He aha nā agonists dopamine? E aʻo kākou e pili ana i kēia mau lāʻau lapaʻau ma nā ʻōlelo maʻalahi!

Aia kekahi o kou ʻohana i loaʻa i kahi maʻi neʻe e like me ka maʻi Parkinson? A i ʻole ua haʻi aku kāu kauka iā ʻoe a i ʻole kekahi āu i ʻike ai e pili ana i kahi ʻano lāʻau i kapa ʻia ʻo dopamine agonists? He mea paʻakikī paha ke kani ʻana o ka inoa, akā mai hopohopo. I kēia lā e kamaʻilio mākou e pili ana i ia mea ma ke ʻano maʻalahi loa e hiki ai iā ʻoe ke hoʻomaopopo. E heluhelu i kēia me he mea lā e kamaʻilio ana ʻoe me kahi hoaaloha.

I ka ʻōlelo maʻalahi, he aha kēia mau agonists dopamine?

I mea e hoʻomaopopo ai i kēia, e aʻo mua kākou e pili ana i ke ʻano o ka hana ʻana o ko kākou lolo. Loaʻa iā kākou nā pūnaewele i loko o kā kākou ʻōnaehana nerve. Hoʻokaʻaʻike kēia mau pūnaewele kekahi i kekahi ma o nā kemika kūikawā. Kāhea mākou i kēia mau neurotransmitters. Ua like kēia me nā ʻelele.

E noʻonoʻo i ko kākou ʻiole aʻalolo he puka me kahi honu i loko. No ka wehe ʻana i kēlā puka, pono ia i ke kī kūpono. Pēlā nō, aia i kēlā me kēia ʻiole kahi mea i kapa ʻia ʻo 'nā mea hoʻokipa' ma kona ʻili, e like me ka honu. Ua like nā neurotransmitters me nā kī e kūpono i kēlā mau honu. E like me kou hoʻokomo ʻana i ke kī, wehe ka honu a wehe ka puka, i ka wā e pili ai ka neurotransmitter i ka mea hoʻokipa, hoʻāla ka ʻiole.

He kī koʻikoʻi loa ka Dopamine i loko o ko kākou lolo, he neurotransmitter. Ke aʻo ʻoe i kekahi mea, ke hauʻoli a māʻona ʻoe, ʻo kēia dopamine ka mea e hoʻokumu ai i kēlā mau manaʻo. Eia kekahi, he mea nui ka dopamine no ko kākou mau ʻiʻo e neʻe pono.

I kēia manawa, e hele kākou i kā mākou kumuhana. He aha nā Dopamine Agonists ? I ka ʻōlelo maʻalahi, he mau lāʻau lapaʻau kēia e hana ana e like me ka dopamine . ʻO ka ʻōlelo pololei, ʻaʻole lākou he dopamine, akā ua hoʻopunipuni ʻia ko mākou mau cell lolo. ʻO ke ʻano o kēia mau molekula lāʻau lapaʻau ua like loa me nā molekula dopamine a kūpono lākou i loko o nā receptors ma kēlā mau cell a mākou i ʻōlelo ai. No laila, ke lawe ʻoe i kēia lāʻau lapaʻau, hele ia a wehe i nā puka e pono ai ka dopamine e wehe. I nā huaʻōlelo ʻē aʻe, hana kēia mau lāʻau lapaʻau i ka mea like me ka dopamine. ʻAʻole ʻike ko mākou mau cell i ka ʻokoʻa ma waena o nā mea ʻelua.

