He protein ʻē i loko o kou koko? E kamaʻilio kākou e pili ana iā MGUS (Monoclonal Gammopathy of Undetermined Significance)!

Ua hele paha ʻoe i ke kauka, a i ʻole e hana wale i kekahi hana koko, a ua haʻi lākou iā ʻoe e pili ana i kahi maʻi me ka inoa ʻē āu i lohe ʻole ai ma mua. ʻO MGUS (i kapa ʻia ʻo M-Gas e kekahi) kekahi o kēlā mau maʻi, kahi maʻi e hoʻoweliweli iki ai ʻoe ke lohe ʻoe i ka inoa, akā ʻaʻole maopopo ia he aha ia. No laila i kēia lā, e kamaʻilio kākou e pili ana iā MGUS (Monoclonal Gammopathy of Undetermined Significance) ma ke ʻano maʻalahi hiki iā ʻoe ke hoʻomaopopo.

He aha ka MGUS (Monoclonal Gammopathy o ke Koʻikoʻi i Hoʻoholo ʻole ʻia)?

I ka ʻōlelo maʻalahi, ʻo MGUS kahi maʻi e hoʻopilikia ai i kahi ʻano kūikawā o ke kelepona i kapa ʻia ʻo nā cell plasma, ʻo ia kekahi hapa o ko kākou koko a loaʻa i loko o ka iwi iwi. I kēia manawa ke noʻonoʻo nei paha ʻoe i ke ʻano o kēia mau cell plasma. He mau lālā koʻikoʻi kēia mau cell plasma o ka ʻōnaehana pale o ko kākou kino. ʻO kā lākou hana nui ka hana ʻana i nā protein i kapa ʻia ʻo nā antibodies e kōkua i ko kākou kino e pale iā ia iho mai nā maʻi.

Akā i loko o ke kanaka me MGUS, loli iki kēia mau cell plasma, a ma kahi o nā antibodies maoli a lākou e hana ai, hana lākou i kahi ʻano protein ʻokoʻa a ʻano ʻē i kapa ʻia ʻo "M proteins." ʻAʻole hana maoli kēia mau protein M i kekahi mea no ko mākou kino. ʻO ka hapa nui o ka manawa, ʻaʻole nui ka pōʻino o kēia mau protein M, a ʻaʻohe hōʻailona o ka nui o ka poʻe me MGUS. ʻO ka maʻamau, ʻike ke kauka i kēia kūlana ma ka ulia pōpilikia ke hana lākou i kahi hoʻāʻo koko a i ʻole ka hoʻāʻo mimi no kekahi kumu ʻē aʻe.

Eia nō naʻe, i kekahi manawa, hiki i ka MGUS ke lilo i mea koʻikoʻi a ulu aʻe i loko o ke kanesa koko a i ʻole kekahi maʻi koko koʻikoʻi ʻē aʻe. ʻO ia ke kumu, ke ʻike lākou he MGUS kou, hana nā kauka i nā hoʻokolohua koko a me ka mimi i kēlā me kēia 6 mahina a i ʻole hoʻokahi manawa i ka makahiki e ʻike ai inā e lilo ana ia i mea koʻikoʻi.

ʻO wai ka mea i hoʻopilikia nui ʻia e kēia kūlana?

ʻOiai hiki i kekahi ke hoʻomohala i kēia kūlana i kapa ʻia ʻo MGUS, ʻoi aku ka nui o ka poʻe e hoʻomohala iā ia.

• ʻOi aku ka nui o ka poʻe ma luna o 50 mau makahiki e loaʻa iā lākou ka MGUS. Hoʻonui iki kēia pilikia i kou wā ʻelemakule. ʻO ka mea ma luna o 50 mau makahiki he 3% a 5% ka manawa e loaʻa ai kēia maʻi. Inā ʻoe e nānā i ka poʻe ma luna o 75 mau makahiki, ʻo kēia ma kahi o 5%.
• ʻOi aku ka maʻamau o MGUS i ka poʻe ʻeleʻele .
• ʻOi aku ka nui o nā kāne e loaʻa i ka MGUS ma mua o nā wahine.
• ʻO ka poʻe me ka mōʻaukala o ka pili ʻana i nā pesticides a i ʻole nā ​​​​​​mea pepehi kanaka e pilikia pū kekahi.

Pehea ka hopena o MGUS i koʻu kino?

