Koj puas xav tias koj lub cev tab tom tawm tsam koj los ntawm sab hauv? Tej zaum nws yog Antisynthetase Syndrome!

Puas muaj tej lub sij hawm koj xav tias muaj ib yam dab tsi ua rau koj mob sab hauv? Tej zaum koj cov pob qij txha mob, koj ua tsis taus pa me ntsis, lossis koj yuav pom qee qhov kev hloov me me ntawm koj daim tawv nqaij. Tsis txhob xav tias tej no yog ib yam dab tsi uas tab tom tshwm sim. Tej lub sij hawm muaj ib zaj dab neeg nyuaj dua tom qab lawv. Hnub no peb yuav tham txog ib qho mob uas tsis tshua muaj, tab sis peb tswj tau hu ua Antisynthetase Syndrome.

Antisynthetase Syndrome yog dab tsi? Hais yooj yim xwb...

Antisynthetase Syndrome yog ib qho mob tsis tshua muaj. Qhov tshwm sim hauv qhov no yog tias muaj kev o thoob plaws peb lub cev, uas yog, ib qho mob zoo li kev o. Qhov no yog ib qho kab mob autoimmune. Tam sim no koj tab tom nug tias kab mob autoimmune yog dab tsi.

Xav txog seb, peb lub cev muaj ib lub cev tiv thaiv kab mob . Nws zoo li ib pab tub rog uas tiv thaiv peb lub teb chaws. Cov hlwb thiab cov kab mob hauv lub cev no tiv thaiv peb ntawm cov kab mob, cov kab mob me me, thiab cov kab mob uas ua rau muaj kab mob. Txawm li cas los xij, hauv ib qho kab mob autoimmune, lub cev tiv thaiv kab mob no mus tsis zoo. Nws xav tias peb cov hlwb thiab cov nqaij noj qab haus huv yog "yeeb ncuab" thiab pib tawm tsam lawv. Nws zoo li peb pab tub rog tawm tsam peb lub tsev. Txawm tias cov kws kho mob tseem tsis tuaj yeem paub meej tias vim li cas qhov no tshwm sim.

Hauv Antisynthetase Syndrome, peb lub cev tiv thaiv kab mob tuaj yeem cuam tshuam rau cov cheeb tsam hauv qab no ntawm peb lub cev:

• Cov leeg nqaij
• Cov pob qij txha
• Lub ntsws
• Tawv nqaij
• Cov hlab ntsha

Qhov tseem ceeb tshaj plaws yog mus ntsib kws kho mob yog tias koj pom muaj mob pob qij txha tshiab, hloov pauv ntawm daim tawv nqaij, lossis ua pa nyuaj, yam tsis txhob tsis quav ntsej.

Kab mob no tsawg npaum li cas?

Tus kab mob no (Antisynthetase Syndrome) yog ib yam kab mob tsis tshua muaj . Nws nyuaj rau hais tias muaj pes tsawg tus neeg muaj tus kab mob no. Vim tias tsuas muaj ob peb tug neeg mob xwb uas tau tshaj tawm txhua xyoo. Qee zaum, cov tsos mob no zoo ib yam li cov tsos mob ntawm lwm yam kab mob, thiab nws yuav tsis pom.

Cov tsos mob ntawm Antisynthetase Syndrome yog dab tsi?

Cov tsos mob uas koj tshwm sim yuav nyob ntawm seb koj lub cev tiv thaiv kab mob ua haujlwm zoo npaum li cas hauv koj lub cev thiab nws ua rau nws puas tsuaj npaum li cas.

Feem ntau, cov neeg uas muaj tus kab mob Antisynthetase Syndrome muaj cov tsos mob ntawm ntau yam mob ua ke. Cia peb saib seb lawv yog dab tsi:

• Mob Pob Qij Txha: Qhov no yog kev o ntawm cov leeg nqaij mus sij hawm ntev. Qhov no ua rau cov leeg mob thiab tsis muaj zog.Nws tshwm sim. Xav txog seb, koj xav tias koj tsis muaj zog heev uas koj tsis tuaj yeem tsa koj txhais tes. Qee zaum cov leeg nqaij hauv koj lub caj pas tsis muaj zog, ua rau nws nyuaj rau nqos zaub mov thiab haus dej. Peb hu qhov ntawd ua dysphagia .

