Yu dɔn gɛt stem sɛl transplant frɔm pɔsin? Lɛ wi no bɔt dis (Graft vs. Host Disease)!

Yu go mɔs dɔn yɛri bɔt stem sɛl transplant. Dɛn na rili impɔtant tritmɛnt fɔ sɔm sik dɛn. Bɔt tide wi go tɔk bɔt wan kɔmplikeshɔn we kin apin afta dis kayn transplant. Dɛn kɔl dis `(Graft vs. Host Disease)` ɔ `(GvHD)` fɔ shɔt. Nɔ wɔri, lɛ wi tɔk bɔt dis simpul wan.

Wetin na `(Graft vs. Host Disease - GvHD)`? Fɔ ɛksplen am simpul wan...

Imajin se yu dɔn gɛt stem sɛl transplant frɔm ɔda pɔsin, we na pɔsin we gi yu . Wi kin kɔl dis allogeneic transplant. Dɛn stem sɛl ya tan lɛk sɛl dɛn we nɔ machɔ na yu bɔdi in faktri we de mek blɔd, ɔ stem sɛl dɛn we de mek blɔd. Dis na di sɛl dɛn we leta go bi di rɛd blɔd sɛl ɛn wayt blɔd sɛl dɛn we yu bɔdi nid.

Naw, ustɛm yu go nid stem sɛl frɔm pɔsin we gi yu lɛk dis? If yu gɛt kansa lɛk lukimiya ɔ limfoma, ɔ ɔda sik usay yu bon mɛrɔ nɔ de wok fayn lɛk aplastik anemia, yu kin nid dis kayn transplant.

Okay, naw wetin na dis `(GvHD)`? insay `(GvHD)`, wetin de apin na di dכna sεl dεm we yu gεt (graft) de si di sεl dεm na yu bכdi (host) lεk sכmtin we strenj, we yu nכ sabi. I tan lɛk se yu bɔdi na nyu ples fɔ dɛn. So, dεn dona sεl dεm ya kin bigin fכ atak yu bכdi in sεl dεm. Na dat mek dɛn kɔl am `(Graft vs. Host Disease)`, we min "graft agens host." Yu ɔndastand?

Wetin na di men kayn GvHD?

Tu men kayn GvHD de. Trade, dɔktɔ dɛn bin de klas am bay di tɛm we i tek fɔ mek di sik bigin. Bɔt naw, dɛn kin luk pan di sayn dɛm ɛn di tɛst rizɔlt fɔ no di rayt kayn.

1. Akyu GvHD (aGvHD) .

Dis kin apin jɔs afta yu dɔn transplant yu stem sɛl, bɔku tɛm insay di fɔs 100 dez . Bɔt sɔntɛnde, di sayn dɛm kin bigin leta. Akyu GvHD kin afɛkt yu skin, dijestiv sistɛm (GI tract), ɔ yu liva.

2. GvHD we nɔ de mɛn (cGvHD) .

Kronik GvHD kin apin eni tεm afta wan allogeneic transplant. Bɔt bɔku tɛm i kin bigin insay tu ia . Krεse GvHD kin afekt yu skin, mכt, liva, lכng, GI trakt, mכsul, jכint, כ jεnital.

Impɔtant: Yu kin gɛt wan, ɔl tu, ɔ nɔr pan dɛn kayn GvHD ya. I kin difrɛn frɔm wan pɔsin to ɔda pɔsin.

Wetin na di sayn dɛm fɔ `(GvHD)`? Una fɔ no bɔt dɛn tin ya!

Di sayn dɛm fɔ GvHD kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin. Sɔm pipul kin gɛt sɔm kayn sik , sɔm kin gɛt smɔl smɔl , ɛn ɔda wan dɛn kin gɛt siriɔs sayn.I kin rili bad (i kin ivin mek pɔsin in layf de pan denja).

Simptom dɛm fɔ akyu `(GvHD)`

Wi dɔn tɔk se akyu GvHD kin afɛkt di skin, di GI trakt, ɛn di liva mɔ.