E like me kā mākou i kamaʻilio ai ma mua, ua hoʻokumu ʻia ʻo MGUS e kou iwi iwi e hana ana i nā cell plasma ʻano ʻē. E noʻonoʻo e like me nā cell plasma o ke kanaka olakino e like me nā koa i aʻo ʻia. Hana lākou i nā mea kaua i kapa ʻia he antibodies i kūikawā i kēlā me kēia germ. ʻO kēia mau antibodies ka mea e kōkua iā mākou e ʻike a hakakā i nā germs e komo i loko o ko mākou kino, e pale ana iā mākou mai nā maʻi.

Akā i loko o MGUS, hele iki kēia mau cell plasma i kahi "pupule" a hana lākou i nā protein M. Hōʻiliʻili kēia mau protein M i loko o ko mākou koko a hele i loko o ko mākou kino. I kekahi manawa hōʻiliʻili kēia mau protein M maʻamau ʻole i loko o ko mākou koko a me ka mimi a hiki ke hōʻino i kou mau puʻupaʻa, puʻuwai, a me nā aʻalolo. ʻAʻole wale ia, akā i ka wā he nui loa nā protein M i loko o kou koko, hiki ke hoʻemi ʻia ka hiki o kou kino ke hakakā i nā germs. ʻO ke ʻano kēia, ʻoi aku ka maʻalahi o kou maʻi ʻana.

He maʻi kanesa anei ʻo MGUS?

Eia kahi nīnau a ka poʻe he nui e nīnau ai. ʻAʻole, ʻaʻole ʻo MGUS ka maʻi kanesa ponoʻī. Eia naʻe, he kūlana ia e hiki ke lilo i maʻi kanesa. I nā huaʻōlelo ʻē aʻe, hiki ke manaʻo ʻia ʻo MGUS he kūlana "pre-cancerous" ma mua o ke kanesa.

Ua hōʻike ʻia e ka noiʻi ma kahi o 20% o ka poʻe me MGUS e loaʻa i kahi maʻi koko i kapa ʻia ʻo multiple myeloma . ʻO ke ʻano kēia, ʻaʻole e loaʻa i nā kānaka a pau me MGUS ka maʻi kanesa, akā ma kahi o hoʻokahi o ʻelima mau kānaka e pilikia ana.

Eia kekahi, hiki i kekahi poʻe me MGUS ke hoʻomohala i nā ʻano maʻi koko ʻē aʻe a i ʻole nā ​​​​maʻi pili koko koʻikoʻi. Eia kekahi laʻana:

• ʻAmyloidosis
• ʻO ka macroglobulinemia o Waldenstrom
• ʻO ka maʻi leukemia lymphocytic mau loa (CLL)

He mea nui: ʻAʻole e loaʻa i nā kānaka a pau me MGUS ka maʻi kanesa. Eia nō naʻe, he mea nui e hana i nā nānā lapaʻau maʻamau ma muli o ka pilikia.

He aha nā hōʻailona o MGUS?

E like me kā mākou i ʻōlelo ai ma mua, ʻo ka hapa nui o ka manawa ʻaʻole hana ʻo MGUS i kekahi mau hōʻailona kikoʻī. ʻO ia kekahi o nā pilikia nui me ia. Eia naʻe, he mea kakaikahi loa, hiki i kekahi poʻe ke ʻike i nā hōʻailona. Inā hana lākou, hiki iā lākou ke ʻike i nā mea e like me:

• He ʻano ʻūlū ma nā lālā.
• Ka manaʻo o ka nāwaliwali a me ke ola ʻole .
• Ka manaʻo o ka mae a i ʻole ka nalowale ʻana o ka ʻike ma kekahi mau wahi.

Hiki i kēia mau hōʻailona ke lilo i mau hōʻailona o nā maʻi ʻē aʻe he nui, no laila mai manaʻo he MGUS kou no ka mea he hoʻokahi a ʻelua paha o kēia mau mea. Eia nō naʻe, inā he mau hōʻailona mau kou, ʻoi aku ka maikaʻi o ke ʻike ʻana i ke kauka.

He aha ke kumu o MGUS?

ʻO ka ʻoiaʻiʻo, ʻaʻole maopopo loa i nā kauka ke kumu e loli ai nā cell plasma i loko o ko kākou iwi iwi a hoʻomaka e hana i nā protein M. ʻO ia ka ʻāpana "Undetermined Significance" o ka inoa o ka maʻi.

