He mea maʻamau ke hopohopo iki a me ka hoihoi i ka wā e kuhikuhi ai kāu kauka i kahi lāʻau lapaʻau hou a kūikawā nou a i ʻole kekahi o kou ʻohana. ʻOi loa aku inā he lāʻau lapaʻau maʻi kanesa. No laila i kēia lā e kamaʻilio mākou e pili ana i kekahi lāʻau lapaʻau kūikawā, ʻo Pexidartinib. Loaʻa pinepine ia ma lalo o ka inoa inoa ʻo Turalio. E kamaʻilio kākou e pili ana i kēia lāʻau lapaʻau, pehea e hoʻohana ai, nā mea hiki iā ia ke hana, a me nā mea e pono ai mākou e makaʻala, ma ke ʻano maʻalahi loa, me he mea lā e kamaʻilio ana mākou me kahi hoaaloha.
I ka ʻōlelo maʻalahi, he aha ka Pexidartinib?
ʻAʻole ʻo Pexidartinib kahi lāʻau lapaʻau e like me ka chemotherapy a mākou i ʻike mau ai. He lāʻau lapaʻau kēia no ka māhele o ka lāʻau lapaʻau i kuhikuhi ʻia . E noʻonoʻo e pili ana i ia mea, hoʻopilikia nā lāʻau lapaʻau maʻamau i nā cell maikaʻi. Akā ʻo kēia lāʻau lapaʻau i kuhikuhi ʻia e pili ana i ka loaʻa ʻana o nā mea e like me nā protein kūikawā i loko o nā cell cancer a me ka hoʻōki ʻana i ko lākou ulu ʻana. Ua like ia me ka hoʻohana ʻana i kahi kī kūikawā e wehe i kahi laka kūikawā.
Hoʻohana nui ʻia kēia lāʻau lapaʻau e mālama i kahi maʻi kanesa i kapa ʻia ʻo Tenosynovial Giant Cell Tumor (TGCT) . He ʻano puʻupuʻu kakaikahi kēia e kū mai ana i loko o nā hono. No laila, ʻo ka hana a kēia lāʻau lapaʻau, ʻo ia ke kāohi i ka ulu ʻana o kēlā mau hunaola kanesa a kāohi i ka maʻi.
Nā mea āu e haʻi aku ai i kāu kauka ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau
He mea nui loa kēia. Ma mua o ka hoʻoholo ʻana o kāu kauka e hāʻawi iā ʻoe i kēia lāʻau lapaʻau, pono ʻo ia e ʻike i kou mōʻaukala olakino piha. No laila, inā loaʻa iā ʻoe kekahi o kēia mau maʻi, e ʻoluʻolu e haʻi i kāu kauka me ka hūnā ʻole.
- Maʻi akepaʻa: Hiki i kēia lāʻau lapaʻau ke hoʻopilikia i ke akepaʻa, no laila pono ʻoe e haʻi i kāu kauka inā loaʻa iā ʻoe kekahi maʻi akepaʻa.
- Maʻi puʻupaʻa: Pono hoʻi ke kauka e makaʻala i ka hana o nā puʻupaʻa.
- Inā ʻoe e hoʻāʻo nei e hāpai a hāpai paha: ʻAʻole loa e ʻōlelo ʻia e hāpai i ka wā e lawe ana i kēia lāʻau. E kamaʻilio mākou e pili ana i kēia ma hope.
- Inā he makuahine hānai waiū ʻoe: ʻAʻole kūpono kēia no nā makuahine hānai waiū, no ka mea hiki i ka lāʻau lapaʻau ke hele i ka pēpē ma o ka waiū umauma.
- Nā Maʻi ʻAleʻale ʻē aʻe: E haʻi mai iā mākou inā he mau maʻi ʻaleʻale kou, ʻaʻole wale i ka pexidartinib, akā i kekahi lāʻau lapaʻau ʻē aʻe, meaʻai, a mea hoʻoluʻu paha.
Ua like kou kauka me kou hoaaloha maikaʻi loa. Mai hūnā i kekahi mea mai ona aku. Aia kou palekana ma ka pololei o ka ʻike āu e hāʻawi ai.
Pehea pololei e pono ai iaʻu ke hoʻohana i kēia lāʻau lapaʻau?
I mea e loaʻa ai ka hopena maikaʻi loa mai kahi lāʻau lapaʻau, he mea nui e hoʻohana pono. E hoʻomanaʻo pono i kēia mau kuhikuhi.
