He aha ka mea e hana nei i kou hoʻomanaʻo? E aʻo kākou e pili ana i ka maʻi Creutzfeldt-Jakob (CJD)?

Manaʻo paha ʻoe i kekahi manawa, "Auē, ua poina iaʻu kēia!"? ʻO ka poina ʻana i nā mea liʻiliʻi a me ka huikau ʻana i kekahi manawa he mea maʻamau ia. Eia nō naʻe, ʻo nā mea e like me ka nalowale mālie o ka hoʻomanaʻo a me nā loli o ke ʻano hiki ke lilo i mau hōʻailona o kahi maʻi koʻikoʻi. I kēia lā e kamaʻilio mākou e pili ana i kahi maʻi kakaʻikahi, akā koʻikoʻi loa, e hoʻopilikia ana i ka lolo. ʻO ia ka maʻi Creutzfeldt-Jakob, a i ʻole CJD e like me kā mākou e kapa nei no ka pōkole.

He aha kēia CJD? I ka pōkole...

E noʻonoʻo e pili ana i ia mea, he mīkini paʻakikī loa ko kākou lolo. I mea e hana pono ai kēia mīkini, pono e olakino kona mau ʻāpana liʻiliʻi, i kapa ʻia he mau cell. He maʻi koʻikoʻi ka CJD e hoʻopau mālie ana i ko kākou mau cell lolo. ʻO ke kumu nui o kēia he ʻano protein ʻano ʻē i kapa ʻia ʻo "prions" .

I kēia manawa, ke noʻonoʻo nei paha ʻoe i ke ʻano o kēia mau 'prions'. I loko o ko mākou kino, ʻoi aku hoʻi i ka lolo, aia nā mea i kapa ʻia he protein. Ua like kēia me nā mīkini liʻiliʻi, he ʻano kikoʻī ko lākou, a inā wale nō lākou i kēlā ʻano hiki iā lākou ke hana pono i kā lākou hana. E noʻonoʻo e like me ka origami. Inā ʻoe e pelu pono, hiki iā ʻoe ke hana i kahi holoholona nani a pua paha. Akā inā ʻoe e pelu pono ʻole? ʻAʻole ia e hana. Pēlā kēia mau protein. I kekahi manawa pelu pono ʻole kēia mau protein. Kāhea mākou i kēlā mau protein pelu pono ʻole ʻia he 'prions'.

Hoʻomaka kēia mau 'prions' i pelu hewa ʻia e hōʻiliʻili i loko o nā hunaola lolo. Hōʻiliʻili lākou a luku i kēlā mau hunaola. Ua like ia me kahi puʻu ʻōpala e hōʻiliʻili ana i kēlā me kēia lā. ʻO ia ke kumu e loaʻa ai i nā maʻi CJD nā hōʻailona o ka dementia , e like me ka nalowale o ka hoʻomanaʻo a me ka huikau. Hiki iā lākou ke ʻike i nā loli ʻano a me ka paʻakikī i ka hele wāwae.

ʻO ka mea nui loa, he make mau ka CJD. ʻAʻohe lāʻau lapaʻau i kēia manawa, a ʻaʻohe ala e hoʻolohi ai i ka holomua o ka maʻi. Eia nō naʻe, aia nā lāʻau lapaʻau a me ka mālama e hiki ke kōkua i ka mea maʻi e ola ʻoluʻolu a hōʻemi i ka ʻeha.

He maʻi laha ʻole kēia. Ma ka honua holoʻokoʻa, loaʻa ka maʻi i hoʻokahi a ʻelua paha kānaka i hoʻokahi miliona i kēlā me kēia makahiki. ʻOiai ma kahi ʻāina e like me ʻAmelika Hui Pū ʻIa, aia wale nō ma kahi o 350 mau hihia o CJD i hōʻike ʻia i kēlā me kēia makahiki.