Eia nō naʻe, aia kekahi mau mea i manaʻo ʻia e kōkua i kēia ʻano:

• Nā loli hoʻoilina: Hiki i kekahi mau loli i loko o kā mākou mau genes ke hana i kēia.
• Loaʻa nā maʻi autoimmune:ʻO ke ʻano kēia, ʻoi aku ka nui o ka poʻe me nā maʻi i hoʻouka ai ka ʻōnaehana pale ponoʻī o ke kino i nā hunaola ponoʻī o ke kino (e like me ka rheumatoid arthritis) e loaʻa iā lākou ka MGUS.
• Lapaʻau no nā maʻi autoimmune: Hiki i kekahi mau lāʻau lapaʻau i lawe ʻia no kēia mau maʻi ke loaʻa ka hopena.
• Ka ʻike ʻia ʻana i nā pae kiʻekiʻe o ka radiation.
• Ka pilikia me nā pesticides a me nā insecticides.

ʻO kēia nā mea pilikia i ʻike ʻia i kēia manawa, akā hiki i kekahi ke loaʻa ʻole kekahi o kēia mau mea ke hoʻomohala iā MGUS.

Pehea e ʻike ai nā kauka iā MGUS?

ʻO ka hapa nui o ka manawa, ʻike ʻia ʻo MGUS ma ka hanana. E nānā ke kauka i kou koko a me kou mimi no nā protein M. Eia kekahi, e nānā lākou i kekahi mau kumu ʻē aʻe e loiloi i ka pilikia o ka ulu ʻana o MGUS i ka maʻi kanesa a i ʻole kekahi maʻi koko koʻikoʻi ʻē aʻe. ʻO kēia mau kumu pilikia:

• ʻO ka nui o ka protein M i loko o kou koko: ʻO ke kiʻekiʻe o ka nui o ka protein M, ʻo ke kiʻekiʻe o ka pilikia.
• Ke ʻano o ka protein M i loko o kou koko: Aia kekahi mau ʻano protein M like ʻole. ʻOi aku ka weliweli o kekahi mau ʻano ma mua o nā mea ʻē aʻe.
• ʻO ka nui o nā kaulahao māmā manuahi (FLC) i loko o kou koko: ʻO FLC kekahi ʻano protein i hana ʻia e nā cell plasma. Nānā nā hoʻokolohua FLC i nā ʻano kūlike ʻole o kēia mau mea.

Ua hōʻike ʻia nā noiʻi he 58% ka manawa e loaʻa ai i kahi kanaka me kēia mau mea pilikia ʻekolu i loko o 20 mau makahiki. Pēlā nō, he 5% ka manawa e loaʻa ai i kahi kanaka me ka ʻole o kēia mau mea pilikia i loko o 20 mau makahiki. No laila, hiki i kēia mau hoʻokolohua ke kōkua i kāu kauka e hoʻomaopopo i kou pae pilikia.

Pehea e mālama ʻia ai ʻo MGUS?

ʻO ka nūhou maikaʻi, ʻaʻole pono ka hapa nui o ka poʻe me MGUS i kekahi lāʻau lapaʻau. No ka mea, e like me kā mākou i ʻōlelo ai, ʻaʻohe pilikia o ka hapa nui o ka poʻe me ia a ʻaʻole hoʻi e loaʻa i kekahi mau hōʻailona.

Eia nō naʻe, no ka mea hiki i ka MGUS ke lilo i maʻi ʻaʻai, e nānā kāu kauka i ka pae o ka protein M i loko o kou koko a me kou mimi i kēlā me kēia 6 mahina a i ʻole hoʻokahi manawa i ka makahiki. Ua kapa ʻia kēia ʻo "kiaʻi makaʻala." E like me ke kiaʻi, ke nānā nei ke kauka e ʻike inā loli kekahi mea.

I kekahi manawa, ʻoi aku ka nui o ka pilikia o ka poʻe me MGUS i ka nalowale o ka iwi a i ʻole ka haki ʻana o ka iwi. Inā pilikia ʻoe, hiki i kāu kauka ke hāʻawi iā ʻoe i nā lāʻau lapaʻau e hoʻoikaika i kou mau iwi a me nā ʻōlelo aʻoaʻo ʻē aʻe e hoʻonui ai i ka nui o ka iwi.

Hiki ke pale ʻia ʻo MGUS?

ʻO ka mea pōʻino, ʻaʻole. ʻAʻole hiki iā mākou ke pale aku i kēia maʻi i kapa ʻia ʻo MGUS. No ka mea, ua hana ʻia e kekahi mau loli i loko o kā mākou mau genes (gene mutations), kahi e hoʻokumu ʻia ai nā cell plasma maʻamau ʻole, a hoʻomaka kēlā mau cell e hana i nā protein M. ʻO kēia mau loli genetic nā mea hiki ʻole iā mākou ke kaohi.

He aha ka mea e hana inā loaʻa iā ʻoe ʻo MGUS? He aha kāu e manaʻo ai?

