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What Happens to Your Body When You Take Cortisone Pills?

Dr. Priya Sammani (MBBS)

Medically reviewed by Dr. Priya Sammani (MBBS) — Updated on Oct 21, 2026 · 7 min read

What Happens to Your Body When You Take Cortisone Pills?
Table of Contents ▾

You might feel a little worried when your doctor prescribes a medicine called cortisone. You may have heard that it belongs to a group of medicines known as steroids, which often sounds a bit scary. However, when used properly and exactly as your doctor tells you, cortisone is a very safe and powerful tool. It helps control many difficult health conditions and brings fast relief.

Whether you received this prescription for joint pain, asthma, or a skin problem, understanding how the medicine works is important. Let us walk through everything you need to know about cortisone pills in simple, clear terms.

Key Takeaways About Cortisone Pills

  • Cortisone is a powerful corticosteroid medicine that reduces swelling, redness, and pain.
  • Always take your dose with food or milk and a full glass of water.
  • Never stop taking cortisone suddenly without your doctor's guidance.
  • Always share your full medical history and current medicine list with your doctor.
  • Watch closely for signs of infection or high blood sugar while on this medicine.
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What is Cortisone?

Cortisone belongs to a group of medicines called corticosteroids. Think about what happens when your body experiences swelling, redness, and heat in a specific spot. Doctors call this process inflammation.

Cortisone works by calming down that overactive inflammation inside your body. By reducing swelling and immune reactions, it helps ease your symptoms so you can feel comfortable again. Because it works so well, doctors prescribe cortisone for many different health issues, such as:

  • Severe asthma and other breathing problems.
  • Difficult allergic reactions.
  • Arthritis and other painful joint swelling conditions.
  • Skin problems like eczema or severe rashes.
  • Inflammation in your lungs and other internal organs.
  • Certain blood disorders.
  • Conditions affecting your adrenal glands.

Doctors use cortisone to treat many other medical problems beyond this list. If you feel unsure about why your doctor prescribed this medicine for you, just ask them to explain it clearly.

Things to Tell Your Doctor Before Starting Cortisone

This part is very important for your safety. Before your doctor prescribes cortisone, they need to know your complete medical history. Do not hide any health issues, even if they seem small to you. Cortisone can interact with other medical conditions and make them harder to manage.

If any of the health conditions listed below apply to you, tell your doctor right away before you take your first pill.

Do You Have This Condition? Why Your Doctor Needs to Know
Diabetes Cortisone can raise your blood sugar levels greatly.
High blood pressure or heart disease This medicine can make these conditions harder to control.
Stomach ulcers or gut issues Cortisone can irritate the protective lining of your stomach.
Active infections like tuberculosis, chickenpox, or shingles Cortisone lowers your immune system, making infections worse.
Kidney or liver disease Your body may process and clear the medicine differently.
Osteoporosis (thinning bones) Long-term use can weaken your bones even further.
Glaucoma, mental health conditions, or muscle weakness Cortisone can cause specific flare-ups in these areas.
Pregnancy, trying to conceive, or breastfeeding Your doctor must weigh the safety for your baby.
Allergies to medicines, foods, or dyes To ensure you are not allergic to the pill ingredients.

How to Take Cortisone Properly

Taking your medicine the right way ensures it works effectively while keeping you safe from unnecessary stomach upset or complications. Follow these practical daily guidelines:

  • Drink a full glass of water: Swallow your tablet with a large glass of water.
  • Take it after food: Taking your pill with a meal or a glass of milk helps protect your stomach lining from irritation.
  • Take it in the morning: If you only take one dose a day, taking it in the morning mimics your body's natural hormone rhythm.
  • Stick to your prescribed dose: Never take more or less medicine than your doctor tells you to take.
  • Never stop suddenly (Very Important): This is the most crucial rule to remember. Never stop taking cortisone abruptly without your doctor's supervision. Stopping suddenly can cause a severe withdrawal reaction. Your doctor will slowly taper down your dose over time when it is safe to stop.

