Luhi i ka migraines? E kamaʻilio kākou e pili ana i nā Triptans!

ʻO ka migraine e like me ka pahū ʻana o kou poʻo, ʻike ʻia nā kukui i mua o kou mau maka, a manaʻo ʻoe e like me ka luaʻi ʻana ... Ua kamaʻāina anei ʻoe i kēia ʻike? I kekahi manawa pono ʻoe e noho i loko o kahi lumi pouli a mālie i ka lā a pau, ʻeā? ʻAʻole wale ka migraine he poʻo ʻeha, he mea ia e ʻike wale ʻia e ka mea i loaʻa iā ia. No laila i kēia lā e kamaʻilio mākou e pili ana i kahi ʻano lāʻau koʻikoʻi i hoʻohana ʻia e mālama i nā migraines. ʻO ia ʻo Triptans.

He aha nā Triptans?

I ka ʻōlelo maʻalahi, ʻo Triptans kahi ʻano lāʻau lapaʻau i hāʻawi ʻia e hoʻōki i ka hoʻouka ʻana o ka migraine ke hoʻomaka . Ua manaʻo ʻia lākou ʻo ia ka lāʻau lapaʻau mua no ka migraines. I ka hapa nui o nā hihia, ʻaʻole pale kēia mau lāʻau i ka hoʻouka ʻana o ka migraine, akā hiki iā lākou ke kōkua i ka hoʻomalu ʻana i ka ʻeha a me nā hōʻailona ʻē aʻe ke hoʻomaka .

ʻAʻole wale ka migraine he ʻeha poʻo. He maʻi neurological ia e hoʻopilikia ai i ko kākou lolo. ʻO ia ke kumu, ma waho aʻe o ke poʻo, aia nā mea e like me nā loli o ka ʻike, ka ʻike ʻana i nā kukui i mua o ko kākou mau maka (aura), ka nausea, ka luaʻi ʻana, a me ka ʻike ʻana i ka mālamalama a me ke kani. No kekahi poʻe, ua koʻikoʻi loa kēia mau hōʻailona ʻaʻole hiki iā lākou ke hana i kekahi mea koe wale nō ka moe ʻana i kahi pouli a mālie a hiki i ka pau ʻana o ka migraine.

Ua hoʻololi nā Triptans, i ʻike ʻia i nā makahiki 1980, i ka mālama ʻana i nā migraines. Ua hoʻolauna ʻia ka triptan mua, ʻo `(Sumatriptan),` i nā makahiki 1990. Ua hoʻolauna ʻia kekahi mau triptans ʻē aʻe ma hope.

He aha nā ʻano triptans i loaʻa?

ʻEhiku ʻano triptan i kēia manawa. Hoʻōla lākou a pau i nā migraines, akā ua ʻae ʻia kekahi no nā ʻano migraines kikoʻī a no ka hoʻohana ʻana i nā keiki a me nā ʻōpio. ʻO ke ala maʻalahi loa e ʻike ai i kēia mau lāʻau lapaʻau, ʻo ia ke ʻimi i ka hopena "-triptan" ma ko lākou mau inoa.

Hōʻike ka papa ma lalo nei i nā ʻano triptans a pehea e hiki ai ke loaʻa.

Pehea e hana maoli ai kēia mau lāʻau i kapa ʻia ʻo Triptans?

I mea e maopopo ai pehea e hana ai kēia lāʻau lapaʻau, pono mākou e hoʻomaopopo iki e pili ana i ke ʻano o ko mākou ʻeha a pehea e hiki ai ka migraines.

E nānā kākou i ke ʻano o ko kākou ʻeha.

E noʻonoʻo ʻoe ua pā ʻoe i kou manamana lima ma kekahi wahi. ʻAʻole ʻike maoli ʻia ka ʻeha e ka manamana lima. Hoʻouna nā aʻalolo ma ka manamana lima i kahi hōʻailona i ka lolo e ʻōlelo ana, "Ua ʻeha kekahi mea ma ʻaneʻi." Unuhi ka lolo i kēlā hōʻailona i "ʻeha" a hoʻomaopopo iā ʻoe.

