ʻO ka maʻi Sickle Cell kahi maʻi e hiki ke lilo i pilikia maoli i ke ola. ʻO ka poʻe wale nō i ʻike iā ia e ʻike i ka paʻakikī o ke ola me ka ʻeha mau, ka luhi, a me nā pilikia ʻē aʻe. Eia nō naʻe, me ka holomua o ka ʻepekema lapaʻau, ua loaʻa nā lāʻau lapaʻau hou e kāohi i kēlā mau maʻi. ʻO kekahi o ia ʻano lāʻau lapaʻau hou a holomua ʻo Voxelotor. No laila, inā ua kuhikuhi kāu kauka i kēia lāʻau lapaʻau nou, he mea nui loa ia e ʻike piha ʻia e pili ana i ia mea. I kēia lā, e kamaʻilio kākou e pili ana i kēia mau pila Voxelotor.
He aha ke ʻano lāʻau lapaʻau ʻo Voxelotor?
I ka ʻōlelo maʻalahi, ʻo Voxelotor kahi ʻano lāʻau lapaʻau kūikawā i hoʻohana ʻia e mālama i ka maʻi cell sickle . Ma ke ʻano lapaʻau, no ka papa o nā lāʻau i kapa ʻia ʻo 'hemoglobin S polymerization inhibitors'.
I kēia manawa, ke noʻonoʻo nei paha ʻoe i ke ʻano o ia mea. He mea maʻalahi loa ia. ʻO ke kanaka me ka maʻi cell sickle he protein i kapa ʻia ʻo hemoglobin i loko o ko lākou mau ʻulaʻula koko ʻulaʻula he ʻokoʻa iki ia. Ke haʻahaʻa nā pae oxygen, pili pū kēia mau mole hemoglobin, e hana ana i nā kaulahao lōʻihi e hoʻololi i ke ʻano o nā ʻulaʻula koko. Kūlou nā ʻulaʻula koko poepoe maʻamau i loko o ke ʻano sickle. ʻO kēia mau ʻulaʻula sickle ka mea e paʻa ai i loko o nā kīʻaha koko liʻiliʻi, e hana ana i nā pilikia e like me ka ʻeha a me ka hōʻino ʻana o nā ʻōkana.
No laila, ʻo ka mea a Voxelotor e hana ai, ʻo ia ke pale aku i nā molekole hemoglobin mai ka hui pū ʻana (polymerization). Hoʻemi kēia i nā hunaola koko ʻulaʻula ʻano sickle a kōkua iā lākou e mālama i ko lākou ʻano kūpono. ʻAe kēia i ke koko e kahe maikaʻi a hoʻemi i nā pilikia o ka maʻi i kahi nui.
Nā mea e haʻi aku i kāu kauka ma mua o ka hoʻomaka ʻana i kēia lāʻau lapaʻau
Ma mua o ka hoʻomaka ʻana i ka lāʻau Voxelotor, he mea nui e hāʻawi i kāu kauka i kahi wehewehe piha o kou kūlana olakino. E hōʻoia e haʻi pono i kēia mau mea.
- Inā he maʻi akepaʻa kou: Inā maikaʻi ʻole ka hana o kou akepaʻa, hiki ke hoʻopilikia i ke ʻano o ka lawe ʻia ʻana o ka lāʻau mai kou kino. No laila, pono paha kāu kauka e hoʻololi i ka nui o ka lāʻau.
- Inā ua loaʻa iā ʻoe kahi hopena maʻi i ka Voxelotor a i ʻole kekahi lāʻau lapaʻau a meaʻai paha: Loaʻa i kekahi poʻe ka maʻi i kekahi mau lāʻau lapaʻau. No laila e hōʻoia e haʻi mai iā mākou inā ua loaʻa iā ʻoe kekahi ʻike ma mua.
- Inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai: Pono ʻoe e makaʻala loa e pili ana i ka hoʻohana ʻana i ka lāʻau lapaʻau i ka wā hāpai. No laila e kamaʻilio me kāu kauka e pili ana i kēia.