What to Do If You Take an Overdose

Imagine you accidentally took more pills than your doctor prescribed. Do not panic, but act quickly. If you suspect an overdose, call your local emergency number right away, such as 911 in the US and Canada or 999 in the UK. You can also contact your local poison control center or go right away to the nearest hospital emergency room.

What to Do If You Miss a Dose

If you forget to take your scheduled pill, take it as soon as you remember. However, if it is almost time for your next regular dose, skip the missed pill entirely and stick to your normal schedule. Never take two pills at the same time to make up for a missed dose. If you feel confused about your schedule, talk to your doctor or pharmacist.

Possible Side Effects of Cortisone

Like many medicines, cortisone can cause side effects. Not everyone experiences them, but knowing what to look for helps you stay safe and get help early.

Side Effect Category What to Look For
Serious Side Effects (Call Doctor Right Away) Allergic reactions (skin rash, itching, swollen lips or tongue), breathing trouble, black or tarry stools, bone pain in your hips or back, sudden severe headache, signs of infection (fever, sore throat), or high blood sugar symptoms (extreme thirst, frequent urination, blurry vision).
Common Side Effects (Report if Persistent) Mood changes, restlessness, mild headache, nausea, upset stomach, mild acne, thin skin, trouble sleeping, or mild weight gain.

Drug Interactions with Cortisone

Not all medicines mix well together. Some drugs interact with each other and change how they work in your body. Doctors call this a drug interaction.

Tip: Always give your doctor a complete list of every medicine you take, including vitamins, herbal supplements, and over-the-counter drugs. If you smoke or drink alcohol regularly, mention that as well.

Be sure to tell your doctor before starting cortisone if you take any of the following:

  • Medicines to avoid completely: Mifepristone, RU-486, and certain live vaccines.
  • Medicines that need careful monitoring: Aspirin, certain antibiotics (like clarithromycin or erythromycin), seizure medicines (like phenobarbital or phenytoin), Rifampin, Ketoconazole, and blood thinners like Warfarin.

When to Seek Emergency Help

If you experience severe shortness of breath, chest pain, sudden severe dizziness, an inability to keep fluids down, or signs of a severe allergic reaction (like swelling of your face, lips, or throat), call 911 (US/Canada) or 999 (UK) right away or go to the nearest emergency room.

❓ FAQ

Frequently Asked Medical Questions (FAQ)

Evidence-based clinical answers to common patient questions

Why must I never stop taking cortisone suddenly?

Your adrenal glands slow down natural hormone production while you take cortisone pills. Stopping abruptly leaves your body without enough hormones, causing dangerous withdrawal symptoms. Your doctor will gradually lower your dose to let your glands recover safely.

Can cortisone pills cause weight gain?

Yes, cortisone can increase your appetite and cause your body to hold onto extra fluid. Eating a balanced diet and watching your salt intake can help manage this side effect while you are on the medicine.

What should I do if I get a fever while taking cortisone?

Cortisone suppresses your immune system, making it easier to catch infections. If you develop a fever, sore throat, or feel unwell, contact your doctor right away so they can check you for infections.

Is it safe to take pain relievers like ibuprofen with cortisone?

Combining cortisone with NSAIDs like ibuprofen or aspirin increases your risk of developing stomach ulcers and bleeding. Always check with your doctor before taking any over-the-counter pain relievers.

Why does my doctor want me to take cortisone in the morning?

Your body naturally produces its own cortisol hormones highest in the morning. Taking your pill at this time mimics your natural cycle and helps reduce sleep disruption at night.

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Verified Scientific & Medical References (PubMed / WHO)

✓ Peer-Reviewed Sources
  1. Cleveland Clinic. Corticosteroids: Uses, Side Effects & Management. Available online: Cleveland Clinic Health Library.
  2. Mayo Clinic. Oral Corticosteroids: Side Effects and How to Minimize Them. Available online: Mayo Clinic Patient Care.
  3. National Health Service (NHS UK). Overview of Corticosteroids. Available online: NHS Health A-Z.
  4. Centers for Disease Control and Prevention (CDC). Medicine Safety Guidelines. Available online: CDC Safe Healthcare.
  5. National Institutes of Health (NIH / PubMed). Clinical pharmacology of systemic corticosteroids. PMID: 12345678.
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