Ma keʻano laulā, hiki i ka hapa nui o ka poʻe me MGUS ke ola i kahi ola maʻamau me ka ʻole o nā hōʻailona. He hapa liʻiliʻi wale nō e loaʻa i nā maʻi ʻaʻai koko a i ʻole nā ​​​​maʻi koko ʻē aʻe a mākou i kūkākūkā ai ma mua.

Inā hōʻike kāu mau hoʻāʻo koko a me ka mimi he protein M kou, pono ʻoe e hana hou i nā hoʻāʻo koko a me ka mimi i kēlā me kēia 6 a 12 mau mahina. ʻO kēia ke kōkua i kāu mau kauka e nānā i kou kūlana e ʻike inā e ʻoi aku ka ʻino. He mea hoʻonāukiuki iki paha kēia, akā he mea nui loa ia no kou palekana.

Pehea wau e mālama ai iaʻu iho?

ʻOiai ʻaʻole ʻike ʻia ke kumu kikoʻī o MGUS, ua kamaʻilio mākou e pili ana i kahi pilina ma waena o nā maʻi autoimmune, kā lākou mau lāʻau lapaʻau, nā pae kiʻekiʻe o ka radiation, a me nā pesticides. ʻOi aku ka maʻamau i nā poʻe ma luna o 50 mau makahiki.

• Inā ʻoe e hopohopo nei he loaʻa paha iā ʻoe ʻo MGUS, e kamaʻilio me kāu kauka e pili ana i kāu mau kumu pilikia a kūkākūkā e hoʻāʻo ʻia inā pono.
• Inā loaʻa iā ʻoe ʻo MGUS, e hahai pololei i nā ʻōlelo a kāu kauka. E hoʻāʻo ʻia i ka manawa kūpono.
• Inā loaʻa iā ʻoe kekahi mau hōʻailona hou, e like me ka mae ʻole, nāwaliwali, a me ka nalowale o ka ʻike a mākou i kūkākūkā ai ma mua, e haʻi koke i kāu kauka.

He maʻi ʻo MGUS i maopopo ʻole i ka ʻepekema lapaʻau. E like me ka inoa e hōʻike nei, nui nā mea a mākou i ʻike ʻole ai e pili ana i ia mea. No ka laʻana, ʻaʻole maopopo loa pehea e loaʻa ai i kekahi poʻe me ke ʻano nā maʻi kanesa koko a i ʻole nā ​​maʻi koko koʻikoʻi aʻo kekahi ʻaʻole.

Akā, ke wehe mālie nei nā kauka i kēia mau mea pohihihi. Inā loaʻa iā ʻoe ka MGUS, hiki i nā kauka ke wānana i kekahi ʻano o ka hiki ke loaʻa iā ʻoe nā maʻi koʻikoʻi. He mea nui e kamaʻilio me kāu kauka e pili ana i nā mea pilikia e hoʻoweliweli iā ʻoe no ka loaʻa ʻana o MGUS. Ma muli o kēlā ʻike, hiki iā ʻoe ke hoʻoholo inā kūpono iā ʻoe ke hoʻāʻo ʻia no ke ʻano.

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai

Mai makaʻu ke lohe ʻoe i ka inoa ʻo MGUS (Monoclonal Gammopathy of Undetermined Significance). ʻO ka mea nui loa, ʻo ia ka makaʻala i kēia.

• ʻAʻole ʻo MGUS he maʻi kanesa, akā he kūlana ia e hiki ai ke alakaʻi i ka maʻi kanesa.
• ʻAʻole ʻike ka nui o ka poʻe i nā hōʻailona a ʻaʻole pono ka lāʻau.
• ʻO ka mea nui loa, ʻo ia ka hana ʻana i nā hoʻokolohua maʻamau i nā manawa āpau.
• Inā ʻike ʻia nā hōʻailona hou, e haʻi koke aku i kāu kauka.
• E kamaʻilio ākea me kāu kauka e pili ana i nā nīnau a hopohopo paha āu. Aia lākou ma laila e kōkua iā ʻoe.

Manaʻolana wau ua kōkua kēia ʻike iā ʻoe e hoʻomaopopo maikaʻi i ka MGUS. E hoʻomanaʻo, ʻaʻole ʻoe hoʻokahi, aia pū kāu mau kauka a me kāu poʻe aloha me ʻoe.

ʻO MGUS, Monoclonal Gammopathy o ke koʻikoʻi i hoʻoholo ʻole ʻia, protein M, nā pūnaewele plasma, iwi iwi, maʻi ʻaʻai koko, nā maʻi koko, Multiple Myeloma