Ke haʻi aku kāu kauka iā ʻoe he maʻi kanesa kou, nui nā nīnau i loko o kou manaʻo, ʻeā? Ua lohe mākou e pili ana i ka 'chemo' a me ka 'radiation', akā ke kamaʻilio nei paha kāu kauka e pili ana i kahi papa lāʻau hou i kapa ʻia ʻo 'Angiogenesis Inhibitors'. He aha ka inoa o kēia lāʻau ʻē? He aha kāna hana maoli? Mai hopohopo, e kamaʻilio maʻalahi kākou e pili ana.
ʻO ka mea mua, e nānā kākou, he aha kēia mau mea hoʻopale angiogenesis?
I ka ʻōlelo maʻalahi, he ʻano lāʻau kēia e hoʻōki ai i ka ulu ʻana o nā kīʻaha koko hou, ʻo ia hoʻi nā kīʻaha koko e hoʻolako i nā puʻupuʻu. ʻO nā inoa ʻē aʻe no kēia he anti-angiogenics, anti-angiogenic agents, a me ka anti-angiogenic therapy.
E noʻonoʻo e pili ana i ia mea, no kekahi mea e ulu ai, pono ia i ka meaʻai, ka meaʻai ponoʻī, ʻeā? Pēlā nō nā hunaola kanesa. Pono nō hoʻi lākou i ka lako mau o ke koko i piha i nā meaʻai e ulu a laha. Ke liʻiliʻi kahi hunaola kanesa, ola ia ma ka omo ʻana i kekahi koko mai nā ʻiʻo olakino a puni. Akā, ke ulu ka hunaola a hiki i kahi o 1-2 milimita, pono ia e hoʻomohala i kāna ʻōnaehana kīʻaha koko hou. A i ʻole, ʻaʻole hiki iā ia ke ulu nui aʻe.
ʻO kēia kahi e komo mai ai nā lāʻau i kapa ʻia ʻo Angiogenesis Inhibitors . Hana kēia mau lāʻau ma ke kāohi ʻana i ke kaʻina hana e ulu ai nā ʻōpū kanesa i nā kīʻaha koko hou. Ua like ia me ke ʻoki ʻana i ka wai i kahi lāʻau. Hoʻolohi kēia i ka ulu ʻana o ke kanesa, a i kekahi manawa hiki i ka puʻupuʻu ke emi iho. ʻAʻole paha e ho'ōla loa kēia lāʻau i ke kanesa, akā hiki iā ia ke kāohi i ka ulu ʻana o ka puʻupuʻu a hiki iā ʻoe ke noho pū me kāu poʻe aloha no kekahi manawa lōʻihi.
Pehea e hana ai kēia lāʻau lapaʻau i loko o ke kino?
Hoʻopilikia kēia mau lāʻau lapaʻau i kahi kaʻina hana i kapa ʻia ʻo angiogenesis . He kaʻina hana maʻamau kēia i loko o ko kākou kino. E noʻonoʻo inā ʻoki ʻoe i kou lima, pono e ulu nā kīʻaha koko hou e ho'ōla i ka ʻeha a lawe mai i ke koko i kēlā wahi. Ua kapa ʻia kēlā ʻo angiogenesis. Hoʻouna nā ʻāpana i ʻeha i kahi hōʻailona, e like me "E kōkua mai iā mākou!" Hoʻoulu kēia hōʻailona i nā kīʻaha koko hou e ulu.
Akā ʻo ka pilikia, hoʻohana pū nā hunaola kanesa i kēia kaʻina hana like no ko lākou pono. Hoʻouna pū nā hunaola kanesa i nā hōʻailona like a hoʻoulu i nā kīʻaha koko hou no lākou iho. ʻO kēia mau kīʻaha koko ka mea e hāʻawi i ka puʻupuʻu me nā meaʻai e pono ai, e ʻae ana iā ia e ulu a laha i nā ʻāpana ʻē aʻe o ke kino.
Hana nā mea hoʻopale Angiogenesis ma ka hoʻopilikia ʻana i kēia ʻōnaehana hōʻailona mai ke kanesa. Hana ka hapa nui o kēia mau lāʻau lapaʻau ma ke kāohi ʻana i kahi protein i kapa ʻia ʻo vascular endothelial growth factor (VEGF) . E noʻonoʻo iā VEGF ma ke ʻano he hōʻailona "kōkua" nui i hoʻokuʻu ʻia e nā cell cancer. Ke hoʻopaʻa kēia hōʻailona VEGF i nā mea loaʻa VEGF ma nā cell cancer, hoʻomaka nā kīʻaha koko hou e hana.
