Wan sikrit rigyulatɔ we de kɔntrol wi blɔd prɛshɔn: Ɔltin bɔt Renin!

Yu dɔn ɛva wɔnda ɔmɔs wɔndaful tin dɛn kin apin insay wi bɔdi? Sɔntɛnde, we wi nɔ kin ivin no, bɔku wɔndaful tin dɛn de we kin mek wi bɔdi gɛt wɛlbɔdi. Fɔ ɛgzampul, di wan we de ɛp fɔ kɔntrol wi blɔd prɛshɔn na in dɛn kɔl Renin. Tide, lɛ wi tɔk bɔt wetin na Renin, aw i de wok, ɛn aw i impɔtant to wi wɛlbɔdi.

Wetin na Renin? Fɔ tɔk am simpul wan...

Okay, naw mek wi si wetin dis renin bi. Fɔ tɔk am simpul wan, renin na wan ɛnzaym we spɛshal sɛl dɛn na yu kidni dɛn mek. Nɔ fred ɛnzaym, na prɔtin we de ɛp fɔ mek difrɛn kεmikכl prכsεs dεm na wi bכdi spid.

Dis man we dɛn kɔl renin nɔ de wok in wan. i de pat pan wan big mεkanism we dεn kכl di rεnin-angiotensin-aldosterone sistεm (RAAS). I tan lɛk se na chen riakshɔn. Di men tin we mek dis wan ol sistɛm na fɔ kɔntrol yu blɔd prɛshɔn. spεshal wan, di renin de kכntro wan כmon we dεn kכl aldosterone, we wi adrenal gland dεm (sכm sכm gland dεm we de oba di kidni dεm) de mek.

So, aw dis Renin de wok?

Naw, na di impɔtant pat. Di men wok we Renin de du na fɔ kɔntrol blɔd prɛshɔn. I de du dis wit tu ɔda impɔtant ɔmon dɛn we dɛn kɔl angiotensin ɛn aldosterone. Tugeda, dεn tri ya de εp fכ kip yu bכdi in sכdiכm (sכlt) εn potashכm lεvεl in chεk.

Imajin se dis de apin:

1. Fɔs, renin de chenj di angiotensinogen (we de bifo di angiotensin) we yu liva mek to angiotensin I ( angiotensin, we na wan ɔmon we de mek yu blɔd vesel dɛn smɔl).

2. Dɔn, dis angiotensin I kin tɔn to angiotensin II .

3. Naw dis angiotensin II na di rial wok ɔs. I de mek yu blɔd vesel dɛn smɔl ɛn i de ɛp bak fɔ pul di ɔmon we dɛn kɔl aldosterone.

4. Fɔ dɔn, dis aldosterone de ɛp yu kidni fɔ kip wata ɛn sɔl (sɔdiɔm) na yu bɔdi. Dis kin mek di wata we de na yu bɔdi bɔku. Dis na wetin de mek yu blɔd prɛshɔn go ɔp.

Fɔ tɔk am simpul wan, we blɔd prɛshɔn go dɔŋ, wan man we dɛn kɔl renin kin kam insay, tek sɔm ɔda pipul dɛn, kɔnstrikt sɔm blɔd vesel dɛn, kip sɔm wata na di bɔdi, ɛn mek blɔd prɛshɔn kam bak to nɔmal.

Aw dɛn kin pul di renin? Us tɛm?

Okay, naw yu geht wan kweshon: dis renin jis mek na di bodi, o i de rilis na spesifik taim? Renin de kɔmɔt na yu blɔd we yu blɔd prɛshɔn go dɔŋ tumɔs, ɔ we yu lɔs inof sodium (sɔl) frɔm yu bɔdi.

spεshal wan, dεn tin ya de afekt di renin sekreshכn:

• di baroreseptכ dεm (dεn na prεshכn-sεnsitiv rεsεpכta dεm) na yu bכdi vεsul dεm de sεns lכw bכdi prεshכn.
• If yu kidni dɛn no se sɔl (sɔdiɔm) nɔ bɔku na yu bɔdi.
• di beta 1 adrenergic risεptor dεm, we de kכntro yu at rεt, de sεns di aktiviti na yu simpatik nεv sεstem (dis kin apin we wi de wɔri כ frayd).

