E aʻo kākou e pili ana i ka Lynch Syndrome, ka mea e hoʻonui ai i kou pilikia o ka maʻi kanesa.

Ua lohe paha ʻoe i ka huaʻōlelo "Lynch Syndrome"? He huaʻōlelo hou paha kēia iā ʻoe. Akā, he mea nui ia iā kākou a pau e ʻike. I ka ʻōlelo maʻalahi, ʻo Lynch Syndrome kahi maʻi e hoʻonui ai i ka pilikia o ka loaʻa ʻana o ka maʻi kanesa ma muli o kekahi mau loli i loko o kā mākou mau genes. ʻO ke kikoʻī, hoʻonui ia i ka pilikia o ka loaʻa ʻana o ka maʻi kanesa ma mua o 50 mau makahiki. No laila, e kamaʻilio kākou e pili ana i kēia me nā kikoʻī hou aku, ea?

He aha maoli ka Lynch Syndrome? ʻO wai ka mea e loaʻa ai?

ʻO ka maʻi Lynch kahi maʻi genetic i hoʻoilina ʻia . ʻO ia hoʻi, ua hoʻokumu ʻia e kahi hoʻololi genetic i loko o nā genes a mākou e hoʻoilina ai mai ko mākou makuahine a makuakāne paha. E noʻonoʻo i ka wā e māhele ai ko mākou mau cell, hiki ke hana ʻia nā hewa liʻiliʻi i kekahi manawa. Loaʻa i ko mākou kino nā genes kūikawā e ʻike a hoʻoponopono i kēia mau hewa. Ua kapa ʻia kēia mau mea ʻo 'Mismatch Repair genes' (MMR genes). Loaʻa i kahi kanaka me Lynch syndrome kahi kīnā i hoʻokahi a ʻoi aku paha o kēia mau genes 'MMR'. A laila, ʻaʻole hiki ke hoʻoponopono ʻia nā hewa ʻē aʻe ke māhele ʻia kēlā mau cell. Hōʻiliʻili kēia mau cell i hōʻino ʻia a lilo i maʻi ʻaʻai .

Hiki ke hana ʻia kēia i kekahi. No ka mea, he ʻano hoʻoilina ia. I kekahi manawa, ʻoiai inā ʻaʻohe mea o ka ʻohana i loaʻa i kēia maʻi ma mua, hiki i ke kanaka ke loaʻa iā ia ma muli o kahi hoʻololi hoʻoilina maʻamau. ʻO ke ʻano kēia, ʻoiai ʻaʻohe mōʻaukala ʻohana, ʻaʻole ia he manaʻo ʻaʻole ia e hana ʻia.

Wahi a nā helu helu ma ʻAmelika Hui Pū ʻIa, ma kahi o hoʻokahi i loko o 279 mau kānaka e loaʻa paha i ka Lynch syndrome. Ua ʻōlelo ʻia he 4,000 mau hihia o ke kanesa colorectal a me 1,800 mau hihia o ke kanesa endometrial i hoʻokumu ʻia e ka Lynch syndrome i kēlā me kēia makahiki. He mea nui loa ia e ʻike i kēia ʻano ma Sri Lanka.

He aha nā hōʻailona o ka Lynch Syndrome?

Hiki ke ʻokoʻa nā hōʻailona ma muli o ke koʻikoʻi o ke kūlana a me ke ʻano o ka maʻi kanesa e hoʻoulu ai. ʻO nā hōʻailona maʻamau o ka maʻi kanesa colorectal:

• Ke koko i loko o kou noho.
• Ka paʻa ʻana o ka ʻōpū .
• ʻEha a ʻūlū paha ka ʻōpū.
• Ka maʻi kahe a i ʻole ka ʻōpala i ʻoi aku ka liʻiliʻi ma mua o ka maʻamau.
• Manaʻo pinepine o ka luhi nui ('Fatigue').
• Manaʻo piha a pehu paha.
• Ka luaʻi a i ʻole ka luaʻi ʻana.

ʻO ka mea nui, ʻaʻole paha e hōʻike kekahi poʻe i kekahi mau hōʻailona a hiki i ka wā e holomua loa ai ke kanesa. No laila, inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona, ​​​​pono ʻoe e ʻike koke i ke kauka .

He aha nā ʻano maʻi kanesa e hiki ke hana ʻia e ka Lynch syndrome?