I kēia manawa, e nānā kākou pehea e hoʻōki ai kēia lāʻau i kēia hōʻailona.
- Ke ālai nei i ka hōʻailona VEGF mai ka nakinaki ʻana i ka mea loaʻa: ʻO kekahi mau lāʻau lapaʻau (no ka laʻana, nā monoclonal antibodies e like me Bevacizumab (Avastin®) e hele pololei i ka protein VEGF a hoʻopili iā ia. A laila ʻaʻole hiki iā ia ke hele i kēlā mea loaʻa a hoʻopaʻa iā ia. Ua like ia me ke kāohi ʻana i kahi leka ma mua o ka hiki ʻana i ka mea loaʻa i manaʻo ʻia.
- Ke ālai nei i nā hōʻailona mai nā mea loaʻa VEGF: ʻO kekahi mau lāʻau ʻē aʻe (no ka laʻana, nā mea hoʻopaʻa tyrosine kinase e like me sorafenib (Nexavar®) a me sunitinib (Sutent®)) e ālai ana i ka mea loaʻa mai ka hoʻouna ʻana i ka leka, ʻoiai inā loaʻa iā ia ka hōʻailona.
- Ke ālai nei i nā ʻōnaehana hōʻailona ʻē aʻe: ʻO kekahi mau lāʻau lapaʻau ʻē aʻe (no ka laʻana, nā immunomodulators e like me ka thalidomide a me lenalidomide (Revlimid®)) ke hoʻopilikia nei i nā ʻōnaehana hōʻailona ʻē aʻe i pili i kēia kaʻina hana.
He aha nā ʻano maʻi kanesa e hoʻohana ʻia ai kēia lāʻau lapaʻau?
Hoʻomaʻamaʻa pinepine nā kauka i kēia mau mea hoʻopaʻa angiogenesis no nā maʻi kanesa holomua a i ʻole e hoʻi hou ana . ʻO kekahi o nā ʻano maʻi kanesa e ʻōlelo ʻia nei kēia lāʻau lapaʻau:
- Ka maʻi ʻaʻai lolo
- Ka maʻi ʻaʻai umauma
- Ka maʻi ʻaʻai o ka ʻōpū
- Ka maʻi ʻaʻai kolona
- Ka maʻi ʻaʻai o ka ʻōpū Fallopian
- Ka maʻi ʻaʻai puʻupaʻa
- Ka maʻi ʻaʻai ate
- Ka maʻi ʻaʻai māmā
- ʻO ka maʻi ʻōpū
- ʻO ka myeloma lehulehu
- Ka maʻi ʻaʻai pancreatic
- Ka maʻi ʻaʻai peritoneal
- Ka maʻi ʻōpū
- Ka maʻi ʻaʻai thyroid
- Ka maʻi ʻaʻai ʻōpū/endometrial
Eia kekahi, hoʻohana ʻia kēia mau lāʻau lapaʻau (nā mea hoʻopale VEGF) e mālama i kekahi mau maʻi maka kahi e ulu ai nā kīʻaha koko i loko o ka maka me ke ʻano ʻē.
He aha ka mea e hana ʻia i ka wā o ka mālama ʻana?
ʻAʻole hāʻawi wale nā kauka i kēia mau lāʻau. Hāʻawi pinepine ʻia lākou me ka hui pū ʻana me nā lāʻau lapaʻau ʻē aʻe no ka maʻi kanesa, e like me ka immunotherapy a me ka chemotherapy .
E noʻonoʻo e like me ke kaua. Hoʻopau nā mea hoʻopale Angiogenesis i ka meaʻai a me nā pōkā (koko) i loaʻa i ka ʻenemi (maʻi ʻaʻai). ʻO nā lāʻau lapaʻau ʻē aʻe (e like me ka chemotherapy) e hele pololei i ka ʻenemi (nā hunaola maʻi ʻaʻai) a hoʻouka iā lākou. Ke hana pū kēia mau ʻano ʻelua, hiki ke holomua hou aʻe nā hopena.
