Ua ʻike paha ʻoe i kekahi o kou ʻohana, he hoahānau a he hoaaloha paha e mālama ʻia ana no ka maʻi kanesa. Ua lohe paha ʻoe e pili ana i ka lāʻau i kapa ʻia ʻo "Chemotherapy" i ka wā e mālama ʻia ai ia ʻano lāʻau. Ua ʻike paha ʻoe i ka wā o kēia mālama chemo, ua emi ka nui o nā hunaola koko keʻokeʻo e hakakā ana i nā maʻi i loko o ke kino. I loko o ia kūlana, ma kēia ʻatikala, e kamaʻilio mākou e pili ana i kahi lāʻau lapaʻau kūikawā a nā kauka e hoʻohana ai e kōkua i ka ʻōnaehana pale o ko mākou kino. ʻO ia ʻo G-CSF.
He aha maoli ka G-CSF?
I ka ʻōlelo maʻalahi, he lāʻau lapaʻau ʻo G-CSF e kōkua i ko mākou kino e hana i nā hunaola koko keʻokeʻo hou aʻe, ʻoiai kahi ʻano i kapa ʻia ʻo "neutrophils."
E noʻonoʻo ʻoe ua like ko kākou kino me kahi ʻāina. A laila ua like kēia mau neutrophils me nā koa ma ia ʻāina. ʻO kēia mau koa i kapa ʻia he neutrophils e hakakā nei i nā germs o waho, ʻo ia hoʻi, nā ʻenemi e like me nā bacteria a me nā virus, a pale iā mākou mai nā maʻi a me nā maʻi. No laila he aha ka mea e hana ai inā emi kēia mau koa? ʻO ko kākou ʻāina, ʻo ia hoʻi ko kākou kino, e lilo i mea maʻalahi i nā maʻi.
ʻOiai paha he mea paʻakikī iki ka inoa ʻo G-CSF, inā mākou e wāwahi iā ia, he maʻalahi loa kona manaʻo.
- Granulocyte: ʻO kēia ka inoa i hāʻawi ʻia i kahi ʻano o ke koko keʻokeʻo. ʻO nā neutrophils kekahi ʻano granulocyte.
- ʻO ke kumu hoʻoulu koloni: He mea kēia e "kauoha" a "hoʻoulu" paha i nā cell. E like me ka luna hale hana e hāʻawi ana i nā hana i nā limahana, hele kēia protein i ko kākou iwi iwi a ʻōlelo, "ʻAe, e hoʻomaka e hana i nā neutrophils i kēia manawa."
No laila, ʻo ka hana a kēia lāʻau i kapa ʻia ʻo G-CSF, ʻo ia ke hele ʻana i ka iwi ʻiʻo , ʻo ia ka ʻāpana e like me ka huʻa i loko o ko kākou mau iwi, a haʻi aku ia i nā hunaola kumu ma laila, "Pono ʻoukou e lilo koke i neutrophils, a ʻo nā neutrophils ma laila e māhele a hoʻonui." A laila, hui pū kēia mau koa neutrophil i hoʻokumu hou ʻia me ke koko a hoʻomaka e hana e pale iā mākou.
ʻO ka mea nui, ʻoiai he lāʻau lapaʻau synthetic ʻo G-CSF, hoʻohālike ia i ke kaʻina hana o kahi protein i hana maoli ʻia i loko o ko mākou kino.
I nā kūlana hea e hoʻohana ʻia ai ʻo G-CSF?
Hoʻohana nui ʻia ʻo G-CSF e mālama a pale i kahi maʻi i kapa ʻia ʻo "neutropenia." ʻO ka Neutropenia he haʻahaʻa wale nō ia ma mua o ka helu maʻamau o nā neutrophils i loko o ke koko.
