Yu dɔn yɛri bɔt di Blood-Brain Barrier, we na di supamakit we de protɛkt yu bren?

Di bren na di ɔgan we gɛt valyu ɛn we kɔmpleks pas ɔl na wi bɔdi, nɔto so? So fɔ mek dis bren gɛt wɛlbɔdi rili impɔtant. Jɔs lɛk aw wi os gɛt wɔl ɛn get fɔ protɛkt am, na so wi bren gɛt spɛshal sikyɔriti sistem bak. Na dat wi kin kɔl di blɔd-bren barɛri ɔ ``Blɔd-Bren barɛri'', ``(BBB)'' fɔ shɔt. Tide, lɛ wi tɔk smɔl bɔt dis fayn fayn tin we de protɛkt wi .

Wetin na di tin we de ambɔg di blɔd ɛn di bren?

Fɔ tɔk am simpul wan, yu blɔd ɛn bren barɛri (BBB) ​​na wan layt we de protɛkt di sɛl dɛn we de layn insay di blɔd vesel dɛn na yu bren. Na wan rili impɔtant pat pan di wok we wi bren ɛn di nervɔs sistɛm de du.

Pan ɔl we di nem se "barrier," i rili nɔto jɔs wan wɔl. I tan lɛk filta mɔ, lɛk sɛntinɛl na di bren . Di men wok we i de du na fɔ kip di tin dɛn we de ambɔg am ɛn kip di gud wan dɛn. I de kɔntrol bak di we aw difrɛn kemikal dɛn (di wan dɛn we wi de mek ɛn di wan dɛn we wi de tek frɔm ɔdasay) de go insay ɛn kɔmɔt na di bren. Yu nɔ tink se dat na wɔndaful tin?

Wetin kin apin na di blɔd ɛn bren barɛri (BBB)?

Insay wi blɔd vesel dɛn, wan spɛshal layt de we gɛt sɛl dɛn we dɛn kɔl ɛndoteyl. Bɔt insay di blɔd vesel dɛn we de insay di bren, dis ɛndoteyl difrɛn smɔl.

dis εndoteyl sεl dεm we de layn insay di bכdi vεsul dεm na di bren dεn pak tכgeda so tayt dat i nכ de ivin sכm sכm spεs. Na so yu blɔd-bren barɛri (BBB) ​​de fɔm. Dɛn kin pak dɛn sɛl dɛn ya tayt so dat natin nɔ go ebul fɔ pas insay dɛn if dɛn nɔ ɛp dɛn. di כta mεmbran fכ dεn sεl dεm ya na mεtirial dεm we de fכm lipid. Dis na pɔynt we rili impɔtant, ɛn lɛ wi si wetin mek.

Wetin na di tin dɛm we kin pas na di blɔd-bren barɛri (BBB)?

Sɔm tin dɛn rili smɔl, dat na, dɛn kin pas dis `(BBB)`. sכm כda tin dεm kin pas tru biכs dεn de `(lipid-soluble)` . Dat min se di fat layt we de na di blɔd-bren barɛri kin tek dɛn insay we dɛn nɔ go drɛb dɛn. כltu, i at fכ big patikyula dεm, כ fכ di wata-sכlubul patikyula dεm, fכ pas tru dis `(BBB)` fכ dεn wan.

Tink bɔt am, big patikyula dɛn nɔ kin ebul fɔ pas tru dɛn tayt pak ɛndoteyl sɛl dɛn de, bikɔs nɔto inof rum de. di patikyula dεm we de sכlv na wata gεt at fכ go tru di BBB, biכs di BBB in sεl mεmbran dεm na lipid-bεys, εn dεn de rεpεl tin dεm we de sכlv na wata. So, if big big tin dεm we de sכlv na wata lεk nyutriεnt dεm want fכ go insay di bren, dεn nid spεshal transpכt εp .

Na sɔm kayn drɔgs ɛn tin dɛn we kin pas na di BBB (in wan ɔ wit ɛp):

• Rum
• Di tin dɛn we dɛn kin yuz fɔ mɛn pɔsin
• Mɛrɛsin dɛn we de mek pɔsin nɔ fil bad
• Di tin dɛn we de mek pɔsin nɔ wɔri
• Medikeshɔn dɛn we de mek pɔsin nɔ gɛt sik
• Mɛrɛsin wae de trit pɔrsin wae gɛt sik wae de mɛk yu sik ɔr wae yu gɛt epilepsy
• Kafin we gɛt kafin
• Asetaminofɛn ɛn bɔku nɔ-stɛroyd anti-inflammatory drɔgs (NSAID) .
• Pils fɔ slip ɛn tin dɛn we de mek pɔsin fil fayn (e.g., barbiturates, benzodiazepines) .