1. Kāpule Waha: He kāpule kēia āu e lawe ai me ke aniani wai.
2. E ale holoʻokoʻa: E ʻoluʻolu, mai uhaʻi, a nau paha i kēia capsule. E ale holoʻokoʻa.
3. E lawe i ka ʻōpū ʻole: ʻO kēia ka mea nui loa. Pono e lawe ʻia kēia lāʻau lapaʻau me ka ʻole o ka meaʻai . ʻO ia hoʻi, pono e lawe ʻia ma ka liʻiliʻi hoʻokahi hola ma mua a i ʻole ʻelua hola ma hope o ka ʻai ʻana . ʻO ka lawe ʻana me ka meaʻai hiki ke hoʻopilikia i ka pono o ka lāʻau lapaʻau.
4. Mai lawe pū me ka wai pomelo: E pale i ka inu ʻana i ka wai pomelo a i ʻole ka wai pomelo i ka wā e lawe ana i kēia lāʻau. Hiki iā ia ke hoʻopilikia nui i ka pono o ka lāʻau.
5. E makaʻala me nā antacids: E pale i ka lawe ʻana i nā antacids i hoʻohana ʻia no ka gastritis (e.g. Digene, Gelusil) i loko o ʻelua hola o ka lawe ʻana i kēia lāʻau.
6. E lawe i ka manawa kūpono: E lawe i kāu lāʻau lapaʻau i ka manawa i kuhikuhi ʻia a ma nā wā i kuhikuhi ʻia. Mai lawe ʻoi aku ma mua o ka nui i kuhikuhi ʻia.
7. Mai ho'ōki i ka lawe ʻana i ka lāʻau lapaʻau me ka ʻole o ke aʻo ʻana a ke kauka: Mai ho'ōki i ka lawe ʻana i ka lāʻau lapaʻau no kekahi kumu me ka ʻole o ke aʻo ʻana a kāu kauka.
He aha kāu e hana ai inā e poina ʻoe i kahi mahele o ka lāʻau lapaʻau?
Inā poina iā ʻoe ke lawe i kahi lāʻau, e hōʻalo i kēlā lāʻau. E lawe i ka lāʻau aʻe i ka manawa maʻamau. Mai lawe i ʻelua lāʻau i ka manawa hoʻokahi e hoʻopiha ai i kahi lāʻau i hala.
He aha inā lawe nui wau i ka lāʻau lapaʻau?
Inā manaʻo ʻoe ua lawe hewa ʻoe i nā lāʻau lapaʻau ma mua o kou manaʻo, e kelepona koke aku i ke Kikowaena ʻIke ʻAi Poisons ma ka Halemai Lahui ʻo Colombo . A i ʻole e hele i ka Emergency Treatment Unit (ETU) o ka haukapila kokoke loa.
Nā mea ʻē aʻe e launa pū me kēia lāʻau lapaʻau (Nā Hana like ʻana)
Hiki i ka Pexidartinib ke launa pū me nā lāʻau lapaʻau ʻē aʻe, nā huaora, a i ʻole nā huahana lāʻau lapaʻau āu e lawe nei. No laila, he mea nui loa ia e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau, ʻoiai nā huaora, āu e lawe nei. Eia kekahi mau mea e makaʻala nui ai.
| ʻAno lāʻau/mea | No ke aha ʻoe e mālama ai? |
|---|---|
| Mai lawe pū me kēia mau mea. | |
| ʻO Dasabuvir, Ombitasvir, Paritaprevir, Ritonavir (nā lāʻau lapaʻau no ka maʻi hepatitis C), Ranolazine (nā lāʻau lapaʻau no ka maʻi puʻuwai) | Hiki i kēia mau mea ke hana i nā hopena ʻaoʻao koʻikoʻi ke hui pū ʻia me Pexidartinib. |
| E kūkākūkā i kēia mau mea me kāu kauka. | |
| ʻO kekahi mau lāʻau lapaʻau no ka gastritis (e.g. Cimetidine, Famotidine, Omeprazole, Esomeprazole) | Hiki i kēia ke hōʻemi i ka omo ʻana o Pexidartinib i loko o ke kino. |
| Nā ʻano hana hoʻomalu hānau hormonal (nā pila, nā ʻāpana, nā inikini) | Hiki paha i ka Pexidartinib ke hōʻemi i ka pono o ka kaohi hānau, no laila e nīnau i kāu kauka e pili ana i ka hoʻohana ʻana i kahi ʻano kaohi hānau ʻē aʻe. |
| Wai ʻāpala | Hiki i nā pae Pexidartinib i loko o ke kino ke lilo i mea kiʻekiʻe loa. |
| ʻO St. John's Wort (huahana lāʻau lapaʻau) | Hoʻemi kēia i ka pono o Pexidartinib. |
| ʻO nā lāʻau antibiotic a me nā antifungal ʻē aʻe e like me Rifampicin, Itraconazole | Hiki paha i kēia ke hoʻopilikia i nā pae o Pexidartinib. |
Nā hopena ʻaoʻao e hiki mai ana i ka wā e lawe ana i ka lāʻau lapaʻau
E like me nā lāʻau lapaʻau āpau, hiki i kēia lāʻau lapaʻau ke hana i nā hopena ʻaoʻao. ʻAʻole loaʻa i nā kānaka a pau. Eia nō naʻe, he mea nui e makaʻala i kēia mau mea.
