Aia kekahi o kou ʻohana, malia paha kou makuahine, kou makuakāne, a kupuna wahine paha, e poina i nā mea liʻiliʻi? Ke hiki ʻole iā ʻoe ke hoʻomanaʻo i nā mea liʻiliʻi loa, kaumaha nui mākou a makaʻu hoʻi. ʻO ke kumu nui o kēia paha ka maʻi Alzheimer. ʻO ka ʻoiaʻiʻo, ʻaʻohe lāʻau lapaʻau no kēia maʻi i kēia manawa. Eia nō naʻe, aia nā lāʻau lapaʻau hou e hiki ke kōkua i ka kaohi ʻana i ka laha wikiwiki o ka maʻi a hoʻolohi i kona holomua. ʻO Kisunla kekahi lāʻau lapaʻau i lawe mai i ka manaʻolana hou. E kamaʻilio kākou e pili ana i kēia me ka maʻalahi a me ka maopopo i kēia lā.
ʻO ka maʻi o Alzheimer a pehea e hana ai ʻo Kisunla
I ka ʻōlelo maʻalahi, he maʻi lolo ʻo Alzheimer e ulu mālie ana i ka hala ʻana o ka manawa. Ua lohe paha ʻoe iā ia he maʻi nalowale hoʻomanaʻo i maʻamau i waena o ka poʻe ʻelemakule. Ke ulu kēia maʻi, ua hōʻino ʻia nā ʻāpana o ko kākou lolo e hoʻomalu ana i nā mea nui e like me ka hoʻomanaʻo, ka hoʻomaopopo ʻana, ka ʻōlelo, ka nānā ʻana, a me ka noʻonoʻo ʻana. ʻO ke kumu nui o kēia, ʻo ia ka hōʻiliʻili ʻana o kahi protein ʻawahia i kapa ʻia ʻo amyloid ma waena o nā hunaola lolo.
E like me ka paipu wai i loko o ko mākou hale e paʻa ana i ka lepo a kāohi i ke kahe ʻana o ka wai, ke hōʻiliʻili kēia protein amyloid ma waena o nā hunaola lolo, ʻaʻole hiki i nā hunaola lolo ke kamaʻilio pū kekahi me kekahi a hana pono.
Ua lohe paha ʻoe he ʻano dementia ka maʻi Alzheimer. ʻO Dementia kahi huaʻōlelo maʻamau no nā kūlana e hoʻoulu ai i ka paʻakikī o ka noʻonoʻo pono a hiki i kahi hiki ʻole iā ʻoe ke hana i nā hana o kēlā me kēia lā.
Hoʻokaʻawale pinepine nā kauka i ka maʻi i kekahi mau pae. I nā pae mua, ʻo ka nalowale o ka hoʻomanaʻo pōkole ka hōʻailona nui. I ka holomua ʻana o ka maʻi, lilo nā hana o kēlā me kēia lā e like me ka hoʻomākaukau ʻana i ka meaʻai, ka ʻimi ʻana i kou ala, a me ka hoʻokele kālā i mea paʻakikī. I nā pae hope, hiki iā ʻoe ke hōʻike i nā hōʻailona noʻonoʻo e like me ka haʻalele ʻana i ka nohona, ka nalowale o ka hoihoi i kekahi mea, a me ka huhū.
No laila, he aha ka hana a kēia lāʻau hou i kapa ʻia ʻo Kisunla? Loaʻa iā ia kahi antibody kūikawā i kapa ʻia ʻo donanemab-azbt . ʻO kāna hana, ʻo ia ke kuhikuhi ʻana i nā protein amyloid aʻu i ʻōlelo ai ma mua e hōʻiliʻili ana i loko o ka lolo a wehe iā lākou mai ka lolo. Ma kēia ʻano, kōkua ʻo Kisunla i ka hōʻemi ʻana i ka hōʻino ʻana o ka lolo a hoʻolohi i ka wikiwiki o ka hoʻonui ʻia ʻana o ka maʻi.
Pehea e hoʻohana ai i ka lāʻau lapaʻau Kisunla?