I ka mālama ʻana i ka maʻi kanesa (Chemotherapy)
Ua hoʻolālā ʻia nā lāʻau lapaʻau chemotherapy i hoʻohana ʻia i ka mālama ʻana i ka maʻi kanesa e pepehi i nā hunaola kanesa e māhele wikiwiki ana. Eia naʻe, ʻaʻole hiki i kēia mau lāʻau ke ʻike ʻaʻole wale i nā hunaola kanesa, akā, i nā hunaola olakino hoʻi e māhele wikiwiki ana i loko o ko kākou kino. No laila, ʻoiai ʻo nā neutrophils, i hana ʻia i loko o ka iwi iwi, he ʻano hunaola māhele wikiwiki hoʻi, ua hōʻino ʻia hoʻi lākou e nā lāʻau chemo.
Ua like kēia me ka pīpī ʻana i ka herbicide e hoʻopau i nā nāhelehele, akā ua hōʻino nō hoʻi ia i nā mea kanu maikaʻi.
ʻO kēia ke kumu i maʻamau ai ka neutropenia ma hope o ka chemotherapy. Inā lilo kēia ʻano i mea koʻikoʻi, hiki i kahi maʻi liʻiliʻi ke hoʻoweliweli i ke ola. I kēlā mau hihia, paipai nā kauka i ka G-CSF e hōʻemi i ka pilikia o ka maʻi a hoʻihoʻi i nā pale o ke kino.
I loko o kahi hoʻoili pūnaewele kumu
I kekahi mau ʻano maʻi kanesa a me nā maʻi koko, pono ka hoʻoili ʻana o nā cell kumu. Hoʻohana ʻia ʻo G-CSF ma mua a ma hope o kēia kaʻina hana.
- Ma mua o ke kāpili ʻana: Ke hāʻawi ʻia ka G-CSF i ka mea maʻi, hana ka iwi iwi i kahi nui o nā hunaola kumu a hoʻokuʻu iā lākou i loko o ke koko. A laila hōʻiliʻili nā kauka i kēlā mau hunaola kumu olakino mai ke koko.
- I ka wā o ke kāpili ʻana: ʻO ka mea aʻe, hoʻopau ka chemotherapy kiʻekiʻe a i ʻole ka radiation therapy i nā ʻāpana ʻē i koe i loko o ke kino.
- Ma hope o ke kāpili ʻana: ʻO ka hope loa, hoʻokomo hou ʻia nā hunaola kumu olakino i hōʻiliʻili mua ʻia i loko o ke kino. Ma hope aku, e lilo kēia mau hunaola i mau hunaola koko hou a olakino.
Inā he mea hāʻawi pūnaewele kumu ʻoe, pono paha ʻoe e loaʻa i kahi inikini G-CSF ma mua o ke kaʻina hana.
Nā kūlana ʻē aʻe e hoʻoulu ai i nā neutrophils haʻahaʻa
Hiki ke haʻahaʻa nā pae Neutrophil ma muli o kekahi mau kūlana i loaʻa i ka wā hānau (neutropenia congenital koʻikoʻi) a i ʻole i nā hihia i ʻike ʻole ʻia ai ke kumu (idiopathic neutropenia). I ia mau hihia, hoʻohana ʻia ʻo G-CSF e hoʻonui i nā pae neutrophil.
Nā ʻano o G-CSF a pehea e hāʻawi ʻia ai
Loaʻa ʻo G-CSF ma ka mākeke ma lalo o nā inoa like ʻole. ʻO nā ʻano ʻelua i hoʻohana nui ʻia:
1. Filgrastim: He ʻano hana pōkole kēia. Pono e hāʻawi ʻia ma ke ʻano he inikini i kēlā me kēia lā.
2. Pegfilgrastim: He ʻano hana lōʻihi kēia o ka lāʻau, no laila ua lawa pinepine ka loaʻa ʻana o hoʻokahi inikini ma waena o ʻelua mau pōʻai o ka chemotherapy.