Hiki i kēia ke hoʻopilikia i nā ʻōpū he nui. Eia kekahi mau ʻano maʻi kanesa i hiki ke hana ʻia e ka Lynch syndrome:

• Ka maʻi ʻaʻai lolo
• ʻO ke kanesa o ka kolona a me ka rectal - ʻO kēia ke kumu nui.
• Ka maʻi ʻaʻai ʻōpū
• Ka maʻi ʻaʻai ate
• Ka maʻi ʻōpū
• Ka maʻi ʻaʻai pancreatic
• Ka maʻi ʻaʻai prostate
• Ka maʻi ʻili
• Ka maʻi ʻōpū liʻiliʻi
• Ka maʻi ʻōpū
• Ka maʻi ʻaʻai o ke ala mimi kiʻekiʻe
• ʻO ke kanesa ʻōpū (endometrial) - ʻO kekahi ʻano maʻi kanesa e hoʻopilikia pinepine ai i nā wahine.

ʻO ka mutation i loaʻa ai ka gene (`gene`) e hoʻoholo ai i ka ʻōkana i ʻoi aku ka nui o ka pilikia o ka maʻi kanesa. ʻElima mau genes nui e pili ana me ka Lynch syndrome. ʻO lākou: `MLH1`, `MSH2`, `MSH6`, `PMS2` a me `EPCAM`.

Hiki i ke kanesa kolona i hoʻokumu ʻia e ka Lynch syndrome ke ulu mua (i loko o 1-2 mau makahiki) ma mua o ka heluna kanaka maʻamau. ʻO ka maʻamau, he 10 mau makahiki ka lōʻihi no ka ulu ʻana o ke kanesa kolona. Eia kekahi, ʻoi aku ka nui o ka pilikia o ka mea i loaʻa i ke kanesa kolona e ulu hou i ke kanesa . Aia ma kahi o 15% ka pilikia i loko o 10 mau makahiki o ke ʻoki ʻana no ke kanesa mua, ma kahi o 40% ka pilikia i loko o 20 mau makahiki, a ma kahi o 60% ka pilikia ma hope o 30 mau makahiki.

He aha ke kumu o ka Lynch Syndrome?

E like me ka mea i ʻōlelo ʻia ma mua, ʻo ke kumu nui o kēia he hoʻololi ʻana o ka genetic i loko o hoʻokahi a ʻoi aku paha o nā genes ʻelima e hoʻoponopono ana i nā hewa i loko o kā mākou DNA (ka "mismatch repair gene" a i ʻole "MMR gene"). ʻO kēlā mau genes ʻelima:

• `MLH1`
• ʻO MSH2
• ʻO ka MSH6
• ʻO ka PMS2
• ʻEPCAM

Inā loaʻa iā ʻoe ka maʻi Lynch, ʻaʻole loaʻa i kāu mau genes 'MMR' nā kuhikuhi e pono ai lākou e hoʻopau i nā cell i hōʻino ʻia. A laila hōʻiliʻili kēlā mau cell i hōʻino ʻia i loko o nā ʻiʻo a hoʻoulu i ka maʻi kanesa.

Pehea lā e hiki mai ai kēia mai kēlā hanauna a i kēia hanauna?

He kūlana "autosomal dominant" ka Lynch syndrome. I ka ʻōlelo maʻalahi, ʻoiai inā hoʻokahi wale nō makua i loaʻa ka gene mutated, hiki i ke keiki ke hoʻoilina iā ia . ʻO ia hoʻi, aia he 50% ka manawa e loaʻa pū ai i ke keiki ke kūlana.

Inā ua ʻike ʻia ʻoe me ka Lynch syndrome, he mea nui e hoʻomaopopo i kou ʻohana a paipai iā lākou e ʻimi i ke aʻoaʻo genetic . Hiki i ke aʻoaʻo genetic ke kōkua iā ʻoe a me kou ʻohana e hoʻomaopopo i ke kūlana a me ka pilikia o kāu keiki e hoʻoilina iā ia. Hiki ke hana ʻia ka hoʻāʻo genetic e ʻike inā loaʻa iā ʻoe ka mutation gene Lynch syndrome.

Pehea e ʻike ʻia ai ka maʻi Lynch?

Hiki i kāu kauka ke ʻike i ka maʻi Lynch ma o nā hoʻokolohua nānā prenatal a me ka hoʻāʻo genetic. Hiki ke hana ʻia ka hoʻāʻo genetic ma hope o ka hānau ʻana o kāu pēpē.

ʻO kahi hoʻāʻo genetic e pili ana i ka lawe ʻana i kahi hāpana koko a i ʻole kahi swab buccal e nānā ai no kahi mutation i loko o nā genes i ʻōlelo mua ʻia ʻo `MLH1`, `MSH2`, `MSH6`, `PMS2` a i ʻole `EPCAM`. Inā hōʻoia kahi hoʻāʻo genetic i ke alo o ia mutation, e ʻike ke kauka i ka Lynch syndrome.

He aha nā hoʻokolohua i hoʻohana ʻia e ʻike ai i nā maʻi kanesa e pili ana me ka Lynch syndrome?

