Koj puas tau txais cov pob txawv txawv ntawm koj daim tawv nqaij? Qhov no puas yog Muir-Torre Syndrome?

Koj puas tau pib muaj cov pob me me ntawm koj daim tawv nqaij tam sim ntawd? Tej zaum koj yuav xav tias cov no yog qhov ib txwm muaj. Txawm li cas los xij, qee zaum cov kev hloov pauv ntawm daim tawv nqaij no kuj tuaj yeem cuam tshuam nrog cov teeb meem sab hauv. Hnub no peb yuav tham txog ib qho mob tsis tshua muaj tab sis tseem ceeb heev uas yuav tsum paub txog. Nws hu ua Muir-Torre Syndrome.

Muir-Torre Syndrome yog dab tsi? Hais yooj yim xwb...

Muir-Torre Syndrome yog ib yam mob caj ces uas tsis tshua muaj uas ua rau koj muaj feem yuav mob qog noj ntshav ntau hom thaum koj tseem muaj sia nyob. Cov neeg uas muaj tus mob no feem ntau yuav mob qog nqaij hlav ntawm daim tawv nqaij, txawm yog qog nqaij hlav lossis qog nqaij hlav tsis muaj teeb meem (piv txwv li, qog nqaij hlav tsis muaj teeb meem) ntawm lawv daim tawv nqaij. Lawv kuj tseem yuav mob qog nqaij hlav ib lossis ntau yam hauv lub cev, tshwj xeeb tshaj yog hauv txoj hnyuv plab .

Xav txog nws, peb lub cev muaj ntau lab lub hlwb me me. Thaum cov hlwb no faib, qee zaum kev hloov pauv me me (kev hloov pauv) hauv cov noob caj noob ces tuaj yeem tshwm sim. Qhov ntawd yog qhov ua rau muaj kev hloov pauv caj ces no.

Yog li Muir-Torre Syndrome puas zoo ib yam li Lynch Syndrome?

Feem ntau, yog lawm. Moore-Torre syndrome yog suav hais tias yog ib qho variant ntawm Lynch syndrome . Lynch syndrome kuj yog ib qho mob uas ua rau muaj kev pheej hmoo ntawm mob qog noj ntshav vim muaj ntau yam kev hloov pauv caj ces. Qee zaum cov kws kho mob kuj hu nws tias Hereditary Non-Polyposis Colorectal Cancer (HNPCC). Qhov no txhais tau tias mob qog noj ntshav tshwm sim hauv cov hnyuv loj tsis muaj polyps. Yog li, Moore-Torre yog ib feem ntawm Lynch syndrome uas qhia txog cov yam ntxwv tshwj xeeb ntawm daim tawv nqaij.

Qhov teeb meem no muaj ntau npaum li cas? Peb puas yuav tsum txhawj txog qhov no hauv Sri Lanka?

Kab mob Moore-Torre syndrome no yeej yog ib yam mob uas tsis tshua muaj neeg paub txog. Tsuas muaj li ntawm 200 tus neeg mob thoob ntiaj teb xwb. Txawm li cas los xij, qhov no tsis tau txhais hais tias peb yuav tsum tsis txhob paub txog nws. Kwv yees li ntawm 9.2% ntawm cov neeg uas muaj 'HNPCC' yuav muaj cov yam ntxwv Moore-Torre no. Nws kuj zoo li cuam tshuam rau cov txiv neej ntau dua li cov poj niam me ntsis (uas yog, kwv yees li 2 tus poj niam rau txhua 3 tus txiv neej). Txawm hais tias tsis muaj cov ntaub ntawv tseeb txog pes tsawg tus neeg nyob hauv Sri Lanka, nws yog ib qho tseem ceeb uas yuav tsum paub txog cov mob no.

Cov tsos mob ntawm Moore-Torre syndrome yog dab tsi? Peb yuav paub nws li cas?

Qhov no feem ntau yog vim muaj cov pob lossis kev hloov pauv ntawm daim tawv nqaij thiab cov tsos mob ntawm mob qog noj ntshav sab hauv . Qee zaum teeb meem ntawm daim tawv nqaij tuaj yeem tshwm sim ua ntej, tib lub sijhawm, lossis tom qab mob qog noj ntshav sab hauv tshwm sim. Txawm li cas los xij, kev hloov pauv ntawm daim tawv nqaij feem ntau yog thawj qhov cim uas yuav pom . Lwm yam mob qog noj ntshav yuav tsis qhia cov tsos mob thaum ntxov.