Yu tink se na di renin nɔmɔ de mek di blɔd prɛshɔn go ɔp?

Nɔ, nɔto jɔs. Renin nɔmɔ nɔ de afɛkt yu blɔd prɛshɔn. Bifo dat, lɛk aw i bin dɔn tɔk, i de wok togɛda wit angiotensin ɛn aldosterone. Angiotensin de mek yu blɔd vesel dɛn smɔl, ɛn aldosterone de ɛp yu kidni fɔ kip wata ɛn sɔl. Dis na wetin de mek yu bɔdi gɛt mɔ wata ɛn yu blɔd prɛshɔn go ɔp.

Usay dɛn kin mek renin?

Yu go mɔs dɔn no dis bay naw. Renin de kɔmɔt na yu kidni dɛn. We yu sistolik blɔd prɛshɔn (di nɔmba we de ɔp we yu de mɛzhɔ blɔd prɛshɔn) go dɔŋ, ɔ we yu kidni dɛn no se yu bɔdi nɔ gɛt bɛtɛ wata, dɛn kin pul renin insay yu blɔd.

Wetin dɛn mek renin wit? (Dis na sayɛns smɔl, bɔt i fayn fɔ no.)

dis na dip sכmtin, bכt fכ put am simpul, renin gεt lεk 340 amino asid rεsidεns dεm. Amino asid dεm lεk di sכm sכm bildin blכk dεm fכ di protin dεm. dis dεm kin kam togεda fכ mek di εnzym we dεn kכl di εnzym we dεn kכl rεnin. I tan lɛk se bɔku brik dɛn de kam togɛda fɔ mek wɔl.

Us mɛrɛsin kin gɛt fɔ du wit di renin prodakshɔn?

Sɔntɛnde di renin lɛvɛl kin go ɔp na di bɔdi. Tin dɛn lɛk dis kin mek i apin:

• Lɔw blɔd prɛshɔn (Hypotension) .
• If yu dɔn lɔs bɔku blɔd (e.g. frɔm aksidɛnt).
• If yu kidni dɛn dɔn ridyus di blɔd flɔ .
• di vכlyum dεplishכn (e.g., dεhaydreshכn bikoz fכ vכmit כ bεlε de at).
• di wok we di simpatik nεv sεstem de du we de go כp (Sympathetic nerve activation) (insay dis kes, di at rεt, di brith rεt, di bכdi prεshכn de inkrεs, εn di blak sεkכl dεm na di yay de big).

Test de fɔ chɛk di renin lɛvɛl?

Yɛs, na fɔ tru. Yu dɔktɔ kin du wan renin aktiviti tɛst ɛn wan aldosterone lɛvɛl tɛst. Dis go tɛl am ɔmɔs aldosterone yu adrenal gland dɛn de mek.

If yu gɛt ay blɔd prɛshɔn, mɔ if yu nɔ de kɔntrol am wit di mɛrɛsin dɛn we yu kin yuz, yu dɔktɔ kin tɛl yu fɔ du dis tɛst.Yu kin gɛt wan sik we dɛn kɔl praymari aldosteronism (PA) (dɛn kin kɔl am bak Conn’s syndrome) . Insay dis kɔndishɔn, dɛn kin mek tumɔs aldosterone, we kin mek yu blɔd prɛshɔn ay. Wan renin tɛst kin ɛp fɔ no if na PA de mek yu gɛt ay blɔd prɛshɔn.

Aw dɛn kin mɛzhɔ di renin?