Inā ua ʻike ʻia ʻoe me ka Lynch syndrome, e paipai pinepine kāu kauka i kekahi mau hoʻokolohua e nānā i ka maʻi kanesa. ʻO nā hoʻokolohua maʻamau:

• Colonoscopy: ʻO kēia ke komo ʻana i kahi ʻōmole (scope) me kahi kāmela i hoʻopili ʻia ma o ka anus e nānā i loko o ka ʻōpū nui a me ka rectum. Hana pinepine ʻia kēia i hoʻokahi manawa i ka makahiki a i ʻole i kēlā me kēia ʻelua makahiki.
• ʻO ka ultrasound transvaginal: Hoʻokomo ʻia kahi mea hana liʻiliʻi (probe) ma o ka vagina e nānā i nā ovaries a me ka uterus. Paipai ʻia kēia i hoʻokahi a ʻelua paha i ka makahiki.
• Urinalysis: Lawe ʻia kahi hāpana o kāu mimi e nānā i nā mea e like me nā puʻupaʻa puʻupaʻa. Hana pinepine ʻia kēia i hoʻokahi manawa i ka makahiki.
• ʻO ka biopsy tumor: Inā manaʻo kāu kauka he puʻupuʻu kou ma kekahi wahi o kou kino, e lawe lākou i kahi ʻāpana liʻiliʻi o ia mea a hoʻāʻo iā ia ma ka lab e ʻike inā he mau cell cancer.
• ʻO ka endoscopy luna a i ʻole ka capsule endoscopy: He hana e hoʻohana ana i kahi ʻōmole liʻiliʻi a lahilahi (scope) a i ʻole kahi kāmela microscopic (kahi ʻōmole liʻiliʻi a lahilahi i ale ʻia e like me ka pila) e nānā i ka maʻi ʻaʻai ma ka ʻōpū a me ka ʻōpū liʻiliʻi. E noi ʻia paha ʻoe e hana i kēia i kēlā me kēia ʻekolu a ʻelima mau makahiki.

Pehea e mālama ʻia ai ka Lynch syndrome?

ʻO ke kī i ka mālama ʻana i ka Lynch syndrome ka ʻike mua ʻana a me ka wehe ʻana i nā ʻōpū . ʻO ke ʻano kēia o ka loaʻa ʻana o nā hoʻokolohua maʻamau a me ka loaʻa ʻana o ka maʻi kanesa i ka wā mua, inā loaʻa.

ʻO wai ka mea nāna e mālama i kēia?

ʻOi aku ka maikaʻi o ka ʻimi ʻana i ka lāʻau lapaʻau mai kahi hui o nā kauka loea no kahi kūlana e like me kēia.Ma muli o ka hiki i ka maʻi Lynch ke hoʻopili i nā ʻōnaehana ʻōpena he nui, hiki i ka hui lapaʻau ke hoʻokomo i nā ʻano loea like ʻole, me nā gastroenterologists, nā kauka ʻokiʻoki, nā oncologists gynecologic, nā urologists, nā dermatologists, nā gynecologists, nā kauka mālama mua, nā geneticists, nā kākā'ōlelo genetic, a me nā oncologists.

Hiki ke hoʻi hou mai ke kanesa ma hope o ka mālama ʻia?

ʻAe, ʻoiai inā e wehe ʻia ke kanesa ma ke ʻoki ʻana, aia kahi manawa e hoʻi hou mai ai ke kanesa . No laila he mea nui e hoʻomau i ka hoʻāʻo ʻana.

ʻO kekahi poʻe me ka Lynch syndrome, no ka mea, ʻoi aku ka nui o ko lākou pilikia o ka loaʻa ʻana o ka maʻi kanesa, hoʻoholo lākou e hana i ke ʻoki ʻana e wehe i ka uterus (hysterectomy), ovaries (oophorectomy), a i ʻole kekahi ʻāpana o ka ʻōpū (colectomy a i ʻole ke ʻoki ʻana o ka ʻōpū) i ka wā mua. He hoʻoholo pilikino kēia, a pono e hana ʻia ma ke aʻo a ke kauka.

Hiki ke pale ʻia ka Lynch Syndrome?

ʻO ka mea pōʻino, he maʻi hoʻoilina ka Lynch syndrome, no laila ʻaʻole hiki ke pale loa ʻia . Eia nō naʻe, hiki ke nānā ʻia ka poʻe me Lynch syndrome no ka maʻi kanesa i ko lākou ola a pau, e hoʻomaka ana i ka wā makua, i hiki ke ʻike mua ʻia ka maʻi kanesa inā ulu ia .

He aha ka mea e hana inā loaʻa iā ʻoe ka Lynch syndrome? He aha kāu e manaʻo ai?

