Ua kuhikuhi anei kāu kauka iā ʻoe i ka lāʻau lapaʻau no ke kaumaha? A i ʻole ke hoʻohana nei kekahi āu i ʻike i kēia lāʻau lapaʻau? ʻOiai he nui nā moʻolelo i loko o ke kaiāulu e pili ana i kēia lāʻau lapaʻau, ehia ka poʻe i ʻike maoli i ke ʻano o kona hopena i ka lolo a me ka hopena? Nui ka poʻe e makaʻu nei i kēia lāʻau lapaʻau, akā ʻo ke kumu o kēlā makaʻu, ʻo ia ka naʻaupō. No laila, e hoʻomaopopo kākou i kēia me ka maʻalahi a me ka maopopo i kēia lā, me he mea lā e kamaʻilio ana kākou me kahi hoaaloha.
He aha kēia mau mea antidepressants?
ʻOiai ua kapa ʻia kēia mau lāʻau lapaʻau he 'antidepressants', ʻaʻole lākou e hoʻohana wale ʻia no ka mālama ʻana i ke kaumaha, kahi maʻi noʻonoʻo e hoʻoulu ai i nā manaʻo o ka hopohopo nui a me ka manaʻolana ʻole. Ua hoʻolauna mua ʻia kēia mau lāʻau lapaʻau i nā makahiki 1950. I kēia lā, me ke kaumaha, ua ʻae ʻia kēia mau lāʻau lapaʻau no nā kūlana e like me OCD (Obsessive-Compulsive Disorder), Social Phobia, Panic Disorder, GAD (Generalized Anxiety Disorder), a me PTSD (Posttraumatic Stress Disorder).
Eia kekahi, hiki i nā kauka ke kuhikuhi i kēia lāʻau lapaʻau i kekahi manawa no nā kūlana e like me ka ʻeha mau loa, ka insomnia, a me ka migraines. Ua kapa ʻia kēia he hoʻohana 'off-label'. ʻO ke ʻano kēia ʻaʻole i ʻae ʻia ka lāʻau lapaʻau no kēlā kūlana, akā manaʻoʻiʻo ke kauka e pōmaikaʻi ka mea maʻi mai ia mea.
Pehea ka hopena o kēia lāʻau lapaʻau i ko kākou lolo?
I ka ʻōlelo maʻalahi, hana kēia mau lāʻau lapaʻau ma ka hoʻololi ʻana i nā pae o kekahi mau kemika i loko o ko kākou lolo. Kāhea mākou i kēia mau kemika he mau neurotransmitters . ʻO kēia nā mea e kaohi ana i nā mea he nui, e like me ko kākou ʻano, nā manaʻo, ka hiamoe, a me ka makemake.
E noʻonoʻo i kēia ʻano. Hoʻohana nā ʻiole nerve i loko o ko kākou lolo i kēia mau 'ʻelele' i kapa ʻia he neurotransmitters e kamaʻilio pū kekahi me kekahi. Hoʻokuʻu kekahi ʻiole nerve i kēia ʻelele, e hoʻouna ana i ka leka i ke kelepona aʻe. Ma hope o ka hāʻawi ʻia ʻana o ka leka, lawe koke ʻia ka ʻelele i loko o ke kelepona mua (ua kapa ʻia kēia he reuptake ).
ʻO ka mea nui a nā lāʻau antidepressants e hana ai, ʻo ia ka hoʻopaneʻe iki ʻana i kēlā kaʻina hana reuptake. A laila noho kēlā ʻelele (no ka laʻana, serotonin) ma ka hakahaka ma waena o nā hunaola nerve ʻelua (ka synapse) no ka manawa lōʻihi. A laila hiki iā ia ke hana lōʻihi a hoʻomaikaʻi i ko mākou ʻano.
ʻO ka ʻoiaʻiʻo, ʻaʻole maopopo 100% i nā loea pehea e hana ai kēia mau lāʻau lapaʻau, no ka mea, he mea paʻakikī loa ka lolo kanaka. Akā ua hōʻike ʻia e ka noiʻi hiki iā lākou ke kōkua i ka kaohi ʻana i nā hōʻailona.
Nā ʻano mea hoʻopale reuptake i hoʻohana pinepine ʻia
No kēia hui nā antidepressants i kuhikuhi pinepine ʻia i kēia manawa. Ua māhele ʻia lākou i kekahi mau ʻano nui.
