Ua manaʻo paha ʻoe i ka wā e maʻi ai a ʻeha paha ko kākou kino, e hana ʻia ana kahi kaua nui i loko e ho'ōla ai? Loaʻa iā kākou ko kākou pūʻali koa akamai loa e hakakā aku i nā ʻenemi e like me nā maʻi a me nā bacteria e puka mai ana mai waho o ko kākou kino. Kāhea mākou i kēia ʻōnaehana pale maʻi. No laila, pono kekahi e alakaʻi i kēia pūʻali koa, e hoʻololi i nā leka, a e hoʻouna iā lākou ma kahi o nā ʻenemi. ʻO kēlā mau ʻelele huna nā cytokines a mākou e kamaʻilio nei i kēia lā.
He aha maoli nā cytokines?
I ka ʻōlelo maʻalahi, he mau protein liʻiliʻi nā cytokines e hoʻouna i nā leka ma waena o nā cell i loko o kā mākou ʻōnaehana pale. Ua like ia me kahi 'hui WhatsApp' i loko o ko mākou kino. Ke hiki mai kahi hoʻoweliweli e like me ka maʻi a i ʻole kahi ʻeha i ke kino, hoʻokuʻu nā cell immune i kēia mau leka i kapa ʻia ʻo cytokines. Ke haʻi aku nei kēia mau leka i nā cell immune ʻē aʻe, "Aia kahi pilikia ma aneʻi, e hele koke mai!", "ʻO kēia ke ʻano o ka ʻenemi e pono ai mākou e hakakā," a "E hana i nā koa hou aku."
E noʻonoʻo i kahi maʻi e komo ana i kou kino. I kēlā manawa, hoʻouna kekahi mau cell i kēia mau leka cytokine, e haʻi ana i nā cell ʻē aʻe e mākaukau e hakakā i ka maʻi. ʻO ke ʻano kēia, me ka ʻole o kēia mau ʻelele liʻiliʻi, ʻaʻole hiki i kā mākou ʻōnaehana pale ke hana pono. Kōkua kēia mau cytokines i ka mālama ʻana i ko mākou ʻōnaehana pale, ʻoiai inā ʻaʻohe hoʻoweliweli.
Aia kekahi mau ʻano nui o kēia mau cytokines?
ʻAe, e like me nā kūlana like ʻole o ka pūʻali koa, aia nā ʻano cytokines like ʻole. Loaʻa i kēlā me kēia ʻano kahi hana kikoʻī. E nānā kākou i kekahi o nā ʻano nui.
| ʻAno cytokine | He aha e hana maʻalahi ai |
|---|---|
| Nā Chemokine | Ua like ia me kahi 'GPS' no nā pūnaewele pale. Hōʻike ia iā lākou i ke ala i kahi o ka maʻi. |
| Nā Interferon | I ka hanana o ka hoʻouka kaua ʻana o kahi maʻi, hoʻouna ia i kahi hōʻailona hōʻike i nā ʻāpana ʻē aʻe, me ka ʻōlelo ʻana, "E kau i kahi pale pale!" Pale ia i nā maʻi mai ka hoʻopili ʻana i ke kino. |
| Nā Interleukins | Hoʻololi kēia i nā leka ma waena o nā pūnaewele pale kino (nā pūnaewele koko keʻokeʻo) a kamaʻilio pū me nā pūnaewele ʻē aʻe. |
| ʻO ka mea necrosis tumor (TNF) | Kōkua ia i ka kaohi ʻana i ka mumū i loko o ke kino a hōʻailona pū i nā pūnaewele pale e luku i nā hunaola kanesa. |
| Nā mea hoʻoulu kolone (CSF) | Hāʻawi kēia i nā ʻōlelo kuhikuhi i nā pūnaewele kumu hematopoietic, e like me "lilo ʻoe i pūnaewele koko keʻokeʻo," "lilo ʻoe i pūnaewele koko ʻulaʻula," a hoʻolilo iā lākou i mau ʻano pūnaewele kikoʻī. |
Eia kekahi, ua kapa ʻia kekahi mau cytokines e like me ke ʻano o ke kelepona e hana ana iā lākou:
- Lymphokines: Hana ʻia e kekahi ʻano keʻokeʻo koko i kapa ʻia ʻo lymphocytes.
- Monokines: Hana ʻia e kekahi ʻano keʻokeʻo koko i kapa ʻia ʻo monocytes.