ʻAʻole he pila ʻo Kisunla. Hāʻawi ʻia ia ma ke ʻano he intravenous (IV) infusion . E like me kā mākou e loaʻa ai ka saline, pono ʻoe e loaʻa i kēia lāʻau lapaʻau ma kahi haukapila a i ʻole keʻena lapaʻau, kahi e lawe ai ma kahi o 30 mau minuke.
Ke hoʻomaka ʻoe i ka lāʻau lapaʻau, e hāʻawi ʻia ʻoe i ʻekolu mau mahele o 700 milligrams (700 mg) i kēlā me kēia ʻehā pule. Ma hope o kēlā, e hoʻonui kāu kauka i ka mahele i 1400 milligrams (1400 mg) i kēlā me kēia ʻehā pule.
Ma mua o ka hoʻomaka ʻana i kēia lāʻau lapaʻau, e kauoha kāu kauka i kahi scan lolo kūikawā i kapa ʻia he tau positron emission tomography (PET) . Nānā kēia i ka nui o ka amyloid i waiho ʻia i loko o kou lolo. Inā hōʻike ka scan ua emi nui ka pae o ka amyloid i loko o kou lolo, hiki i kāu kauka ke hoʻoholo e hoʻōki i ka lāʻau lapaʻau.
Nā kiko kūikawā e makaʻala ai a me nā hopena ʻaoʻao
Aia kekahi hopena koʻikoʻi e pono ai mākou e makaʻala nui i ka wā e mālama ai iā Kisunla. Ua kapa ʻia ʻo ia ʻo ARIA (amyloid-related imaging abnormalities) . I ka ʻōlelo maʻalahi, ʻo kēia lāʻau lapaʻau ke kumu o nā loli maʻamau e ʻike ʻia ma kahi MRI scan o ka lolo. ʻAʻole kēia e hana mau i nā hōʻailona.
Eia nō naʻe, i nā hihia kakaikahi, hiki i kekahi poʻe ke ʻike i nā hōʻailona e like me kēia:
- ʻEha poʻo
- Ka huikau
- Ka luaʻi ʻana
- Nā loli o ka ʻike
- Ka nalowale o ke kaulike i ka wā e hele ana
I kekahi manawa, hiki ke like loa nā hōʻailona o ARIA me nā hōʻailona o ka hahau ʻana. No laila, he mea nui loa ia e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe nei i hiki iā ia ke hoʻoholo inā he ARIA a i ʻole kekahi mea ʻē aʻe.
ʻO wai ka mea i ʻoi aku ka nui o ka pilikia o ka ARIA?
ʻOi aku ka nui o ka pilikia o kekahi poʻe i ka loaʻa ʻana o ARIA ma muli o ko lākou ʻano hoʻoilina. ʻO ka poʻe me ʻelua kope o ka gene i kapa ʻia ʻo apolipoprotein E e4 (ApoE e4) he kiʻekiʻe aʻe ko lākou pilikia o ka loaʻa ʻana o nā hopena ʻino e like me ka pehu ʻana o ka lolo a i ʻole ke kahe ʻana o ke koko i loko o ka lolo. No laila, e kauoha paha kāu kauka i kahi hoʻāʻo hoʻoilina e nānā i kou pilikia o ARIA ma mua o kou hoʻomaka ʻana i ka mālama ʻana me Kisunla. Pono nō hoʻi ʻoe e loaʻa i nā scan MRI maʻamau e nānā i kēia kūlana i ka wā o ka mālama ʻana.
Pehea i aʻo ʻia ai ka holomua o ka lāʻau Kisunla?
Ua hana ʻia kahi noiʻi lapaʻau nui e ʻike i ka hopena o kēia lāʻau. Ua komo ka nui o nā maʻi me ka maʻi Alzheimer mua i kēia.
Ua māhele nā kānaka noiʻi i kēia poʻe i ʻelua mau pūʻulu.
1. Ua hāʻawi ʻia kekahi hui: ka lāʻau lapaʻau Kisunla.
2. ʻO ka hui ʻē aʻe: ua hāʻawi ʻia i kahi mea e like me ka lāʻau lapaʻau, akā ʻaʻohe mea hana nui (kapa mākou i kēia he placebo ).
