Wetin na Somatostatin? Lɛ wi lan bɔt dis wɔndaful ɔmon we de na wi bɔdi!

Tide wi go tɔk bɔt wan rili strenj ɛn rili impɔtant kemikal mɛsenja insay wi bɔdi. I nem na somatostatin. Sɔntɛm yu nɔ bin dɔn yɛri bɔt dis nem bifo. Bɔt yu no, i de ɛp fɔ kɔntrol bɔku tin dɛn na wi bɔdi, lɛk sikrit masta maynd. Lɛ wi tek wan luk pan wetin na somatostatin, aw i de wok, ɛn aw i impɔtant to wi wɛlbɔdi.

Wetin na Somatostatin rili?

Fɔ tɔk am simpul wan, somatostatin na ɔmon we dɛn kin mek na wi bɔdi. Naw yu kin de wɔnda wetin na ‘ɔmon’. I rili simpul. Ɔmon na kemikal dɛn we kin kɛr mɛsej bitwin difrɛn pat dɛn na wi bɔdi. Dɛn tan lɛk ‘postman’ na wi bɔdi. Dɛn mɛsej ya kin tɛl wi ɔgan, skin, ɛn mɔsul dɛn fɔ du sɔntin ɔ fɔ stɔp fɔ du sɔntin.

so, dis spεshal כmon we dεn kכl somatostatin de mεntal stכp fכ mek כda כmon dεm, i de kכntro sכm wok dεm na wi dijestiv sistεm (gεstrointestinal (GI) trakt), εn i de kכntrכl bak di rεpid divεlכpmεnt fכ di sεl dεm (especially di kεnsar sεl dεm). Na laik trafik polis, wen somtin get tu moch, im giv signal, "Okay, okay, stop now."

Usay dɛn kin mek dis somatostatin?

Naw lɛ wi si usay dis wɔndaful somatostatin ɔmon de mek na wi bɔdi. Dɛn kin rili mek am na bɔku say dɛn:

• di gεstrointestinal (GI) trakt: Dis na di כgan sistεm we lεk tyub we de kכmכt frכm di mכt to di an we de εp wi fכ digεst di it we wi de it. Dis na di say we yu intestines de.
• Pankrias: Dis na gland we de insay wi bɛlɛ. Gland na ɔgan we de mek sɔm kemikal dɛn. di pankrias de mek enzym dεm we de εp fכ digεst it, εn imכtant כmon dεm lεk insulin εn glukagon .
• Hypothalamus: Dis de na wi bren. I tan lɛk di ‘kɔntrol sɛnta’ na wi bɔdi. i de εp fכ mεnten homכstasis (i.e., fכ mεnten wan stebul intanal envayroment). I de gi kɔmand bak to di pituitary gland we de dɔŋ di haypothalamus fɔ mek sɔm ɔmon dɛn kɔmɔt.
• Sεntri Nεv Sεstem (CNS): Dis inklud wi bren εn spεnal kכd. Na tru dis nεv sistεm we di bren de sεnd mεsej to di rεst כf di bכdi.

Ɔda nem dɛn fɔ somatostatin

Dɛn kin kɔl somatostatin bak sɔm ɔda nem dɛn. If yu dɔktɔ tɔk bɔt wan pan dɛn nem ya, i go mɔs bi se dɛn de tɔk bɔt di sem tin:

• SS, SST ɔ SOM
• Ɔmon we de stɔp di ɔmon we de mek pɔsin gro (GHIH) .
• Somatotropin rilis -inhibitin fכktכr (SRIF) .
• Somatotropin rilis -inhibit ɔmon (SRIH) .

Yu tink se dɛn kin yuz somatostatin bak as mɛrɛsin?

Yɛs, sɔntɛnde, dɔktɔ dɛn kin yuz sintetik somatostatin as mɛrɛsin fɔ mɛn sɔm sik dɛn. Fɔ ɛgzampul:

• Sɔm sik dɛn we kin apin na di bɛlɛ
• Akromegali na wan sik we nɔ kin apin so ɔltɛm we di bɔdi kin mek tumɔs ɔmon we de mek pɔsin gro .
• Sɔm kayn kansa we dɛn kɔl nyuroɛndokrin tɔŋ (NET) .
• sכm כda εndokrin sistεm (i.e., di glandular sistεm we de prodyuz כmon) sik dεm.

Wetin na di men wok we di ɔmon we dɛn kɔl somatostatin de du?

Okay, naw lɛ wi si wetin na di men wok we dis somatostatin ɔmon de du.