ʻAʻohe lāʻau lapaʻau no ka Lynch syndrome i kēia manawa. Eia nō naʻe, loaʻa nā hopena maikaʻi loa inā ʻike ʻia ka maʻi kanesa a wehe ʻia i ka wā mua, ma mua o ka laha ʻana i nā ʻāpana ʻē aʻe o ke kino . No laila, he mea nui loa i ka poʻe me Lynch syndrome ke loaʻa i nā hoʻokolohua nānā makahiki, e like me ka colonoscopy.

E hoʻoulu anei ka Lynch syndrome i nā ʻōpū i loko o koʻu kolona?

Hiki i nā kānaka me ka Lynch syndrome ke loaʻa i kekahi mau 'adenomas', kahi ʻano ulu ʻole o ke kanesa i loko o ko lākou colon a i ʻole rectum. Inā ʻaʻole ʻike ʻia a wehe ʻia kēia mau 'polyps', hiki iā lākou ke lilo i kanesa. ʻO ia ke kumu he mea nui ka loaʻa ʻana o nā colonoscopies maʻamau e nānā i kēia mau mea a wehe iā lākou inā loaʻa lākou.

Āhea wau e ʻike ai i ke kauka?

Inā loaʻa iā ʻoe ka Lynch syndrome, he mea nui e hana i nā hoʻokolohua makahiki a me nā hoʻokolohua screening ma kahi papa hana maʻamau .

Inā ʻike ʻoe i kekahi mau puʻupuʻu, nā ulu hou, a i ʻole nā ​​​​loli ʻili ma kekahi wahi o kou kino, e ʻike koke aku i ke kauka , no ka mea, he mau hōʻailona paha kēia o ka maʻi kanesa.

He aha nā nīnau e pono iaʻu e nīnau aku i kaʻu kauka?

• ʻEhia pinepine e pono ai iaʻu e hana i nā hoʻokolohua nānā ʻana i ka maʻi kanesa?
• Aia kēia puʻupuʻu ma luna o koʻu maʻi ʻili?
• He aha ka hoʻololi ʻana o ka gene iaʻu?
• Hiki iaʻu ke hana i kahi hoʻokolohua genetic ma mua o koʻu hoʻolālā ʻana e hāpai?

He like anei ka Lynch Syndrome a me ka HNPCC?

ʻO Lynch syndrome a me ka "Hereditary Non-Polyposis Colorectal Cancer" (``HNPCC``) i kekahi manawa hoʻohana like ʻia e pili ana i ke kūlana like. Eia nō naʻe, aia kahi ʻokoʻa iki ma waena o nā mea ʻelua i ke ʻano o ko lākou hoʻoili ʻia ʻana ma o nā hanauna.

Hoʻokumu ʻia ka maʻi Lynch e kahi mutation i loko o ka gene `MMR`. Hoʻopilikia pū ka mutation gene like i nā poʻe me `HNPCC`. Eia nō naʻe, hāʻawi ʻia ka inoa `HNPCC` ke hana ʻia kēia ʻano me ka mōʻaukala ʻohana . ʻO ia hoʻi, ua hoʻoilina mau ʻia ʻo `HNPCC` mai kēlā hanauna a i kēia hanauna. Hiki ke hana ʻia ka maʻi Lynch i kekahi manawa me ka ʻole o kekahi o ka ʻohana i loaʻa iā ia, a hiki nō hoʻi ke hana ʻia ma muli o kahi mutation gene random. ʻO ia ke kumu i hoʻohana nui ʻia ai ka inoa Lynch syndrome i kēia manawa.

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai (Leka Lawe-Home)

ʻAʻohe mea makemake e lohe i nā huaʻōlelo, "He maʻi kanesa kou." Ke ʻike ʻoe he Lynch syndrome kou, pono paha ʻoe e lohe i kēlā mau ʻōlelo mai kāu kauka mai. Akā, ʻaʻole pono ia he mea maikaʻi ʻole.

Ke ʻike ʻia ʻoe me ka Lynch syndrome, e hana pū kāu kauka me ʻoe e hoʻonohonoho i nā hoʻokolohua nānā maʻamau e kōkua i ka ʻike mua ʻana i ka maʻi kanesa. ʻO ka ʻike mua ʻana a me ka mālama ʻana nā ala maikaʻi loa e hoʻomaikaʻi ai i kou manawa e ola ai . A laila hiki iā ʻoe ke ola i kahi ola hauʻoli a olakino.

No laila, ma kahi o ka makaʻu i kēia ʻike, e makaʻala, e ʻimi i ke aʻo lapaʻau inā pono, a e hoʻāʻo e ola i kahi ola olakino . Inā loaʻa i kekahi o kou ʻohana kēia maʻi, he mea nui loa ia e hoʻomaopopo iā lākou e pili ana i kēia.

ʻO ka maʻi Lynch, HNPCC, maʻi ʻaʻai, nā hoʻololi genetic, nā maʻi hoʻoilina, ka maʻi ʻaʻai colon, ka maʻi ʻaʻai uterine