Ke makewai mau nei ʻoe a mimi paha ma kahi o iwakālua manawa i ka lā? ʻO kēia anei nā maʻi Arginine Vasopressin / Diabetes Insipidus?

Loaʻa iā ʻoe kekahi makewai hiki ʻole ke hoʻomanawanui? Manaʻo ʻoe ʻaʻole hiki iā ʻoe ke inu i ka wai lawa? Pono ʻoe e hele i ka lua i nā manawa he nui i ka lā, i kekahi manawa hoʻokahi a ʻelua paha i ka hola? Inā pono ʻoe e ala i ka pō e mimi me ka hiamoe ʻole, ʻaʻole kēia he mea e lawe māmā ʻia. I kēia lā e kamaʻilio mākou e pili ana i kahi maʻi kakaikahi akā hiki ke mālama ʻia e hōʻike ana i nā hōʻailona like. Ma mua, ua kapa ʻia kēia ʻo 'Diabetes Insipidus'.

He aha ka maʻi Arginine Vasopressin?

I ka ʻōlelo maʻalahi, ʻo kēia ke ʻano o ka hana ʻana o kou kino i ka mimi nui loa. ʻO ia hoʻi, ʻaʻole hiki i kou kino ke mālama i ka wai lawa. ʻO ke kumu nui o kēia, he pilikia ia me kahi hormone i kapa ʻia ʻo Arginine Vasopressin (AVP) . Kāhea pū nā kauka i kēia hormone ʻo "AVP" ʻo ka Antidiuretic Hormone (ADH) . He kuleana koʻikoʻi kēia hormone "AVP" i ka mālama ʻana i ka nui o ka wai i loko o ke kino i kaulike ma o ko kākou mau puʻupaʻa.

ʻElua ʻano nui o kēia mau kūlana:

1. Ka hemahema o ka AVP (AVP-D): ʻO kēia ka manawa ʻaʻole hana kou kino i ka nui o ka hormone AVP.

2. Ke kū'ē ʻana i ka AVP (AVP-R): ʻO kēia ka manawa ʻaʻole pane pono kou mau puʻupaʻa i ka hormone AVP. ʻO ke ʻano kēia, ʻoiai aia ka hormone, ʻaʻole hoʻohana nā puʻupaʻa ia mea.

He aha nā hōʻailona o kēia maʻi?

ʻO nā hōʻailona nui o ka hemahema o AVP a me ke kū'ē ʻana o AVP:

• Ka pinepine ʻana o ka mimi: ʻO kahi hōʻailona koʻikoʻi o kēia , ʻo ia ke ala ʻana e mimi ʻaʻole wale i ke ao akā i ka pō hoʻi (Nocturia) .
• Ka hoʻokahe ʻana i ka nui o ka mimi māmā a wai paha: ʻO ka maʻamau, hele ke kanaka ma waena o 1 a me 3 lita o ka mimi i kēlā me kēia lā. Eia nō naʻe, hiki i ke kanaka me kēia maʻi ke hoʻokahe a hiki i 20 lita o ka mimi i kēlā me kēia lā. E noʻonoʻo i ka nui o ia mea!
• Makewai nui (Polydipsia): Manaʻo ʻoe ʻaʻole ʻoe e kinai ana i kou make wai me ka nānā ʻole i ka nui o ka wai āu e inu ai.

He hōʻailona ikaika kēia mau hōʻailona e hana pono ʻole ana kekahi mea i loko o kou kino. He mea nui loa e ʻimi i ke kōkua lapaʻau i ka wā hikiwawe loa.

Pehea ka hopena o kēia mau hōʻailona i nā keiki ʻōpio?

Inā loaʻa kēia maʻi i nā keiki ʻōpio, ʻokoʻa iki paha nā hōʻailona. ʻO kekahi o lākou:

• Ka maloʻo nui o ka wai.
• Ka paʻa ʻana o ka ʻōpū.
• Ka luaʻi ʻana.
• Nā kuni pinepine.
• Ke hōʻike nei i kahi ʻano huhū a me ka huhū loa.
• Ka nāwaliwali o ka ulu ʻana / Ka holomua ʻole.

Inā loaʻa i nā pēpē a i ʻole nā ​​​​keiki liʻiliʻi kēia mau hōʻailona, ​​​​pono e ʻike koke ʻia lākou e ke kauka.

No ke aha e kū mai ai kēia mau maʻi arginine vasopressin?

ʻOkoʻa nā kumu, ma muli o ke ʻano i ʻōlelo ʻia ma luna.

