Hiki iā ʻoe ke noʻonoʻo i ko mākou kino e like me kahi puke kuhikuhi nui. Kāhea mākou i nā kuhikuhi liʻiliʻi ma kēia puke kuhikuhi he "genes" . Hoʻoholo kēia mau genes i nā mea āpau i loko o ko mākou kino, no ka laʻana, ke kala o ko mākou mau maka, ke ʻano o ko mākou lauoho. No laila, i kekahi manawa he hewa liʻiliʻi i kekahi o nā kuhikuhi ma kēia puke kuhikuhi, ʻo ia hoʻi, inā hoʻololi ʻia kahi leka, hiki ke hoʻoulu i nā maʻi koʻikoʻi. I kēia lā ke kamaʻilio nei mākou e pili ana i kahi ʻano lapaʻau holomua loa e hoʻoponopono ana i kēlā mau kuhikuhi hewa, a i ʻole e hoʻokomo i kahi kuhikuhi pololei hou. Ua kapa ʻia kēia he gene therapy.
He aha ka maʻalahi o ka gene therapy?
I ka ʻōlelo maʻalahi, he ʻano kūikawā ka lāʻau lapaʻau gene no ka mālama ʻana i nā maʻi genetic. Hāʻawi nā genes o ko mākou kino i nā ʻōlelo kuhikuhi no ka hana ʻana i nā protein. Inā loli a hewa paha kahi gene, hiki ke hana hewa ʻia ka protein āna e hana ai a i ʻole e hoʻōki loa ʻia. ʻO kēia ke kumu o nā maʻi genetic.
Hoʻololi ka lāʻau lapaʻau Gene i ka gene hewa e hoʻoulu ai i ka maʻi , a i ʻole e hāʻawi i kāu mau cell i kope hana hou o kahi gene . He lāʻau lapaʻau hoʻokahi manawa kēia. Ma hope o kēia lāʻau lapaʻau, hiki i kou kino ke hana i nā protein e pono ai me ka pololei, kahi e hōʻoluʻolu ai i nā hōʻailona.
Pehea e hana ai kēia lāʻau lapaʻau?
ʻEkolu mau ala nui e hana ai ka lāʻau lapaʻau gene. E nānā kākou i ka papa ma lalo nei e hoʻomaopopo pono ai i kēia.
| ʻAno lapaʻau | I ka ʻōlelo maʻalahi... | E aha hana ʻoe? |
|---|---|---|
| Hoʻohui Gene | Ke hoʻokomo nei i kahi gene maikaʻi hou. | Inā ʻaʻole i hana ʻia kahi protein e pono ai i loko o ke kino ma muli o kahi kīnā i loko o kahi gene kikoʻī, hoʻokomo ʻia kahi kope o kahi gene olakino e hiki ke hana i kēlā protein i loko o nā pūnaewele. |
| Hoʻoponopono Gene | Ke hoʻoponopono nei i ka gene hewa. | Hoʻohana nā kānaka ʻepekema i nā mea hana kūikawā e like me CRISPR/cas9 e "ʻoki a kāpili" i ka gene hewa e hoʻoulu ai i ka maʻi. A laila, hoʻomaka kēlā gene e hana i ka protein kūpono. |
| Hoʻopau ʻana i nā Gene | Ke hoʻopau nei i ka gene hewa. | Hana hewa kekahi mau genes a hana i nā protein e hōʻino i ke kino. Hoʻōki kēia ʻano hana i ka hana o kahi gene e hāʻawi ana i kēlā mau kuhikuhi hewa. ʻO ia hoʻi, ua hāmau ʻia. |
Pehea ʻoe e hoʻokomo ai i kēia mau genes i hoʻololi ʻia i loko o ke kino?
ʻAe, i kēia manawa he nīnau kāu: Pehea ʻoe e hoʻokomo ai i kēia mau genes i hoʻololi ʻia i loko o ke kino? Hoʻopili nā kānaka ʻepekema i kēia mau genes i loko o kahi mea e like me kahi pūʻolo. Ua kapa ʻia kēia pūʻolo he "vector." ʻO kēia vector he virus i hoʻololi kūikawā ʻia.
Mai hopohopo! ʻAʻole kēia he maʻi e hoʻomaʻi ai iā kākou. Ua hoʻopau loa ia i kona hiki ke hoʻomaʻi iā kākou, a ua hoʻokomo ʻia me ko kākou mau genes olakino. E like me ke kaʻa lawe, ʻo ka hana wale nō a kēia mea lawe ka lawe ʻana i nā genes a hāʻawi iā lākou i nā cell kūpono.
I kekahi mau lāʻau lapaʻau, lawe ʻia kekahi o kāu mau hunaola koko ponoʻī, hoʻololi ʻia i loko o kahi keʻena hoʻokolohua, a laila hoʻihoʻi ʻia i loko o kou kino. I nā hihia ʻē aʻe, hāʻawi ʻia kahi mea lawe i loaʻa kēia mau genes ma ke ʻano he injection a i ʻole he infusion i loko o kahi aa. I ka hala ʻana o ka manawa, māhele a hoʻonui nā cell me kēia mau genes hou, e pani ana i nā cell maʻi. No laila, pono e lōʻihi nā hopena o kēia lāʻau lapaʻau.
He aha nā maʻi e hiki ke ho'ōla ʻia me ka gene therapy?