• "Tes Kws Kho Tshuab": Lub npe no puas yog ib lub npe txawv txawv me ntsis? Qhov no yog qhov uas daim tawv nqaij ntawm xib teg thiab sab ntawm cov ntiv tes tuab thiab tawg. Nws zoo li txhais tes ntawm tus kws kho tshuab uas ua haujlwm nrog roj thiab roj thoob plaws hnub.

• Kab mob ntsws interstitial (ILD): Qhov no yog thaum cov nqaij ntawm cov hnab cua me me (alveoli) hauv peb lub ntsws thiab cov hlab ntsha nyob ib puag ncig lawv puas tsuaj. Qhov no tuaj yeem ua rau ua tsis taus pa (dyspnea) , hnoos qhuav , qaug zog , thiab mob hauv siab . Nws zoo li poob ntaiv.

• Mob pob qij txha ntau yam: Qhov no yog thaum muaj tsib lossis ntau dua cov pob qij txha raug cuam tshuam tib lub sijhawm. Qhov no ua rau mob, tawv, thiab o hauv cov pob qij txha . Koj yuav hnov ​​​​​​mob tawv thaum koj sawv thaum sawv ntxov.

• Raynaud's phenomenon (Raynaud's syndrome theem ob): Hauv qhov no, cov ntiv tes thiab cov ntiv taw hloov xim (hloov daj ntseg, tom qab ntawd xiav, tom qab ntawd liab) thiab ua loog, tshwj xeeb tshaj yog thaum raug cua txias. Nws zoo li koj cov ntiv tes yuav loog tom qab muab lub ice box tawm ntawm lub tub yees.

• Kub taub hau: Ib txhia neeg tsuas yog kub taub hau xwb yam tsis muaj kab mob hauv lawv lub cev. Qhov no txhais tau tias lub cev kub nce siab vim yog qhov kev ua haujlwm ntawm lub cev tiv thaiv kab mob.

Dab tsi ua rau muaj tus kab mob Antisynthetase Syndrome?

Qhov ua rau muaj tus kab mob no tseem tsis tau paub meej . Tab sis cov kws kho mob tau pom tias ntau tus neeg uas muaj tus kab mob no muaj ib hom tshuaj tiv thaiv kab mob tshwj xeeb hauv lawv cov ntshav. Cov tshuaj tiv thaiv kab mob no qhia tias lawv lub cev tiv thaiv kab mob tab tom tawm tsam lawv lub cev es tsis yog tiv thaiv lawv. Peb hu cov no (autoantibodies) , uas txhais tau tias "cov tshuaj tiv thaiv tus kheej".

Tam sim no, saib seb, cov tshuaj tiv thaiv kab mob yog cov protein uas tiv thaiv peb thaum muaj qee yam phem nkag mus rau hauv peb lub cev. Lawv zoo li cov cim tshuaj uas peb lub cev tiv thaiv kab mob siv. Cov tshuaj tiv thaiv kab mob no cim cov neeg nkag teb chaws phem xws li cov kab mob me me thiab cov kab mob me me ua "kev phom sij." Tab sis yog tias koj muaj tus kab mob autoimmune, koj lub cev tiv thaiv kab mob yuav tsim thiab tso cov tshuaj tiv thaiv kab mob uas tawm tsam cov nqaij noj qab haus huv tsis raug.

Cov neeg uas muaj tus kab mob Antisynthetase Syndrome feem ntau muaj cov autoantibodies uas tawm tsam cov enzymes hu ua tRNA synthetases . Cov tRNA synthetases no yog cov enzymes tseem ceeb thiab muaj txiaj ntsig uas peb lub cev xav tau kom ua haujlwm tau zoo.