Ma muli o ke ʻano o ka lāʻau lapaʻau i hāʻawi ʻia iā ʻoe, pono paha ʻoe e lawe iā ia ma ke ʻano he pila i hoʻokahi a ʻelua paha i ka lā, a i ʻole pono paha ʻoe e hoʻokomo iā ia ma ke ʻano he IV (e like me ka saline ) i loko o kahi aa koko ma kahi papa hana maʻamau.
Pehea ka lōʻihi o kēia lāʻau lapaʻau?
ʻO ka lōʻihi o kāu mālama ʻana e pili ana i nā kumu he nui, me ke ʻano o ka lāʻau lapaʻau i hāʻawi ʻia iā ʻoe a me ke ʻano o ka maʻi kanesa āu. Hoʻomau ka hapa nui o ka poʻe i ka lawe ʻana i kēia mau lāʻau lapaʻau inā e hana ana. I kekahi manawa, hiki ke hoʻōki ʻia ka mālama ʻana inā lilo nā hopena ʻaoʻao i mea nui loa e hoʻomanawanui. E kūkākūkā kāu kauka i nā pono a me nā hopena ʻaoʻao o ka mālama ʻana me ʻoe a hana i ka hoʻoholo maikaʻi loa.
He aha nā hopena ʻaoʻao a me nā pilikia?
E like me nā lāʻau lapaʻau āpau, hiki i kēia mau lāʻau lapaʻau ke loaʻa nā hopena ʻaoʻao a me nā pilikia. ʻO ka hapa nui o kēia mau mea he mau pilikia me ke kahe ʻana o ke koko (ke kahe ʻana o ke koko) a me ke kāpili ʻana o ke koko. I nā hihia kakaikahi, hiki i kēia mau hopena ʻaoʻao ke hoʻoweliweli i ke ola. No laila he mea nui e makaʻala i kēia mau mea.
E nānā mau ana kāu kauka i kou olakino e hōʻemi i kēia mau pilikia.
| Ka hopena ʻaoʻao/pilikia paha | He wehewehe maʻalahi |
|---|---|
| Ke koko kiʻekiʻe | Ke koko kiʻekiʻe. Pono e nānā a hoʻomalu pinepine ʻia kēia. |
| Ke kahe koko ʻana o loko | Ke kahe ʻana o ke koko i loko o ke kino. |
| Ho'ōla lohi ʻia ka ʻeha | Ma muli o ke keakea ʻana i ka hoʻokumu ʻia ʻana o nā kīʻaha koko hou, hiki iā ia ke hoʻonui i ka manawa e pono ai no ka ho'ōla ʻana o nā ʻeha. |
| Ka puka ʻana o ka ʻōpū | ʻAʻole pinepine loa, aia kahi pilikia o ka perforation o ka ʻōpū a i ʻole nā ʻōpū. |
| Hoʻemi ʻia ka hana thyroid | Ke lohi nei o ka hana o ka thyroid gland, ka mea e kaohi ana i nā hormones o ke kino. |
| Ka pōʻino o ke akepaʻa | I kekahi manawa hiki ke hoʻopilikia ʻia ka hana o ke akepaʻa. |
| Nā ʻūpā koko | Aia kahi pilikia o ka hoʻokumu ʻia ʻana o nā ʻōpū koko weliweli i loko o nā kīʻaha koko. Hiki i kēia ke hana i nā kūlana e like me ka hōʻeha puʻuwai a i ʻole ka hahau ʻana. |
ʻO ka mea nui loa hiki iā ʻoe ke hana, ʻo ia ke hoʻomaopopo i kēia mau hopena ʻaoʻao a me nā pilikia ma mua o kou hoʻomaka ʻana i ka lāʻau lapaʻau. Ke ʻike ʻoe i ka mea e manaʻo ai, hiki iā ʻoe ke ʻike hou aku i nā loli i kou kino. Inā ʻike ʻoe i kekahi mea ʻē, e hoʻomaopopo koke i kāu kauka. A laila hiki iā ia ke aʻo iā ʻoe pehea e hoʻokele ai i nā hopena ʻaoʻao a hoʻoponopono paha i kāu nui o ka lāʻau.
Aia kekahi mau mea e hiki ke hoʻōki maoli i kēia kaʻina hana?
