Yu pikin kin gɛt fiva ɔltɛm? Yu tink se na bikɔs ɔf SAID (Systemic Autoinflammatory Diseases)?

Oh, yu smɔl pikin kin gɛt fiva bɔku tɛm dɛn tɛm ya? Jɔs we yu tink se yu dɔn bɛtɛ, i kin flay bak? Sɔntɛnde, di tin we kin mek dis apin nɔto kɔmɔn vayrɔs ɔ baktri. Tide wi go tɔk bɔt wan kɔndishɔn we kɔmplikt smɔl, bɔt i rili impɔtant fɔ no bɔt. Dɛn kɔl dis SAID, we tinap fɔ Systemic Autoinflammatory Diseases . Trade, dɛn bin de kɔl dis `(Periodic Fever Syndromes)` ɔ `(Rɛkɔrɛnt Fiva Sindrom)`.

Wetin na SAID dɛn? Lɛ wi ɔndastand am simpul wan.

Fɔ tɔk am simpul wan, SAID na wan grup fɔ sik dɛn we kin kam bikɔs ɔf wan prɔblɛm we de na wi bɔdi in innate immune system we nɔ de wok fayn ɔ we de rigul . Dis na di rizin we mek pikin kin gɛt fiva ɔltɛm ivin if i nɔ gɛt infekshɔn (lɛk vayrɔs ɔ baktri).

Di tin we impɔtant pas ɔl na dat dɛn nɔ fɔ kɔnfyus dɛn kɔndishɔn ya we dɛn kɔl SAID wit di `(Autoimmune Diseases)` (fɔ ɛgzampul `(Rheumatoid Arthritis)` ɔ `(Lupus)` we yu go dɔn yɛri bɔt. Insay `(Autoimmune)` sik dɛm, bikɔs ɔf sɔm mistek na wi bɔdi in `(adaptive immune system)`, da sistɛm de atak in yon wɛlbɔdi sɛl dɛm. Bɔt na SAID, sɔntin difrɛn kin apin.

SAID dεm nכ kin bכku pas כtoimyun sik dεm. Bɔku tɛm dɛn kin kɔmɔt frɔm dɛn mama ɛn papa ɛn na wan chenj we dɛn mek na dɛn jɛnɛtiks kin mek dɛn .

Bɔku tɛm, bɔt nɔto ɔltɛm, di SAID simptom dɛn kin bigin we pikin rili yɔŋ, ilɛksɛf i smɔl ɔ we i smɔl . Yu pikin kin gɛt "period" fɔ fiva ɛn ɔda sayn dɛm wit dis kɔndishɔn. bitwin dɛn tɛm ya, yu pikin nɔ kin gɛt ɛni sayn atɔl. Pan ɔl we no mɛrɛsin nɔ de fɔ SAID, bɔku tɛm tritmɛnt dɛn de fɔ ɛp fɔ kɔntrol yu pikin in sik dɛn.

Wetin na di men kayn SAID dɛm?

Risach pipul dɛm dɔn no lɛk 60 kayn SAID dɛm, ɛn dɛn stil de fɛn nyu wan dɛm. Na sɔm pan di kayn SAID dɛm we dɛn kin gɛt:

• Famili Mɛditarenian fiva (FMF): Dis na di mɔs kɔmɔn pan di jɛnɛtik inhɛrit, fiva sindrom we kin kam bak. I kin mek pikin dɛn bɛlɛ, chɛst, ɛn jɔyn dɛn swel wit pen.
• Fiva we kin kam wan wan tɛm, aphthous-stomatitis, pharyngitis, adenitis (PFAPA): Dis kin bigin pan yɔŋ pikin dɛn bifo dɛn rich 4. Sɔntɛnde, di sik kin bɛtɛ fɔ insɛf afta dɛn dɔn ol 10 ia.
• Tumor necrosis factor receptor-associated periodic syndrome (TRAPS): Dis kin apin we i smɔl, we i yɔŋ, ɔ ivin we i big.
• Mevalonate kinase deficiency (MKD): Fכs dεn bin de kכl am ``Hyper-IgD syndrome'', dis kin bigin bifo di pikin ol wan ia.
• NLRP3-asכsiet כtoinflammatory sik dεm:dis dεn bin de kכl dis fכs `(Cryopyrin-associated periodic syndromes - CAPS)`. Tri ɔda sɔbtayp dɛn de insay dis.
• Still’s disease (AOSD) we kin bigin fɔ big pipul dɛn (AOSD): As di nem sho, dis na wan we we kin bigin fɔ big pipul dɛn we kin gɛt di sik we dɛn kin gɛt we dɛn smɔl ``Systemic Juvenile Idiopathic Arthritis (JIA)``.
• NOD-2-associated granulomatous disease (Blau syndrome): Dis kin bigin bifo i ol 4. I kin mɔs afɛkt di pikin in skin, in yay, ɛn in jɔyn dɛn.