Aia kekahi ʻano like ʻole o kēia i kapa ʻia ʻo "variant CJD" (a i ʻole "vCJD") . He mea kākaʻikahi loa nō hoʻi ia. Hoʻokumu ʻia ia e ka ʻai ʻana i ka pipi i loaʻa i ka maʻi "bovine spongiform encephalopathy" (BSE), he maʻi ia e hoʻopilikia ai i nā pipi.

He aha nā hōʻailona o CJD? E nānā kākou mai kinohi mai.

ʻIke mālie ʻia nā hōʻailona o CJD. Eia naʻe, i ka holomua ʻana o ka maʻi, hiki i kēia mau hōʻailona ke piʻi koke. E nānā kākou i nā hōʻailona nui, mai nā pae mua o ka maʻi a hiki i nā pae hope:

• Nā pilikia poina a me ka hoʻomanaʻo:Hoʻomaka ia me ka poina ʻana i nā mea liʻiliʻi. Nā mea e like me ka inoa o kahi hoaaloha, ke alanui, a i ʻole ka hana āu e hana nei. Mālie mālie, e lilo kēia i mea ʻino.
• Ka huikau a me ka nalowale ʻana: ʻAʻole hiki iā ʻoe ke hoʻomanaʻo i kou wahi, ka manawa hea, a ʻo wai paha ka poʻe a puni.
• Nā loli i ke ʻano a me ke ʻano: ʻAʻole paha ʻoe e like me ke kanaka ma mua. Hiki iā ʻoe ke huhū koke, kaumaha, a nalowale paha nā manaʻo āpau.
• Nā pilikia hihiʻo, paʻakikī ke hoʻomaopopo i kāu mea e ʻike ai: Lilo kou ʻike maka i nāwaliwali, a ʻaʻole hiki iā ʻoe ke hoʻomaopopo i kāu mea e ʻike ai.
• Nā hallucinations a i ʻole nā ​​​​​​mea kuhihewa: ʻO ka ʻike ʻana a i ʻole ka lohe ʻana i nā mea i ʻike ʻole ʻia, a i ʻole ka manaʻo wahaheʻe e hoʻāʻo nei kekahi e hana ʻino iā ʻoe.
• Nā pilikia me ka hoʻonohonoho ʻana (ataxia): ʻAʻole paha ʻoe e hiki ke hele pono, pilikia ka kaohi ʻana i kou mau lālā, a e luliluli paha e like me ka mea ʻona.
• Nā pilikia me ke kaulike o ke kino: Hāʻule ʻana i ke kū ʻana a i ʻole ke hele ʻana.
• ʻO ka ʻūlū ʻana o nā ʻiʻo i kāohi ʻole ʻia (`myoclonus`) a me ka ʻoʻoleʻa o nā ʻiʻo (`dystonia`): Ka lī koke ʻana o ka lima a i ʻole ka wāwae, a i ʻole ka manaʻo o ka paʻa ʻana o nā ʻiʻo o ke kino.
• Nā hopu ʻana: Hiki ke hele mai me he mea lā he maʻi lā.
• Paralysis: Lilo nā ʻāpana o ke kino i ka paralysis.
• ʻAtrophy o nā ʻiʻo: Ua nalowale ka nui o nā ʻiʻo o ke kino.

Hiki ke ʻike ʻia kēia mau hōʻailona pākahi, a i ʻole e ʻike pū ʻia kekahi mau hōʻailona. ʻO ka mea nui loa, ʻo ia ke ʻike koke i ke kauka inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona.

He aha ke kumu o CJD? E hoʻomanaʻo hou kākou i kēlā mau 'prions'

E like me kā mākou i kūkākūkā ai ma mua, ʻo ke kumu nui o CJD nā protein i pelu hewa ʻia i kapa ʻia ʻo "prions." ʻO ka mea weliweli loa e pili ana i kēia mau "prions" ʻo ia ka hiki iā lākou ke pelu hewa i nā protein maʻamau a olakino. E like me ka hiki i hoʻokahi ʻāpala maikaʻi ʻole ke hoʻolilo i nā ʻāpala ʻē aʻe a pau i mea ʻino.

