ akpɔ dɔlélea gbɔ. Dzesi siwo woatsɔ awɔ (SMM)e nye:

• Ʋudodokpɔ si ɖee fia be M protein ƒe agbɔsɔsɔ si wu 3g/dl (gram 3 le ʋu desilita ɖeka me).
• Gaƒoƒo 24 ƒe aɖuɖɔ dodokpɔ si ɖe protein miligram 500 alo esi wu nenema fia. Alo...
• Ƒumeŋuɖui ŋuti numekuku ɖee fia be ʋumenugbagbevi dzĩwo nye ʋumenugbagbevi siwo katã le wò ƒumeŋuɖui me ƒe 10% va ɖo 59%. Kple...
• Dzesi aɖeke meli be ƒu ƒe abi alo ayiku ƒe gbegblẽ si mebɔ o si ate ŋu atso myeloma gbɔ o, wò ʋumenugbagbeviɣiwo sɔ, eye wò calcium ƒe agbɔsɔsɔ hã sɔ.

Aleke wodaa nɔnɔme siae?

Fifia la, atikewɔwɔ si wozãna ɖaa na SMM enye "lala ŋudzɔnɔnɔ." Esia bia be ɖɔktawo nawɔ dodokpɔwo edziedzi be woalé ŋku ɖe M protein ƒe agbɔsɔsɔ si le wò ʋu me kple ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ si le wò ƒumeŋuɖui me ŋu. Abe dzɔla ene la, wole ŋku lém ɖe eŋu be dɔlélea le sesẽm ɖe edzi hã.

Afɔku ate ŋu anɔ ame aɖewo ŋu be woaxɔ active multiple myeloma. Le nɔnɔme mawo me la, ɖɔkta aɖewo ate ŋu aɖo aɖaŋu be woadze multiple myeloma dada gɔme kaba. Ne multiple myeloma (MM) le ŋuwò la, wò ɖɔktae nye ame nyuitɔ si ana nyatakaka kple atikewɔwɔ ŋuti aɖaŋuɖoɖo siwo nèhiã la wò.

Ðe mate ŋu aɖe afɔku si le dɔlélea xɔxɔ me (SMM) dzi akpɔtɔa?

Nublanuitɔe la, fifia la, womenya mɔ aɖeke si dzi woato axe mɔ ɖe (SMM) ƒe wɔwɔ nu o.

Ɣeyiɣi didi kae nàte ŋu anɔ agbe kple (SMM)?

Alesi nɔnɔme sia kpɔa ŋusẽ ɖe amesiame dzii la to vovo. Ame aɖewo ate ŋu axɔe gake womexɔa dɔléle si nye multiple myeloma gbeɖe o. Ame aɖewo xɔa multiple myeloma ɣleti alo ƒe geɖe le esi wokpɔ dɔlélea le wo ŋu vɔ megbe. Ne ètsi dzi ɖe SMM nɔnɔ ŋu la, bia wò ɖɔkta nusi nàte ŋu akpɔ mɔ na. Woawoe nye ame nyuitɔ kekeake siwo ana nyatakaka tɔxɛwo wò.

Ɣeyiɣi didi kae nàte ŋu anɔ agbe kple multiple myeloma?

Esia hã nye kuxi na ame geɖe. Ame siwo ŋu multiple myeloma le la dometɔ siwo ade 40% va ɖo 82% nɔa agbe ƒe atɔ̃ le dɔlélea kpɔkpɔ vɔ megbe. Esia nɔ te ɖe nu geɖe dzi, siwo dometɔ aɖewoe nye dɔlélea ƒomevi kple alesi wowɔa nui ɖe atikewɔwɔ ŋu.

Aleke mawɔ akpɔ nye lãmesẽ dzi?