Loaʻa kēia mau lāʻau lapaʻau ma lalo o nā inoa inoa like ʻole a me nā biosimilars. No ka laʻana, hiki paha i kāu kauka ke haʻi iā ʻoe e pili ana i nā inoa e like me Neupogen®, Neulasta®, Nivestym®, a me Zarxio®.
| ʻAno o G-CSF | Ka nui o nā manawa i hāʻawi ʻia (maʻamau) |
|---|---|
| Filgrastim (manawa pōkole) | I kēlā me kēia lā (i kekahi mau lā a i ʻole mau pule) |
| Pegfilgrastim (lōʻihi) | Hoʻokahi manawa i kēlā me kēia pōʻaiapuni chemo |
Pehea e hāʻawi ʻia ai kēia lāʻau i ke kino?
Hāʻawi pinepine ʻia ʻo G-CSF ma ke ʻano he inikini subcutaneous , akā i kekahi mau hihia hiki ke hāʻawi ʻia ma ke ʻano he infusion IV .
- Pono paha ʻoe e hele i ke keʻena lapaʻau i kēlā me kēia lā e loaʻa ai ka lāʻau pale.
- A i ʻole, e aʻo maopopo aku kekahi kahu maʻi iā ʻoe a i ʻole kekahi lālā o ka ʻohana pehea e hoʻokomo ai i ka lāʻau pale ma ka home. ʻAʻole ia he mea paʻakikī.
Pono anei nā kānaka a pau i ka G-CSF?
ʻAʻole. ʻAʻole hāʻawi ʻia ʻo G-CSF i nā mea a pau e hana ʻia ana i ka chemotherapy a i ʻole ka poʻe i loaʻa nā neutrophils haʻahaʻa. E like me nā lāʻau lapaʻau a pau, loaʻa iā G-CSF nā pono a me kekahi mau pilikia o nā hopena ʻaoʻao. E noʻonoʻo kāu kauka i kekahi mau mea ma mua o ke kuhikuhi ʻana i kēia lāʻau.
- kou mau makahiki
- Kou kūlana olakino holoʻokoʻa
- ʻO ke ʻano o ka maʻi kanesa āu i loaʻa ai
- ʻO ke ʻano o ka chemotherapy āu e loaʻa nei
- Inā loaʻa iā ʻoe nā hōʻailona o ka neutropenia (e like me ke kuni)
No laila, ʻo ka hoʻoholo inā pono a ʻaʻole paha ʻo G-CSF na ke kauka e mālama nei iā ʻoe. ʻAʻole pono ʻoe e hopohopo no ia mea.
Nā pōmaikaʻi a me nā hopena ʻaoʻao o G-CSF
Inā ʻōlelo ʻia ʻo G-CSF, e hoʻomanaʻo he ʻoi aku ka nui o nā pono ma mua o nā pilikia.
Nā pono nui:
- Ua hoʻemi nui ʻia ka pilikia o nā maʻi koʻikoʻi e hoʻoweliweli ana i ke ola.
- Hiki i nā pae neutrophil haʻahaʻa ke pale i ka hoʻopaneʻe ʻia ʻana a i ʻole ka hoʻemi ʻia ʻana o ka nui o ka chemotherapy , e ʻae ana i ka hoʻomau ʻana o ka mālama ʻana i ka maʻi kanesa e like me ka hoʻolālā.
Nā hopena ʻaoʻao hiki ke loaʻa
He manawa pōkole ka hapa nui o nā hopena ʻaoʻao a nalo ma hope o ka hoʻōki ʻana o G-CSF.