Wetin na di sayn dɛm fɔ SAID?

Di sayn dɛm fɔ SAID kin bigin we dɛn smɔl. Di men ɛn kɔmɔn sayn na fiva we kin kam wan wan tɛm . Insai di fiva tɛm, pipul dɛn kin gɛt wɛl bɔdi ɛn nɔr kin gɛt ɛni sayn. Bɔt ɔda sayn dɛn kin de we spɛshal fɔ ɛni kayn SAID. Lɛ wi si wetin dɛn bi:

• FMF: Dis kin mek di pikin in bɛlɛ, in chɛst, ɛn in jɔyn dɛn swel ɛn gɛt bad bad pen . Rash kin de bak na di leg ɔ ankles we de dɔŋ.
• PFAPA: Dis kin mek yu trot at, yu mɔt de at, ɛn di limf no dɛm na yu nɛk swel . Fɔ ɛgzampul, if yu pikin de sho sɔm sayn dɛm lɛk fɔ gɛt tonsilaytis ɔltɛm ɛn fɔ gɛt ɔlsa na in mɔt, i kin bi PFAPA.
• TRAPS: Dis kin mek yu kol εn di mכsul dεm de pen na di trכnk/torso εn di an dεm . I kin mek bak yu gɛt rɛd rɛd rɔsh we de mek yu fil pen we kin bigin na di an ɛn leg ɛn i kin skata dɔŋ di bɔdi.
• MKD: Dis kin mek yu gɛt sɔm kayn sik lɛk kol, ed we de at, bɛlɛ we de at, we yu nɔ want fɔ it, ɛn tin dɛn we tan lɛk flu .
• NLRP3 sik dɛm: Dis sik kin mek yu skin gɛt rash, ed kin at, yu nɔ kin fil fayn, yu gɛt pen na yu jɔyn, ɛn yu kin gɛt pink yay/kɔnjɔktiviti .
• AOSD: Dis na kɔmɔn tin we kin mek yu skin gɛt rash, yu jɔyn dɛn kin pen, ɛn yu mɔsul dɛn kin pen . Sɔm pipul dɛn kin gɛt bak trot we kin at, bɛlɛ kin at, taya, ɛn nɔ kin fil fayn.
• Blau syndrome: Dis kin mek yu pikin in an, in leg, ɔ in midsekshɔn gɛt lɛsin na in skin . I kin mek yu jɔyn dɛn pen ɛn yu yay pen bak .

Wetin na di tin dɛn we kin mek pɔsin gɛt SAID?

Bɔku SAID dɛn na sik dɛn we dɛn kin gɛt frɔm dɛn jɛnɛtiks . dat min se, wan spεsifi k mכtεshכn (vεryכnt) na wan spεsifi k jin de mek εvri sεndrכm. Imajin se wi bɔdi gɛt sɔm instrɔkshɔn (jin) we de tɛl wi aw fɔ du ɛni wok, so if wan lɛta na da buk de nɔ rayt, i kin mek di ɔda pat pan di wok go rɔng.

Na di men kayn SAID dɛm ɛn di jin dɛm we gɛt fɔ du wit dɛn:

• FMF: 1.di jin `MEFV` na in de gi instrכkshכn fכ aw fכ mek di protin `(pyrin)`.
• PFAPA: Dɛn nɔ dɔn no yet di rayt tin we mek dis apin .
• TRAPS: Di jin `TNFRSF1A`. dis de instrכkt di prodyushכn fכ wan protin we dεn kכl `(tכmכr nεkrכsis fכktכ rεsεpכta - TNFR)`.
• MDK: Di jin we dɛn kɔl `MVK`. dis de instrכkt di prodyushכn fכ wan protin we dεn kכl `(mevalonic kinase)`.
• NLRP3 sik dɛm: Di jin `NLRP3`. dis de instכkt fכ prodyuz wan protin we dεn kכl `(cryopyrin)`.
• AOSD: Dɛn nɔ dɔn fɛn di rayt rizin fɔ dis yet .
• Blau sindrom: Di jin `NOD2`. dis de instrכkt di prodyushכn fכ wan protin we dεn kכl `(NOD2)`.

