E aʻo kākou e pili ana i nā Neuroendocrine Tumors ma ke ala maʻalahi.

Ke luhi pinepine nei ʻoe, ʻeha ka ʻōpū, a i ʻole he ʻoluʻolu ʻole i wehewehe ʻole ʻia? Hoʻokuʻu pinepine mākou i kēia mau mea me he mea maʻamau. Akā i kekahi manawa, ma hope o kēia mau hōʻailona liʻiliʻi, aia paha kahi kūlana kakaikahi akā koʻikoʻi e pono ai mākou e makaʻala. ʻO kekahi o ia ʻano, ʻaʻole maʻamau akā koʻikoʻi, ʻo ia nā tumors neuroendocrine, a i ʻole e like me kā mākou e ʻōlelo nei ma ka ʻōlelo Pelekania, 'Neuroendocrine Tumors (NETs).' No laila i kēia lā, e kamaʻilio kākou e pili ana i ia mea ma nā ʻōlelo maʻalahi.

He aha kēia mau puʻupuʻu neuroendocrine (NETs)?

I ka ʻōlelo maʻalahi, he ʻano puʻupuʻu kakaikahi kēia e hana ʻia i loko o ko kākou kino. Hoʻomaka kēia mai kā kākou 'nā pūnaewele neuroendocrine'. I kēia manawa ke noʻonoʻo nei paha ʻoe i ke ʻano o kēia mau pūnaewele. ʻO ka mea kupaianaha, loaʻa i kēia mau pūnaewele nā ​​​​​​ʻano o nā pūnaewele nerve a me nā ʻano o nā pūnaewele endocrine, e hana ana i nā hormones. ʻO ia hoʻi, hiki i kēia mau pūnaewele ke loaʻa nā leka mai ka ʻōnaehana nerve a hoʻokuʻu i nā hormones i loko o ke koko ma ke ʻano he pane.

Loaʻa kēia mau pūnaewele neuroendocrine ma nā wahi he nui o ko kākou kino. Loaʻa pinepine lākou ma nā wahi e like me nā māmā, ka ʻōpū, ka pancreas, a me nā ʻōpū. No laila, i ka wā e hoʻomaka ai kēia mau pūnaewele e māhele a hoʻonui me ke kāohi ʻole ʻia, e hana ʻia kahi puʻupuʻu. He nui o kēia mau puʻupuʻu he ʻino, ʻo ia hoʻi hiki iā lākou ke lilo i maʻi kanesa.

He ʻokoʻa loa kēia mau puʻupuʻu kekahi i kekahi. Ulu mālie kekahi, aʻo kekahi e ulu wikiwiki ana. Eia kekahi, ʻokoʻa loa kā lākou mau hōʻailona a me nā ʻano lapaʻau ma muli o ka wahi a me ke ʻano o ka puʻupuʻu.

He aha nā ʻano nui o kēia mau nati?

Hoʻokaʻawale nā ​​kauka i kēia mau puʻupuʻu ma ʻelua ʻano nui. Hoʻokumu ʻia kekahi ma muli o ka hana ʻana o lākou i nā hormones a i ʻole.

• Nā NET Hana: Hoʻopuka kēia ʻano NET i nā hormones. No laila, ke piʻi aʻe ka hormone i nīnau ʻia i loko o ke kino, hiki i kēia poʻe ke ʻike i nā hōʻailona e like me ka ʻulaʻula koke, ka hou ʻana, a me ka pehu ʻana.
• Nā NET Hana ʻole: ʻAʻole hana kēia ʻano NET i nā hormones. No laila, ʻaʻohe paha o lākou hōʻailona i nā pae mua. ʻIke wale ʻia nā hōʻailona ke ulu nā NET, kau i ke kaomi ma luna o ke kino a lākou e noho ai, a i ʻole e hoʻopilikia i kāna hana.

Eia kekahi, ua hoʻokaʻawale ʻia kēia mau puʻupuʻu e like me kahi e hana ʻia ai lākou ma ke kino. ʻO kēia nā ʻano maʻamau.