Muaj kev hloov pauv dab tsi ntawm daim tawv nqaij?

Cov hauv qab no yuav pom tau ntawm daim tawv nqaij ntawm ib tus neeg uas muaj Moore-Torre syndrome:

• Cov qog sebaceous adenomas: Cov no yog cov teeb meem ntawm daim tawv nqaij feem ntau (80% - 99%). Cov no yog cov qog tsis yog mob qog noj ntshav (benign). Lawv tsim nyob rau hauv cov qog sebaceous, uas yog cov qog roj hauv peb daim tawv nqaij. Lawv feem ntau pom ntawm lub taub hau thiab caj dab, thiab rau cov neeg uas muaj tus kab mob Moore-Torre, lawv feem ntau pom ntawm lub hauv siab, plab, lub duav, thiab nraub qaum . Lawv zoo li cov pob me me, tawv, daj lossis xim tawv nqaij .
• Mob qog nqaij hlav sebaceous: Qhov no yog ib qho mob qog nqaij hlav (malignant) uas loj hlob hauv cov qog sebaceous. Nws zoo li ib qho mob qog nqaij hlav sebaceous adenoma. Tab sis nws kis tau sai, tshwj xeeb tshaj yog nyob ib ncig ntawm lub qhov muag . Cov qog nqaij hlav no yuav los ntshav lossis tawm cov khoom tawv.
• Keratoacanthoma: Qhov no yog lwm hom qog nqaij hlav ntawm daim tawv nqaij. Nws tuaj yeem loj hlob ntawm lub taub hau, caj dab, lub cev, thiab caj npab ze ntawm cov plaub hau follicles. Nws tuaj yeem yog mob qog noj ntshav lossis tsis yog mob qog noj ntshav . Nws zoo li lub pob me me, kheej kheej, qee zaum muaj cov hlab ntsha pom tseeb nyob rau sab saum toj, thiab ib lub pob keratin nyob hauv nruab nrab . Nws loj hlob sai heev, li 3 centimeters hauv ob peb lub lis piam, thiab tom qab ntawd maj mam ntsws dhau lub hlis lossis xyoo. Tej zaum yuav muaj ib lossis ntau dua.
• Cov pob Fordyce: Vim tias cov qog sebaceous feem ntau koom nrog Moore-Torre syndrome, qee tus kws kho mob xav tias cov "Fordyce spots" no yog ib qho tsos mob. Cov no yog cov qog sebaceous uas nce siab, me ntsis loj hlob uas tshwm sim hauv thaj chaw tsis muaj plaub hau, xws li nyob ib ncig ntawm daim di ncauj . Cov kev tshawb fawb tau qhia tias lawv feem ntau tshwm sim hauv Moore-Torre syndrome.

Nco ntsoov, yog tias koj pom ib lub qog tshiab lossis kev hloov pauv zoo li no ntawm koj daim tawv nqaij, tshwj xeeb tshaj yog tias nws loj hlob sai, hloov xim, lossis los ntshav, koj yuav tsum mus ntsib kws kho mob.

Cov mob qog noj ntshav twg muaj feem cuam tshuam nrog Moore-Torre syndrome?

Muaj ntau hom mob qog noj ntshav uas tshwm sim tau nrog tus mob no. Cov mob qog noj ntshav uas tshwm sim ntau tshaj plaws thiab lawv cov tsos mob yog:

• Mob qog noj ntshav hauv plab hnyuv: Qhov no yog hom mob qog noj ntshav uas feem ntau tshwm sim . Nws cuam tshuam rau kwv yees li ib nrab ntawm txhua tus neeg. Nws yog tshwm sim los ntawm kev loj hlob ntawm cov hlwb qog noj ntshav hauv daim ntaub ntawm txoj hnyuv lossis lub qhov quav. Qhov sib piv, nrog Moore-Torre, mob qog noj ntshav no tuaj yeem tshwm sim 15-20 xyoo ua ntej dua li niaj zaus, feem ntau yog thaum muaj hnub nyoog li ntawm 50 xyoo. Nws kuj tseem tuaj yeem kis tau sai . Cov tsos mob suav nrog mob plab, o, hloov pauv hauv kev coj ua hauv plab, thiab ntshav hauv cov quav .
• Mob qog noj ntshav hauv plab: Qhov no kuj yog ib hom mob qog noj ntshav uas feem ntau pom nrog Moore-Torre. Cov tsos mob yuav muaj xws li mob plab, o, ntshav hauv cov quav, nyuaj zom zaub mov, xeev siab, thiab tsis xav noj mov .
• Mob qog nqaij hlav ntawm lub cev:Kuj hu ua '(Urothelial carcinoma)' lossis '(transitional carcinoma)'. Qhov no cuam tshuam rau cov ntaub ntawm lub cev tso zis. Nws tuaj yeem ua rau mob thaum tso zis thiab muaj ntshav hauv cov zis .
• Mob qog nqaij hlav endometrial: Qhov no yog mob qog nqaij hlav uas tshwm sim hauv endometrium, sab hauv ntawm lub tsev menyuam . Nws tuaj yeem ua rau mob plab qis, mob lub duav, thiab muaj cov kua tawm lossis los ntshav txawv txawv ntawm qhov chaw mos .

Tsis tas li ntawd xwb, ntau hom mob qog noj ntshav kuj yuav muaj feem cuam tshuam nrog tus mob no, xws li:

• Mob qog nqaij hlav zes qe menyuam
• Mob qog nqaij hlav prostate
• Mob qog nqaij hlav
• Mob qog nqaij hlav
• Mob qog nqaij hlav me
• Mob qog nqaij hlav
• Mob qog nqaij hlav ntsws
• Mob qog ntshav
• Muaj mob qog nqaij hlav hauv hlwb thiab lwm hom.

Daim ntawv teev npe no yuav zoo li txaus ntshai. Tab sis qhov tseem ceeb yog tias tsis yog txhua tus mob qog noj ntshav no yuav loj hlob rau txhua tus. Thiab, yog tias kuaj pom thaum ntxov, lawv tuaj yeem kho tau .

Vim li cas tus mob Moore-Torre syndrome no thiaj tshwm sim? Dab tsi yog qhov ua rau?

Hais yooj yim xwb, Moore-Torrell syndrome yog tshwm sim los ntawm kev hloov pauv hauv ib qho ntawm koj cov noob caj noob ces . Kev hloov pauv yog kev hloov pauv hauv qhov sib lawv liag ntawm peb cov DNA. Cov DNA no raug theej thaum peb cov cell faib thiab ua cov cell tshiab. Qee zaum yuam kev tuaj yeem tshwm sim. Yog tias cov cell txawv txav zoo li no txuas ntxiv faib, nws tuaj yeem ua rau muaj ntau yam kab mob, suav nrog mob qog noj ntshav.

Cov kev hloov pauv ntawm cov noob caj noob ces twg cuam tshuam rau qhov no?

Muaj ob hom feem ntau:

• Hom 1 Moore-Torre syndrome (Hom 1 MTS): Qhov no yog tshwm sim los ntawm kev hloov pauv hauv ib qho ntawm cov noob caj noob ces uas ua yuam kev hauv koj cov DNA sequence . Thaum cov noob caj noob ces no tsis tuaj yeem kho qhov yuam kev, cov hlwb tsis zoo yuav sib sau ua ke hauv cov nqaij. Hauv 90% ntawm cov neeg mob, cov noob caj noob ces hu ua MSH2 raug cuam tshuam. Txawm li cas los xij, ntau lwm cov noob caj noob ces, xws li MLH1, MSH6, thiab PMS2, tej zaum yuav koom nrog.
• Hom 2 Moore-Torrell Syndrome (MTS): Qhov no yog tshwm sim los ntawm kev hloov pauv hauv MUTYH gene. Cov gene no yog lub luag haujlwm rau kev kho qhov puas tsuaj oxidative rau peb cov DNA. Kwv yees li ib feem peb ntawm cov neeg uas muaj MTS muaj hom no. Oxidation ua rau muaj kev hloov pauv hauv DNA molecule, uas tuaj yeem ua rau cov cell loj hlob tsis tswj tau (piv txwv li, mob qog noj ntshav). Thaum cov gene hloov pauv tsis tuaj yeem kho qhov kev puas tsuaj no, qhov kev puas tsuaj tseem nyob.