Bɔku tɛm, dɛn kin mɛzhɔ di rɛnin bay sɔntin we dɛn kɔl plasma renin aktiviti (PRA) . dis de mכsu aw di renin de mek angiotensin I (di prεkursכr fכ angiotensin II). Dɛn kin mɛzhɔ am bak as dairekt renin .

Wetin i min if yu renin lɛvɛl ay?

If yu renin lɛvɛl ay, i kin bi bikɔs ɔf:

• Addison in sik (we yu adrenal gland dεm nכ de prodyuz inof כmon) - spεshal wan wit di bכdi wata we de dכn.
• Dihaydreshɔn (we nɔ gɛt wata na di bɔdi).
• di potashכm we de sכmtεm na di bכdi (hypokalemia) .
• Ɛmoraji (bɔku blɔd we de flɔ insay ɔ ausayd wan ɔgan).
• di kidni tכmכro dεm we de prodyuz rεnin .
• di rεnal haypatεnshכn (di ay blכd prεshכn we de kכz bay we di blכd vεsul dεm we de go na di kidni dεm de sכmtεm).
• Malignant hypertension (dis na ay blɔd prɛshɔn we kin kam wantɛm wantɛm, we nɔ gɛt ɛni wɔnin ).
• Praymari haypatɛnshɔn (dis na ay blɔd prɛshɔn we nɔto di rizɔlt fɔ ɔda mɛrɛsin).
• at fεil כ sirosis na di liva (we di bכdi in wok blכd vכlyum de dכn wit dεn kכndyushכn dεm ya).

Wetin fɔ du if di renin lɛvɛl smɔl?

Rizin dεm de bak we mek di renin lεvεl kin lכw. Fɔ ɛgzampul:

• Praymari aldosterɔnizm (PA) .
• If yu de yuz sterɔyd mɛrɛsin dɛn we de mek sɔl nɔ de na di bɔdi.
• Sɔl-sɛnsitiv haypatɛnshɔn (sɔm pipul dɛn kin gɛt ay blɔd prɛshɔn ivin we dɛn it smɔl tumɔs sɔl, dat na kɔndishɔn).

Aw a go kip mi renin lɛvɛl dɛn wɛl?

If yu renin lɛvɛl nɔrmal ɔr smɔl, yu dɔktɔ go no di ɔndalayn kɔz ɛn mek wan tritmɛnt plan. Dɛn nɔ go jɔs gi yu mɛrɛsin fɔ mek yu renin dɔŋ ɔ rayz.

Fɔ ɛgzampul, if yu gɛt ay renin lɛvɛl ɛn ay blɔd prɛshɔn, yu dɔktɔ kin gi yu mɛrɛsin fɔ mek yu blɔd prɛshɔn go dɔŋ lɛk beta-blɔka ɛn klonidin .

Fɔ dɔn, wetin fɔ mɛmba (Take-Home Message) .

So, renin nɔto jɔs wan ɛnzaym. na wan rili imכtant pat pan di renin-angiotensin-aldosterone sistεm (RAAS). I kin rili ɛp fɔ mek yu nɔ ebul fɔ kɔntrol yu blɔd prɛshɔn.

Difrɛn rizin kin de we mek yu renin lɛvɛl nɔr nɔr fayn. So if yu gɛt ɛni dawt, di bɛst tin fɔ du na fɔ go to dɔktɔ, no di rayt tin we mek yu gɛt am, ɛn gɛt di tritmɛnt we yu nid. Nɔ jɔs go wit yu gut filin, bikɔs dɛn tin ya kɔmplikt smɔl.

Yu dɔktɔ kin ɛp yu di rayt we. Stay wit wɛlbɔdi!

` Renin, Blɔd Prɛshɔn, Kidni, Aldosterone, Angiotensin, Ay Blɔd Prɛshɔn, Lɔw Blɔd Prɛshɔn, Renin, Blɔd Prɛshɔn, Kidni, Aldosterone, Angiotensin, RAAS