He nīnau kēia a ka poʻe he nui e nīnau ai. Loaʻa i kekahi mau meaʻai nā hui e ālai ana i kekahi mau hōʻailona e pili ana i ke kaʻina hana o ka angiogenesis. Loaʻa ka nui o kēia mau meaʻai i ka ʻai Mediterranean. Eia kekahi laʻana:
- ʻAseparagus
- Aʻa Dandelion
- Kī ʻōmaʻomaʻo
- ʻAila ʻoliva
- Pīnati
- Waina ʻulaʻula
- Nā hua waina ʻulaʻula
Ke hoʻāʻo nei nā kānaka noiʻi lapaʻau e hoʻohana i kēia mau pūhui e hana i nā lāʻau lapaʻau hou, akā aia nō kēlā noiʻi i kona wā mua.
Akā ʻo ka mea nui e hoʻomanaʻo ai ma ʻaneʻi, ʻaʻole loa e lilo kēia mau meaʻai i mea pani no nā lāʻau lapaʻau maʻi kanesa. I nā huaʻōlelo ʻē aʻe, ʻo ka ʻai ʻana i nā hua waina ʻulaʻula he nui a me ka inu ʻana i ke kī ʻōmaʻomaʻo ʻaʻole ia e pale i ka hoʻokumu ʻia ʻana o ke kanesa. He manaʻo hewa loa kēlā.
Eia nō naʻe, he mea nui loa ka ʻai ʻana i ka meaʻai momona e hoʻoikaika ai i kou kino. He mea nui e hāʻawi i ka meaʻai maikaʻi i ke kino i ka wā a ma hope o ka mālama ʻana i ka maʻi kanesa.
Āhea ʻoe e pono ai e kamaʻilio me ke kauka?
Inā loaʻa iā ʻoe kekahi mau hōʻailona i manaʻo ʻole ʻia i ka wā o ka mālama ʻana, e kelepona koke aku i kāu kauka.
ʻOiai inā ʻike ʻoe i nā hōʻailona o kahi maʻi e hoʻoweliweli ana i ke ola, e like me ka hōʻeha puʻuwai a i ʻole ka hahau ʻana, e hele koke i ka Emergency Department (ETU).
He lāʻau lapaʻau koʻikoʻi loa nā mea hoʻopaʻa angiogenesis e ālai ana i ka hiki o nā hunaola kanesa ke hao i ke kaʻina hana ho'ōla ponoʻī o ko mākou kino. ʻAʻole paha lākou e ho'ōla loa i ke kanesa, akā hiki iā lākou ke kōkua i ka kaohi ʻana i kona laha ʻana a hāʻawi iā ʻoe i ka manawa hou aʻe e ola ai. Inā ʻōlelo kāu kauka i kēia lāʻau lapaʻau, e kamaʻilio me kāu kauka e pili ana i kona kuleana i kāu hoʻolālā lapaʻau holoʻokoʻa.
Leka Lawe-Home
- ʻO nā mea hoʻōki Angiogenesis kahi ʻano lāʻau lapaʻau e kāohi ana i ke kūkulu ʻia ʻana o nā kīʻaha koko hou e hoʻolako i nā hunaola kanesa me ke koko. Pale kēia i nā hunaola kanesa mai ka loaʻa ʻana o nā meaʻai e pono ai lākou a kāohi i ko lākou ulu ʻana.
- ʻOiai ʻaʻole kēia e ho'ōla loa i ke kanesa, hiki iā ia ke kāohi i ka laha ʻana o ka maʻi a hoʻolōʻihi i ke ola.
- Hoʻohana pinepine ʻia kēia ʻano lāʻau me nā ʻano lāʻau ʻē aʻe e like me ka chemotherapy.
- He mea nui e makaʻala i nā hopena ʻaoʻao e like me ke koko kiʻekiʻe, ke kāpili ʻana o ke koko, a me ka lohi o ka ho'ōla ʻana o nā ʻeha, a e hoʻomaopopo i kāu kauka inā loaʻa iā ʻoe kekahi mau mea ʻē.
- ʻOiai kekahi mau meaʻai kūlohelohe i loaʻa nā mea hoʻohui e hoʻopilikia i kēia kaʻina hana, ʻaʻole loa lākou e hoʻohana ʻia ma ke ʻano he pani no ka lāʻau lapaʻau.
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