E aʻo wale kākou e pili ana i ka Apoptosis: ke ala kupaianaha e 'make' ai nā hunaola o ko kākou kino!

He mīkini kupaianaha maoli ko kākou kino, ʻeā? Nui nā mea e hana nei i loko o kākou a ʻaʻole kākou i ʻike. I kekahi manawa, hāʻawi ʻia ko kākou mau hunaola i kahi hōʻailona, ​​"ʻAe, ua pau kou manawa," a ua hoʻopau ʻia lākou ma ke ʻano maʻamau, me ka ʻole o ka hōʻino ʻana i kekahi mea a puni lākou. ʻO ia ka mea a mākou e kapa nei he apoptosis i ka lāʻau lapaʻau. Ua like ia me ka pepehi kanaka i hoʻolālā ʻia, akā hana ia no ko kākou pono ponoʻī.

He aha maoli ka apoptosis?

I ka ʻōlelo maʻalahi, ʻo ka apoptosis kahi hana i kapa ʻia ʻo 'programmed cell death' a ko mākou kino e hoʻohana ai e hoʻopau i nā cell i hōʻino ʻia, kahiko, a i ʻole nā ​​​​​​cells i pono ʻole ʻia. He mea nui ka huaʻōlelo 'programmed' ma ʻaneʻi. ʻO ia hoʻi, ua ʻike ko mākou kino e pono e make kēia mau cell, a ke hoʻokele nei ke kino i kēia kaʻina hana mai ka hoʻomaka a hiki i ka hopena.

Ma kahi o ka māhele ʻana a me ka ulu ʻana e like me nā pūnaewele olakino, kahi pūnaewele e hana ʻia ana i ka apoptosis e haki ma ke ʻano maʻamau a make.

E noʻonoʻo ua hōʻino ʻia ka ʻike genetic i loko o kahi cell, ʻo ia hoʻi ka DNA. Inā hoʻomau kēlā cell i ka māhele ʻana, e hoʻomaka nā cell hou e hana a hōʻiliʻili i loko o ke kino me kēlā DNA i hōʻino ʻia. He kumu nui kēia o nā maʻi weliweli e like me ke kanesa . ʻO kekahi o nā hana nui o ke kaʻina hana apoptosis, ʻo ia ka pale ʻana i ia mau mea mai ka hana ʻana.

Ke hana ʻia kēia kaʻina hana e like me ka hoʻolālā ʻana, pōmaikaʻi mākou mai ia mea. Akā inā hewa kekahi mea me kēia ʻōnaehana, hiki i ka apoptosis ke hana nui a ʻaʻole lawa paha. Hiki i nā mea ʻelua ke hōʻeha iā mākou.

No ke aha he mea nui kēia no ko mākou kino?

ʻO ka apoptosis kahi hana e pale ai i ko kākou olakino ma ka hoʻopau ʻana i nā pūnaewele i pono ʻole i loko o ko kākou kino. Hoʻomaka kēia hana ma mua o ko kākou hānau ʻia ʻana.

• Ka ulu ʻana o ka ʻōpū: E noʻonoʻo, hana mua ka lima o kahi pēpē i loko o ka ʻōpū ma ke ʻano he membrane hoʻokahi. A laila, i ka manawa kūpono, make nā ʻāpana ma waena o nā manamana lima ma o ke kaʻina hana i kapa ʻia ʻo apoptosis. ʻO ia ka manawa e kaʻawale maikaʻi ai nā manamana lima ʻelima.
• No ka hoʻololi ʻana i nā pūnaewele kahiko me nā mea hou: Ke hoʻohou mau nei nā pūnaewele a me nā ʻiʻo i loko o ko kākou kino iā lākou iho. Hoʻopau kēia kaʻina hana i nā pūnaewele kahiko.
• No ke kōkua ʻana i ka ʻōnaehana pale: Kōkua kēia i kā mākou ʻōnaehana pale e hakakā i nā maʻi.
• No ka wehe ʻana i nā pūnaewele i hōʻino ʻia:Hoʻopau ʻia nā pūnaewele i hōʻino ʻia me ka hiki ʻole ke hoʻoponopono hou ʻia mai ke kino.
• Ke kāohi nei i ka māhele ʻana o nā ʻāpana i hōʻino ʻia: ʻO kēia ka mea e kaohi ai i ka ulu ʻana o nā mea e like me ke kanesa.
• No ka mālama ʻana i ka homeostasis i loko o ke kino: He mea nui kēia no ka mālama ʻana i kahi kaulike olakino o nā ʻiʻo o ke kino.

Pehea e hana ai kēia kaʻina hana?

Hoʻomaka kekahi mau protein i loko o ko kākou kino i kēia kaʻina hana o ka apoptosis. ʻO kahi laʻana nui o kēia he protein i kapa ʻia ʻo p53 . Ua kapa ʻia hoʻi ia he 'protein suppressor tumor' no ka mea pale ia i ka mahele cell i kāohi ʻole ʻia (hiki ke alakaʻi i nā tumors).