He mea hoʻoikaika maoli nā hopena. E hoʻomaopopo kākou i kēlā mau hopena mai ka papa ma lalo nei.
| Pōmaikaʻi | Ka mea i loaʻa i ke aʻo ʻana |
|---|---|
| Ke hoʻolohi nei i ka laha ʻana o ka maʻi | ʻO ka wikiwiki o ka holomua o ka maʻi i ka poʻe i loaʻa iā Kisunla ma kahi o 20% lohi ma mua o ka poʻe i loaʻa i ka placebo. |
| ʻAʻole e ʻoi aku ka ʻino o nā hōʻailona | He kanahākumamāhiku pakeneka o ka poʻe i loaʻa iā Kisunla ʻaʻohe mea i ʻoi aʻe ka maʻi i loko o hoʻokahi makahiki, ke hoʻohālikelike ʻia me 29% wale nō o ka poʻe ma ka hui placebo. |
| Ua emi ka amyloid i loko o ka lolo | I ka pau ʻana o ke aʻo ʻana, he haʻahaʻa loa nā pae o nā waihona amyloid i loko o ko lākou lolo i ka 76% o ka poʻe i loaʻa iā Kisunla. |
Hōʻike kēia mau hopena hiki iā Kisunla ke hoʻolohi nui i ka holomua o ka maʻi o Alzheimer.
ʻEhia ka lōʻihi o ka hana ʻana o ka lāʻau lapaʻau a aia kekahi mau pilina me nā lāʻau lapaʻau ʻē aʻe?
I ka manawa e loaʻa ai iā ʻoe kāu mahele mua o Kisunla, hoʻomaka ia e hana ma ke kuhikuhi ʻana i ka amyloid i loko o ka lolo. Eia nō naʻe, hiki ke hala kekahi mau mahina no ʻoe, kou poʻe mālama, a me kāu kauka e ʻike ai e emi ana kāu mau hōʻailona a ke lohi nei ke ala o ka maʻi.
Nā pilina me nā lāʻau ʻē aʻe
Ma muli o ka pilikia o ke kahe ʻana o ke koko o ka lolo me ARIA, pono e mālama pono ʻia i ka wā e hoʻohana ai iā Kisunla me nā lāʻau hoʻokahe koko . ʻOiai ʻaʻohe hōʻike maopopo, inā ʻoe e lawe ana i nā lāʻau hoʻokahe koko, pono ʻoe e kūkākūkā i kēia me kāu kauka ma mua o ka hoʻomaka ʻana i ka lāʻau Kisunla.
ʻO ka mea nui loa, ʻo ia ka hoʻomaopopo ʻana i kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe nei - inā paha i kauoha ʻia e kāu kauka, nā lāʻau lapaʻau ma ke kūʻai ʻole ʻia, nā wikamina, nā lāʻau Ayurvedic a i ʻole nā lāʻau Sinhala.
Inā ʻike ʻoe i kekahi mau hōʻailona e like me ke poʻo ʻeha i ka wā o ka mālama ʻana, mai hoʻowahāwahā iā ia. He hōʻailona paha ia o ARIA, no laila e hoʻomaopopo koke i kāu kauka .
Leka Lawe-Home
- He lāʻau lapaʻau hou ʻo Kisunla i hoʻohana ʻia no ka mālama ʻana i nā pae mua o ka maʻi o Alzheimer.
- Hana kēia ma ka wehe ʻana i ka protein ʻawahia i kapa ʻia ʻo amyloid e hōʻiliʻili ana i loko o ka lolo a hoʻolohi i ka wikiwiki o ka hoʻonui ʻia ʻana o ka maʻi.
- He lāʻau hoʻokomo intravenous (IV) kēia a pono e lawe ʻia ma ka haukapila a i ʻole ke keʻena lapaʻau.
- He mea nui loa ia e makaʻala i ka hopena koʻikoʻi i kapa ʻia ʻo ARIA. Pono kēia i nā scan MRI maʻamau ma mua a i ka wā o ka mālama ʻana.
- He mea nui e kamaʻilio ākea me kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe nei (me nā lāʻau hoʻokahe koko) a me nā hōʻailona hou āu e ʻike nei.
- ʻOiai ʻaʻole kēia he lāʻau lapaʻau, hoʻolohi nui ia i ke ala o ka maʻi a hāʻawi i ka manaʻolana hou i nā mea maʻi a me ko lākou mau ʻohana.
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