ʻAʻohe hopena aʻalolo ʻike ʻeha o ko kākou lolo, ʻo ia ke kumu i maopopo ʻole ai i nā kānaka ʻepekema pehea e hiki ai ke loaʻa nā migraines. Akā ua ʻike lākou i kekahi mau ʻano hana e hiki ke kōkua i kēia.

ʻO ka moʻolelo ma hope o nā migraines

Ua manaʻo ʻia he ʻekolu mau kumu nui e kōkua i ka loaʻa ʻana o ka migraines:

1. Hoʻāla ʻia ʻana o nā neuron: Hana ʻia ko kākou lolo, ke kaula kuamoʻo, a me nā aʻalolo i nā pūnaewele i kapa ʻia he neurons. Ke loaʻa kahi migraine, hoʻā kekahi mau neurons i loko o ka lolo ma ke ʻano kikoʻī. ʻO kēia hoʻāla ʻana o ka lolo ke kumu e ʻeha ai mākou a me nā hōʻailona ʻē aʻe o ka migraine.

2. Nā loli i ke kahe koko: I ka wā o ka migraine, ʻūlū a hoʻonui ʻia nā kīʻaha koko i loko o ka lolo. Hoʻololi kēia i ke kahe koko. ʻOiai ua hoʻopilikia nā triptans i kēia mau kīʻaha koko, ua manaʻo ʻia hoʻi he kumu kēia o ka migraines.

3. Ka mumū:He hana ka mumū e hoʻohana ai ko mākou kino e pale a ho'ōla iā ia iho. Ua ʻike ʻia hoʻi ua hoʻokuʻu ʻia nā kemika e hoʻoulu ai i ka mumū i ka wā o ka migraines.

Pehea ka hopena o nā triptans i kēia kaʻina hana?

I kēia manawa, e nānā kākou pehea e komo ai nā Triptans i kēia. Hoʻopili ʻia nā pūnaewele o kā mākou ʻōnaehana nerve kekahi i kekahi ma o nā kemika i kapa ʻia he neurotransmitters. Ua like kēia me nā kī. Loaʻa i nā pūnaewele nerve nā ʻāpana i kapa ʻia he receptors. Ua like kēia me nā kī. Ke hoʻopili ke kī ʻākau (neurotransmitter) i ke kī ʻākau (receptor), e hoʻāla ʻia ke kelepona.

Hana nā Triptans ma ke hoʻohālike ʻana i ka neurotransmitter serotonin i loko o ka lolo. ʻO ke ʻano kēia e hoʻopaʻa a hoʻāla kēia mau lāʻau i nā mea loaʻa no ka serotonin. Hoʻopilikia nui lākou i ʻekolu ʻano o nā mea loaʻa:

• Nā mea hoʻokipa 5HT1B: Loaʻa kēia mau mea i loko o nā kīʻaha koko o ka lolo. Ke hoʻāla nā triptans i kēia mau mea hoʻokipa, ʻūlū nā kīʻaha koko i hoʻonui pono ʻole ʻia ma muli o ka migraines. Hoʻemi kēia i ka ʻeha.
• Nā mea hoʻokipa 5HT1D: Aia kēia mau mea i loko o ka ʻōnaehana nerve "Trigeminal", ka mea e pili ana i ko mākou ʻike ʻana i ka ʻeha. Ke hoʻāla nā triptans i kēia mau mea, hoʻōki lākou i ka hoʻokuʻu ʻana o nā kemika e hoʻoulu ai i ka ʻeha.
• Nā mea loaʻa 5HT1F: Kōkua pū kēia i ka palena o ka hoʻoili ʻana o nā hōʻailona ʻeha i ka lolo.

He aha nā pōmaikaʻi o ka hoʻohana ʻana i nā Triptans?

He nui nā pono o Triptans i hoʻohālikelike ʻia me nā lāʻau migraine ma mua.