Nā kumu o ka hemahema o ka AVP `(AVP-D)`

Ua kapa ʻia ma mua ʻo ka maʻi diabetes insipidus waena , ua hana ʻia kēia e ka nele o ka hormone arginine vasopressin (AVP). ʻO kēia ke ʻano maʻamau.

Hiki paha kēia ma muli o:

• Ka hōʻino ʻana i ka hypothalamus a i ʻole ka pituitary gland (he mau ʻāpana koʻikoʻi kēia o ka lolo e kaohi ana i nā hormones). Hiki ke hana ʻia kēia hōʻino mai ke ʻoki ʻana a i ʻole kahi ʻeha poʻo.
• Kekahi mau ʻokoʻa genetic (ʻokoʻa gene i hoʻoilina ʻia)
• Ka hoʻokumu ʻia ʻana o nā puʻupuʻu .
• ʻO ka mumū / Granulomas i hoʻokumu ʻia e kekahi mau kūlana olakino, e like me ka sarcoidosis a i ʻole ka maʻi puʻupuʻu.
• I kekahi manawa, ʻaʻole paha e loaʻa ke kumu (idiopathic) . ʻO ke ʻano kēia, ma kahi o ka hapalua o nā maʻi, ʻaʻole ʻike ʻia ke kumu.

Nā kumu o ke kū'ē ʻana o AVP (AVP-R)

Ua kapa mua ʻia kēia ʻano he nephrogenic diabetes insipidus . I kēia hihia, hana ka pituitary gland i ka hormone AVP, akā ʻaʻole pane pono nā puʻupaʻa iā ia.

Aia kekahi mau kumu no kēia:

• ʻO kekahi mau loli genetic.
• Ala mimi i ālai ʻia .
• Ka hoʻohana lōʻihi ʻana i kekahi mau lāʻau lapaʻau , ʻoi aku ka lithium .
• Hoʻonui ʻia ka nui o ka calcium i loko o ke koko (Hypercalcemia) .
• Ka haʻahaʻa o ka potassium i loko o ke koko (Hypokalemia) .

He ʻano kūikawā e kū mai ana i ka wā hāpai

Ua kapa ʻia kēia ʻo Gestational Arginine Vasopressin Disorder (gAVP-d) . He mea kākaʻikahi loa kēia. I ka wā hāpai, hana ka placenta i ka nui o kahi enzyme e wāwahi ana i ka hormone AVP.

ʻOi aku ka nui o kou loaʻa ʻana i kēia maʻi, no kekahi kumu :

• Inā ʻoe e hāpai ana i nā māhoe a ʻoi aku paha mau keiki .
• Inā he maʻi kou e hoʻopilikia ai i ka hana o ke akepaʻa, e like me ka preeclampsia a i ʻole ka HELLP syndrome .

ʻO ka nūhou maikaʻi, ʻo ka maʻamau, e nalowale ana kēia maʻi 'gAVP-d' i ʻelua a ʻekolu mau pule ma hope o ka hānau ʻana.

He aha nā pilikia o kēia maʻi?

ʻO ka pilikia nui o AVP-D a me AVP-R ka dehydration , ʻo ia hoʻi ka nalowale ʻana o nā wai a me nā electrolytes e pono ai ke kino e hana.

Hiki iā ʻoe ke kaohi i kāu hoʻopuka mimi ma ka inu ʻana i ka wai ma mua o kou pono, akā inā ʻaʻole, hiki iā ʻoe ke maloʻo koke.

Hiki i ka maloʻo ʻana o ka wai ke hoʻoweliweli i ke ola. Inā loaʻa iā ʻoe nā hōʻailona o ka maloʻo ʻana o ka wai, e like me ka poniuniu, ka luaʻi, a i ʻole ka luhi nui, e hele koke i ka haukapila kokoke loa.

Pehea e ʻike ai nā kauka i kēia?

Ma muli o nā hōʻailona o ka makewai pinepine a me ka mimi ʻana hiki ke hana ʻia e nā kūlana maʻamau ʻē aʻe, hoʻopau mua nā kauka i nā kūlana ʻē aʻe i ka wā e ʻike ai i ka 'AVP-D' a i ʻole 'AVP-R'. Inā loaʻa iā ʻoe kēia mau hōʻailona, ​​​​e kauoha paha kāu kauka i kekahi mau hoʻokolohua.

I ka wā e ʻike ai i kēia maʻi, pono e hoʻoholo inā he 'AVP-D' a i ʻole 'AVP-R' a he aha ke kumu.