ʻAʻole hiki i nā ʻāpana lolo ke hoʻopau i kēia mau 'prions' i pelu hewa ʻia. No laila, hōʻiliʻili lākou, a laila luku i nā ʻāpana lolo. I ka laha ʻana o kēia mau 'prions' ma loko o ka lolo, e holomua koke ana ka maʻi.

Aia kekahi mau ʻano like ʻole o CJD?

ʻAe, aia kekahi mau ʻano nui o CJD:

• CJD Sporadic: ʻO kēia ke ʻano CJD maʻamau. ʻAʻole maopopo ke kumu pololei. Hiki koke mai ia, me ke kumu ʻole.
• ʻO Genetic CJD: He hoʻoilina kēia. Hoʻokumu ʻia e kahi gene kīnā i hoʻoilina ʻia mai kekahi a i ʻole nā ​​mākua ʻelua. Aia ʻelua mau ʻano like ʻole o kēia: ʻo Gerstmann-Sträussler-Scheinker (GSS) syndrome a me ka fatal familial insomnia . He mea paʻakikī iki kēia, akā he mau kūlana kikoʻī loa ia.
• CJD i loaʻa (`CJD i loaʻa`):Hiki ke hana ʻia kēia ma muli o nā kumu o waho. No ka laʻana, hiki ke hana ʻia ma o kahi hoʻoili kino mai kahi kanaka me CJD, kahi hoʻoili ʻiʻo, a i ʻole ka hoʻohana ʻana i nā mea hana ʻoki kino i haumia. Akā, he mea kākaʻikahi loa kēia. I kēia mau lā, nui ka hopohopo e pili ana i kēia.
• ʻAno CJD (vCJD): Ua kamaʻilio mua mākou e pili ana i kēia. Hoʻokumu ʻia ia e ka ʻai ʻana i ka pipi i loaʻa i ka maʻi bipi pupule (BSE). Hiki i nā prion e hoʻoulu ai i ka BSE ke hoʻopili i nā kānaka a me nā holoholona ʻē aʻe.

ʻO wai ka mea i ʻoi aku ka nui o ka pilikia o ka hoʻomohala ʻana i ka CJD?

Hiki i kekahi ke loaʻa iā CJD. I kekahi manawa, hiki i nā 'prions' i loko o kou kino ke noho no nā makahiki me ka ʻole o ka hōʻike ʻana i nā hōʻailona. Akā i ka wā e ʻike ʻia ai nā hōʻailona, ​​​​hiki i ka maʻi ke lilo koke i mea koʻikoʻi i ka wā e hōʻino ʻia ai ka lolo.

Hoʻopilikia pinepine kēia maʻi i nā kānaka ma waena o 50 a me 80 mau makahiki. Eia nō naʻe, hiki ke ʻike ʻia ke ʻano CJD genetic ma waena o 30 a me 50 mau makahiki.

He maʻi lele anei ʻo CJD?

He pilikia kēia no nā kānaka he nui. ʻAʻole laha ka CJD ma o ka launa pū ʻana, e like me ka lulu lima ʻana, ke kamaʻilio ʻana, a i ʻole ka ʻai pū ʻana. ʻO ke ala wale nō e hiki ai ke laha ka CJD mai kekahi kanaka a i kekahi kanaka ma o ka hoʻoili ʻana o kahi ʻōpū a i ʻole ka ʻiʻo mai kahi mea i loaʻa iā CJD, a i ʻole ma o ka hoʻohana ʻana i kekahi mau hormones mai kahi mea i loaʻa iā ia.

Wahi a lākou hiki ke laha ke ʻano i kapa ʻia ʻo `vCJD` ma o ke kahe koko ʻana, akā he mea kākaʻikahi loa ia. ʻO ka maʻi i kapa ʻia ʻo `vCJD` ponoʻī he mea kākaʻikahi loa ia.