• Skin (aGvHD): Di sayn we kin apin mɔs na we yu skin de rɔsh ɔ rɛd (lɛk we yu bɔn wit san). I kin gɛt pen ɛn it. Bɔku tɛm, di rash kin bigin na di nɛk, di sholda, di yes, di an, ɛn di fut. Dɔn i kin skata to ɔda pat dɛn na di bɔdi.
• Gastrointestinal (GI) tract (aGvHD): Di sayn dɛm we kin apin pas ɔl na fɔ nɔs, vɔmit, ɛn dayarɛa (blɔt). Dɛn sayn ya kin smɔl ɔr kin tranga fɔ mek yu go na ɔspitul.

Di kɔmɔn simptom dɛm fɔ akyu GvHD na:

• Wan skin rash ɛn/ɔ it.
• Rɔnbɛlɛ.
• Nɔs ɛn vɔmit.
• Bɛlɛ de at, i de limp.
• Jandis (di skin ɛn/ɔ di yay dɛn we de yɔlɔ).

Di simptom dɛm fɔ GvHD we nɔ de mɛn

Krεse GvHD kin afekt yu skin, liva, GI trakt, εn lכng. Bɔt, i kin afɛkt ɛni pat na yu bɔdi.

Di sayn dɛm kin bi:

• Wan skin rash ɛn/ɔ it.
• Skin de tayt ɛn swel.
• Di ia we de lɔs na di ed ɛn bɔdi.
• Dray mɔt.
• Sɔl dɛn na yu mɔt.
• Di sik we de na di gɔm.
• Dray yay, fil lɛk se wan gren sand dɔn stɔp insay.
• Di chenj dɛn we de apin na di we aw pɔsin de si tin.
• Rɔnbɛlɛ.
• Nɔs ɛn vɔmit.
• Di skin ɛn/ɔ di yay dɛn we de yɔlɔ (jaundice).
• I nɔ izi fɔ blo (dyspnea).
• Dray, kɔf we nɔ de chenj.
• Taya.
• Di mɔsul dɛn we wik, we yu de limp, ɔ we yu de fil pen.
• Nɔ ebul fɔ bɛn ɛn ɛkstɛnd di jɔyn dɛn fayn fayn wan.
• Uman dɛn kin gɛt vagina dray, it, ɔ pen we dɛn de du mami ɛn dadi biznɛs.
• Man dɛn kin gɛt it na dɛn penis ɔ tɛstikul, ɔ dɛn kin fil pen we dɛn de du mami ɛn dadi biznɛs.

Wetin mek dis `(GvHD)` kin apin? Wetin na di kɔz?

fכ simpul wan, GvHD kin apin we di stεm sεl dεm frכm di dכna we yu gεt di transplant si yu כwn bכdi sεl dεm as "fכrin" εn bigin fכ atak dεm.

Dis na wetin kin apin: Yu imyun sistεm sεl dεm (sεl dεm na yu bכdi) de protεkt yu frכm sik. Dɛn kin fɛt fɔrina tin dɛn lɛk vayrɔs ɛn baktri dɛm. Bɔt dɛn sɛl ya nɔ de atak yu yon sɛl dɛn. dis na biכs yu sεl dεm gεt spεshal protin we dεn kכl ``Human Leukocyte Antigens'', כ ``HLA''. Dis tan lɛk tag we gɛt nem pan am. dis ``HLA'' na in de tεl yu imyun sεl dεm, "Ei, dis na wan pan wi."

di mכst imכtant tin na dat, εksεpt fכ twin dεm we di sem, כlman in `(HLA)` difrεn frכm wan an.

afta yu gεt stεm sεl transplant frכm כda pכsin, di nyu bכdi sεl dεm na yu bכdi nכ gεt yu `(HLA)`, bכt di `(HLA)` fכ di wan we gi yu . So, if di `(HLA)` fכ dis dona rili difrεn frכm di `(HLA)` na yu bכdi, dεn nyu bכdi sεl dεm de bigin fכ atak yu bכdi in sεl dεm. Na da tɛm de `(GvHD)` de apin.