Nā hoʻokolohua diagnostics

• Hoʻāʻo nele wai: ʻO kēia ke ala hilinaʻi loa e ʻike ai i ka AVP-D a i ʻole AVP-R. E nānā pono ʻia ʻoe i ka wā o kēia hoʻāʻo, no ka mea hiki i kēia ke alakaʻi i ka maloʻo. ʻO kēia hoʻāʻo e pili ana i ka inu ʻole ʻana i kekahi wai no kekahi mau hola a ʻike i ke ʻano o ka pane ʻana o kou kino. Inā loaʻa iā ʻoe kēia ʻano, e hoʻomau ʻoe i ka hoʻohele ʻana i ka nui o ka mimi wai a māmā. Inā ʻaʻohe ou ʻano, e hoʻohele wale ʻoe i kahi liʻiliʻi o ka mimi melemele ʻeleʻele i hoʻopaʻa ʻia.
• Hoʻāʻo koko Copeptin: ʻO Copeptin kahi huahana ʻaoʻao o ka hormone AVP.
• Hoʻāʻo glucose koko: Hana ʻia kēia e nānā no ka maʻi diabetes mellitus, nona nā hōʻailona like.
• Urinalysis: Hoʻāʻo kēia i ka osmolality ( ka nui o ka mimi) a me nā ketones i loko o ka mimi.
• Nā hoʻāʻo kiʻi e like me nā scan MRI (MRI - Magnetic Resonance Imaging): Hana ʻia kēia e ʻike inā he pōʻino i ka pituitary gland a i ʻole hypothalamus.

Pehea e mālama ʻia ai kēia mau ʻAVP-D a me ʻAVP-R?

Aia ka lāʻau lapaʻau ma muli o ka loaʻa ʻana o ka `AVP-D` a i ʻole `AVP-R` iā ʻoe. Me ka nānā ʻole i ka lāʻau lapaʻau, he mea nui e inu i ka wai he nui e pale aku ai i ka maloʻo ʻana o ka wai.

Lapaʻau AVP-D (Kālohelohe)

ʻO Desmopressin ka lāʻau lapaʻau nui no AVP-D. He lāʻau ia e hana like me ka hormone AVP. Hiki ke lawe ʻia ma nā ʻano like ʻole (e.g., ma ke ʻano he pīpī ihu, ma ke ʻano he pila).

Hoʻohana ʻia ʻo Desmopressin i kekahi manawa no ke kūlana hāpai kakaʻikahi "(gAVP-d)". Eia nō naʻe, i kekahi manawa i ka wā hāpai, hiki ke hoʻomalu ʻia ma ka inu ʻana i ka wai hou aku.

Lapaʻau AVP-R (Kūʻē)

He mea paʻakikī iki ka mālama ʻana i ka `AVP-R`. I kekahi manawa pono e hoʻohana pū ʻia kekahi mau ʻano hana. Eia kekahi laʻana:

• Nā lāʻau diuretic Thiazide(ʻOiai he ʻano lāʻau lapaʻau kēia e hoʻonui ai i ka mimi, hana like ʻole lākou ma kēia kūlana)
• Nā lāʻau anti-inflammatory nonsteroidal (NSAIDs)

Inā loaʻa ke kūlana `AVP-R` i kahi lāʻau lapaʻau āu e lawe nei, hiki paha i kāu kauka ke mālama i ke kūlana ma ka hoʻololi ʻana iā ʻoe i kahi lāʻau lapaʻau ʻē aʻe.

Āhea wau e ʻike ai i ke kauka?

Inā loaʻa iā ʻoe ka ʻAVP-D a i ʻole ka ʻAVP-R, he mea nui loa ia e ʻike pinepine i kāu kauka no ka ʻōlelo aʻo. Ma kēia ʻano, hiki i kāu kauka ke hana i nā hoʻokolohua e nānā i kou kūlana a hōʻoia i ka hana pono ʻana o kāu lāʻau lapaʻau.

Hiki paha iā ʻoe ke nīnau i kāu kauka i kēia mau nīnau:

• Loaʻa iaʻu ka `AVP-D` a i ʻole `AVP-R`?
• He aha ke kumu o kēia?
• He maʻi mau loa kēia (he maʻi lōʻihi) a he maʻi manawa pōkole paha?
• He aha nā koho lapaʻau e loaʻa iaʻu?
• ʻEhia ka wai e pono ai iaʻu e inu i ka lā?
• He aha hou aʻe kaʻu e hana ai e mālama i kēia kūlana?
• Aia anei koʻu ʻohana i ka pilikia o ka loaʻa ʻana o ka maʻi arginine vasopressin?