Pehea e ʻike ai nā kauka i ka CJD?

Hoʻomaopopo ke kauka iā CJD ma ka nānā pono ʻana i kāu mau hōʻailona a me nā hōʻailona. Ma waho aʻe o ka hoʻokolokolo kino, e hana pū lākou i kahi hoʻokolokolo neurological. E noi lākou iā ʻoe e hana i kekahi mau hana maʻalahi e hoʻāʻo e ʻike i nā pilikia me ka hana o kou lolo.

Hoʻokaʻawale nā ​​loea i ka CJD ma ke ʻano he 'transmissible spongiform encephalopathy' . ʻOiai paha he paʻakikī iki kēia inoa, pili ia i ke ʻano o ka lolo i hōʻino ʻia e nā 'prions' ma lalo o kahi microscope. ʻO ia hoʻi, ua like ia me kahi huʻa me nā puʻupuʻu.

No ka hōʻoia ʻana i kahi hōʻoia o CJD, hana ʻia nā hoʻokolohua e like me ka MRI scan a i ʻole ka spinal tap (lumbar puncture).

Eia kekahi, hiki i nā kauka ke hoʻohana i nā hoʻokolohua e like me kēia e hoʻoponopono i nā kūlana ʻē aʻe i loaʻa nā hōʻailona like me CJD a e noiʻi hou aku iā CJD:

• Nā hoʻāʻo koko
• Ka hoʻāʻo ʻana i ka genetics - ʻoi aku hoʻi e ʻike inā he hoʻoilina kahi ʻano
• ʻO kahi electroencephalogram (EEG)
• Ka nānā ʻana i ka mimi
• ʻO ka biopsy lolo - Hana pinepine ʻia kēia, inā ʻaʻole hiki i nā hoʻokolohua ʻē aʻe ke hāʻawi i kahi hōʻoia paʻa.

Aia kekahi lāʻau lapaʻau no CJD?

ʻO ka mea pōʻino, ʻaʻohe lāʻau lapaʻau no CJD, ʻaʻohe lāʻau e kāohi i ka laha ʻana o ka maʻi, a ʻaʻohe lāʻau e hoʻolohi i kona holomua. ʻO ka mea wale nō e hiki i nā kauka ke hana, ʻo ia ke kōkua i ka hōʻemi ʻana i ka ʻoluʻolu ʻole i hoʻokumu ʻia e nā hōʻailona. Ua kapa ʻia kēia he mālama palliative .

Eia kekahi laʻana, hiki ke hāʻawi ʻia nā lāʻau lapaʻau e mālama i nā maʻi ʻōhū, nā loli o ke ʻano, a i ʻole ka ʻūlū ʻana o nā ʻiʻo hiki ʻole ke kaohi. Eia nō naʻe, ua kaupalena ʻia nā pono o kēia mau lāʻau lapaʻau.

Hiki i kēia maʻi ke lilo i mea ʻino loa me ka wikiwiki. No laila, he mea nui loa nā koho mālama kākoʻo nou a me kāu poʻe aloha. I nā pae hope o ka maʻi, hiki i nā lawelawe hospice ke kōkua nui.

I kekahi manawa, inā kūpono ʻoe, hiki i kāu hui lapaʻau ke kuhikuhi iā ʻoe e komo i kahi hoʻokolohua lapaʻau e noiʻi ana i nā lāʻau lapaʻau hou.

He aha ke ʻano o ka wā e hiki mai ana e hiki i kekahi me CJD ke manaʻo?

No ka mea, ʻaʻohe mea e ho'ōla ʻia ai ʻo CJD a ʻaʻohe ona lāʻau lapaʻau, he mea kaumaha loa ka nānā ʻana no ke kanaka me ka maʻi. Ke hoʻomaka nā hōʻailona, ​​ʻaʻole i liʻuliʻu ma mua o ka nalowale ʻana o ka hiki ke hana kūʻokoʻa, neʻe a puni, a ʻōlelo.