Tseem yog ib qho paub tsis meej tias vim li cas peb lub cev tiv thaiv kab mob pib tsim cov autoantibodies no. Txawm li cas los xij, yog tias koj muaj pov thawj ntawm cov autoantibodies no hauv koj cov ntshav, nws muaj feem ntau tias koj muaj Antisynthetase Syndrome.

Zoo li no, xav txog ib tug neeg teeb cov phom tua hluav taws rau ntawm koj lub tsev. Thaum koj saib nws thaum sawv ntxov tom qab, muaj cov phom tua hluav taws thiab cov kev hlawv tawg thoob plaws hauv av. Tej zaum koj yuav tsis paub tseeb tias leej twg teeb cov phom tua hluav taws, thaum twg lawv teeb tawm, lossis vim li cas. Tab sis muaj pov thawj tias nws tau tshwm sim. Hauv Antisynthetase Syndrome, es tsis txhob muaj lub suab nrov uas koj hnov ​​​​thaum koj teeb cov phom tua hluav taws thiab cov dev ntshai, koj ntsib cov tsos mob uas peb tau tham txog ua ntej.

Leej twg muaj feem yuav mob no tshaj?

Txhua tus neeg yeej muaj tus kab mob Antisynthetase Syndrome. Txawm li cas los xij, cov poj niam thiab cov neeg hnub nyoog tshaj 50 xyoo yuav muaj tus kab mob no ntau dua. Cov poj niam muaj feem yuav muaj tus kab mob no li ob npaug ntau dua li cov txiv neej.

Yuav kuaj mob Antisynthetase Syndrome li cas?

Tus kws kho mob kuaj mob no raws li koj cov tsos mob, kev kuaj lub cev, thiab ntau yam kev kuaj ntxiv.

Tej zaum koj yuav tau mus ntsib kws kho mob uas tshwj xeeb hauv cov kab mob autoimmune, hu ua rheumatologist . Nws yuav kuaj koj thiab nug koj txog koj cov tsos mob. Koj yuav tsum qhia rau kws kho mob tias koj cov tsos mob yog dab tsi, thaum twg koj pom lawv thawj zaug, thiab seb puas muaj dab tsi ua rau lawv hnyav dua.

Tsis tas li ntawd xwb, koj yuav tsum tau kuaj ntau zaus kom paub tseeb tias koj muaj Antisynthetase Syndrome thiab kom paub tseeb tias tsis muaj lwm yam mob uas ua rau muaj cov tsos mob zoo sib xws.

Cov kev kuaj twg siv los kuaj mob?

Qhov no tsis yog ib qho kev kuaj mob uas tuaj yeem lees paub qhov kev kuaj mob. Qhov no feem ntau yog ib feem ntawm cov txheej txheem hu ua kev kuaj mob sib txawv . Qhov no txhais tau tias koj tus kws kho mob yuav khiav ntau qhov kev kuaj mob kom paub seb dab tsi ua rau koj cov tsos mob, tshem tawm lwm yam mob, thiab thaum kawg kuaj mob Antisynthetase Syndrome. Qee qhov kev kuaj mob uas koj yuav muaj yog:

• Kev kuaj ntshav: Txhawm rau xyuas seb koj lub cev tiv thaiv kab mob ua haujlwm li cas thiab saib seb koj puas muaj cov tshuaj tiv thaiv kab mob (autoantibodies), uas yog ib qho cim ntawm Antisynthetase Syndrome. Kev kuaj ntshav kuj tseem tuaj yeem kuaj xyuas seb puas muaj cov enzymes uas raug tso tawm rau hauv cov ntshav thaum cov leeg nqaij raug puas tsuaj.
• Kev Kuaj Zis: Txhawm rau kuaj xyuas kev ua haujlwm ntawm lub raum thiab kuaj xyuas seb puas muaj kab mob lossis lwm yam teeb meem hauv cov zis uas yuav ua rau koj cov tsos mob.
• Kev ntsuam xyuas kev ua haujlwm ntawm lub ntsws: Xyuas seb koj lub ntsws lossis lub cev ua pa puas raug cuam tshuam.
• Kev thaij duab computer tomography (CT) lossis lwm yam kev kuaj duab: Thaij duab ntawm cov nqaij thiab cov kabmob hauv lub cev.
• (Kev kuaj mob ntawm lub cev - EMG):Xyuas seb cov leeg nqaij ua haujlwm li cas.
• Ib daim duab magnetic resonance imaging (MRI) scan ntawm cov leeg nqaij uas raug mob: los xyuas seb puas muaj kev o.
• Kev kuaj nqaij yog ib qho kev kuaj uas siv ib daim me me ntawm cov leeg nqaij lossis cov ntsws.