He aha kaʻu e manaʻo ai inā loaʻa iaʻu ka `AVP-D` a i ʻole `AVP-R`?

Ma ke ʻano laulā, maikaʻi ka nānā ʻana (hopena) no nā kūlana `AVP-D` a me `AVP-R`. Inā lawe ʻoe i ka lāʻau lapaʻau kūpono a inu i ka wai lawa, ʻaʻole pono ʻoe e loaʻa i kekahi pilikia koʻikoʻi.

Eia nō naʻe, ʻoi aku ka nui o ka pilikia o kēia poʻe i nā pilikia:

• Nā pēpē
• Nā kānaka ma luna o 65 mau makahiki
• ʻO nā kānaka me kekahi mau kūlana olakino noʻonoʻo a i ʻole nā ​​​​kīnā ulu

Hiki i kēia poʻe ke paʻakikī i ka ʻike ʻana i ko lākou make wai, a i ʻole hiki ʻole ke hana i kahi hana no ia mea.

No ke aha i kapa ʻole ʻia ai kēia ʻo 'Diabetes Insipidus' i kēia manawa?

I ka makahiki 2022, ua hoʻoholo kekahi mau hui lapaʻau e hoʻololi i ka inoa ʻo 'Diabetes Insipidus' i 'Arginine Vasopressin Deficiency' a me 'Arginine Vasopressin Resistance'. ʻO ke kumu nui o kēia, ʻo ia ka huikau i hoʻokumu ʻia e ka huaʻōlelo 'diabetes' a me nā hopena maikaʻi ʻole i hoʻokumu ʻia e ia.

Ke ʻōlelo wale ka hapa nui o ka poʻe "diabetes", ʻo ia hoʻi ka maʻi diabetes mellitus . Hoʻokumu ʻia ia e ke kiʻekiʻe o ke kō koko. Loaʻa iā ia nā hōʻailona e like me ka makewai pinepine a me ka mimi ʻana. Eia nō naʻe, ʻoi aku ka maʻamau ma mua o nā kūlana `AVP-D` a me `AVP-R` (i kapa ʻia ma mua ʻo `Diabetes Insipidus`). Eia kekahi, ʻokoʻa loa ka lāʻau no ka maʻi diabetes mellitus mai ka lāʻau no `AVP-D` a me `AVP-R`.

Mai ka huaʻōlelo Helene "diabetesine" mai ka huaʻōlelo "diabetesine" ka huaʻōlelo "e hele." Hoʻohana ʻia kēlā inoa no ka mea, e like me ka maʻi diabetes, hele wikiwiki nā wai i loko o ke kino, ʻo ia ka mea e hana ʻia i kēia mau maʻi o ka arginine vasopressin.

ʻO ka mea hope loa, pono wau e haʻi aku iā ʻoe... (Leka Lawe-Home)

Inā loaʻa iā ʻoe ka `AVP-D` (arginine vasopressin deficiency) a i ʻole `AVP-R` (arginine vasopressin resistance), manaʻo paha ʻoe e like me ʻoe e noho ana i ka hapa nui o kou ola i loko o ka lumi ʻauʻau, ʻaʻole hiki ke hoʻopau i kou make wai me ka nānā ʻole i ka nui o ka wai āu e inu ai. Akā ʻo ka nūhou maikaʻi, hiki ke kāohi ʻia kēia mau kūlana.

E hoʻomohala kāu kauka i kahi hoʻolālā lapaʻau e kūpono iā ʻoe, a e haʻi pū iā ʻoe i ka nui o ka wai āu e pono ai e inu i kēlā me kēia lā e noho hydrated. Mai hopohopo. E kiʻi i ke kākoʻo a me ke alakaʻi a kāu kauka. E hoʻomanaʻo, ʻaʻole kēia he "diabetes." ʻO ia ke kumu he mea nui ka loaʻa ʻana o kahi hōʻailona kūpono a me ka lāʻau lapaʻau. ʻAʻole ʻoe hoʻokahi, e noho hoʻomaopopo, a e noho ikaika.

Nā maʻi Arginine Vasopressin, Diabetes Insipidus, AVP, ADH, Makewai nui, Mimi pinepine, Dehydration, Polydipsia, Nocturia, Desmopressin, Nā puʻupaʻa, Nā hormones