He aha ka hana a ka dopamine i ko mākou kino a me nā kūlana olakino e hoʻohana ai i kēia lāʻau lapaʻau

ʻAʻole kōkua wale ka Dopamine i ka neʻe ʻana o nā ʻiʻo. Pono nō hoʻi ia e kāohi i nā kaʻina hana koʻikoʻi ʻē aʻe i loko o ko kākou kino. Eia kekahi laʻana:

• Hana o ka puʻuwai
• Hana puʻupaʻa
• Hana o ka pancreas
• Ka hana o ka pituitary gland
• ʻO kā mākou ʻōnaehana endocrine
• ʻŌnaehana hoʻoheheʻe
• Nā ʻōnaehana hānau wahine a me ke kāne

No laila hiki paha iā ʻoe ke hoʻomaopopo i ka nui o nā pilikia e hiki mai ana inā emi nā pae dopamine i loko o ke kino. Hoʻohana ʻia nā agonists Dopamine e mālama i nā kūlana he nui i hoʻokumu ʻia e ka nele o ka dopamine.

E nānā i ka papa ma lalo no nā ʻano kūlana olakino e hoʻohana nui ʻia ai kēia mau lāʻau lapaʻau.

He aha nā pōmaikaʻi o ka hoʻohana ʻana i kēia mau lāʻau lapaʻau?

ʻAʻole nā ​​​​​​agonists Dopamine he ʻano lāʻau lapaʻau wale nō i hāʻawi ʻia. Nui nā pono maopopo o ka hoʻohana ʻana iā lākou.

• Nā hopena kūpono loa: Ua hōʻoia ka noiʻi he kūpono loa kēia mau lāʻau lapaʻau i ka mālama ʻana i nā kūlana he nui a mākou i kūkākūkā ai ma luna.
• Hiki ke hoʻohana ʻia no nā ʻano kūlana like ʻole: E like me kāu e ʻike ai, hiki ke hoʻohana ʻia kēia mau mea no nā ʻano kūlana like ʻole, mai nā maʻi neʻe o ka lolo a hiki i nā pilikia hormonal.
• Ka Hoʻohālikelike ʻana me nā lāʻau lapaʻau ʻē aʻe: He mea nui loa kēia. No ka laʻana, ke hāʻawi pū ʻia kahi agonist dopamine me ka lāʻau Parkinson ʻo 'Levodopa', hiki ke hoʻemi i ka nui o ka levodopa. ʻOiai me kahi nui haʻahaʻa, hiki ke hoʻokō ʻia nā hopena hou aʻe. Hoʻemi pū kēia i nā hopena ʻaoʻao o ka levodopa.
• Ke hoʻōla ola: Ma ke kūlana weliweli i kapa ʻia ʻo 'Neuroleptic Malignant Syndrome' a mākou i kūkākūkā ai ma luna, hiki i nā lāʻau lapaʻau dopamine agonist ke kōkua i ka hoʻopakele ʻana i nā ola.

Nā pilikia a me nā pilikia hiki ke loaʻa (nā hopena ʻaoʻao)

E like me nā lāʻau lapaʻau āpau, hiki i nā dopamine agonists ke hana i kekahi mau hopena ʻaoʻao. ʻAʻole loaʻa i nā kānaka a pau iā lākou, a ʻoi aku ka nui o ka hiki ke loaʻa iā lākou i ka piʻi ʻana o ka nui. He mea nui e makaʻala i kēia mau mea.

Nā hopena ʻaoʻao maʻamau

Eia nā hopena ʻaoʻao maʻamau:

• Ka paʻa ʻana o ka ʻōpū
• Pōʻino
• ʻEha poʻo
• ʻO ka ʻōpū ʻeha
• Nā ʻano hewa o ka puʻuwai (arrhythmia)
• Ka luaʻi a me ka luaʻi
• Ke kū koke ʻoe i luna, lilo kou mau maka i polū a manaʻo ʻoe e like me ʻoe e maule ana (Orthostatic hypotension)
• Nā neʻe ʻana o nā ʻiʻo i kāohi ʻole ʻia

Nā loli noʻonoʻo a me ke ʻano e hiki mai ana me ka hoʻohana lōʻihi

Ke hoʻohana ʻia kēia lāʻau lapaʻau no ka manawa lōʻihi, hiki ke loli kekahi mau loli noʻonoʻo a me ke ʻano.

