Yu bɔdi in difens dɛn dɔn wik? Lɛ wi lan bɔt agranulocytosis.

Bɔku tɛm yu kin gɛt kol ɛn flu ɛn fil bad bad wan? Sɔntɛnde, ivin smɔl sik kin kam siriɔs ɛn tek lɔng tɛm fɔ mek i wɛl? Di men rizin fɔ dis kin bi we yu bɔdi in imyun sistɛm wik, dat na di ami we de protɛkt wi frɔm sik. Tide wi de tɔk bɔt wan sik we dɛn kin sɔprayz pan dɛn kayn tɛm ya, we kin denja smɔl, bɔt dɛn kin trit am.

Fɔ tɔk am simpul wan, wetin na Agranulocytosis?

Agranulocytosis (dεn kin kכl am: "a-gra-nu-lo-cy-to-sis") na wan kכndyushכn we de mek wi layf de pan denja we di nכmba fכ nyutrofil dεm, we na wan kayn wayt bכdi sεl, na wi bכdi de rεdכks bad bad wan.

Imajin se wi bɔdi tan lɛk kɔntri. Dɔn di wayt blɔd sɛl dɛn na di ami we de protɛkt da kɔntri de. Difrɛn batalyɔn dɛn de na dis ami. Pan dɛn wan ya , nyutrofil na spɛshal kɔmando grup we kin go atak di jem dɛn jɔs afta dɛn si dɛn . So when the number of these commandos decreases greatly, even a small germ from outside can easily attack our body and make us sick.

Dis sik kin mek yu gɛt siriɔs infɛkshɔn, ivin frɔm jem dɛm wae nɔr kin du wi bad.

So wetin na di difrɛns bitwin Nyutropenia ɛn Agranulocytosis?

Yu go dɔn yɛri bak di wɔd nyutropenia. Pan ɔl we dɛn tu tin ya kin tan lɛk, smɔl difrɛns de.

• Nyutropenia: εni kכndyushכn we di nכmba fכ nyutrofil dεm sכm pas nכmal.
• Agranulocytosis: Dis na di kayn we we rili bad ɛn we denja pas ɔl fɔ mek yu gɛt nyutropenia.

Fɔ tɔk am simpul wan, we di nyutrofil lɛvɛl dɛn de drɔp tumɔs, wi kin kɔl am Agranulocytosis.

Wetin na di rizin dɛn we mek dis kayn tin de apin?

Agranulocytosis kin apin tu men we dεm.

1. Inherited Agranulocytosis: Dis kin kכz fכ difεkt na di jin dεm we de mek nyutrofil dεm. Dis nɔ kin apin so ɔltɛm ɛn i kin apin mɔ pan yɔŋ bebi ɛn pikin dɛn.

2. Acquired Agranulocytosis: Dis na di kayn we we kכmכn pas כl. Bɔku tin dɛn kin de we kin mek dis apin. Bɔt na lɛk 70% pan di kes dɛm, na sayd ɛfɛkt fɔ sɔm mɛrɛsin dɛm we wi kin tek. Dis kayn tin kin bɔrku pan big pipul dɛm.

di men tin dεm we de mek di agranulocytosis we de afta dat

• Sɔm mɛrɛsin dɛm: Dis sik kin kam bikɔs ɔf mɛrɛsin dɛm lɛk sɔm antibayɔtik, mɛrɛsin fɔ mɛntɛl sik (e.g. clozapine), ɛn mɛrɛsin fɔ tayroyd disɔda (e.g. methimazole).
• Kimotɛrapi: We dɛn dɔn pwɛl di kansa sɛl dɛn, di nyutrofil dɛn we na wɛlbɔdi sɛl dɛn we de sheb kwik kwik wan kin pwɛl bak.
• Ɔtoimyun sik dɛm: Dis na we wi bɔdi in yon imyun sistɛm nɔ de biev fayn ɛn atak in yon wɛlbɔdi sɛl dɛm. Sɔm ɛgzampul dɛn na sik dɛn lɛk Lupus ɛn Rheumatoid Arthritis.
• Bɔn Mכro Sik dεm: Bon mכro na di fכktri we de mek כl wi bכdi sεl dεm. So, sik dɛm we de afɛkt dis faktri, lɛk kansa lɛk lukimiya ɔ aplastik anemia, kin mek nyutrofil nɔ wok fayn.
• Sɔm infɛkshɔn: Dis sik kin kam bak bikɔs ɔf bad bad infɛkshɔn lɛk malaria ɛn TB.
• di nyutrishכnal dεfichεshכn: Dis risk de bak wit lכng tεm dεfisiεns fכ nyutriεnt lεk vaytam in B12 εn fכlet.
• Pɔyzin kemikal: We pɔsin it pɔyzin kemikal lɛk lid ɔ mɛkkyuri.

Wetin na di sayn dɛm fɔ agranulocytosis?

Bikɔs di nyutrofil dɛn nɔ bɔku, di men sayn dɛn we de sho se dis sik na di wan dɛn we de sho se pɔsin gɛt infɛkshɔn . Dɛn tin ya kin apin wantɛm wantɛm ɔ dɛn kin kam smɔl smɔl.