Ma waho aʻe o kēia mau wahi nui ʻekolu, hiki ʻole i kēia mau puʻupuʻu ke ulu pinepine i nā wahi e like me ka thyroid gland, nā parathyroid glands, ka pituitary gland, a me nā adrenal glands.

Pehea ka maʻamau o kēia maʻi?

Ma ka honua holoʻokoʻa, hoʻopilikia kēia maʻi i kahi 6 o 100,000 mau kānaka . ʻO ia hoʻi, he maʻi laha ʻole loa ia. Eia nō naʻe, ua piʻi iki ka nui o ka poʻe i ʻike ʻia me kēia maʻi i nā makahiki i hala iho nei. Malia paha kēia no ka mea ʻo nā hoʻokolohua diagnostic holomua e ʻae i kēia mau puʻupuʻu e ʻike mua ʻia a maʻalahi hoʻi.

ʻOiai hiki i kēia maʻi ke hoʻopilikia i nā kānaka o kēlā me kēia makahiki, he mea kakaikahi loa ia i nā keiki a me nā ʻōpio. ʻO ka mea maʻamau ka poʻe ma waena o 50 a me 60 mau makahiki .

He aha nā hōʻailona o kēia maʻi?

ʻO kēia ka pilikia nui loa. I ka manawa pinepine, ʻaʻole kēia mau puʻupuʻu e hōʻike i kekahi mau hōʻailona a hiki i ko lākou ulu nui ʻana e hoʻopilikia i nā kino kokoke. ʻOiai ke kū mai nā hōʻailona, ​​​​​​ʻokoʻa lākou ma muli o kahi o ka puʻupuʻu. Eia kekahi, ua like loa kēia mau hōʻailona me nā maʻi maʻamau ʻē aʻe a hiki ke kuhihewa maʻalahi ʻia no nā kūlana ʻē aʻe.

Eia kekahi o nā hōʻailona i ʻike pinepine ʻia:

• Luhi
• ʻeha ka ʻōpū
• Ka maʻi pākī
• Ka luaʻi a me ka luaʻi
• Paʻakikī ka hanu ʻana
• ʻŪhū (i kekahi manawa me ke koko)

No ke aha i hoʻokumu ʻia ai kēia mau puʻupuʻu? He aha nā kumu pilikia?

ʻAʻole maopopo i nā kauka ke kumu e hoʻomaka koke ai kēia mau pūnaewele neuroendocrine e māhelehele me ka ʻole o ke kāohi ʻia. ʻO ia hoʻi, ʻaʻole lākou i ʻike i ke kumu pololei.

Eia nō naʻe, ua ʻike ʻia he nui ka pilikia o ka poʻe me kekahi mau maʻi hoʻoilina laha ʻole (syndromes) i ka loaʻa ʻana o kēia mau puʻupuʻu. ʻO ke ʻano kēia, hiki ke hana ʻia ke ʻano e nā loli (mutations) i kekahi mau genes.

• ʻO ka Multiple Endocrine Neoplasia (MEN): ʻO kēia kūlana ke kumu o ka hoʻokumu ʻana o nā puʻupuʻu i loko o nā kelepa a me nā ʻōkana like ʻole. ʻO ka poʻe me ke kūlana, i kapa ʻia ʻo MEN type 1 (MEN1), ʻoi aku ka pilikia o ka loaʻa ʻana o nā puʻupuʻu pancreatic (P-NETs).
• ʻO ka maʻi Von Hippel-Lindau: Hoʻonui kēia ʻano i ka pilikia o ka hoʻomohala ʻana i ka maʻi kanesa a me nā puʻupuʻu maʻamau i nā ʻāpana like ʻole o ke kino.
• ʻAno Neurofibromatosis 1: Ma kēia kūlana, hoʻokumu ʻia nā ʻōpū ma ka ʻili a me nā aʻalolo.
• ʻO ka paʻakikī sclerosis tuberous: Hiki i kēia ke hana i nā ʻōpū e hana i nā wahi āpau o ke kino, ʻoi aku hoʻi ma ka lolo.
• ʻO Cowden syndrome: Hoʻonui pū kēia ʻano i ka pilikia o ka hoʻomohala ʻana i nā ʻōpū a me kekahi mau ʻano maʻi kanesa.