Qhov no puas yog ib yam dab tsi uas los ntawm ntau tiam neeg los?

Feem ntau, yog, nws yog los ntawm noob caj noob ces . Txawm li cas los xij, qee zaum ib tus neeg tuaj yeem tsim kev hloov pauv tshiab yam tsis muaj leej twg hauv tsev neeg muaj nws ua ntej. Kwv yees li 60% ntawm cov neeg mob tuaj yeem pom keeb kwm tsev neeg ntawm Moore-Torre syndrome. Txawm li cas los xij, vim tias tsis yog txhua tus neeg uas muaj kev hloov pauv no tshwm sim cov tsos mob, qhov kev sib txuas ntawm tsev neeg no tsis yog ib txwm pom tseeb.

Tej zaum ib txhia neeg yuav muaj tus mob no yam tsis muaj tsos mob, thiab tej zaum yuav tsis paub txog nws. Tsis tas li ntawd, qee zaum thaum lub cev tiv thaiv kab mob tsis muaj zog, qhov 'latent MTS' no tuaj yeem ua haujlwm. Ib txhia neeg tau muaj tus mob no tom qab tau txais 'khoom siv hauv lub cev' thiab noj cov tshuaj tiv thaiv kab mob.

Qhov no kis mus rau ntau tiam neeg li cas?

• Hom 1 MTS yog ib qho mob "autosomal dominant". Qhov no txhais tau tias koj tsuas yog yuav tsum muaj ib daim qauv ntawm cov noob caj noob ces hloov pauv kom tau txais tus mob no. Yog tias ib tug ntawm koj niam koj txiv muaj qhov kev hloov pauv noob caj noob ces no, koj muaj 50% feem pua ​​​​​​ntawm kev tau txais nws thiab. Txawm li cas los xij, txoj kev uas koj tsim cov tsos mob yuav txawv ntawm niam txiv uas koj tau txais cov noob caj noob ces los ntawm.
• Hom 2 MTS yog ib yam mob "autosomal recessive". Qhov no txhais tau tias yog koj yuav tau tus kab mob no, koj niam koj txiv ob leeg yuav tsum muaj tib yam gene mutation. Qhov no tsis tshua muaj. Txawm li cas los xij, cov niam txiv uas tsuas muaj ib daim qauv ntawm cov gene "autosomal recessive" no yuav tsis muaj tsos mob dab tsi, yog li ntawd lawv yuav tsis paub tias lawv muaj tus kab mob no.

Cov kws kho mob kuaj mob Muir-Torre Syndrome li cas?

Yog tias koj muaj cov pob khaus ntawm daim tawv nqaij zoo li cov uas tau hais los saum toj no, tshwj xeeb tshaj yog ntawm koj lub cev, lossis yog tias lawv tau tshwm sim thaum tseem hluas, tus kws kho mob yuav xav tias muaj tus kab mob Moore-Torrell syndrome. Nws kuj tseem yuav nug koj txog lwm cov tsos mob uas yuav qhia tau tias muaj mob qog noj ntshav sab hauv, thiab seb puas muaj leej twg hauv koj tsev neeg muaj keeb kwm mob qog noj ntshav.

Yuav ua li cas thiaj kuaj tau qhov no?

Koj tus kws kho mob yuav ua ntau qhov kev kuaj ua ntej ua ntej pom zoo kom kuaj cov noob caj noob ces. Piv txwv li:

• Immunohistochemistry (IHC): Yuav muab ib qho qauv me me ntawm ib lub pob ntawm koj daim tawv nqaij, pleev xim rau nrog ib qho xim tshwj xeeb, thiab kuaj xyuas hauv qab lub tshuab microscope kom pom tias cov qauv puas muaj kev hloov pauv tshwj xeeb ntawm cov noob caj noob ces.

Nrog cov txiaj ntsig ntawm cov kev kuaj no thiab lwm cov ntaub ntawv, koj tus kws kho mob yuav pom zoo kom kuaj cov noob caj noob ces los xyuas seb puas muaj kev hloov pauv hauv cov noob caj noob ces uas cuam tshuam nrog Moore-Torre syndrome. Tom qab ntawd lawv yuav coj koj cov ntshav mus kuaj thiab nrhiav seb puas muaj kev hloov pauv hauv cov noob caj noob ces kho qhov tsis sib xws MSH2, MLH1, MSH6, PMS2, lossis cov noob caj noob ces kho qhov tsis sib xws MUTYH.