Yuav kho tus kab mob Antisynthetase Syndrome li cas?

Tsis muaj tshuaj kho tau tus kab mob Antisynthetase Syndrome. Txawm li cas los xij, koj tus kws kho mob tuaj yeem pab koj nrhiav kev kho mob ua ke uas tuaj yeem pab tswj koj cov tsos mob, txo lawv cov kev cuam tshuam rau koj lub neej txhua hnub, thiab txo qhov kev puas tsuaj rau koj cov kab mob.

Hom kev kho mob uas koj xav tau yuav nyob ntawm seb koj cov tsos mob nyob qhov twg thiab lawv hnyav npaum li cas. Nov yog qee qhov kev kho mob uas feem ntau siv:

• Cov tshuaj Corticosteroids: Cov no yog cov tshuaj uas kws kho mob sau ntawv kom txo qhov mob thiab o. Cov kws kho mob feem ntau sau ntawv kom siv cov tshuaj corticosteroids nrog rau cov tshuaj hu ua cov tshuaj tiv thaiv kab mob.
• Cov Tshuaj Tiv Thaiv Kab Mob: Cov tshuaj no ua haujlwm los ntawm kev tiv thaiv koj lub cev tiv thaiv kab mob kom tsis txhob tawm tsam cov hlwb thiab cov nqaij noj qab haus huv. Hom tshuaj uas koj xav tau yuav nyob ntawm seb cov kabmob twg raug cuam tshuam. Cov tshuaj tiv thaiv kab mob feem ntau yog methotrexate, azathioprine, thiab mycophenolate . Tej zaum koj kuj tseem yuav xav tau cyclophosphamide, rituximab, lossis tacrolimus .
• Kev Kho Mob Rau Kab Mob Ntsws Interstitial Lung Disease (ILD): Tej zaum koj yuav tau txais tshuaj kom ua pa tau yooj yim dua, lossis kev kho mob oxygen yog tias koj xav tau oxygen ntxiv. Koj yuav tsum tau ua haujlwm nrog kws kho mob ntsws kom tswj koj cov teeb meem ua pa.
• Kev Kho Mob Lub Cev: Tus kws kho mob lub cev tuaj yeem pab koj txhim kho koj lub cev txoj kev txav mus los. Lawv tuaj yeem pab tswj cov tsos mob ntsig txog cov leeg nqaij lossis qhia cov kev tawm dag zog ua pa kom txhawb koj lub ntsws. Tej zaum koj kuj tseem yuav xav tau kev kho mob ntsws .

Yog tias kuv muaj Antisynthetase Syndrome, yuav ua li cas?

Koj tus kws kho mob tuaj yeem pab koj nrhiav kev kho mob ua ke uas tuaj yeem tswj koj cov tsos mob.

Kab mob Antisynthetase yog ib yam kab mob uas kav ntev . Qhov no txhais tau tias koj yuav tsum tswj cov tsos mob mus ntev (tej zaum tag nrho koj lub neej).

Puas yog (Antisynthetase Syndrome) tuag taus?

Feem ntau tus kab mob Antisynthetase Syndrome tsis ua rau neeg tuag taus . Lub neej ntev ntawm cov neeg uas muaj tus kab mob no feem ntau tsis raug cuam tshuam loj heev. Muaj ntau tus neeg nyob nrog tus kab mob no mus tas lawv lub neej, tab sis lawv tuaj yeem tswj lawv cov tsos mob nrog kev kho mob.