Pehea e ʻike ai i ka maʻi? (Diagnosis)

E like me kā mākou i kūkākūkā ai ma mua, ua laulā loa nā hōʻailona o kēia ʻano, hiki ke lōʻihi ka manawa e ʻike ai. Inā kānalua kāu kauka i kēia, e kauoha lākou i nā hoʻokolohua like ʻole ma muli o kahi a lākou e manaʻo ai he puʻupuʻu paha.

He aha ke kahua a me ke ʻano o kahi puʻupuʻu?

Ke hōʻoia ʻia ua loaʻa iā ʻoe kēia maʻi, e kūkākūkā ke kauka i kona pae a me kona ʻano.

• Pae: Pili kēia i ka mamao o ka laha ʻana o ke kanesa. Hoʻokaʻawale pinepine ʻia mai ke kahua 1 a i ka 4. ʻO ka haʻahaʻa o ka helu, ʻo ka liʻiliʻi o ka puʻupuʻu a ʻo ka emi ʻana o kona laha ʻana. ʻO ke kahua 4, ʻo ia hoʻi, ua laha ka kanesa i nā wahi mamao o ke kino (metastatic).
• Papa: Pili kēia i ke ʻano ʻē o nā ʻāpana ma lalo o kahi microscope a me ka wikiwiki o ko lākou māhele ʻana. Ulu mālie nā ʻōpū papa 1 a me 2 (Well-differentiated), ʻoiai ulu wikiwiki nā ʻōpū papa 3 (Poorly differentiated).

E kamaʻilio me kāu kauka e ʻike pehea e pili ai kēia pae a me ke ʻano i kou kūlana.

He aha nā lāʻau lapaʻau?

ʻO ke ʻano o ka mālama ʻana e pili ana i nā kumu he nui, e like me ke ʻano o ka puʻupuʻu āu, kona nui, inā ua pālahalaha, a me kou olakino holoʻokoʻa.

ʻO ke ʻoki kino ke ʻano nui a hoʻohana pinepine ʻia no kēia. Inā hiki ke wehe loa ʻia ka puʻupuʻu ma ke ʻoki kino, kiʻekiʻe ka manawa e ho'ōla ʻia ai.

Eia nō naʻe, inā nui nā ʻōpū a ua pālahalaha paha i nā wahi ʻē aʻe, pono paha nā ʻano lapaʻau ʻē aʻe.

• Nā analog Somatostatin: He ʻano lāʻau lapaʻau kēia e pale ai i ke kino mai ka hana ʻana i ka nui o ka hormone. Hiki iā lākou ke hōʻemi i nā hōʻailona a kāohi i ka ulu ʻana o ka puʻupuʻu.
• Kemokalama:Nā lāʻau lapaʻau ikaika e pepehi ai i nā hunaola kanesa.
• Lapaʻau i hoʻolālā ʻia: Hoʻolālā kēia mau lāʻau i nā genes kikoʻī a i ʻole nā ​​​​protein i loaʻa wale i nā cell cancer a hoʻouka iā lākou, no laila e hōʻemi ana i ka hōʻino ʻana i nā cell olakino.
• Lapaʻau radiation: Hoʻohana ʻia nā lāʻau lapaʻau radiation kikoʻī no kēia. No ka laʻana, hoʻohana kahi ʻano hana i kapa ʻia ʻo `peptide receptor radionuclide therapy (PRRT)` i kahi mea radioactive e kuhikuhi i nā ʻōpū e hana ana i nā hormone a luku iā lākou.

Pehea e ola ai me kēia maʻi?

Ke ʻike ʻoe he NETs kāu, nui paha kāu mau nīnau. Hiki ke ho'ōla ʻia kēia? Pehea lā koʻu wā e hiki mai ana?

