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Low thyroid hormone? What you need to know about Liothyronine Injection

Dr. Priya Sammani (MBBS)
Medically Reviewed by Dr. Priya Sammani (MBBS) ✓ Medically Reviewed
📅 Updated: Dec 7, 2025 • ⏱ 6 min read • Editorial Policy
Low thyroid hormone? What you need to know about Liothyronine Injection
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Do you also feel tired all the time? Do you feel lifeless? Are you gaining weight? These are some of the symptoms that can occur when the level of thyroid hormone in our body decreases ( hypothyroidism ). Sometimes, when this condition becomes a little serious, you have to be hospitalized and treated. Today, we are talking about a very important medicine that is given at such times. That is the Liothyronine Injection.
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What kind of medicine is Liothyronine?

Simply put, Liothyronine is a synthetic hormone that is similar to the thyroid hormone naturally produced by our body's thyroid gland. When your body's thyroid hormone levels are too low (this is called Hypothyroidism), this medicine is given to fill that deficiency. Think of our body as a car. Thyroid hormones are like the fuel that the engine of that car needs to run smoothly. These hormones are essential for many things in our body, such as metabolism, which means converting the food we eat into energy, controlling body temperature, and heart rate. So when this hormone is low, everything in the body starts to work very slowly. That's when Liothyronine helps to restore the body's functions to normal.
The important thing is that this is not a medicine that you can usually buy from a pharmacy and use at home. It is used in a hospital, as an injection into a vein, under medical supervision.

Things you need to tell your doctor before taking this medicine

Before deciding to give you this medicine, your doctor should know your complete health history. Because some medical conditions require special care when using this medicine. Therefore, if you have any of the conditions listed below, be sure to tell your doctor without hiding anything .
Inform your doctor if you have these conditions.
Addison's disease or other adrenal gland problems.
Heart disease, especially chest pain (angina).
Diabetes.
Bone problems (e.g. osteoporosis).
Pituitary gland problems.
If you are engaged in a weight loss program.
If you are taking medication to prevent or treat blood clots (e.g. Warfarin).
If you are pregnant or trying to get pregnant.
If you are a breastfeeding mother.
If you have had an allergic reaction to other types of thyroid hormones, other medications, foods, or dyes.

What happens if you take too much medicine?

Since this is administered by doctors and nurses in a hospital, the chances of getting the wrong dose are very low. However, if you think you have taken too much of the medicine, you should inform the medical staff immediately. Alternatively, you can call the National Poisons Information Centre at the Colombo National Hospital . You can also go to the nearest Emergency Treatment Unit (ETU).

What other things can interact with this medicine?

Liothyronine may interact with some medications, vitamins, and herbal products you are taking, which could decrease the effectiveness of your treatment or increase side effects.
So give your doctor a complete list of all the medications you take (prescribed, over-the-counter, herbal , vitamins , etc.) . Also tell them if you smoke or drink alcohol .
Here are some things that can interact with this medication:
  • Some medications for heart disease (e.g. Amiodarone, Digoxin )
  • Diabetes medication
  • Blood thinners (e.g. Warfarin)
  • Some medications for depression
  • Female hormones (e.g., birth control pills, patches)
  • Steroids (e.g. Prednisone)
  • Soy isoflavones (dietary supplements containing soy)
  • Weight loss medications or supplements
This list is not complete, so it's best to tell your doctor about everything you're taking.

Side effects that may occur due to medication

Like any medication, Liothyronine can cause side effects. Some of these can be serious, so it's important to be aware of them.
Side effects that should be reported to your medical team immediately: Side effects that are usually not serious (but should be reported to your doctor if they persist)
Allergic reactions Skin rash, itching, swelling of the face, lips, tongue or throat.
Changes in heart rate Palpitations, irregular heartbeat, dizziness, chest pain, difficulty breathing.
Other serious symptoms Severe restlessness, excessive sweating, fever, severe diarrhea, tremors, insomnia.
For women Irregular menstruation or intermittent bleeding.
Headache
Temporary hair loss
Nausea or vomiting
Changes in appetite

Things to consider during treatment

Your doctor will check you regularly to see how this medicine is affecting you. He or she will also order blood tests to check your thyroid hormone levels. It may take a few weeks for your symptoms to improve and you to feel better. So don't worry. But if your symptoms don't improve after a while, talk to your doctor.

💡 Take-Home Message

  • Liothyronine is a special injection given intravenously in a hospital to people with low thyroid hormone levels.
  • Be sure to tell your doctor about any other medical conditions you have and all medications you are taking.
  • If you experience any serious side effects such as rapid heartbeat, chest pain, or severe restlessness, notify medical staff immediately.
  • It may take several weeks for the results of the treatment to appear. Be patient and follow your doctor's instructions.
  • This medicine is for you only. Never share it with others.
Liothyronine, Liothyronine Injection, Triostat, Hypothyroidism, Thyroid, Thyroid hormone, Thyroid deficiency, Sri Lanka

❓ FAQ

Frequently Asked Medical Questions (FAQ)

Evidence-based clinical answers to common patient questions

What other things can interact with this medicine?

Key points include: Some medications for heart disease (e.g. Amiodarone, Digoxin ); Diabetes medication; Blood thinners (e.g. Warfarin); Some medications for depression.

When should you consult a doctor or healthcare professional?

If you experience persistent, worsening, or concerning symptoms, or before starting any new treatment or medication, always consult a qualified physician or healthcare provider for personalized medical advice.

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⚠️ Important: Medical articles and information on Nirogi Lanka are strictly for educational and awareness purposes and do not substitute professional medical advice, diagnosis, or treatment. Always consult a qualified physician for any medical concerns.