ʻO ka hana nui o nā cytokines: ka kaohi ʻana i ka mumū
Ke lohe ka hapa nui o ka poʻe i ka huaʻōlelo 'inflammation', manaʻo lākou he mea maikaʻi ʻole ia, he hōʻailona o ka maʻi. Akā, ʻo ka mumū he hōʻailona koʻikoʻi ia e pale aku ana kā mākou ʻōnaehana pale i nā ʻenemi a i ʻole e hoʻoponopono ana i nā ʻiʻo i hōʻino ʻia. E noʻonoʻo inā ʻoki ʻoe i kou manamana lima, e ʻulaʻula ia, e pehu, a wela iki, ʻeā? ʻO ia ke ʻano o ka mumū.
ʻO nā cytokines ka mea e hoʻouna i ka leka i nā pūnaewele pale, "Aia kahi pilikia ma ʻaneʻi, e hele koke mai e ho'ōla i kēia ʻeha, e ho'ōki i nā germs mai ke komo ʻana!"
ʻO nā cytokines ke hōʻailona nui i kēia mau mea:
- Hoʻāla ʻana o nā kelepona: Ke haʻi ʻana i nā kelepona i kahi e hele ai a me ka mea e hana ai. No ka laʻana, ke kuhikuhi ʻana i nā kelepona pale i kahi o kahi maʻi.
- Ka hoʻokaʻawale ʻana o ke kelepona: Ua ʻōlelo ʻia kahi kelepona ʻōpiopio e "lilo i ʻano kūikawā o ke kelepona koko keʻokeʻo e hiki ke hakakā i kēia maʻi."
- Ka hoʻonui ʻana o nā pūnaewele: He hōʻailona e hana i nā pūnaewele hou aku, a i ʻole nā pūnaewele hou aku. No ka laʻana, hāʻawi ʻia kēia hōʻailona ke pono nā pūnaewele koko keʻokeʻo hou aku e hakakā i kahi maʻi nui.
Nā cytokine pro-inflammatory a me anti-inflammatory
Ua like kēia me ka mea hoʻolalelale a me nā paleki ma ke kaʻa. He mea nui nā mea ʻelua no ka hoʻomalu pono ʻana i ka pane o kā mākou ʻōnaehana pale.
- ʻO nā cytokine pro-inflammatory: ʻO kēia nā mea hoʻolalelale . Ke komo mai kahi germ, hoʻoulu lākou i ka mumū a hoʻolalelale i ka pane ʻana o ka pale kino. ʻO kēia ka poʻe e hāʻawi i ka hōʻailona e hoʻomaka i ke kaua.
- ʻO nā cytokine anti-inflammatory: ʻO kēia nā paleki . Ma hope o ka lanakila ʻana i ka ʻenemi, hoʻōki lākou i ka hōʻino hou ʻana i ko mākou mau ʻiʻo olakino ponoʻī ma ka hōʻemi ʻana i ka mumū a hoʻihoʻi i nā mea āpau i ka maʻamau.
Ke hoʻomaka ka hakakā, he mea nui loa hoʻi e hoʻōki iā ia i ka manawa kūpono. A i ʻole, hiki ke hōʻino ʻia ko kākou mau hunaola ponoʻī a hiki ke loaʻa nā maʻi koʻikoʻi.
Pehea lā e hana ʻia ai kēia hoʻololi leka?
He hana hoihoi loa kēia. E hoʻohālikelike kākou iā ia me ke kī a me ka lua kī.
Ua like ka cytokine me ke kī . Ma luna o ka ʻili o ke kelepona e pono ai ke loaʻa ka leka, aia kahi puka kī (mea loaʻa) e kūpono i kēlā kī. Ke hele ka cytokine (ke kī) a pili i ka mea loaʻa (ka puka kī) ma kēlā kelepona, loaʻa i kēlā kelepona ka leka. A laila hana kēlā kelepona e like me kēlā leka.
ʻEkolu ala e hoʻouna ai i kēia mau leka:
1. Hōʻailona Autocrine: Hoʻouna kahi cell i kahi leka iā ia iho.
2. Hōʻailona paracrine: Hoʻouna kahi kelepona i nā leka i nā kelepona kokoke.
3. Hōʻailona endocrine: Hoʻouna kahi cell i nā leka ma o ke koko i nā cell mamao loa mai ia mea.
ʻO wai nā pūnaewele e hana i ka nui o nā cytokines?