Dis list jɔs inklud sɔm drɔg klas dɛm we kin krɔs di BBB. Bɔku ɔda drɔgs klas dɛn kin du dis. Infakt, di list fɔ tin dɛn we kin krɔs di BBB rili lɔng. Frɔm di we aw dɛn de du tin naw, dɛn dɔn no lɛk 5,000 kemikal spɛshal dɛn (inklud drɔgs) we kin krɔs di BBB. Dɛn kin no dɛn tin ya bay we dɛn de yuz kɔmpyuta algɔritm ɛn program dɛn we rili kɔmpleks.

So, wetin nɔ kin pas tru di blɔd-bren barɛri (BBB)?

Nɔmal wan, di patɔjɛns dɛn , lɛk baktri ɔ vayrɔs, ɛn bɔku pɔyzin tin dɛn, nɔ kin ebul fɔ pas tru di BBB. Dis na di big big protɛkshɔn we di BBB gɛt.

Wetin na di kɔmɔn tin dɛm wae kin afɛkt di blɔd ɛn bren barɛri?

Pan ɔl we yu blɔd-brɛyn barɛri (BBB) ​​rili sikrit, i nɔ pafɛkt 100%. I kin wik bay tin dɛm lɛk inflamɛns. Ɔda mεdikal kɔndishɔn dεm kin ridyus di bεlε in εfεktivεshכn bak. If dis apin, bad tin ɔ patɔjɛns kin go insay di bren. (Bɔt sɔm tɛm dis kin bɛnifit. Fɔ ɛgzampul, antibayɔtik lɛk penisilin we dɛn kin yuz fɔ mɛn infɛkshɔn na di bren kin go insay izi wan we di BBB wik.)

di kכndishכn dεm we de wik di integriti fכ di BBB inklud כl tu di akyu εn krכnik kכndishכn dεm.

Situeshɔn dɛm we de ridyus di trɛnk fɔ `(BBB)` wantɛm wantɛm

Dis na wɛl bɔdi prɔblɛm wae kin kam wantɛm wantɛm ɔr kin apin dis biɛn tɛm. Sɔm ɛgzampul dɛn na:

• Kansa dɛn na di bren
• Infεkshכn dεm na di bren (e.g., εnsefalaytis, Mεningaytis) .
• Injury na ed, mɔ di kɔnkyushɔn ɛn traumatik bren injuri (TBI) .
• Di kabon dayɔgzayd we de na di blɔd de go ɔp (Hypercapnia) .
• Sεribral haypoksia (we di כksijεn nכ de na di bren bikoz di bכdi כksijεn lεvεl dεm lכw) .
• Strok
• Sizhɔ, mɔ wan sik we de kɔntinyu fɔ sik we dɛn kɔl ``Status Epilepticus''.

Kondishכn dεm we de ridyus di trεnk fכ di `(BBB)` ova tεm

Dis na tin wae kin teik lɔng tɛm, sɔmtɛm kin de fɔ sɔm mɔnt, sɔm ia, ɔr ivin fɔ ɔl yu layf. Ɛgzampul dɛn:

• Dis sik we dɛn kɔl Alzaima
• Amyotrofik lateral sklεrosis (ALS) .
• Kronik haypakapnia we kin kam bikɔs ɔf tin dɛn lɛk COPD (Chronic Obstructive Pulmonary Disease) .
• Epilepsy we pɔsin kin gɛt
• Frɔntotemporal Dimɛnshɔn
• Ay blɔd prɛshɔn (Hypertension) .
• Di blɔd shuga lɛvɛl (Hyperglycemia) ɛn ɔda tin dɛn we gɛt fɔ du wit am lɛk Tayp 2 Dayabitis
• Di bɔku bɔku kɔlɔstrel we de na di blɔd (Hyperlipidemia) .
• Mɔltipɛl Sklɛrosis
• Nyuromaylaytis Ɔptika (NMO) .
• Dis sik we dɛn kɔl Parkinson

Di masta sabi pipul dɛm tink se bɔku ɔda krɛse sik kin afɛkt di BBB, bɔt dɛn nid fɔ du mɔ risach fɔ kɔnfirm dis.

Wetin na di kɔmɔn sayn ɔr sayn dɛm wae de sho se blɔd-bren barɛri (BBB) ​​brok?

Infakt, naw, no klia we nɔ de fɔ no dairekt wan prɔblɛm wit di BBB. sכm labכtכri tεst dεm, spεshal wan dεm we de egzamin di sεribrospεnal fכluid, kin indaykt wan sho se prכblεm de wit di BBB. Bɔt bɔku tɛm, dɛn kin no di kɔndishɔn dɛn we kin mek di BBB brok wit ɔda sayn dɛn we nɔ gɛt natin fɔ du wit di barɛri.