Ib tug neeg uas muaj tus kab mob Moore-Torre syndrome yuav tsum tau kuaj mob qog noj ntshav li cas tsis tu ncua?

Nws yog ib qho tseem ceeb heev rau cov neeg uas muaj tus mob no kom mus kuaj mob qog noj ntshav tsis tu ncua , vim tias kev kuaj pom thaum ntxov yuav ua rau muaj feem kho tau zoo. Kev kuaj uas cov kws kho mob pom zoo yuav suav nrog:

• Kev kuaj mob plab hnyuv loj: Kev kuaj mob plab hnyuv loj.
• Kev kuaj mob sab saud (EGD): Kev kuaj mob ntawm txoj hlab pas, plab, thiab thawj feem ntawm txoj hnyuv me.
• Kev kuaj mob prostate ( rau cov txiv neej)
• Kev kuaj mob mammogram:Kev kuaj mob qog noj ntshav hauv lub mis (rau cov poj niam)
• Kev kuaj mob plab mog ( rau cov poj niam)
• Pap smear: Kev kuaj mob qog nqaij hlav ntawm lub tsev menyuam (rau cov poj niam)
• Kev kuaj mob ntawm cov zis: Rau cov mob qog nqaij hlav ntawm lub cev tso zis.
• Kev ntsuam xyuas kev ua haujlwm ntawm daim siab
• Kev suav cov ntshav tag nrho (CBC)
• Kev kuaj lub cev
• Kev kuaj tawv nqaij
• Kev X-ray hauv siab

Koj tus kws kho mob yuav txiav txim siab seb koj yuav tsum tau kuaj mob no ntau npaum li cas.

Cov kev kho mob rau Moore-Torre syndrome yog dab tsi?

Lub hom phiaj tseem ceeb ntawm kev tswj hwm Moore-Torre syndrome yog nrhiav thiab tshem tawm cov qog nqaij hlav yog tias nws tshwm sim . Koj yuav tsum tau kuaj mob qog nqaij hlav tsis tu ncua thiab coj cov nqaij ntawm cov nqaij uas xav tias muaj qog nqaij hlav. Yog tias koj tus kws kho mob pom muaj qog nqaij hlav, lawv yuav kho nws raws li nws hom thiab theem. Kev phais kom tshem tawm cov qog nqaij hlav feem ntau yog thawj kab kev kho mob .

Lwm yam kev kho mob qog noj ntshav yuav muaj xws li:

• Kev kho mob qog noj ntshav
• Kev kho mob hluav taws xob
• Kev kho mob hormone
• Kev kho mob tiv thaiv kab mob
• Kev kho mob tsom mus rau
• Kev hloov pob txha

Ntxiv mus, ib qho tshuaj retinoid hu ua isotretinoin uas noj tau yuav pab tiv thaiv kom tsis txhob muaj cov qhov txhab tshiab ntawm daim tawv nqaij. Yog tias koj qhov kev kuaj mob plab hnyuv pom ntau cov polyps hauv plab hnyuv (uas muaj feem yuav mob qog noj ntshav), koj tus kws kho mob yuav pom zoo kom ua qhov kev phais plab hnyuv tiv thaiv, uas yog kev tshem tawm ib feem lossis tag nrho koj cov plab hnyuv.

Yuav ua li cas thiaj paub tias tus neeg uas muaj tus mob Moore-Torre syndrome yuav muaj mob dab tsi?

Koj qhov kev kwv yees nyob ntawm seb koj muaj pes tsawg tus mob qog noj ntshav thiab lawv kis mus deb npaum li cas. Cov ntaub ntawv qhia tau tias kwv yees li ib nrab ntawm cov neeg uas muaj tus kab mob Moore-Torre syndrome muaj ntau dua ib hom mob qog noj ntshav. Ntau tshaj ib nrab muaj mob qog noj ntshav metastatic (mob qog noj ntshav uas tau kis mus rau lwm qhov ntawm lub cev thiab nyuaj kho).