1. Nā SSRI (Nā mea pale i ka hoʻihoʻi hou ʻana o ka serotonin koho)
ʻO kēia nā lāʻau lapaʻau mua a nā kauka e kuhikuhi pinepine ai. E like me ka inoa e hōʻike nei, kuhikuhi pono kēia i ka neurotransmitter serotonin . He mea nui ka Serotonin no nā mea e like me ko kākou ʻano, ke ʻano, a me ka hoʻomanaʻo.
Ke hoʻomaka ʻoe e lawe i kēia lāʻau lapaʻau, hiki ke hala i kekahi mau pule, i kekahi manawa a hiki i 2-3 mau mahina, e ʻike i nā hopena piha. No laila he mea nui e hoʻomanawanui. Eia kekahi, mai hoʻōki koke i ka lawe ʻana i kēia lāʻau lapaʻau me ka ʻole o ke aʻo ʻana a kāu kauka. ʻO ka hana ʻana pēlā e hiki ai ke hana i nā hōʻailona ʻoluʻolu ʻole (antidepressant discontinuation syndrome).
ʻO ka maʻi Serotonin - He mea e hopohopo ai!
I kekahi manawa, ke lawe ʻoe i nā lāʻau lapaʻau ʻē aʻe e hoʻonui ai i nā pae serotonin, e like me SSRIs, hiki i ka nui o ka serotonin i loko o ka lolo ke piʻi pono ʻole. Hiki ke lilo kēia i mea weliweli.
| Nā hōʻailona maʻamau o ka Serotonin Syndrome | |
|---|---|
| - Hopohopo, hoʻomaha ʻole | - Nā haumāna i hoʻonui ʻia |
| - Ka luaʻi, ka ʻeha o ka ʻōpū, ka ʻeha o ka naʻau | - Ka ʻūlū ʻana o nā ʻiʻo, ka ʻoʻoleʻa |
| - Ka hou nui ʻana, ka haʻalulu | - Ka neʻe wikiwiki ʻana o nā maka mai kēlā ʻaoʻao a i kēia ʻaoʻao |
| Nā hōʻailona koʻikoʻi e pono ai ke komo koke ʻana i ka haukapila: | |
| - Huikau nui a i ʻole delirium | - Kuni kiʻekiʻe |
| - He wikiwiki loa ka helu o ka puʻuwai | - Nā hopu ʻana |
| - Ke koko kiʻekiʻe | - Poho o ka ʻike |
Inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona koʻikoʻi, e hele koke i ka Emergency Treatment Unit (ETU) o ka haukapila kokoke loa .
2. Nā SNRI (Serotonin-Norepinephrine Reuptake Inhibitors)
He papa lāʻau lapaʻau holomua iki kēia i hele mai ma hope o nā SSRI. Hoʻopilikia lākou i nā neurotransmitters serotonin a me norepinephrine . He mea nui ka Norepinephrine no ko mākou nānā a me ka makaʻala. ʻO ia ke kumu e hoʻohana ʻia ai kēia mau lāʻau lapaʻau i kekahi manawa e mālama i ka ʻeha mau (e.g., diabetic neuropathy, fibromyalgia).
- Nā laʻana maʻamau: Duloxetine (Cymbalta), Venlafaxine (Effexor)
- Nā hopena ʻaoʻao maʻamau: ka nausea, ka waha maloʻo, ka luhi, ka hiamoe, ka poniuniu, ka hou.
3. Nā NDRI (Nā mea pale i ka hoʻihoʻi ʻana o Norepinephrine a me Dopamine)
Hoʻonui kēia lāʻau lapaʻau i nā pae o nā neurotransmitters norepinephrine a me dopamine . He mea nui ka Dopamine no ko mākou hauʻoli, ka hoʻoikaika, a me ka nānā ʻana.
- ʻO kahi laʻana nui: Bupropion (Wellbutrin). He lāʻau lapaʻau kēia e hiki ke kōkua iā ʻoe e hoʻōki i ka puhipaka.
- Hoʻomaopopo kūikawā: He emi iki nā hopena ʻaoʻao moekolohe ma mua o nā lāʻau antidepressant ʻē aʻe. Eia nō naʻe, ʻaʻole kūpono ia no ka poʻe i pilikia i ka loaʻa ʻana o nā hopu.
Nā ʻano ʻē aʻe, kahiko akā he mea nui nō naʻe
ʻOiai ʻaʻole hoʻohana nui ʻia kēia mau lāʻau lapaʻau i kēia manawa, hiki iā lākou ke lilo i mea pono loa no kekahi poʻe i pane ʻole i nā lāʻau lapaʻau hou. Eia nō naʻe, he nui nā hopena ʻaoʻao.