Fɔ tɔk am simpul wan, di men wok we i de du na fɔ stɔp ɔda ɔmon dɛn we wi ɛndokrin sistɛm de mek ɛn fɔ kɔntrol di we aw sɔm tin dɛn we de kɔmɔt na di ɛkzokrin sistɛm de kɔmɔt.

di ‘εndokrin sistεm’ de tכk bכt di sistεm we de kכl כmon dεm frכm di gland dεm na wi bכdi dεn de go insay di bכdi. Sɔm ɛgzampul dɛn na di tayroyd gland, di pituitary gland, ɛn di adrenal gland dɛn . di ‘exocrine system’ de tכk bכt di sistεm we de rilis di prodak dεm we di gland dεm mek tru wan dakt. Sɔm ɛgzampul dɛn na di saliva gland dɛn ɛn di swet gland dɛn .

So, jɔs lɛk we yu ɔf wata tap, somatostatin kin stɔp sɔm ɔmon ɛn tin dɛn we wi bɔdi nɔ nid fɔ flɔ fɔ sɔm tɛm. Jɔs tink, if yu jɔs lɛf wata tap opin, wata de west, nɔto so? Semweso, if di bɔdi de mek bɔku ɔmon pas aw i nid, prɔblɛm kin kam. Somatostatin de kɔntrol dat.

כda tin na dat somatostatin de εp bak fכ stכp di sεl dεm fכ divayd abnכmal kwik kwik wan, lεk kεnsar sεl dεm.

i de wok bak lεk nyurotransmitta na wi sεntri nεv sεstem (CNS). Nyurotransmitta na kεmikכl mεsenja we wan nεv sεl (nyuron) de rilis fכ infכlכw כda sεl.

Aw somatostatin de afɛkt difrɛn pat dɛn na wi bɔdi

Naw lɛ wi si aw somatostatin de afɛkt ɛni pat na wi bɔdi:

• Insay di haypothalamus: Somatostatin de stɔp di ɔmon dɛn we wi pituitary gland de mek, lɛk di ɔmon we de mek pɔsin gro , di ɔmon we de mek pɔsin gɛt tayroyd (TSH) , ɛn prolaktin .
• Insay di pankrias: Na ya, insulin , .i de mek di pankrias כmon dεm lεk glukagon εn gastrin , εn i de kכntrכl bak di pankrεas εnzym dεm we de εp fכ daygεst it.
• insay di dijestiv sistεm (GI tract): I de ridyus di gastric sekreshכn, we de stimulate we wi de it. i de mek bak di כmon dεm we de mek di digεstiv lεk sekretin εn gastrin nכ de kכmכt .
• insay di sεntri nεv sεstem (CNS): na ya, i de kכntribyut fכ chenj di we aw mεsej dεn de transmit tru nεv dεm (nyurotransmishכn) εn di we aw mεmכri dεm de fכm.

Wetin kin mek di somatostatin kɔmɔt?

Okay, so naw yu go mɔs de wɔnda, ‘Aw dis somatostatin de kɔmɔt? Wetin kin mek i apin?’ Fɔ tɔk tru, sayɛnsman dɛn stil nɔ ɔndastand gud gud wan aw wi bɔdi de kɔntrol di we aw dis somatostatin de kɔmɔt, ɛn us tisu dɛn de mek i kɔmɔt. te naw, dεn dכn fכ no se bכku difrεn tכp sεl dεm εn protin dεm de involv.

Wan stɔdi dɔn sho se glukɔs , we na di men tin we wi bɔdi de gi wi, nɔ jɔs de kɔntrol di we aw somatostatin de kɔmɔt, bɔt i de ɛp bak fɔ mek i kɔmɔt. Insay da stכdi de, sayɛnsman dεm bin si se we di glukכs lεvεl na di bכdi lכw, insulin de mek di somatostatin kכmכt (i.e., i de stכp insulin prodakshכn), εn we di blכd glukכs lεvεl hכy , glukagon de mek di somatostatin kכmכt (i.e., i de stכp glukכn prodakshכn).

In ɔda wɔd, bikɔs insulin de mek di blɔd shuga go dɔŋ, we yu blɔd shuga smɔl, dɛn kin pul somatostatin fɔ mek i nɔ go dɔŋ, fɔ stɔp di insulin we de kɔmɔt. I wɔndaful aw dɛn kin kɔntrol tin dɛn na wi bɔdi, nɔto so?

Prɔblɛm ɛn kɔndishɔn dɛn we gɛt fɔ du wit somatostatin

Bɔku tɛm, big prɔblɛm dɛn wit somatostatin nɔ kin bɔku. Bɔt di men tin we kin apin na wan kayn kansa we nɔ kin bɔku we dɛn kɔl somatostatinoma . dis na tכmכro we de divεlכp na di εndokrin sistεm. dis tכmכro de divεlכp na di pankrias כ di dijestiv sistεm (GI trakt). dis kin mek di somatostatin prodyuz pasmak.