Txawm li cas los xij, yog tias koj muaj kab mob ntsws loj heev lossis lwm yam teeb meem uas cuam tshuam rau koj lub cev ua pa, nws tuaj yeem ua rau tuag taus. Tab sis nws tsis tshua muaj. Koj tus kws kho mob yuav qhia koj tias yuav tsum xav li cas, thiab cov tsos mob hloov pauv twg yuav yog cov cim qhia ntxov ntawm cov teeb meem ua pa hnyav.

Kuv puas tuaj yeem tiv thaiv kev mob Antisynthetase Syndrome?

Tsis muaj ib txoj kev los tiv thaiv Antisynthetase Syndrome, vim cov kws tshaj lij tsis paub meej tias dab tsi ua rau nws lossis dab tsi ua rau muaj kev pheej hmoo ntxiv.

Kuv yuav tsum mus ntsib kws kho mob thaum twg?

Yog tias koj muaj cov tsos mob tshiab, tshwj xeeb tshaj yog tias lawv hnyav zuj zus, mus ntsib kws kho mob . Yog tias koj xav tias koj cov tsos mob tsis raug tswj hwm zoo li yav dhau los nrog koj txoj kev kho mob, lossis yog tias koj cov tsos mob ua rau nws nyuaj rau ua koj cov dej num txhua hnub, tham nrog koj tus kws kho mob.

Kuv yuav tsum mus rau chav kho mob ceev thaum twg?

Yog koj muaj ib qho ntawm cov tsos mob no, mus rau chav kho mob ceev tam sim ntawd lossis hu rau 911 (lossis koj tus xov tooj xwm ceev hauv zos) :

• Ua pa nyuaj tam sim ntawd.
• Ua tsis taus pa hnyav heev (zoo li koj ua tsis tau pa).
• Xim xiav ntawm daim tawv nqaij, daim di ncauj, lossis rau tes (cyanosis).
• Mob hauv siab los yog hnyav.

Kuv yuav tsum nug kuv tus kws kho mob li cas?

• Kuv puas muaj Antisynthetase Syndrome lossis lwm yam kab mob autoimmune?
• Kuv yuav tau ua cov kev ntsuam xyuas zoo li cas?
• Cov kev kho mob zoo tshaj plaws los tswj kuv cov tsos mob yog dab tsi?
• Kuv puas yuav tsum tau kev kho lub cev lossis kev kho kom rov qab ua pa?
• Kuv muaj feem yuav muaj teeb meem loj heev ntawm lub ntsws npaum li cas?

Lwm lub npe rau Antisynthetase Syndrome yog dab tsi?

Cov kws kho mob qee zaum hu Antisynthetase Syndrome ua lwm lub npe. Piv txwv li:

• (Cov tsos mob tsis txaus Antisynthetase)
• (AS syndrome)
• (Tshuaj Anti-Jo1)

Cov no yog txhua lub npe sib txawv rau tib yam mob.

Thaum kawg, yuav tsum nco ntsoov li cas (Cov Lus Coj Mus Tsev)

Antisynthetase Syndrome yog ib yam mob tsis tshua muaj uas koj lub cev tiv thaiv kab mob tawm tsam koj lub cev es tsis tiv thaiv koj. Tham nrog koj tus kws kho mob txog kev kho mob uas tuaj yeem pab txo qhov cuam tshuam ntawm koj cov tsos mob rau koj lub neej txhua hnub.

Kev nyob nrog tus kab mob autoimmune tuaj yeem ua rau koj ntxhov siab heev - nws tuaj yeem zoo li koj lub cev dag koj. Yog tias koj xav tau kev pab hloov kho rau qhov kev hloov pauv hauv koj lub neej lossis daws qhov teeb meem, nug koj tus kws kho mob txog cov hau kev los tau txais kev sab laj txog kev noj qab haus huv ntawm lub hlwb. Kev tu siab thiab kev nyuaj siab yog qhov ib txwm muaj, tab sis koj tsis tas yuav dhau los ntawm nws ib leeg.

`Antisynthetase Syndrome, kab mob autoimmune, myositis, interstitial lung disease, Raynaud's phenomenon, autoantibodies, mob pob qij txha, leeg tsis muaj zog