Dis na di rizin we mek dɔktɔ dɛn kin tek tɛm chɛk di pɔsin in HLA fɔ mek shɔ se i de nia yu yon as i pɔsibul bifo dɛn du stem sɛl transplant. Fɔ fɛn wan mach lɛk dat de ridyus di risk fɔ gɛt GvHD. Bɔt if yu nɔ gɛt sɛl frɔm wan twin we fiba, chans stil de fɔ mek yu gɛt GvHD, ilɛksɛf yu tray fɔ du bɔku mats.

Udat de pan denja fɔ gɛt GvHD?

Di impɔtant tin we kin mek yu gɛt prɔblɛm na aw yu dona in HLA de mach yu yon. Yu de pan ay risk fɔ gɛt GvHD if:

• Yu bin gɛt stem sɛl frɔm wan fambul, bɔt nɔto wan ɛksaktɔl HLA mach .
• Yu bin gɛt stem sɛl frɔm pɔsin we nɔto yu fambul, bɔt na `(HLA)` mach .

Ɔda tin dɛn we kin mek pɔsin gɛt dis sik na:

• Di pɔsin we gi di mɔni fɔ bi uman we dɔn gɛt bɛlɛ bifo.
• Di ej fɔ di pɔsin we gi di mɔni ɔ yusɛf.
• jεnda inkompatibiliti bitwin di dכna εn yu (e.g. fכ gεt sεl frכm man dכna to uman, כ frכm uman dכna to man).
• if dεn tek di dכna in stεm sεl dεm frכm di bכdi vεsεl dεm (bכdi) insted fכ kכmכt frכm di bon mכro (we di bכdi sεl dεm de kכmכt).

If yu dɔn ɔlrɛdi gɛt akyu `(aGvHD)`, yu de pan risk fɔ gɛt kronik `(cGvHD)`.

Aw dɛn kin no se pɔsin gɛt GvHD?

Yu dɔktɔ kin no se yu gɛt GvHD bay we i de chɛk yu, luk yu sayn dɛm, ɛn luk pan lab tɛst ɛn bayɔpsi rizɔlt. Bayopsi min fɔ tek smɔl sampul pan yu tisu ɔ sɛl dɛn ɛn sɛn am na lab fɔ mek dɛn tɛst am.

Insay kronik GvHD (cGvHD), sɔm pan de sayn dɛm kin tan lɛk ɔda sik dɛm. So, di dɔktɔ go pul ɔl di ɔda tin dɛn we kin mek i apin bifo i mek difinitiv diagnosis fɔ cGvHD.

Wetin na di tritmɛnt dɛm fɔ GvHD?

Afta yu gɛt stem sɛl transplant, dɛn go gi yu imyunosuprɛsiv mɛrɛsin dɛn as prɔfylaktik mɛsej fɔ ridyus di abiliti fɔ di dona sɛl dɛn fɔ atak yu yon tisu dɛn.

If dɛn mɛrɛsin ya nɔr stɔp fɔ gɛt GvHD, yu dɔktɔ go gi yu tritmɛnt bay aw yu sik ɛn di kayn GvHD.

Tritmɛnt fɔ akyu GvHD

Bɔku tɛm, dɔktɔ dɛn kin trit pipul dɛn we gɛt akyu GvHD fayn fayn wan bay we dɛn kin ad di doz fɔ di mɛrɛsin dɛn we de stɔp di imyun sistɛm. Dɛn tin ya de insay wan klas ɔf drɔgs we dɛn kɔl kɔtikosterɔyd. Dɛn kin gi dɛn bay mɔt, insay dɛn bɛlɛ, ɔ put dɛn na di bɔdi. If stɛroyd nɔ wok, yu dɔktɔ kin gi yu wan mɛrɛsin lɛk Ruxolitinib (Jakafi®). Yu kin gɛt di chans bak fɔ tek pat pan klinik trial dɛm we de tɛst nyu tritmɛnt dɛm.