ʻO nā antidepressants Tricyclic a me tetracyclic (TCAs)
He mau lāʻau lapaʻau kahiko kēia i hoʻohana ʻia mai ka makahiki 1950. ʻOiai ua like ko lākou hopena me nā lāʻau lapaʻau hou, ʻoi aku ka nui o nā hopena ʻaoʻao. Eia kekahi laʻana, hiki iā lākou ke hoʻoulu i ka hiamoe, ka waha maloʻo, ka piʻi ʻana o ke kaumaha, a me nā loli i ka helu o ka puʻuwai.
- Nā laʻana maʻamau: Amitriptyline, Nortriptyline, Clomipramine.
Nā mea hoʻopaʻa monoamine oxidase (MAOI)
He mau lāʻau lapaʻau kahiko loa kēia a kākaʻikahi ka hoʻohana ʻia. I ka hoʻohana ʻana i kēia mau mea , pono ʻoe e makaʻala loa i kāu mea e ʻai ai. No ka mea, inā ʻoe e ʻai i nā meaʻai i loaʻa ka waikawa amino 'Tyramine' (e.g., tīhi kahiko, soy sauce, kekahi mau ʻiʻo, kekahi mau huaʻai), hiki i kou koko ke piʻi aʻe i ka weliweli. Eia kekahi, ʻo ka lawe ʻana i kēia mau mea me nā antidepressants ʻē aʻe he mea weliweli loa ia.
He mea nui loa e hoʻomaopopo i kāu kauka e pili ana i nā lāʻau lapaʻau, nā huaora, a i ʻole nā huahana lāʻau āu e lawe nei, no ka mea, hiki i kēia mau lāʻau ke launa pū.
Nā Nutraceuticals e hiki ke lawe ʻia e kōkua me ka lāʻau lapaʻau
ʻAʻole kēia he mau lāʻau lapaʻau, akā he mau mea hoʻohui meaʻai a i ʻole nā mea hoʻohui meaʻai e hiki ke kōkua i kekahi mau kūlana olakino. ʻAʻole ʻōlelo ʻia lākou no ka hoʻohana wale ʻana no ke kaumaha. Eia nō naʻe, hiki ke hoʻohana ʻia me ka lāʻau lapaʻau maʻamau, e like me ka ʻōlelo a kāu kauka.
- SAMe (S-adenosyl-methionine): He kemika i hana ʻia e ke kino e kōkua ai i ka hana ʻana i nā neurotransmitters.
- ʻO nā Omega-3 Momona ʻakika: ʻO kēia mau mea, i loaʻa nui i ka ʻaila iʻa, hiki ke kōkua i ka hōʻemi ʻana i kekahi mumū i loko o ka lolo.
- Wikamina D: Hōʻike nā noiʻi aia kahi pilina ma waena o ka nele o kēia wikamina, i loaʻa mai ka lā, a me ke kaumaha.
Akā e hoʻomanaʻo, ʻaʻole ia he manaʻo maikaʻi e lawe i kēia mau mea ma kou manaʻo ponoʻī. E kamaʻilio me kāu kauka a hoʻohana wale iā lākou me kāna ʻae. No ka mea, i kekahi manawa hiki i kēia ke launa pū me nā lāʻau lapaʻau ʻē aʻe āu e lawe nei.
Leka Lawe-Home
- ʻO nā antidepressants kahi ʻano lāʻau lapaʻau e hoʻololi i ka hana o nā kemika lolo (neurotransmitters).
- Hiki ke hala i kekahi mau pule a i ʻole mau mahina no ka hopena piha ʻana o kēia mau lāʻau lapaʻau, no laila he mea nui e hoʻomanawanui .
- Mai hoʻomaka, hoʻololi i ka nui, a i ʻole e hoʻōki koke i ka lawe ʻana i kekahi lāʻau lapaʻau me ka ʻole o ke aʻo ʻana a kāu kauka. Hiki i ka hana ʻana pēlā ke lilo i mea weliweli.
- E haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe, nā huaora, a i ʻole nā huahana lāʻau āu e lawe nei.
- Inā loaʻa nā hōʻailona koʻikoʻi e like me ka huikau nui, ke kuni nui, a me nā hopu ʻana, e hele koke i ka ʻOihana Pilikia o ka haukapila (ETU), no ka mea, he serotonin syndrome paha ia.
- Inā he mau hopohopo a hopohopo paha kāu e pili ana i kēia lāʻau lapaʻau, e kamaʻilio ākea me kāu kauka e pili ana.
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