ʻO ka wānana no kēia maʻi e pili ana i kekahi mau kumu. ʻO kēia mau mea ke ʻano o ka puʻupuʻu, inā ua pālahalaha, a pehea ka maikaʻi o kāna pane ʻana i ka lāʻau. Ma ka awelika, ʻo ka nui o ke ola ʻelima makahiki ma hope o ka ʻike ʻana ma kahi o 39%.

ʻAʻole manaʻo ka hoʻopau ʻana i ka mālama ʻana ua pau nā mea āpau. No ka mea, ulu koke kēia mau puʻupuʻu a hiki ke hoʻi hou ma hope o ka mālama ʻana, e nānā kāu kauka iā ʻoe no nā makahiki.

Pehea ʻoe e mālama ai iā ʻoe iho?

Hiki i kēia maʻi a me kāna mau lāʻau lapaʻau ke hoʻopilikia nui i kou kino a me kou noʻonoʻo.

• E hui pū me nā hui kākoʻo: He paʻakikī ke hakakā wale ʻana me ka maʻi kanesa. ʻOiai inā loaʻa iā ʻoe kahi maʻi laha ʻole e like me kēia, hiki ke paʻakikī ke loaʻa ka poʻe e hoʻomaopopo i kou ʻeha. E nīnau i kāu hui lapaʻau e pili ana i nā hui kākoʻo no ka poʻe me kēia maʻi.
• E ʻai i ka meaʻai momona: Hiki i nā hopena ʻaoʻao o ka lāʻau lapaʻau ke hoʻemi i ka makemake. E kūkākūkā me kahi meaʻai no ka ʻōlelo aʻoaʻo e pili ana i nā meaʻai e kōkua i ka mālama ʻana i kou pae ikehu.
• E kiʻi i ke kākoʻo noʻonoʻo: ʻAʻole maʻalahi kēia huakaʻi e like me kou manaʻo. Inā ʻoe e manaʻo nei ua kaumaha loa ʻoe, mai hilahila e ʻimi i ke kōkua mai kahi loea olakino noʻonoʻo.
• E makaʻala i ka inu ʻana i ka waiʻona: Hiki i ka waiʻona ke hoʻonui i kekahi mau hōʻailona, ​​​​no laila e kūkākūkā me kāu kauka e pili ana i ka inu ʻana i ka waiʻona.

Āhea wau e ʻike ai i ke kauka?

Inā loaʻa iā ʻoe ka NET, e makaʻala i nā loli i kou kino. ʻOi aku hoʻi, inā ʻike ʻoe i ka ʻulaʻula koke, ka pehu ʻana o ka ʻōpū, a i ʻole ka hanu ʻana, he mau hōʻailona paha kēia o kahi maʻi i kapa ʻia ʻo carcinoid syndrome. I ia mau hihia, e hoʻomaopopo koke i kāu kauka.

Eia kekahi, inā e ʻoi aʻe ka ʻino o kāu mau hōʻailona, ​​a inā paʻakikī ke ʻae i nā hopena ʻaoʻao o ka lāʻau lapaʻau, e ʻimi i ke kōkua lapaʻau.

Āhea ʻoe e hele ai i ka Emergency Treatment Unit (ETU)?

Aia kekahi mau hihia kahi e hiki ai i nā NET ke hoʻopilikia i ka puʻuwai. Inā ʻike ʻoe i ka pehu ʻano ʻē i kou mau wāwae a i ʻole nā ​​kuʻekuʻe wāwae, a manaʻo koke ʻoe i ka hanu ʻole, e hele koke i ka ʻOihana Pilikia (ETU) o ka haukapila kokoke loa.

ʻO ka mea hope loa, he mea maʻamau ka loaʻa ʻana o nā nīnau he nui ke aʻo ʻoe e pili ana i kahi maʻi laha ʻole e like me kēia. ʻO ke kamaʻilio ākea ʻana me kāu kauka a me ka nīnau ʻana i kāu mau nīnau a pau e hiki ke kōkua nui iā ʻoe e kāohi i kou olakino.