Tritmɛnt fɔ GvHD we nɔ de mɛn

Dɛn kin trit Kronik GvHD wit lɔng tɛm imyunɔsuprɛsiv mɛrɛsin. If dɛn mɛrɛsin ya nɔ ɛp, yu dɔktɔ kin gi yu mɛrɛsin lɛk:

• `Rɔksolitinib (Jakafi®)`
• `Bɛlumosudil (RɛzurɔkTM)`
• `Ibrutinib (Imbruvica®)`
• Fɔtofɛrɛsis (Dis na spɛshal tritmɛnt we dɛn kin yuz) .

Yu kin fit bak fɔ ``klinik trial.'' Di dɔktɔ go tɛl yu bɔt dat.

Wetin na di kɔmplikeshɔn/sayd ifɛkt dɛm wae de kam wit tritmɛnt?

Bikɔs dɛn mɛrɛsin ya we de mek yu bɔdi nɔ ebul fɔ fɛt di sik kin mek yu imyun sistɛm wik, dat kin mek yu gɛt fungal, baktri, ɛn vayral infɛkshɔn . So, yu dɔktɔ go gi yu sɔm ɔda mɛrɛsin dɛn fɔ protɛkt yu frɔm dɛn denja infɛkshɔn ya.

Yu tink se dɛn kin ebul fɔ stɔp GvHD?

di tisu tayp lab dεm de divεlכp כltεm εn de yuz nyu, mכr akכrd DNA-bεys tεst dεm. Dis kin mek yu mɛdikal tim ebul fɔ pik di pɔsin we gɛt di mɔs HLA mats fɔ yu. Di beta di mats, di beta chans fo prevent GvHD.

Dɔn bak, yu dɔktɔ go gi yu immunosuppressants fɔ mek yu nɔ gɛt GvHD afta yu dɔn transplant yu stem sɛl.

Yu tink se GvHD kin wɛl ɔltogɛda?

Bɔrku tɛm, dɔktɔ kin ebul fɔ mɛn di sik fayn fayn wan (GvHD). Dat min se dɛn kin kɔntrol di sayn dɛm ɛn ɛp yu fɔ liv nɔrmal layf.

Na da tɛm de, risach pipul dɛn de stɔdi nyu we fɔ mek dɛn nɔ gɛt GvHD tru klinik trial. Fɔ ɛgzampul, dɛn de chɛk difrɛn mɛrɛsin dɛn we de mek pɔsin nɔ ebul fɔ fɛt di sik ɛn nyu mɛrɛsin dɛn we de mek pɔsin nɔ gɛt sik.

GvHD kin mek pɔsin in layf de pan denja?

Yɛs, sɔntɛnde, GvHD kin mek pɔsin in layf de pan denja. Krכnik GvHD na di big tin we de mek pipul dεm we de gεt allogeneic stem cell transplant, apat frכm dεn praymar sik.

So, bifo yu du ɛni tritmɛnt – ivin stem sɛl transplant – i rili impɔtant fɔ tɔk bɔt di prɔblɛm dɛn wit yu dɔktɔ. I kin ɛksplen to yu di bad tin dɛn we kin apin to yu ɛn ɛp yu fɔ no di gud ɛn bad tin dɛn we di tritmɛnt kin du.

Sɔntɛnde, advantej de fɔ `(GvHD)`?

Nɔ sɔprayz, pan ɔl we GvHD kin gɛt bad bad impak pan yu kwaliti layf, i gɛt sɔm bɛnifit dɛn bak. Di sem imyun rεspכns we de atak yu nכmal sεl dεm de luk bak εn pwεl εni kεnsar sεl dεm we kin lεf na yu bכdi. Dɛn kɔl dis di graft-versus-tumor effect. Dɛn dɔn si se pipul dɛm wae gɛt GvHD nɔr kin gɛt dɛn praymar sik (especially kansa) kam bak.