Di men tin dɛn we pɔsin kin si na dɛn tin ya:

• Fɔ fil kol bad bad wan, shek shek, ɛn gɛt fiva .
• Di at rit ɛn di brith rit we de go ɔp.
• Fɔ fil se yu taya ɛn wik na yu bɔdi we nɔ bin de bifo .
• Trot we de at, di gam we swel ɛn we de blɔd.
• I nɔ izi fɔ swɛla bikɔs ɔf ɔlsa na yu mɔt ɛn yu trot .
• Wantɛm we yu blɔd prɛshɔn go dɔŋ (haypotension) we kin mek yu fil lɛk se yu nɔ gɛt bɛtɛ maynd ɛn yu ed kin tɔn.

Aw dɔktɔ kin no bɔt dis sik?

If yu gɛt ɛni wan pan di sayn dɛn we wi dɔn tɔk bɔt, mɔ if yu gɛt infɛkshɔn ɔltɛm, dɔktɔ go chɛk yu. Di tɛst we impɔtant pas ɔl fɔ no if yu gɛt dis sik na fɔ kɔnt ɔl yu blɔd (CBC) . Sɔntɛnde wi kin kɔl dis bak ful blɔd kɔnt (FBC).

Dis tɛst de mɛzhɔ di rayt nɔmba fɔ di nyutrofil dɛn we de na yu blɔd. if di nyutrofil kכnt less dan 100 pan wan maykrolit, dεn kin no se na Agranulocytosis.

Apat frɔm dat, di dɔktɔ kin tɛl dɛn fɔ du ɔda tɛst fɔ no wetin mek dɛn du dis.

• Bone Marrow Biopsy: Dɛn kin du dis tɛst fɔ si if ɛni prɔblɛm de na di bon marrow, we na di faktri we de mek blɔd sɛl.
• Jɛnɛtik Tɛst: If dɛn tink se dis na sik we dɛn bɔn wit, dɛn kin rifer yu fɔ dis tɛst.

Wetin na di tritmɛnt dɛm fɔ agranulocytosis?

Pan ɔl we dis na denja sik, di gud nyus na dat, fayn tritmɛnt dɛn de fɔ am. De tritmɛnt dipen pan wetin de kɔz de sik.

• Stɔp di mɛrɛsin we de mek yu gɛt dis sik: If di tin we de mek yu gɛt dis sik na wan mɛrɛsin we yu de tek, di fɔs ɛn impɔtant tin fɔ du na fɔ stɔp fɔ tek da mɛrɛsin de. Bɔt, nɔ ɛva stɔp fɔ tek yu mɛrɛsin fɔ yusɛf. Mek shɔ se yu tɔk to yu dɔktɔ ɛn fala in instrɔkshɔn fɔ du dat sef wan.

• Antibayɔtik: If yu dɔn ɔlrɛdi gɛt infekshɔn na yu bɔdi, yu dɔktɔ go gi yu strɔng antibayɔtik fɔ fɛt am.

• G-CSF injεkshכn: dεn kכl dεm ya Granulocyte Colony-Stimulating Factor (G-CSF). dis injεkshכn dεm de mek di bon mכro wok εn i de εp fכ mek nyutrofil sεl dεm kwik kwik wan.

• Immunosuppressants: If di kɔz na ɔtoimyun sik, dɛn kin gi mɛrɛsin lɛk prɛdnisɔn fɔ mek di imyun sistɛm we de wok pasmak kol.

• Bɔn Mɛro Transplant: If ɔda tritmɛnt dɛn nɔ wok, dɛn kin du bon mɛrɔ transplant frɔm pɔsin we gɛt wɛlbɔdi as las tin fɔ du.

Aw a go protɛkt misɛf frɔm infɛkshɔn we a de du tritmɛnt?

I rili impɔtant fɔ avɔyd infɛkshɔn we yu de trit pɔsin we gɛt dis sik.

• Wash yu an fayn fayn wan wit sop ɔltɛm.
• Minimiz fɔ go na ples dɛn we pipul dɛn kin bɔku as yu ebul.
• Wear fes mask we yu de go na do.
• Na it nɔmɔ it we dɛn kuk fayn ɛn we klin.

I pɔsibul fɔ mek yu wɛl gud gud wan frɔm dis sik?

Yɛs, bɔku tɛm i pɔsibul. Di tɛm we pɔsin kin wɛl kin dipen pan di tin we kin mek i wɛl.

If di kɔz na mɛrɛsin, di nyutrofil kɔnt kin kam bak to nɔmal insay 1 to 3 wik afta dɛn dɔn stɔp di mɛrɛsin.

If dɛn no bɔt dis sik ɛn trit am kwik, dɛn kin kɔntrol dis sik ɔltogɛda. Bɔt if dɛn nɔ trit am, i kin mek pɔsin gɛt siriɔs infɛkshɔn ɛn tin dɛn we kin mek pɔsin in layf de pan denja lɛk sepsis . Pipul wae dɔn pas 65 ia ɛn wae gɛt ɔda sik na dɛn at, kidni, ɔr lɔng kin gɛt bɔrku prɔblɛm.