Naw, masta sabi pipul dɛn de tray fɔ si if dɛn kin wik di BBB fɔ sɔm tɛm bay we dɛn de yuz wan we we dɛn kɔl magnɛtik rɛsɔnans imej-gayd fɔs ɔltrasɔund. If dɛn ebul fɔ du dat, sɔm pat dɛn na di bren go ebul fɔ miks wit di blɔd ɛn i go izi fɔ no dɛn. Sɔntɛm dɛn patikyula tin dɛn de kin bi di men tin fɔ no kwik kwik wan fɔ no tin dɛn lɛk bren kansa, Alzaima, ɛn Pakinsin sik. I kin ɛp bak fɔ mek sɔm mɛrɛsin dɛn go insay di bren fɔ trit tin dɛn lɛk kansa. Bɔt dis risach stil de na in fɔs stej. Dɛn nid fɔ du bɔku mɔ risach fɔ no if dis rili pɔsibul.

Yu tink se kɔmɔn tritmɛnt dɛn de we de tɔch di blɔd ɛn bren barɛri (BBB)?

Naw, no tritmɛnt nɔ de we de tɔch yu blɔd-brɛyn barɛri (BBB) ​​dairekt wan. Bifo dat, dɔktɔ dɛn kin trit di ɔndalayn mɛdikal kɔndishɔn dɛn we kin ambɔg di BBB. Na sɔm ɛgzampul dɛn ya:

• Mɛrɛsin fɔ ay blɔd prɛshɔn, ay kɔlɔstrel, ɔ ay blɔd shuga lɛvɛl.
• Tritmɛnt fɔ mek di blɔd go bak na di bren afta ischemic strok, we kin apin we di blɔd saplai to wan pat na di bren kin ambɔg bikɔs di blɔd vesel dɔn blok.
• Mɛrɛsin dɛn we de mek pɔsin nɔ gɛt kɔnvuls.
• Tritmɛnt fɔ kansa na di bren.

Wetin a go du fɔ mek mi blɔd-brɛyn barɛri (BBB) ​​kɔntinyu fɔ gɛt wɛlbɔdi?

Infakt, no we nɔ de fɔ mek dɛn nɔ ambɔg di `(BBB)` dairekt wan. Bifo dat, di bɛst tin fɔ du na fɔ avɔyd kɔndishɔn ɔ sityueshɔn we kin ambɔg di `(BBB)`. Na sɔm tin dɛn we yu kin du:

• It fayn it ɛn kɔntinyu fɔ gɛt wɛlbɔdi wet. Di tin dɛn we kin afɛkt di wɛlbɔdi we di blɔd de go, mɔ we pɔsin kin gɛt strok, kin ambɔg di blɔd ɛn di bren we de ambɔg am. Fɔ mek yu gɛt wɛl bɔdi we go fayn fɔ yu ɛn fɔ ajɔst yu it akɔdin to yu dɔktɔ in advays rili impɔtant. Dɛn tin ya kin ɛp fɔ mek yu nɔ gɛt strok, ɔ at ɔl kin delay ɔ ridyus di kayn we aw i kin tranga. I de ɛp bak fɔ protɛkt yu BBB.
• Nɔ ignore infɛkshɔn.Infεkshכn na ples lεk di yay εn yes kin spre εn mek yu inflameshn, we kin ambɔg di BBB. If dat apin, di infekshɔn kin go insay di bren ɛn mek pɔsin gɛt siriɔs sik, ivin kil pɔsin.
• Wear sefty gia. Di injuri na di ed kin ambɔg di BBB. We yu wɛr sef gia – mɔ ɛlmɛt ɛn sit bɛlt (ɔ ɔda sef hans) we yu de rayd insay motoka – i kin ɛp fɔ mek yu nɔ gɛt injury na yu ed we kin pwɛl yu BBB.
• Manej yu wɛlbɔdi kɔndishɔn. Fɔ lɔng tɛm lɛk Tayp 2 Dayabitis, ay blɔd prɛshɔn, ay kɔlɔstrel, ɛn ɛpilepshi kin kɔmprɔmis di BBB ɛn di blɔd vesel dɛm we de rawnd am. Fɔ kɔntrol dɛn sik ya, ilɛksɛf na mɛrɛsin ɔ ɔda tritmɛnt, na impɔtant tin we yu kin du fɔ protɛkt yu blɔd ɛn bren barɛri.

Aw dɔktɔ dɛn kin yuz wetin dɛn no bɔt di blɔd ɛn bren barɛri (BBB)?