| Nā hōʻailona e pono e hōʻike koke ʻia i kāu kauka a i ʻole ka haukapila (ETU) | |
|---|---|
| Nā hōʻailona o ka hōʻino ʻana o ke akepaʻa | Mimi melemele ʻeleʻele a ʻeleʻele paha, melemele o nā maka a i ʻole ka ʻili, ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū, luhi loa, nausea, nalowale o ka makemake e ʻai, a me nā ʻōpala māmā. |
| Nā maʻi ʻaleʻale koʻikoʻi | ʻŌhūhū ʻili, maneʻo, pehu o ka maka, lehelehe a i ʻole ke alelo, paʻakikī ke hanu. |
| Ka luaʻi ʻana a i ʻole ke kuni | Ka luaʻi ʻana a i ʻole ke kuni hiki ʻole ke hoʻōki. |
| Inā hoʻomau a lilo paha i mea hoʻopilikia, e hoʻomaopopo i kāu kauka. | |
| Ka loli ʻana o ka ʻono i loko o ka waha | Nā loli i ka ʻono o ka meaʻai. |
| Ka paʻa ʻana o ka ʻōpū | Ka paʻakikī o ka hoʻokahe ʻana. |
| Ka pehu ʻana a i ʻole ka ʻūlū ʻana i nā lālā | ʻUlili, ʻeha, a pehu paha ma nā lima, nā wāwae, a i ʻole nā manamana lima. |
Hoʻolaha kūikawā e pili ana i ka hāpai ʻana a me ka hānau keiki ʻana
He mea nui loa kēia.
- Nā wāhine: E pale i ka hāpai ʻana i ka wā e lawe ana i kēia lāʻau lapaʻau a no hoʻokahi mahina ma hope o ka hoʻōki ʻana i ka lāʻau lapaʻau. E hoʻohana i kahi ʻano kaohi hānau hilinaʻi loa i kēia manawa.
- Nā kāne: Inā ʻoe e lawe nei i kēia lāʻau lapaʻau, e pale i ka hānau ʻana i kahi keiki i ka wā e lawe ana i ka lāʻau lapaʻau a no hoʻokahi pule ma hope o ka hoʻōki ʻana.
Hiki i kēia lāʻau lapaʻau ke hōʻeha nui i kahi pēpē i hānau ʻole ʻia. Hiki iā ia ke hoʻopilikia i ka hānau keiki no kekahi manawa a mau loa paha. Inā he mau hopohopo kāu e pili ana i kēia, e kamaʻilio me kāu kauka ma mua o ka hoʻomaka ʻana i ka lāʻau.
Leka Lawe-Home
- He lāʻau lapaʻau kūikawā ʻo Pexidartinib e kuhikuhi ana i nā hunaola kanesa. He mea nui e lawe pololei ia e like me ke kauoha a kāu kauka, ʻoi aku ka maikaʻi ma ka ʻōpū ʻole.
- E haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe, nā huaora, a me nā huahana lāʻau āu e lawe nei. E pale i ka inu ʻana i ka wai pomelo.
- E ʻimi koke i ke kōkua lapaʻau inā loaʻa iā ʻoe nā hōʻailona o ka hōʻino ʻia o ke akepaʻa (melemele o ka ʻili/maka, mimi ʻeleʻele) a i ʻole nā hopena maʻi ʻaleka koʻikoʻi.
- He mea nui loa ia e pale aku i ka hāpai ʻana i ka wā e lawe ana i kēia lāʻau lapaʻau a no ka manawa i kuhikuhi ʻia. Pili kēia i nā wahine a me nā kāne.
- Inā he mau hopohopo, nīnau, a hopohopo paha kāu e pili ana i kēia lāʻau lapaʻau, e ʻoluʻolu e kūkākūkā me kāu kauka. Ua mākaukau mau lākou e kōkua iā ʻoe.
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