• Nā hopena ʻaoʻao liʻiliʻi: ʻOi aku ka liʻiliʻi o nā hopena ʻaoʻao o Triptans ma mua o nā lāʻau lapaʻau kahiko, a ʻaʻole lākou i ʻoi aku ka koʻikoʻi.
• ʻAʻole hoʻomake: Hiki i kekahi mau lāʻau ʻeha no ka migraines, ʻoiai nā opioids, ke hoʻomake. Eia nō naʻe, ʻaʻole hoʻomake nā triptans.
• Palekana loa: ʻO nā Triptans ma ke ʻano laulā he papa lāʻau lapaʻau palekana loa. ʻO nā lāʻau lapaʻau e like me `(Sumatriptan)` he palekana loa ia ma kekahi mau ʻāina hiki ke kūʻai ʻia ma luna o ke kūʻai ma kahi hale kūʻai lāʻau me ka ʻole o ke kauoha a ke kauka.
• Loaʻa i nā ʻano like ʻole: E like me kā mākou i ʻike ai ma ka papa ma mua, hiki ke loaʻa kēia mau mea ma nā ʻano like ʻole e like me nā pila, nā pīpī ihu, a me nā inikini. ʻOi aku ka maʻalahi o ka pīpī ihu no ka mea paʻakikī ke ale i kahi pila a i ʻole e luaʻi ana.

Aia kekahi mau pilikia, nā hopena ʻaoʻao, a me nā hemahema?

E like me nā lāʻau lapaʻau a pau, loaʻa iā Triptans kekahi mau hopena ʻaoʻao a me nā mea e pono ai ke makaʻala.

Nā pōʻino o nā Triptans

ʻO ka hemahema nui, ʻaʻole lākou e pale i ka migraines . Hoʻohana ʻia lākou ma ke ʻano he lāʻau hoʻopakele e "hoʻōki" i ka migraine ma hope o kona hoʻomaka ʻana. Eia nō naʻe, aia kekahi hihia kūikawā, ʻo ia ka menstrual migraine. Hiki i kekahi mau triptans ke kōkua i ka pale ʻana i ka migraines inā lawe ʻia ma kahi o ʻelua lā ma mua o kou wā. E aʻo aku kāu kauka iā ʻoe i kēia.

ʻO kekahi mea ʻē aʻe , ʻaʻole maikaʻi ka hoʻohana nui ʻana iā lākou . Pono kekahi poʻe i ʻoi aku ma mua o hoʻokahi mahele o ka lāʻau lapaʻau e hōʻemi i ka migraines. Eia nō naʻe, inā ʻoe e lawe pinepine i nā Triptans, e emi paha ko lākou pono. ʻAʻole wale ia, akā hiki iā ʻoe ke loaʻa i kahi "lāʻau lapaʻau-overuse headache" ma muli o ka hoʻohana nui ʻana i ka lāʻau lapaʻau. No laila, he mea nui loa ka hoʻohana ʻana i kēia mau mea ma ka nui a me ka pinepine i kuhikuhi ʻia, e like me ka ʻōlelo a ke kauka .

Nā hopena ʻaoʻao maʻamau

ʻOiai ʻaʻole loaʻa i nā kānaka a pau kēia mau hopena ʻaoʻao i ka wā e lawe ai i nā triptans, hiki i kekahi poʻe ke ʻike iā lākou.

I ka manawa hea ʻoe e pono ʻole ai e lawe i nā triptans?

ʻAʻole kūpono nā Triptans no ka poʻe me kekahi mau kūlana olakino (Contraindications).

• Nā pilina me nā lāʻau lapaʻau ʻē aʻe: Inā ʻoe e lawe ana i nā lāʻau lapaʻau ʻē aʻe i loaʻa ka "Ergotamine" no nā migraines a i ʻole no nā kūlana ʻē aʻe, hiki iā lākou ke launa pū me nā Triptans. No laila, he mea nui e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau, nā huaora, a me nā mea hoʻohui āu e lawe nei .
• Maʻi puʻuwai a i ʻole nā ​​pilikia kahe koko: ʻAʻole kūpono nā Triptans inā loaʻa iā ʻoe ka maʻi puʻuwai, ke koko kiʻekiʻe i kāohi ʻole ʻia (hypertension), a i ʻole ka maʻi peripheral artery. ʻAʻole ʻōlelo nā kauka i kēia mau lāʻau lapaʻau inā ua loaʻa iā ʻoe a i ʻole he pilikia no nā maʻi puʻuwai, nā hōʻeha puʻuwai, nā hahau, a i ʻole nā ​​​​TIA.
• Hāpai a me ka hānai waiū: Inā hāpai ʻoe, e hoʻāʻo ana e hāpai, a hānai waiū paha, pono ʻoe e kamaʻilio me kāu kauka e pili ana i ka hoʻohana ʻana i nā triptans.