| Ka hopena ʻaoʻao | Ka wehewehe a me ka hoʻokele |
|---|---|
| Nā hopena ʻaoʻao maʻamau | |
| ʻEha i nā iwi a me nā ʻiʻo | ʻO kēia ka hopena ʻaoʻao maʻamau. Ua like ia me "nā ʻeha ulu" no ka mea ke hana koke nei ka iwi iwi i nā cell he nui loa. Hiki iā ʻoe ke nīnau i kāu kauka e pili ana i ka lawe ʻana i kahi lāʻau hoʻopau ʻeha e like me ka paracetamol. |
| Luhi | E luhi paha ʻoe no ka mea ke hoʻohana nei kou kino i ka ikehu hou aʻe e hana i nā ʻāpana hou. E hoʻomaha nui. |
| ʻEha poʻo, nausea, diarrhea | He ʻoluʻolu kēia mau mea maʻamau. E kuhikuhi ke kauka i nā lāʻau lapaʻau kūpono no kēia mau mea. |
| ʻUlaʻula, maneʻo, a ʻeha paha ma kahi i hoʻokomo ʻia | Nalo pinepine kēia i hoʻokahi a ʻelua paha lā. |
| Nā hōʻailona koʻikoʻi (akā kakaikahi) e pono e hōʻike koke ʻia i ke kauka | |
| Nā hōʻailona o kahi maʻi | Kuni, anu, ʻeha ka puʻu, ʻū. He mau hōʻailona paha kēia o kahi maʻi. E haʻi koke aku i kāu kauka. |
| Nā hōʻailona o kahi hopena alerika | ʻŌhūhū ʻili, maneʻo, pehu o ka maka a i ʻole nā lehelehe, paʻakikī ka hanu ʻana. He pilikia kēia. E hele koke i ka ʻOihana Pilikia o ka haukapila (ETU). |
| ʻEha nui ma ka ʻaoʻao hema o luna o ka ʻōpū | He hōʻailona paha kēia o kahi pilikia kakaikahi loa me ka spleen. |
| ʻO ka pehu koke ʻana o nā lālā, ka paʻakikī o ka hanu ʻana | He mau hōʻailona paha kēia o nā kūlana kakaikahi loa akā koʻikoʻi e like me ka capillary leak syndrome a i ʻole ARDS. E ʻimi koke i ke kōkua lapaʻau. |
Nā mea e hoʻomanaʻo ai i ka wā e lawe ai iā G-CSF
- E haʻi i kāu kauka i kāu mōʻaukala olakino piha. E hōʻoia e hoʻomaopopo iā ia e pili ana i nā maʻi ʻē aʻe āu e loaʻa nei a me nā lāʻau lapaʻau ʻē aʻe āu e lawe nei (me nā huaora).
- ʻAʻole ʻōlelo ʻia e lawe i ka G-CSF inā ʻoe e hāpai ana, e hoʻāʻo ana e hāpai, a i ʻole e hānai waiū ana . E kamaʻilio me kāu kauka e pili ana i kēia.
- Mai hopohopo e pili ana i nā hopena ʻaoʻao. Inā loaʻa iā ʻoe kekahi mau hopena ʻaoʻao, e haʻi i kāu kauka a kahu maʻi paha. Na lākou e kōkua iā ʻoe e hoʻokele iā lākou.
- E hana i kāu mau hoʻāʻo koko i ka manawa kūpono. E nānā kāu kauka i kāu mau pae neutrophil a hoʻoholo i ka lōʻihi o ka lāʻau e pono ai.
He mea kōkua koʻikoʻi loa ʻo G-CSF i ke kaʻina hana mālama maʻi kanesa. Hāʻawi ia i kahi hoʻoikaika nui e hoʻolilo i nā lāʻau lapaʻau chemotherapy i mea palekana a ʻoi aku ka holomua. Inā he mau nīnau hou kāu e pili ana i kēia, mai kānalua e nīnau i kāu kauka lapaʻau.
Leka Lawe-Home
- ʻO G-CSF kahi lāʻau lapaʻau e hoʻonui ai i ka hana ʻana o kahi ʻano koko keʻokeʻo i kapa ʻia ʻo neutrophils i loko o ke kino.
- Hoʻemi kēia i ka pilikia o nā maʻi koʻikoʻi e hiki ke loaʻa i ka wā o ka mālama ʻana i ka chemotherapy.
- ʻO ka ʻeha o ka iwi a me nā ʻiʻo ka hopena maʻamau loa a hiki ke mālama ʻia.
- Inā loaʻa iā ʻoe ke kuni, pilikia ka hanu ʻana, a i ʻole nā hōʻailona maʻi ʻaleka koʻikoʻi, e hoʻomaopopo koke i kāu kauka a i ʻole e hele i ka haukapila.
- Inā he mau hopohopo kāu e pili ana i kēia lāʻau lapaʻau, mai kānalua e kūkākūkā me kāu kauka.
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