ʻO ka hoʻōla ʻana o ka gene ka mea i kūleʻa pinepine no nā maʻi i hoʻokumu ʻia e kahi kīnā gene hoʻokahi. Eia kekahi o nā maʻi i ʻae ʻia ai kēia lāʻau lapaʻau i kēia manawa:
- Nā maʻi hoʻoilina e hoʻopilikia ai i ka lolo, e like me Cerebral Adrenoleukodystrophy .
- Nā maʻi koko hoʻoilina: No ka laʻana , ka maʻi sickle cell, thalassemia, a me ka hemophilia .
- Nā maʻi neuromuscular i hoʻoilina: Nā kūlana e like me Duchenne Muscular Dystrophy a me Spinal Muscular Atrophy.
- Nā maʻi maka i hoʻoilina ʻia: Nā maʻi e hoʻopilikia ai i ka ʻike maka, e like me ka Leber's Congenital Amaurosis.
- Nā maʻi ʻē aʻe e like me ka Metachromatic Leukodystrophy.
Eia kekahi, ʻo ka maʻi kanesa a me ka maʻi HIVKe noiʻi nei nā kānaka ʻepekema inā hiki ke hoʻohana ʻia ka lāʻau lapaʻau gene no nā maʻi e like me ...
He aha nā pōmaikaʻi a me nā pōʻino o ka gene therapy?
E like me nā lāʻau lapaʻau āpau, loaʻa i ka lāʻau lapaʻau gene kona mau pono a me kekahi mau pilikia a me nā hemahema. He mea nui e makaʻala i kēia mau mea.
| Nā Pōmaikaʻi | Nā Pōʻino a me nā Palena |
|---|---|
| Manaʻolana Hou: Hāʻawi i nā koho lapaʻau hou no nā maʻi he nui i nele i nā koho lapaʻau ʻē aʻe. | Paʻakikī i ka loaʻa ʻana: Ma muli o ke kumukūʻai kiʻekiʻe a me nā palena o ka ʻenehana, ʻaʻole hiki i nā kānaka āpau ke loaʻa i kēia lāʻau lapaʻau. |
| Ka maʻalahi: ʻO ka hapa nui o nā lāʻau lapaʻau gene he mau lāʻau lapaʻau hoʻokahi wale nō i ke ola. ʻAʻole pono ʻoe e lawe i ka lāʻau lapaʻau i kēlā me kēia lā. | Nā hopena ʻaoʻao: E like me nā lāʻau lapaʻau āpau, aia kahi pilikia o nā hopena ʻaoʻao. No ka laʻana, hiki i ka ʻōnaehana pale o ke kino ke pane i ka mea lawe gene (virus). |
| Lāʻau lapaʻau mua: Inā hiki ke loaʻa kēia lāʻau lapaʻau ma mua o ka hōʻeha nui ʻana o ka maʻi i ke kino, hiki ke pale ʻia kēlā hōʻino. | Ke kaʻina hana hoʻomākaukau: Pono kekahi mau lāʻau lapaʻau gene i nā lāʻau ʻē aʻe, e like me ka chemotherapy, ma mua o ka mālama ʻana, hiki ke hana i nā hopena ʻaoʻao maikaʻi ʻole. |
| Ke mālama ʻana i ke kumu o ka maʻi: Ma kahi o ka mālama wale ʻana i nā hōʻailona, mālama mākou i ke kumu nui o ka maʻi, ʻo ia hoʻi ke kīnā hoʻoilina ponoʻī. | He kahua hou nō naʻe: ʻOiai ua noho kēia i ke kahua noiʻi no nā makahiki he ʻumi, he mea hou nō kona hoʻohana ʻana i ka lāʻau lapaʻau. Nui nō nā mea e aʻo ai. |
He manaʻolana nui ka lāʻau lapaʻau Gene no ka poʻe me nā maʻi genetic. Hiki iā ia ke mālama i ke kumu o kahi maʻi, ma mua o nā hōʻailona wale nō. ʻOiai he kahua hou kēia, loaʻa iā ia ka hiki ke hāʻawi i nā hopena hoʻololi ola no nā poʻe maʻi i loaʻa ʻole nā koho lapaʻau i ka wā ma mua. Inā loaʻa iā ʻoe a i ʻole kekahi o kou ʻohana kahi maʻi genetic, ʻoi aku ka maikaʻi o ke kamaʻilio ʻana me kāu kauka e pili ana i kēia a aʻo hou aʻe.
Leka Lawe-Home
- ʻO ka Gene therapy kahi ʻano lapaʻau holomua e hoʻoponopono ana i ke kīnā genetic ma lalo e kumu ai kekahi mau maʻi genetic.
- Hoʻoponopono kēia i kahi gene hewa a hoʻokomo paha i kahi kope o kahi gene olakino i loko o ke kino.
- ʻOiai he hana hoʻokahi wale nō kēia, ʻaʻole ia he mea maʻamau ma nā wahi āpau o ka honua a he pipiʻi hoʻi.
- E like me kēlā me kēia lāʻau lapaʻau, aia nā pōmaikaʻi, nā pilikia, a me nā hopena ʻaoʻao.
- He mea nui mau e kūkākūkā i kēia me kāu kauka ma mua o ka hoʻoholo ʻana e pili ana i ia mau lāʻau lapaʻau.
💬 Comments (0)
ʻAʻohe manaʻo i kau ʻia. Hoʻohui i kāu manaʻo ma ʻaneʻi no ka manawa mua.
Hoʻohui i kāu manaʻo