• Hoʻomanaʻo a me ka huikau o ka noʻonoʻo
• Kaumaha
• Nā pilikia kaohi impulse
• ʻO ke ʻano hana ʻole a pīhoihoi paha (Mania)
• Nā hōʻailona like me ka psychosis, e like me ka ʻike ʻana a i ʻole ka lohe ʻana i nā hallucinations
• Ka hiamoe nui i ke ao a me nā hoʻouka hiamoe koke

Nā pilikia kaohi impulse

He hopena ʻaoʻao kēia e hopohopo nui ai. ʻOiai ua pili ka dopamine me ko kākou leʻaleʻa a me ka māʻona, ke hoʻoulu ʻia kēia ʻōnaehana e kēia mau lāʻau lapaʻau, e nalowale paha kekahi poʻe i ke kāohi ponoʻī. ʻO ia hoʻi, e hoʻowalewale ʻia paha lākou e hana i nā mea hiki ʻole iā lākou ke kāohi iā lākou iho.

E noʻonoʻo, ma hope o ka hoʻomaka ʻana o kekahi mea makemake ʻole i ka piliwaiwai e hoʻohana i kēia lāʻau lapaʻau, hoʻomaka lākou e piliwaiwai me ka ʻole o ke kāohi ʻia. Hana lākou a hiki i ka nalowale ʻana o kā lākou kālā āpau. Manaʻo paha kekahi kanaka e kūʻai me ka ʻole o ke kāohi ʻia. Hiki i kekahi ke ʻike i ka moekolohe nui.

He aha ka mea e hana ai inā e ho'ōki koke ʻoe i ka lawe ʻana i ka lāʻau lapaʻau? - Dopamine Agonist Withdrawal Syndrome (DAWS)

He mea nui loa kēia. Mai ho'ōki koke i ka lawe ʻana i kēia lāʻau lapaʻau a i ʻole e hōʻemi i ka nui me ka ʻole o ke aʻo ʻana a kāu kauka. ʻO ka hana ʻana pēlā e hiki ai ke hana i kahi maʻi i kapa ʻia ʻo Dopamine Agonist Withdrawal Syndrome (DAWS). ʻAʻole kēia he mea hoʻohui i ka lāʻau lapaʻau, akā he hopena e kū mai ana i ka wā i maʻa ai ke kino i ka lāʻau lapaʻau a hoʻōki koke i ka lawe ʻana.

I kēia kūlana, hiki ke loaʻa nā hōʻailona penei:

• Hopohopo a me nā hoʻouka kaua panic
• Ka hou nui ʻana (diaphoresis)
• Hoʻomaha ʻole
• Luhi nui
• ʻEha kino
• Ka luaʻi
• ʻO ka poniuniu i ke kū ʻana (Orthostatic hypotension)

Aia kekahi mau kumu e hoʻonui ai i ka pilikia o ka hoʻomohala ʻana i kēia kūlana DAWS. E nānā i ka papa ma lalo.

Aia kekahi mau hihia kahi e pono ʻole ai ke lawe ʻia kēia mau lāʻau lapaʻau?

ʻAe, aia kekahi mau hihia kahi i kūpono ʻole ai kēia mau lāʻau lapaʻau e hoʻohana. E noʻonoʻo kāu kauka i kēia mau mea āpau ma mua o ke kuhikuhi ʻana i ka lāʻau lapaʻau. Akā he mea maikaʻi iā ʻoe ke makaʻala i kēia.