Yu ``(BBB)`` na rili impɔtant tin we yu de trit bɔku mɛdikal kɔndishɔn insay ɛn ausayd di bren. Bikɔs, if bɔku tritmɛnt dɛn – mɔ di mɛrɛsin dɛn – kin pas tru di ``(BBB)``, dɛn kin afɛkt yu bren indaykt wan.

Sɔntɛnde, dɔktɔ dɛn kin gɛt fɔ wok rawnd di BBB. Dat na bikɔs sɔntɛnde di BBB kin du ɛksaktɔli wetin i fɔ du! Drug dεm wae kin trit infεkshכn כ kansa insay di bren kin nכ kin pas tru di BBB.

As sɔlv, masta sabi pipul dɛn de yuz drɔgs we dɛn mek spɛshal fɔ baypas di BBB. lεk "Trojan horse approach," di dכg dεm de "lod" pan imyun sεl dεm כ כda patikyula dεm we kin pas tru di BBB εn delivεr to di bren. Preti kleva, nɔto so?

Wi de yuz wi yon natura kemikal prɔses bak fɔ baypas di BBB. Wan gud ɛgzampul fɔ dis na fɔ yuz di mɛrɛsin we dɛn kɔl levodopa fɔ mɛn di sik we dɛn kɔl Pakinsin. Pakinsin sik kin apin we sɔm pat dɛn na di bren nɔ gɛt bɛtɛ kemikal we dɛn kɔl dopamine, we dɛn nid fɔ kɔntrol di mɔsul dɛn we de muv. Dopamin nɔ kin ebul fɔ krɔs di BBB, bɔt levodopa kin krɔs. we i go insay di bren, di lεvodopa de kכnvכlt to dopamin. Dis kin mek yu nɔr gɛt di sik wae de kam pan pɔrsin wae gɛt dis sik.

Udat bin fɛn di blɔd-bren barɛri (BBB)? Aw dɛn bin kam fɔ no am if i bin smɔl so?

Bɔku sɔs dɛm se na sayɛnsman dɛm lɛk Pɔl Ɛrlich ɔ Maks Lɛwandɔski bin fɛn di barɛri insay di let 1800 ɛn ali 1900 dɛm. Bɔt dɛn bin yuz di wɔd "blɔd-brɛyn barɛri" fɔ di fɔstɛm insay wan 1921 pepa we Lina Shtern (sɔntɛnde dɛn kin spɛl am "Stern") we kɔmɔt na Rɔshia (we dɛn de kɔl naw Latvia) ɛn wan Swis dɔktɔ we nem Raymond Gautier.

di risach we Stern εn Gautier bin du bin sכpכt di fכs εlektrכn maykroskכp imej dεm we dεn tek insay di 1960 εn 1970 dεm, we bin dεskrεb klia wan di strכkchכ fכ di BBB insay animal εn mכtalman bren.

Fɔ dɔn, wetin fɔ mɛmba (Take-Home Message) .

Yu blɔd-bren barɛri (BBB) ​​na layt we gɛt sɛl dɛn we de rawnd di blɔd vesel dɛn na bɔku say dɛn na yu bren ɛn i de wok lɛk filta. Na wan rili impɔtant protɛktiv wɔl fɔ wi bren. I de ɛp fɔ kip bɔku pan di bad tin dɛn kɔmɔt ɛn bɔku pan di gud tin dɛn insay.

Bɔt, dis nɔ kɔmplit. Bɔrku mɛrɛsin kin afɛkt dis. Dɔn bak, dɔktɔ dɛn nid fɔ tek tɛm wit dis ``(BBB)`` we dɛn de trit sik ɛnisay na di bɔdi, nɔto jɔs di bren.

Pan ɔl we masta sabi pipul dɛn dɔn fɛn bɔku tin bɔt di BBB, dɛn nid fɔ du mɔ risach fɔ ɔndastand gud gud wan aw i de wok. If yu ɔndastand aw i de wok insay, dat go opin di domɔt fɔ fɛn fayn tritmɛnt fɔ bɔku sik dɛn we gɛt fɔ du wit bren. Dɔn, yu BBB go jɔs bi wan barɛri fɔ tin dɛm wae de ambɔg yu, ɛn nɔr go bi wan tin wae de ambɔg yu fɔ tritmɛnt dɛm wae de ɛp yu. So, nɔ fɔgɛt se fɔ tek kia ɔf yu ɔl wɛlbɔdi biznɛs go ɛp fɔ protɛkt di wɛlbɔdi fɔ dis BBB indaykt wan!

` Blɔd-Bren Barɛri, Bren Protɛkshɔn, Bren Blɔd Vesɛl, Nɛvɔs Sistɛm, Bren Drug, BBB Fɔnkshɔn