I impɔtant fɔ ɔndastand se we dɛn tin ya kin apin bikɔs ɔf di jɛnɛtiks, nɔto di mama ɛn papa fɔlt. Dis na rili kɔmpleks bayolojikal prɔses dɛm.

Kɔmplikɛshɔn dɛn we SAID kin kam wit

I rili impɔtant fɔ gɛt di rayt tritmɛnt fɔ dɛn kayn tin ya. biכs, if inflameshn kכntinyu na di bכdi, i kin mek yu gεt wan kכndyushכn we dεn kכl `(Amyloidosis). `(Amyloidosis)` na di protin dεm we de na di kidni dεm . Dis kin mek di kidni dɛn pwɛl fɔ ɔltɛm . So, if sɔm sayn dɛn de, i impɔtant fɔ go to dɔktɔ wantɛm wantɛm.

Aw dɛn kin no di SAID dɛn?

Fɔ tɔk tru, fɔ no bɔt SAID kin tranga smɔl bikɔs di sayn dɛm kin tan lɛk ɔda siriɔs sik dɛm, lɛk lupus ɔ lymphoma. So, i impɔtant fɔ go to dɔktɔ we gɛt spɛshal trenin fɔ inflammatory diseases (wan rεumatɔlɔjis) fɔ no ɛn manej yu pikin in kɔndishɔn kɔrɛkt wan.

Yu pikin in rεumatɔlɔjis go yuz sɔm tin fɔ no if i gɛt SAID. I go aks bɔt yu pikin in sik ɛn if ɛnibɔdi na yu famili dɔn gɛt dɛn kayn sik ya (bayolojikal famili histri). Di dɔktɔ kin tink se yu pikin gɛt Piɔriɔdik Fiva Sindrom if:

• If yu gɛt fiva ɔltɛm
• If ɛnibɔdi na di famili gɛt histri fɔ gɛt fiva lɛk dis wan wan tɛm
• If yu de pan wan grup fɔ pipul dɛn we kin gɛt dɛn kayn fiva ya

Us tɛst dɛn dɛn kin yuz?

Di dɔktɔ kin tɛl yu fɔ du bɔku tɛst fɔ no if yu gɛt di sik. Dɛn tin ya kin bi:

• Lab tεst dεm: tεst dεm lεk `(C-reactive protein - CRP)` εn `(Complete Blood Count - CBC)` kin chεk fכ inflameshn na di bכdi. Dɛn tɛst ya na `(positiv)` we fiva de, ɛn kin kam bak to nɔmal valyu we di fiva dɔn go.
• Urin tɛst: .dεn kin du wan urine protin tεst fכ chεk fכ hכy lεvεl fכ protin na di urine. insay MKD, wan urine tεst fכ כrganik asid dεm go sho εlevεt lεvεl dεm fכ mεvalכnik asid.
• Jεnεtik tεst: Dis kin chεk fכ jεnεtik vεryכnt dεm. Bɔt sɔm pikin dɛn we gɛt SAID nɔ kin gɛt di jɛnɛtik we dɛn dɔn fɛn. So, ivin if di tɛst rizɔlt na ``negativ``, dɛn nɔ go ebul fɔ pul di pɔsibiliti fɔ SAID.

Aw dɛn kin trit SAID dɛn?

Di tritmɛnt fɔ SAID kin difrɛn difrɛn wan bay di kayn ɛn aw di sik siriɔs . Pan ɔl we dɛn nɔ kin ebul fɔ mɛn dɛn sik ya kpatakpata, dɛn kin kɔntrol di pikin in sayn dɛn fayn fayn wan we dɛn yuz mɛrɛsin . Fɔ ɛgzampul, if yu pikin kin gɛt dɛn kol ya fɔ sɔm tɛm nɔmɔ insay di ia, bɔku tɛm, mɛrɛsin dɛn we de mek pɔsin fil pen ɛn di mɛrɛsin dɛn we nɔ de mek pɔsin fil pen (NSAID) kin kɔntrol di sik dɛn. Bɔt if di sik rili bad, di dɔktɔ kin tɛl yu ɔda tritmɛnt dɛn.

