You may have heard of a condition called Cushing's disease from your doctor. Simply put, this is a condition where your body produces too much of a hormone called glucocorticoid. One of the medications used to treat this condition is called Osilodrostat. Today, we'll talk about this medication, how it's used, what to watch out for, and its side effects.
What exactly is this medicine used for?
Osilodrostat is a drug mainly used to treat Cushing's disease . Doctors prescribe this drug when surgery is not possible or when surgery has not been successful. The brand name is Isturisa.
This medicine may also be used for other medical conditions, so if you have any questions about it, it's best to ask your doctor for clarification.
Things you need to tell your doctor before taking medicine
Before starting this medication, it is very important to give your doctor a complete account of your health. Do not hide anything. Be sure to tell him/her, especially if you have any of these conditions:
- If acne develops
- If you have heart disease
- If you have high blood pressure
- If you have had irregular heartbeats before
- If you have liver disease
- If you have been told that your blood potassium or magnesium levels are low
- If you have had an allergic reaction to Osilodrostat or any other medicine, food, or dye.
- If you are trying to get pregnant or are already pregnant
- If a mother is breastfeeding her child
By telling you these things accurately, your doctor can choose the most appropriate and safest treatment method for you.
How should I use this medicine?
This is a pill that you take by mouth. Take this pill with a glass of water. It is very important to take it exactly as your doctor has prescribed, and at the right time.
- You can take this medicine with or without food. However, if you experience stomach upset, it is best to take it with a meal.
- Make it a habit to take your medicine at the right time every day. Do not take more than the doctor tells you to, or more often than prescribed.
- The most important thing is not to stop taking the medication suddenly without your doctor's advice. Doing so may cause other problems.
This medicine has been prescribed for you only . Never share this medicine with anyone else. It can be dangerous.
Should this medicine be given to children?
Special care should be taken when giving this medicine to children. Therefore, if your child has been prescribed this medicine, talk to your pediatrician about it and get advice.
What to do if you take too much medicine?
If you think you have taken too much medicine, don't delay. Immediately call the National Poisons Information Centre at the Colombo National Hospital . Or go to the Emergency Treatment Unit (ETU) of the nearest hospital.
What to do if you miss a dose of medication?
Please don't worry about missing a dose. If you miss a dose, skip it completely. Take the next dose at the next scheduled time. Never take two doses at once to make up for a missed dose.
What other medications may interact with this medicine?
This is a very important part. Osilodrostat can interact with some other medications. So, tell your doctor about all the medications you are taking.
The following medications should never be taken with Osilodrostat:
- Cisapride
- dofetilide
- dronedarone
- pimozide
- thioridazine
In addition, the following medications may interact with Osilodrostat:
- carbamazepine
- Some antiviral drugs for HIV or Hepatitis
- Medicines for fungal infections, such as ketoconazole and itraconazole
- clarithromycin
- Other medications that cause irregular heartbeats (prolong the QT interval)
- phenobarbital
- rifampin
- theophylline
- tizanidine
This list is not complete. Therefore, tell your doctor about all medications , vitamins, herbal remedies, and supplements you are taking, as well as if you smoke or drink alcohol.
Things to be careful about when taking medicine
If your symptoms do not improve or if they seem to get worse while taking this medicine, tell your doctor right away. Your doctor may order blood tests to monitor your health during this time.
If you are a breastfeeding mother, avoid breastfeeding your baby while taking this medicine and for one week after stopping the medicine.
What are the possible side effects of the medication?
Like any medicine, Osilodrostat can cause some side effects. Some of these can be serious, so it's important to be aware of them.
| Side effect | Description |
|---|---|
| Side effects that you should report to your doctor immediately | |
| Allergic reactions | Skin rash, itching, swelling of the face, lips or tongue. |
| Changes in heart rate | Chest pain, dizziness, fast or irregular heartbeat, fainting, trouble breathing. |
| Symptoms of low potassium levels in the body | Muscle twitching or pain, chest pain, dizziness, fainting, abnormal heartbeat. |
| Other serious symptoms | Swelling of the ankles, feet, hands, unusual tiredness, loss of appetite, vomiting, acne in women, or excessive hair growth on the face and body. |
| Side effects that should be reported to the doctor if they persist or are bothersome | |
| Common side effects | Headache, nausea, fatigue. |
If you experience any other unusual symptoms not mentioned in this list, talk to your doctor about them as well.
How should the medicine be stored?
- Keep it out of the reach of children .
- Store at room temperature (between 15-30 degrees Celsius).
- Protect from moisture. So don't keep medicine in places like the bathroom.
- Discard expired medication immediately.
Take-Home Message
- Osilodrostat is a special medication given for the condition Cushing's disease.
- Before starting the medication, tell your doctor about all your medical conditions and all other medications you are taking.
- Take your medicine exactly as prescribed by your doctor, at the right time. Do not stop taking your medicine without advice.
- Be aware of serious side effects (changes in heart rate, allergic reactions, excessive fatigue). If any of these occur, seek medical advice immediately.
- If you miss a dose, skip it and take the next dose at the scheduled time. Never take two doses at the same time.
- This medicine is for you only. Never share it with others.


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