No ka mea hiki ke loli koke nā loli, he mea nui e hana pū me kāu hui lapaʻau e hoʻolālā mua e hōʻoia i ka hoʻokō ʻia ʻana o kāu mau makemake a me nā pono. ʻOiaʻiʻo, me ka nānā ʻole inā he maʻi kou a ʻaʻole paha, he manaʻo maikaʻi no nā mea āpau e loaʻa kahi 'kuhikuhi mua' . ʻO ke ʻano kēia ua kākau mua ʻoe i ka mālama olakino āu e makemake ai inā ʻaʻole hiki iā ʻoe ke haʻi aku i kāu mau makemake. He mea nui loa ka hoʻokumu ʻana i kēia hoʻolālā i ka wā mua i kahi maʻi e laha wikiwiki ana e like me CJD.

Ma muli o ke koʻikoʻi o kēia maʻi, he mea maikaʻi ke ʻimi i ka ʻōlelo aʻo mai kahi loea olakino noʻonoʻo e kōkua iā ʻoe a me kou ʻohana e kū i kēia mau loli a noho ikaika i ka noʻonoʻo.

He aha ka manaʻolana e ola ai kahi maʻi CJD?

Make ka hapa nui o nā maʻi CJD i loko o kekahi mau mahina a i ʻole hoʻokahi makahiki o ka ʻike ʻana. ʻO ka ʻokoʻa wale nō ke ʻano genetic o CJD, kahi e hiki ai i nā kānaka ke ola mai hoʻokahi a ʻumi mau makahiki ma hope o ka hoʻomaka ʻana o nā hōʻailona.

Hiki i kāu kauka ke hāʻawi iā ʻoe i ka ʻike kikoʻī a hou e pili ana i kou kūlana. E hoʻomanaʻo, ʻaʻole like ka hopena o nā helu helu i nā kānaka a pau.

Hiki ke pale ʻia ka CJD?

ʻAʻole hiki ke pale ʻia ka hapa nui o nā ʻano CJD. ʻO ka ʻokoʻa wale nō ke ʻano i kapa ʻia ʻo `vCJD`. Loaʻa ia mai ka ʻai ʻana i ka pipi i loaʻa i ka `BSE` (maʻi bipi pupule).

Kōkua ka hoʻāʻo ʻana i nā holoholona i ka pale ʻana i nā pipi i loaʻa i ka maʻi BSE mai ke komo ʻana i ke kaulahao lako meaʻai. Eia nō naʻe, hiki i ka ʻiʻo i hoʻāʻo ʻole ʻia a hoʻomākaukau pono ʻole ʻia ke hoʻoweliweli. I mea e palekana ai, e pale i ka ʻai ʻana i ka ʻiʻo i hoʻāʻo ʻole ʻia a hoʻoponopono ʻole ʻia, ʻoiai nā ʻāpana o ka lolo a i ʻole ka iwi iwi.

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai

He ʻike hoʻololi ola ka maʻi CJD. Hiki iā ia ke manaʻo ua nalowale ʻoe a me ke ao a puni ʻoe i ka ʻimo o ka maka. Hiki i kēlā ʻano loli ke paʻakikī loa iā ʻoe a me kāu poʻe aloha ke hoʻomanawanui.

Inā kānalua ʻoe i ka mea e manaʻo ai a pehea e hoʻoponopono ai, eia kāu hui lapaʻau e kōkua. Hiki iā lākou ke kōkua iā ʻoe e hoʻolālā mua a hoʻomākaukau no ka mea e hiki mai ana. E hoʻomanaʻo, ʻaʻole ʻoe hoʻokahi.

ʻO CJD, ka maʻi Creutzfeldt-Jakob, prion, maʻi lolo, maʻi neurological, nalowale hoʻomanaʻo, dementia, maʻi bipi pupule