Aw a kin kia fɔ misɛf? Fɔ fala dɛn advays ya!

Yu dɔktɔ go ɛksplen to yu aw yu fɔ tek kia ɔf yusɛf afta dɛn dɔn transplant yu stem sɛl. Fɔ ɛgzampul, us sayn dɛm fɔ wach fɔ ɛn us sayn dɛm fɔ kɔl yu mɛdikal tim wantɛm wantɛm if yu gɛt am. If yu de pan denja fɔ gɛt GvHD, dɛn kin gi yu ɔda instrɔkshɔn fɔ kia fɔ yu bak. Dɛn instrɔkshɔn dɛn ya na:

• Protɛkt yu skin frɔm di san. Wear lɔng-sliv shirt ɛn lɔng pant. Yuz sanskrin we gɛt at le SPF 50. (We yu de na di san, i kin mek GvHD wɔs ɔ i kin mek yu gɛt GvHD.)
• Mek yu gɛt gud wɛlbɔdi na yu mɔt. Dis go mek yu nɔ gɛt bɔku sik na yu gɔm.
• Nɔ it tin dɛn we gɛt spays we kin mek yu bɛlɛ pwɛl ɛn mek yu gɛt ɔlsa na yu mɔt.
• Tek step fɔ protɛkt yusɛf frɔm jem. (Yu dɔktɔ go tɛl yu mɔ bɔt dis.)

Ustɛm a fɔ go to di dɔktɔ?

I impɔtant fɔ tɛl yu dɔktɔ wantɛm wantɛm if yu gɛt ɛni chenj na yu bɔdi, mɔ di sayn dɛn we de sho se yu gɛt di sik ɛn yu gɛt fiva (100.4 Fahrenheit / 38 Celsius ɔ pas dat). We yu tek di immunosuppressants, yu kin gɛt mɔ risk fɔ gɛt infɛkshɔn we kin mek yu layf de pan denja.

afta yu dכn transplant allogeneic stεm sεl, yu dכkta go mכnitor yu gud gud wan fכ komplikashכn dεm lεk Graft vs. Host Disease (GvHD). If yu gɛt sayn dɛm fɔ akyu ɔr krɛse GvHD, yu dɔktɔ kin chenj yu mɛrɛsin ɔ gi yu nyu mɛrɛsin. Tek ɔl di mɛrɛsin dɛn jɔs lɛk aw dɛn tɛl yu fɔ tek. Fɔ fala yu dɔktɔ in instrɔkshɔn bɔt aw fɔ kia fɔ yusɛf, mɔ bɔt aw fɔ protɛkt yusɛf frɔm infɛkshɔn.

Di tin dɛn we impɔtant pas ɔl fɔ mɛmba insay shɔt tɛm!

Okay, so Graft vs. Host Disease, ɔ GvHD, na kɔmplikeshɔn we kin apin afta dɛn dɔn gɛt stem sɛl transplant frɔm ɔda pɔsin. Fɔ tɔk am simpul wan, na we di sɛl dɛn we de gi di mɔni atak yu yon sɛl dɛn.

Mɛmba se, tritmɛnt dɛn de fɔ GvHD, ɛn dɛn kin ebul fɔ kɔntrol di sik. De tin wae impɔtant pas ɔl na fɔ fala yu mɛdikal tim in instrɔkshɔn fayn fayn wan ɛn fɔ mek dɛn no bɔt ɛni nyu sayn kwik kwik wan.

If yu gɛt ɛni ɔda kwɛstyɔn bɔt dis, nɔ fred fɔ aks yu dɔktɔ. Na di wan dɛn we go ebul fɔ ɛp yu di bɛst we.

` GvHD, stεm sεl transplant, allojenik transplant, imyun sistεm, HLA, dכna sεl dεm, simptom dεm