- Inā he makuahine hānai ʻoe: Hiki i kekahi mau lāʻau lapaʻau ke hele i kāu pēpē ma o ka waiū umauma. No laila, e hoʻomaopopo i kāu kauka e pili ana i kēia.
Pehea e pono ai iaʻu ke hoʻohana i kēia mau pila?
No ka loaʻa ʻana o ka hopena maikaʻi loa mai ka lāʻau lapaʻau, he mea nui loa ia e hoʻohana pono.
- E ale i kēia papa me ke aniani wai. Mai uhaʻi, kuʻi, a nau paha i ka papa. E ale i ka papa. Inā ʻaʻole pēlā, e loli paha ke ʻano o ka komo ʻana o ka lāʻau i loko o ke kino, e hōʻemi ana i kona pono.
- Hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau me ka meaʻai a me ka ʻole. Eia nō naʻe, inā ʻeha kou ʻōpū a nausea paha, ʻoi aku ka maikaʻi o ka lawe ʻana ma hope o ka ʻai ʻana.
- E lawe i kāu lāʻau lapaʻau i kēlā me kēia lā, e like me ke kauoha a kāu kauka. Mai lawe i hoʻokahi lā a laila e kāpae i ka lā aʻe.
- ʻOiai inā ʻoe e ʻoi aku ka maikaʻi, mai hoʻōki i ka lawe ʻana i ka lāʻau me ka ʻole o ke aʻo ʻana a kāu kauka.
Mea nui: Ua kuhikuhi ʻia kēia lāʻau lapaʻau nou wale nō. Mai hāʻawi i kēia lāʻau lapaʻau i kekahi mea ʻē aʻe i loaʻa nā hōʻailona like me ʻoe. He mea weliweli paha ia.
Inā hāʻawi ʻoe i kēia lāʻau lapaʻau i nā keiki ...
Hoʻomaopopo pū nā kauka i kēia lāʻau lapaʻau i nā keiki ma luna o 12 mau makahiki i kekahi mau hihia kūikawā. Eia nō naʻe, pono i kahi kauka keiki ke hoʻoholo. No laila, inā ʻoe e hāʻawi ana i kēia lāʻau lapaʻau i kāu keiki, e kamaʻilio pono me kāu kauka a e kiʻi i ka ʻōlelo aʻo.
He aha kāu e hana ai inā e poina ʻoe i kahi mahele o ka lāʻau lapaʻau?
Inā poina iā ʻoe ke lawe i kahi lāʻau lapaʻau, mai hopohopo. E hōʻalo i ka lāʻau lapaʻau i hala ʻole a lawe i ka lāʻau lapaʻau aʻe i ka manawa maʻamau. Mai lawe i kahi lāʻau lapaʻau pālua e hoʻopiha no kahi lāʻau lapaʻau i poina.
He aha inā lawe nui wau i ka lāʻau lapaʻau?
Inā manaʻo ʻoe ua lawe ʻoe ma mua o ka nui i kuhikuhi ʻia, e kelepona koke i ke Kikowaena ʻIke Poisons National ma ka Halemai Lahui ʻo Colombo . A i ʻole, e hele i ka Emergency Treatment Unit (ETU) o ka haukapila kokoke loa me ka hoʻokaʻulua ʻole.
Nā lāʻau lapaʻau ʻē aʻe e hiki ke launa pū me Voxelotor
Hiki i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei ke hoʻopilikia i ke ʻano o ka hana ʻana o Voxelotor. Hiki iā Voxelotor ke hoʻololi i ke ʻano o ka hana ʻana o nā lāʻau lapaʻau ʻē aʻe. No laila, e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe nei (me nā huaora, nā lāʻau lapaʻau lāʻau, a me nā mea hoʻohui) .