Na sɔm pan dɛn kayn tritmɛnt ya:

• FMF: Dɛn kin trit dis wit wan mɛrɛsin we dɛn kɔl `(Colchicine)` fɔ ridyus inflamɛns. If yu nɔ ebul fɔ tek `(Colchicine)`, yu kin tray wan `(Biologic)` kayn drɔg we dɛn kɔl `(Canakinumab)`.
• PFAPA: Dɛn kin shɔt di flawa-ap dɛm fɔ PFAPA bay we dɛn gi stɛroyd (bɔku tɛm prɛdnisɔn). Sɔm pikin dɛn dɔn ebul fɔ kɔntrol dɛn sik bay we dɛn de yuz cimetidine, we na wan mɛrɛsin we dɛn kin yuz fɔ mɛn ɔlsa na dɛn bɛlɛ.
• TRAPS: Di drɔg `(Canakinumab)` rili wok fɔ TRAPS. Dɔn bak, prɛskrishɔn anti-inflammatory mɛrɛsin dɛm lɛk `(Glucocorticoids)` kin ɛp bak fɔ pul di simptom dɛm.
• MKD: `(Canakinumab)` na gud opshɔn fɔ MKD tritmɛnt. Yuz `(NSAIDs)` ɔ `(Steroids)` we yu gɛt fiva kin ɛp bak.
• NLRP3 sik dɛm: Dɛn kin yuz ɔda ``Immunomodulators'' drɔgs dɛm lɛk ``Canakinumab'' ɛn ``Rilonacept'' ɛn ``Anakinra'' fayn fayn wan fɔ trit NLRP3 sik dɛm.
• AOSD: Dɛn kin yuz difrɛn kayn anti-inflammatory mɛrɛsin fɔ AOSD. Dɛn tin ya na `(Stɛroyd)`, `(Disease-Modifying Anti-Rheumatic Drugs - DMARDs)`, ɛn `(Biologics)`.
• Blau sindrom: I kin dipen pan di pikin in simptom dɛm, dɛn kin tray fɔ yuz imyunosuprɛsant, tumor necrosis factor (TNF) inhibitors, ɛn/ɔ topical eye medications.

SAIDs kondishɔn kin bɛtɛ pan in yon?

Sɔm SAID kin las fɔ ɔl yu layf . Ɔda wan dɛn kin las fɔ sɔm ia ɛn dɛn kin bɛtɛ we dɛn de ol. Pan ɔl we sɔm tin dɛn kin apin to yu layf, di frɛkuɛns we pɔsin kin gɛt fiva kin go dɔŋ as tɛm de go ɛn di sayn dɛn nɔ kin rili bad . Yu dɔktɔ kin gi yu patikyula tin dɛn bɔt di patikyula sik we yu pikin gɛt.

Fɔ kia fɔ pikin we gɛt SAID kin tranga. Sɔntɛm yu dɔn SAID yusɛf, bɔt yu kin yuz yu pasɔnal ɛkspiriɛns fɔ ɛp yu fɔ kia fɔ yu pikin ɛn ɛp am fɔ bia wit dis sik we de apin to am ɔl in layf.

Di tin we impɔtant pas ɔl na fɔ aks fɔ tritmɛnt frɔm spɛshal pipul dɛn we sabi di kayn we aw SAID dɛn kin tranga. Dɛn kin ɛp fɔ kɔntrol yu pikin in sik ɛn ɛp am fɔ gɛt di bɛst pikin tɛm.

Di tin dɛn we impɔtant pas ɔl fɔ mɛmba (Take-Home Message) .

Okay, so lɛ wi sɔma sɔm pan di tin dɛn we yu nid fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt.

• If yu pikin kin gɛt fiva ɔltɛm, we yu nɔ kin ɛksplen , tɔk to dɔktɔ bɔt am. I kin bi sayn fɔ SAID.
• SAID na prɔblɛm fɔ di innate immune system , nɔto kɔmɔn sik we kin kam pan pɔsin.
• Dis dεm difrεn frכm ``Autoimmune'' sik dεm .
• Bɔku tɛm, na di tin dɛn we de apin na di bɔdi kin mek dɛn tin ya .
• I impɔtant fɔ go to Riumatɔlɔjis fɔ no di kɔrɛkt diagnosis.
• Tritmɛnt kin kɔntrol di sik dɛn fayn fayn wan .
• Fɔ trit yu kwik kwik wan impɔtant fɔ mek yu nɔ pwɛl di kidni.

If yu gɛt ɛni ɔda kwɛstyɔn bɔt dis, nɔ fred fɔ aks yu famili dɔktɔ ɔ dɔktɔ we de mɛn pikin dɛn. Dɛn go ebul fɔ ɛp yu mɔ.

` SAID, hereditary fiva, fiva we kin kam ɔltɛm, fiva na pikin dɛm, imyun sistɛm, jenɛtik sik dɛm, rεumatɔlɔjis