• I ka wā hāpai a me ka hānai waiū: Hiki i kēia mau lāʻau ke kāohi i ka lactation, no laila ʻaʻole lākou e ʻōlelo ʻia i kēia mau manawa.
• Inā he koko kiʻekiʻe kou (hypertension): Hiki i kekahi mau agonists dopamine ke hoʻonui i ke koko.
• Ka pilikia o ka hoʻomohala ʻana i kekahi mau kūlana fibrosis: Aia kahi pilikia o ka hoʻomohala ʻana i nā kūlana e like me ka pulmonary fibrosis, ʻoi aku hoʻi me nā agonists dopamine kahiko (ergot-based).
• Maʻi puʻupaʻa a i ʻole ke akepaʻa: Hoʻoneʻe ʻia nā lāʻau lapaʻau mai ke kino e nā puʻupaʻa a me ke akepaʻa. Hiki i nā poʻe me nā maʻi o kēia mau ʻōkana ke hōʻiliʻili i kēia lāʻau lapaʻau i loko o ko lākou kino, e hoʻonui ana i ka pilikia o nā hopena ʻaoʻao.
• Inā ʻoe e lawe ana i kekahi mau lāʻau lapaʻau ʻē aʻe: ʻAʻole hiki ke lawe ʻia kēia mau mea inā ʻoe e lawe ana i nā lāʻau lapaʻau i kapa ʻia ʻo 'monoamine oxidase inhibitors' (MAOIs), ʻoiai nā mea i hoʻohana ʻia no ka maʻi noʻonoʻo.
• Inā ua loaʻa iā ʻoe ka psychosis ma mua: Aia kēia poʻe i ka nui o ka pilikia o ka loaʻa hou ʻana o kēia mau hōʻailona me kēia mau lāʻau lapaʻau.

He aha ka ʻokoʻa ma waena o ka Dopamine a me nā Dopamine Agonists?

E noʻonoʻo paha kekahi, inā haʻahaʻa ka dopamine, no ke aha e hiki ʻole ai ke hāʻawi pololei ʻia ka dopamine iā ia iho ma ke ʻano he lāʻau lapaʻau, a no ke aha e hāʻawi ai i kahi lāʻau lapaʻau e hana penei? Nui nā kumu no kēlā.

1. Pale Koko-Lolo: Akahele loa ko kākou lolo. ʻAʻole ia e ʻae i nā mea āpau i loko o ke koko e komo i loko o ka lolo. Loaʻa iā ia kahi kānana pale i kapa ʻia ʻo 'pale koko-lolo'. Ua like ia me kahi 'kiaʻi palekana' no ka lolo. ʻAʻole hiki i ka dopamine i lawelawe ʻia ma waho ke hele ma mua o kēia kiaʻi palekana a komo i loko o ka lolo. Eia nō naʻe, hiki i nā agonists dopamine ke hele ma mua o kēia pale a hele pololei i loko o ka lolo.

2. Nā hopena ʻaoʻao: Ke hāʻawi pololei ʻia ka dopamine ma ke ʻano he inikini, hiki iā ia ke hana i nā hopena ʻaoʻao makemake ʻole ʻia no ka mea e pili ana i ke kino holoʻokoʻa. Ua hoʻolālā ʻia nā agonists Dopamine e hana ma ke ʻano i kuhikuhi ʻia.

3. Hoʻohana lōʻihi:I ka maʻi o Parkinson, hāʻawi ʻia kahi lāʻau i kapa ʻia ʻo 'Levodopa'. Hele ia i loko o ka lolo a lilo i dopamine. Akā i ka hala ʻana o ka manawa, pono e hoʻonui ʻia ka nui o kēlā lāʻau, a laila piʻi aʻe nā hopena ʻaoʻao. No laila, ma ka hoʻohana ʻana i nā agonists dopamine i nā pae mua o ka maʻi, hiki ke hoʻopaneʻe i ka hoʻomaka ʻana o ka levodopa. Kōkua kēia i ka mea maʻi e noho maikaʻi no ka manawa lōʻihi.

Inā ua kuhikuhi ʻia kēia mau lāʻau lapaʻau iā ʻoe a i ʻole kekahi āu i ʻike ai, mai hopohopo. He mau lāʻau lapaʻau waiwai nui kēia e hiki ke hoʻomaikaʻi nui i kou ola inā hoʻohana pololei ʻia. ʻO ka mea nui loa, ʻo ia ka mālama mau ʻana i ka launa pū ʻana me kāu kauka a kamaʻilio ākea e pili ana i nā pilikia a i ʻole nā ​​​​hopena ʻaoʻao.