Dis sik, we dɛn kɔl somatostatinoma, kin apin randomly, ɔ i kin gɛt fɔ du wit sɔm jenɛtik sindrom . Sɔm pan dɛn tin ya na:

• Mכltipכl εndokrin Nioplasia (MEN tayp 1):dis na bak wan rili rare, jεnεtik kכndyushכn we mכtalman tכmכro dεm de divεlכp na difrεn pat dεm na di εndokrin sistεm.
• Nyurofibromatosis tayp 1 (NF1): Dis na bak wan sik we pɔsin kin gɛt frɔm in mama ɛn papa. I kin mek yu gɛt kafe-au-lait spat ɛn benign tumor na di skin.
• Von Hippel-Lindau sik: Dis na wan sik bak we nɔ kin apin we pɔsin kin gɛt frɔm in mama ɛn papa. I kin mek fayn ɔ bad bad tumbu dɛn fɔm na di bren, spɛshal kɔd, yay, kidni, pankrias, ɛn adrenal gland dɛn.

we dεn prodyuz somatostatin pasmak, di prodyushכn fכ plεnti כda εndokrin כmon dεm de rεdכks bכku bכku wan. De sayn dɛm fɔ dis kin tan lɛk de sayn dɛm fɔ bɔrku ɔda sik dɛm. So, sɔmtɛm i kin tranga fɔ no kɔrɛkt wan bɔt wan sik we dɛn kɔl somatostatinoma.

Di impɔtant tin na dat dɛn prɔblɛm ya we gɛt fɔ du wit somatostatin nɔ kin bɔku , we min se bɔku pipul dɛn nɔ gɛt natin fɔ wɔri bɔt.

Dɔn bak, na smɔl ripɔt dɛn de we de sho se di somatostatin lɛvɛl smɔl pas di nɔmal tin na pɔsin in bɔdi.

Us tɛst dɛn kin chɛk di somatostatin lɛvɛl?

Bikɔs prɔblɛm dɛn we gɛt fɔ du wit somatostatin nɔ kin bɔku, dɔktɔ dɛn nɔ kin tɛst ɔlman in somatostatin lɛvɛl. Bɔt if dɛn tink se wan tumbu we nɔ kin bɔku we kin mek tumɔs somatostatin we dɛn kɔl somatostatinoma, lɛk aw wi bin dɔn tɔk, dɛn kin yuz blɔd tɛst we dɛn kɔl somatostatin-like-immunoreactivity (SLI) fɔ no am.

Ustɛm a fɔ go to dɔktɔ bɔt mi somatostatin lɛvɛl?

Yu nɔ kin wɔri bɔt yu somatostatin lɛvɛl, bikɔs na smɔl prɔblɛm dɛn de we gɛt fɔ du wit dis.

Bɔt if dɛn dɔn no se pɔsin we de nia yu fambul (mama ɔ papa ɔ brɔda ɛn sista) gɛt wan sik lɛk multiple endocrine neoplasia type 1 (MEN type 1), neurofibromatosis type 1 (NF1), ɔ Von Hippel-Lindau sik, i impɔtant fɔ tɛl yu dɔktɔ. Bikɔs dɛn tin ya na tin dɛn we yu kin gɛt frɔm yu mama ɛn papa, yu kin gɛt prɔblɛm bak wit somatostatinoma. Dɔn yu dɔktɔ kin du tɛst fɔ si if yu gɛt dis sik.

Di tin dɛn we impɔtant pas ɔl fɔ mɛmba (Take-Home Message) .

Okay, so, na di impɔtant tin dɛn we yu nid fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt tide:

• Somatostatin na ‘masta’ ɔmon we de ple rili impɔtant pat na wi bɔdi, we de kɔntrol ɔda ɔmon dɛn.
• i de mεntal kכntrכl tin dεm lεk di prodakshכn fכ כda כmon dεm, di wok we di dijestiv sistεm de wok, εn di divεlכpmεnt fכ di sεl dεm kwik kwik wan.
• Prɔblɛm wit somatostatin kin jɔs rili rare.Di men prɔblɛm na wan tɔŋ we nɔ kin bɔku we dɛn kɔl somatostatinoma.
• If ɛnibɔdi na yu famili gɛt jenɛtik kɔndishɔn lɛk MEN tayp 1, NF1, ɔ Von Hippel-Lindau sik , tɔk to yu dɔktɔ bɔt am.
• Nɔ fred dis fɔ natin. I impɔtant fɔ no bɔt dɛn wɔndaful sistɛm ya na wi bɔdi.

So, somatostatin na saylεnt, bכt i rili imכtant, ejen na wi bכdi. As lɔng as i de du in wok fayn, wi nɔ gɛt natin fɔ fred!

` Somatostatin, Somatostatin, Ɔmon, Pankrias, Haypothalamus, Dijestiv Sistɛm, Somatostatinoma, Somatostatinoma, GHIH, Ɛndɔkrin Sistɛm, Kansa