| ʻAno lāʻau lapaʻau | Hoʻomaopopo |
|---|---|
| Nā lāʻau antifungal (e.g. fluconazole, ketoconazole) | Hiki i kēia ke hoʻonui i ka pae o Voxelotor i loko o ke kino. |
| Nā lāʻau lapaʻau no ka maʻi puʻupuʻu (e.g. `rifampin`) | Hiki paha i kēia ke hōʻemi i ka pono o Voxelotor. |
| Ka lāʻau lapaʻau HIV (e.g. efavirenz) | Hiki ke hoʻololi ʻia nā hopena o Voxelotor. |
| ʻO kekahi mau lāʻau hoʻomaha (e like me midazolam) | Hiki paha iā Voxelotor ke hoʻololi i nā hopena o kēia mau lāʻau lapaʻau. |
ʻAʻole i piha kēia papa inoa. No laila e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe ai, inā ʻoe e puhipaka, a inā ʻoe e inu waiʻona.
Nā hopena ʻaoʻao e hiki mai ana ma muli o kēia lāʻau lapaʻau
E like me nā lāʻau lapaʻau āpau, hiki iā Voxelorator ke hana i nā hopena ʻaoʻao i kekahi poʻe. Hiki i kekahi o kēia mau mea ke hoʻoweliweli, no laila he mea nui e makaʻala iā lākou.
| Nā hopena ʻaoʻao koʻikoʻi e pono e hōʻike koke ʻia i ke kauka | |
|---|---|
| Nā hopena maʻi ʻaleka | ʻŌhūhū ʻili, maneʻo, pehu o nā lehelehe, ke alelo a i ʻole ka maka, paʻakikī ke hanu. |
| Nā Hōʻailona o ke Koko Paʻa | ʻEha koke ka umauma, paʻakikī ka hanu ʻana, ʻeha koke, pehu, a ʻulaʻula paha i ka wāwae. |
| Nā hopena ʻaoʻao ʻaʻole ia he mea weliweli, akā pono e hōʻike ʻia i ke kauka inā hoʻomau lākou | |
| Nā pilikia o ka ʻōnaehana hoʻoheheʻe | ʻEha ʻōpū, maʻi pākīkī, nausea. |
| Nā pilikia liʻiliʻi ʻē aʻe | ʻEha poʻo, luhi, kuni. |
Inā loaʻa iā ʻoe kekahi mau hōʻailona ʻē aʻe i ʻōlelo ʻole ʻia ma kēia papa inoa, e kamaʻilio pū me kāu kauka e pili ana iā lākou.
Pehea e mālama ai i ka lāʻau lapaʻau?
- E mālama iā ia mai ka hiki ʻana aku o nā keiki liʻiliʻi .
- E mālama ma ka mahana o ka lumi, ma lalo o 30 kekelē Celsius (86 kekelē Fahrenheit). E pale mai ka wela nui a me ka makū.
- E hoʻolei i ka lāʻau lapaʻau i pau me ka hoʻohana ʻole ʻana.
Leka Lawe-Home
- He lāʻau lapaʻau koʻikoʻi ʻo Voxelorator e pale ai i ke ʻano o nā hunaola koko ʻulaʻula i ka maʻi sickle cell a hōʻemi i nā pilikia o ka maʻi.
- Ma mua o ka hoʻomaka ʻana i kēia lāʻau lapaʻau, e haʻi i kāu kauka e pili ana i kāu ʻike olakino a me nā lāʻau lapaʻau ʻē aʻe āu e lawe nei.
- E ale holoʻokoʻa i ka pila, me ka ʻole o ka haki ʻana, ka wili ʻana, a me ka nau ʻana. E lawe i ka nui i kuhikuhi ʻia i ka manawa i kuhikuhi ʻia.
- Inā loaʻa iā ʻoe kekahi mau hopena ʻino e like me ka pehu ʻana o ka maka, ka paʻakikī o ka hanu ʻana, a i ʻole ka ʻeha o ka umauma, e ʻimi koke i ke kōkua lapaʻau.
- Nou wale nō kēia lāʻau lapaʻau. Mai kaʻana like me nā poʻe ʻē aʻe. Inā loaʻa iā ʻoe kekahi pilikia, e kamaʻilio mau me kāu kauka.
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