I ka ʻōlelo maʻalahi, ua like ʻo p53 me kahi 'kahu' i loko o kā mākou mau cell. Nānā mau kēia protein i ka DNA o nā cell no ka hōʻino. Inā liʻiliʻi ka hōʻino, hāʻawi ia i nā ʻōlelo kuhikuhi e hoʻoponopono iā ia. Akā inā nui loa ka hōʻino e hoʻoponopono ai, hoʻōki ka protein p53 i ka mahele ʻana o ke cell. Akā, hōʻailona ia i ke cell e hoʻomaka i ka apoptosis.

Ke hoʻomaka ka apoptosis, hana ʻia kekahi mau loli kemika e wāwahi i ke kelepona i mau ʻāpana liʻiliʻi. A laila, hoʻouna kēia kelepona make i kahi hōʻailona i nā 'kelepona hoʻomaʻemaʻe' i kapa ʻia ʻo phagocytes (kahi ʻano kelepona koko keʻokeʻo) e "hele mai e ʻai i kēia mau ʻāpana." He mea maikaʻi loa kēia e hana ai. Ua like ia me ka hoʻopaʻa ʻana i ka ʻōpala a hāʻawi iā ia i ke kaʻa ʻōpala. ʻO ke ʻano kēia, ʻaʻole e ʻeha nā kelepona a puni, ʻaʻohe mumū.

He aha ka mea e hana ai inā nui loa a liʻiliʻi paha ka apoptosis?

E like me nā mea āpau, pono e kaulike ʻia kēia kaʻina hana. He pilikia ka nui, he pilikia ka liʻiliʻi. E nānā kākou pehea e hele ai.

He aha ka ʻokoʻa ma waena o Apoptosis a me Necrosis?

ʻOiai ʻo kēia nā ala ʻelua o ka make ʻana o nā cell, aia nā ʻokoʻa nui ma waena o lāua. He nui ka poʻe e huikau i nā mea ʻelua.

Ua manaʻo nā kānaka noiʻi ma mua he make i hoʻolālā ʻia a hoʻonohonoho ʻia ka apoptosis, a ʻo ka necrosis he make i manaʻo ʻole ʻia, haunaele, a haunaele. I kekahi ʻano, he ʻoiaʻiʻo kēlā. I ka necrosis, pehu a pahū ke kelepona. A laila e kiola ʻia nā mea o loko o ke kelepona, e hoʻoulu ai i ka mumū i loko o nā ʻiʻo a puni. Akā i ka apoptosis, ʻaʻole ia e hana. Hoʻopaʻa pono ʻia ke kelepona a hele aku me ka ʻole o ka haunaele.

Eia nō naʻe, ua ʻike ʻia e ka noiʻi hou kekahi mau ʻano necrosis, e like me ka apoptosis, e hana ʻia ma ke ʻano hoʻolālā. Hoʻohana ʻia nā inoa e like me ka necroptosis a me ka pyroptosis no kēia. No laila, ʻaʻole maopopo mau ka ʻokoʻa ma waena o kēia mau kaʻina hana ʻelua.

Ke kuleana o ka apoptosis i ka mālama ʻana i nā maʻi

Ua ʻike nā kānaka noiʻi hiki i nā loli i ke kaʻina hana apoptosis ke alakaʻi i kekahi mau maʻi, no laila ke hoʻāʻo nei lākou e hoʻomohala i nā lāʻau lapaʻau e hiki ke kāohi i ka apoptosis.

• No ke kanesa: No ka mea, ʻaʻole hana pono ke kaʻina hana apoptosis i loko o nā hunaola kanesa, hoʻomau kēlā mau hunaola i ka māhele ʻana me ka make ʻole. No laila, ke hana ʻia nei ka noiʻi ʻana i nā lāʻau lapaʻau e hiki ke hoʻomaka a hoʻolalelale paha i ke kaʻina hana apoptosis i loko o nā hunaola kanesa.
• No nā maʻi neurological: I nā maʻi e like me Alzheimer's, loaʻa i nā hunaola lolo olakino ka apoptosis nui loa. I nā hihia e like me kēia, ke hoʻāʻo nei nā kānaka noiʻi e hoʻomohala i nā lāʻau lapaʻau e ālai a hoʻolohi paha i ke kaʻina hana apoptosis.

Ke hoʻomau nei kēia noiʻi. He mea nui loa kēia ʻike i ka mālama ʻana i nā maʻi he nui i ka wā e hiki mai ana. Inā loaʻa iā ʻoe kahi maʻi ma kēia ʻano, hiki iā ʻoe ke nīnau i kāu kauka no nā kikoʻī hou aku a me ka ʻike hou loa e pili ana i ia mea.