Āhea ʻoe e ʻimi ai i ke aʻo lapaʻau?

I ka manawa hea e kāhea aku ai i ke kauka

Inā loaʻa iā ʻoe nā hopena ʻino mai nā triptans, inā hoʻopilikia lākou i kāu mau hana o kēlā me kēia lā, a inā manaʻo ʻoe ʻaʻole e hana hou ana kahi lāʻau āu i lawe ai no ka manawa lōʻihi, e kamaʻilio me kāu kauka. Hiki paha iā ia ke hāʻawi iā ʻoe i kahi triptan ʻokoʻa a i ʻole kekahi lāʻau ʻē aʻe.

Nā kūlana e pono ai ka mālama koke ʻana

Hoʻokumu nā Triptans i nā hopena ʻaoʻao koʻikoʻi loa (ʻaʻole iʻoi aku ma mua o 1%), akā inā ʻike ʻoe i kekahi o kēia mau hōʻailona o ka maʻi puʻuwai a i ʻole ka hahau ʻana, pono ʻoe e hele koke i ka keʻena pilikia o ka haukapila (ETU) .

Nā hōʻailona e pili ana i ka maʻi puʻuwai:

• ʻEha a ʻeha paha ka umauma
• Puʻuwai wikiwiki (Tachycardia) a i ʻole ka puʻuwai lohi (Bradycardia)
• Ka paʻakikī o ka hanu ʻana (Dyspnea)

Nā hōʻailona e pili ana i ka hahau ʻana:

ʻO kekahi o nā hōʻailona nui o ka hahau ʻana, ʻo ia ka maʻi lolo, ka ʻeha, a i ʻole ka nāwaliwali ma kekahi ʻaoʻao o ke kino (hemiplegia). Hiki ke loaʻa kēia mau hōʻailona i kekahi mau hihia koʻikoʻi o ka migraine.

Inā ʻaʻole ʻoe i loaʻa i ka migraine ma mua a loaʻa iā ʻoe kahi ʻeha poʻo nui me nā hōʻailona like me kēia, e noʻonoʻo he pilikia ia.

ʻO wai ka Triptan i kūpono iaʻu?

He nīnau kēia a nā poʻe he nui e nīnau ai. ʻAʻohe mea e like me ka "triptan maikaʻi loa." ʻO kahi lāʻau lapaʻau e hana maikaʻi loa no kekahi kanaka ʻaʻole paha e hana maikaʻi no kekahi. Na kāu kauka e hoʻoholo i ka triptan maikaʻi loa iā ʻoe a pehea e lawe ai (nā pila a i ʻole ka pīpī) ma muli o nā kumu he nui, me ke ʻano o kou migraines, kou mau kūlana olakino ʻē aʻe, a me nā lāʻau lapaʻau ʻē aʻe āu e lawe ai .

Ma mua o ka ʻike ʻia ʻana o nā triptans, ua paʻakikī loa ke ola o ka poʻe maʻi migraine. I kēia lā, mahalo i kēia mau lāʻau lapaʻau, ua noa nā miliona o ka poʻe mai ka ʻeha o ka migraines a hiki ke ola maʻamau. Inā ʻeha ʻoe i ka migraines, mai hoʻomanawanui wale i ka ʻeha. E kamaʻilio me kāu kauka a ʻike inā hiki i nā triptans ke kōkua iā ʻoe. Hiki i kēia mau lāʻau lapaʻau ke kōkua iā ʻoe e ola i kou lā ma ke ʻano maʻamau, ma kahi o ka lolo ʻia e ka migraines.