Hoʻopuka pinepine ʻia nā cytokines e nā pūnaewele i loko o kā mākou ʻōnaehana pale. Eia naʻe, ʻaʻole lākou wale nō nā pūnaewele. Hiki i nā ʻano pūnaewele ʻē aʻe i loko o ko mākou kino ke hana iā lākou.
Nā pūnaewele pale
- Nā Macrophage
- Nā pūnaewele dendritic
- Nā Lymphocytes
- Nā monocyte
- Nā Neutrophils
- Nā Basophil
- Nā Eosinophils
- Nā pūnaewele mast
Nā pūnaewele ʻē aʻe
- Nā pūnaewele Endothelial (nā pūnaewele e uhi ana i loko o nā kīʻaha koko)
- ʻO nā pūnaewele epithelial nā pūnaewele e uhi ana i ka ʻili o kā mākou mau kino.
- Nā pūnaewele i loko o nā ʻiʻo hoʻopili (Fibroblasts, Stromal cells)
- Nā pūnaewele e hoʻopuni ana i nā aʻalolo (nā pūnaewele Schwann)
He aha ka mea e hana ai inā nalowale ke kaulike o ka cytokine?
ʻOiai he mea nui nā cytokines no ko kākou olakino, e like me nā mea ʻē aʻe, ʻaʻole maikaʻi ka nui o lākou. I kekahi manawa, ma muli o kahi maʻi a i ʻole kekahi mau lāʻau lapaʻau, hoʻonui nui ʻia ka ʻōnaehana pale a hoʻomaka e hana i nā nui nui o nā cytokines ma waho o ke kaohi.
Ua kapa mākou i kēia kūlana ʻo Cytokine Release Syndrome (CRS) a i ʻole cytokine storm . Ua like ia me ko mākou ʻōnaehana pale ponoʻī e hele ana i ka pupule, e hoʻouka ana ʻaʻole wale i ko mākou poʻe ʻenemi akā i ko mākou mau cell olakino ponoʻī. Hiki i kēia ke alakaʻi i ka mumū nui, ka hōʻino ʻana i nā ʻiʻo, a me nā ʻano maʻi like ʻole.
Nā maʻi e hiki ke hana ʻia e nā cytokines keu:
- Nā maʻi Autoimmune: Ma kēia, hoʻouka hewa ka ʻōnaehana pale i kāna mau hunaola olakino ponoʻī.
- Nā maʻi metabolic: Nā pilikia me ke kaʻina hana o ka hoʻololi ʻana i ka meaʻai i ikehu.
- Ka maʻi ʻaʻai.
- Sepsis: He maʻi koʻikoʻi loa kēia. ʻO ka mumū nui i loko o ke kino ke kumu o ka emi ʻana o ke kahe koko i nā ʻōpū nui. He pilikia olakino kēia a hiki ke make inā ʻaʻole mālama ʻia.
Inā he kānalua kou e pili ana i kēia maʻi, he mea nui loa e ʻike koke i kāu kauka no ka ʻōlelo aʻo .
Hoʻāʻo panela cytokine
Hiki i nā kauka ke haʻi inā he nui loa a he kakaikahi paha nā cytokines o kou kino. Ua kapa ʻia ka hoʻāʻo koko he cytokine panel . Ana ia i nā pae o nā cytokines i loko o kou koko e pili ana i ka mumū. Ma muli o nā hopena, hiki i kāu kauka ke kuhikuhi i nā lāʻau lapaʻau e kāohi i ka mumū inā he nui loa kāu.
Leka Lawe-Home
- He mau ʻelele kemika nā Cytokines e pono ai no ke kamaʻilio ʻana i loko o kā mākou ʻōnaehana pale.
- Hana kēia mau hana e hakakā i nā hoʻoweliweli i ke kino, e hoʻoulu i ka 'mumū', a e hoʻōki iā ia ke pau ke kaua.
- He mea nui ke kaulike kūpono o nā cytokines no ke olakino maikaʻi. ʻO ka nui a i ʻole ka liʻiliʻi o lākou e alakaʻi ai i ka maʻi.
- He maʻi koʻikoʻi ka 'ʻino cytokine' i hoʻokumu ʻia e ka pane nui ʻana o ka ʻōnaehana pale.
- Inā he mau hopohopo a i ʻole nā hōʻailona e pili ana i kāu ʻōnaehana pale, e ʻimi mau i ka ʻōlelo aʻo mai kahi loea lapaʻau kūpono.
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