Cov mob qog nqaij hlav uas muaj Moore-Torre syndrome feem ntau tshwm sim thaum muaj hnub nyoog li ntawm 50 xyoo . Cov mob qog nqaij hlav no tuaj yeem loj hlob thiab hnyav zuj zus sai dua li cov pej xeem feem ntau. Yog li ntawd, kev kuaj pom thaum ntxov yog qhov tseem ceeb . Tsis tas li ntawd, muaj feem ntau uas mob qog nqaij hlav yuav rov qab los txawm tias tom qab nws raug tshem tawm lawm los xij. Yog li ntawd, kev kuaj xyuas tsis tu ncua tom qab kev kho mob yog qhov tseem ceeb.

Puas muaj ib txoj kev los tiv thaiv qhov no?

Feem ntau tsis yog. Qhov no yog vim nws yog ib qho mob uas koj yug los nrog. Txawm li cas los xij, tsis yog txhua tus yuav muaj cov tsos mob. Txawm tias cov neeg uas muaj cov tsos mob kuj yuav raug kev cuam tshuam los ntawm tus kab mob ntau dua lossis tsawg dua li lawv niam lawv txiv. Cov kws tshawb fawb tseem tsis tau paub meej tias vim li cas qhov no tshwm sim. Txawm li cas los xij, tau pom tias tus mob tuaj yeem hnyav dua yog tias lub cev tiv thaiv kab mob tsis muaj zog .

Kev paub tias koj muaj qhov kev hloov pauv caj ces no yuav pab koj txiav txim siab tiv thaiv. Piv txwv li, kev kuaj caj ces thiab kev qhia txog caj ces tuaj yeem pab koj tiv thaiv kev kis tus mob mus rau koj cov menyuam. Tsis tas li ntawd, kev paub txog qhov no tuaj yeem pab koj txheeb xyuas mob qog noj ntshav thaum ntxov thiab pib kho, tiv thaiv cov teeb meem tsis zoo.

Txawm hais tias Moore-Torre syndrome tsis tshua muaj, nws tsis yooj yim los daws qhov teeb meem zoo li no. Nws zoo li nyuaj heev rau kev tawm tsam qee yam uas nyob hauv peb cov DNA. Tab sis, kev paub yog lub hwj chim . Yog tias koj paub thiab kho raws sijhawm, koj thiab koj tus kws kho mob tuaj yeem ntsib qhov teeb meem no.

Thaum kawg, cov lus coj mus tsev

Zoo, yog li cia peb sau qee yam uas koj yuav tsum nco ntsoov los ntawm qhov peb tau tham txog:

• Muir-Torre Syndrome yog ib yam mob caj ces uas ua rau muaj feem yuav mob qog nqaij hlav thiab mob qog nqaij hlav sab hauv (tshwj xeeb tshaj yog hauv txoj hnyuv plab).
• Yog koj pom ib lub pob tshiab txawv txawv ntawm koj daim tawv nqaij, tshwj xeeb tshaj yog ntawm koj lub cev, nrhiav kev pab kho mob tam sim ntawd. Tej zaum yuav tsis muaj dab tsi li, tab sis qhov zoo tshaj plaws yog coj nws mus kuaj mob.
• Qhov no yog ib qho kev hloov pauv ntawm Lynch syndrome. Yog tias leej twg hauv koj tsev neeg muaj keeb kwm mob qog noj ntshav, qhia rau koj tus kws kho mob txog qhov ntawd thiab.
• Kev kuaj pom thaum ntxov thiab kev kuaj mob tsis tu ncua yog qhov tseem ceeb heev. Qhov no tuaj yeem pab kuaj pom mob qog noj ntshav thaum ntxov thiab kho nws kom zoo.
• Kev kuaj mob caj ces thiab kev sab laj nrog kws kho mob tuaj yeem pab txiav txim siab seb qhov mob no puas muaj tseeb thiab seb nws puas cuam tshuam rau cov tswv cuab hauv tsev neeg.
• Tsis txhob ntshai, tab sis yuav tsum paub. Koj tsis nyob ib leeg xwb, thiab cov kws kho mob yeej npaj txhij pab koj.

Vam tias cov ntaub ntawv no yuav pab tau koj. Nyob zoo!

Muir -Torre Syndrome, Lynch Syndrome, Mob Cancer Ntawm Tawv Nqaij, Cov Kab Mob Genetic, Mob Cancer Ntawm Txoj Hnyuv, Kev Tshuaj Xyuas Mob Cancer, Kev Hloov Pauv Genetic