Ne multiple myeloma le ŋuwò la, ɖewohĩ màhiã atikewɔwɔ enumake o – alo gbeɖe o. Wò ɖɔkta agblɔ na wò be nàge ɖe eme be woado wò kpɔ edziedzi. Esia nye be woatsɔ akpɔe ɖa be wò nɔnɔmea trɔ zu multiple myeloma hã. Agbenɔnɔ kple multiple myeloma ate ŋu anye nuteɖeamedzi kple dzimaɖitsitsi . Ðewohĩ àsusu be, “Oo, ne ɖe mawɔ nane tso nya sia ŋu.” Ema nye nusi sɔ. Gake nu aɖewo li nàte ŋu awɔ atsɔ akpɔ wò lãmesẽ bliboa dzi:

• Ƒo nuɖuɖu si da sɔ nyuie. Ne mèka ɖe esia dzi o la, ke yi nuɖuɖuŋutinunyala aɖe gbɔ.
• Ne atamanolae nènye la, taflatse dze agbagba nàdzudzɔ.
• Gbɔ ɖe eme wòade edeƒe.
• Takpɔ ɖokuiwò ta tso dɔlékuiwo me. Bia wò ɖɔkta tso mɔ siwo dzi nàto axe mɔ ɖe dɔlékuiwo xɔxɔ nu ŋu.
• De kame edziedzi.Gake, ƒo nu kple wò ɖɔkta gbã eye nàbia kamedede ka ƒomevie sɔ na wò kple agbɔsɔsɔme si wòle be nàwɔ. Menyo be nàwɔ nu geɖe hã o.
• Lé ŋku ɖe wò susu ƒe lãmesẽ hã ŋu. Ne èle nu xam alo le nu xam le wò nɔnɔmea ta la, ƒo nu tso eŋu na wò ɖɔkta. Kpɔ egbɔ be yegblɔe na wo, vevietɔ ne blanuiléle alo blanuilélea xɔ wu kwasiɖa eve alo do kplamatse wò gbesiagbedɔwo.

Nya kawoe wòle be mabia nye ɖɔkta?

Ne (SMM) le ŋuwò la, nya aɖewo siwo nàte ŋu abia wò ɖɔktae nye esi:

• Nukatae esia dzɔ ɖe dzinye?
• Aleke esia kpɔa ŋusẽ ɖe nye gbesiagbegbenɔnɔ dzii?
• Ɣeyiɣi didi kae wòxɔna hafi multiple myeloma va dzea ame dzi?
• Ðe dzesi aɖewo koŋ li siwo ate ŋu afia be dɔléle si nye multiple myeloma, eye ɖe wòle be manya woa?
• Ðe atike aɖewo li siwo woatsɔ axe mɔ na dɔlélea (SMM) be wòagava zu multiple myeloma oa?

Mlɔeba la, nusi dzi nàɖo ŋkui (Take-Home Message) .

Smoldering Multiple Myeloma (SMM) nye dɔléle si dona do ŋgɔ na kansa si nye multiple myeloma (MM). Gake menye amesiame si ŋu SMM le lae axɔ active multiple myeloma o. Zi geɖe la, amesiwo ŋu SMM le dina be yewoanya nenye be yewoaxɔ active multiple myeloma, eye ne ele nenema la, ɣekaɣie. Nyabiase siawo ŋu ɖoɖo sesẽ ŋutɔŋutɔ. Ðɔktawo mekpɔ ŋuɖoɖoawo katã haɖe o.

Gake numekuku siwo wowɔ nyitsɔ laa ɖee fia be to domenyiŋusẽfianu aɖewo ƒe tɔtrɔwo ƒe nɔnɔmetatawo wɔwɔ me la, woate ŋu agblɔe ɖi vaseɖe afi aɖe nenye be (SMM) ava zu multiple myeloma, eye ne ele nenema la, ɣekaɣie.

Ne dɔléle sia le ŋuwò la, bia wò ɖɔkta ne nyatakaka yeye aɖe li ku ɖe wò nɔnɔmea ŋu. Adzɔ dzi na wo wu be yewoakpe ɖe ŋuwò. Nu vevitɔe nye be nàwɔ ɖe wò ɖɔkta ƒe aɖaŋuɖoɖo dzi eye nànɔ susu me sẽm.

` Smoldering Multiple Myeloma, SMM, Multiple Myeloma, kansa, ʋu ƒe dɔléle, ƒumeŋuɖui, M protein, ʋu me kansa, ʋumenugbagbevi dzĩwo