Yu an ɛn yu fes de chenj shep smɔl smɔl ɛn big? Mek wi tok abaut Acromegaly.

Yu dɔn ɛva fil lɛk se yu sus saiz de big, ɔ di ring we yu bin de wɛr trade dɔn stɔp na yu finga naw? Sɔntɛm yu fes shep kin luk difrɛn smɔl we yu luk ol foto dɛn? Bɔku pan dɛn tin ya kin apin as tɛm de go, sɔntɛnde dɛn kin apin fɔ lɔng lɔng tɛm, so wi nɔ kin pe atɛnshɔn to dɛn bɛtɛ. Bɔt dis kin bi sayn fɔ wan sik we nɔ kin apin so ɔltɛm we dɛn kɔl Acromegaly . Nɔ wɔri, wi go tɔk bɔt ɔltin insay simpul wɔd dɛn.

Fɔ tɔk am simpul wan, wetin na Akromɛgali?

Akromegaly na wan sik we wi bɔdi de mek tumɔs growth ɔmon, ɔ Growth Hormone (GH) . Dis ɔmon de ɛp wi fɔ gro we wi yɔŋ. Bɔt if dis ɔmon kɔntinyu fɔ kɔmɔt afta wi dɔn gro, dat na afta wi dɔn big, sɔm pat dɛn na wi bɔdi, mɔ di bon dɛn na wi an, fut, ɛn fes, kin bigin fɔ big we nɔmal.

Dɛn kin si dis sik bɔrku pan pipul dɛm wae gɛt midul ej. Bɔt dis nɔ min se i nɔ kin apin to yɔŋ pipul dɛn. If di ɔmon we de mek pɔsin gro go bɔku dis we we i yɔŋ, dɛn kin kɔl di sik gigantism. Dɔn dɛn kin gro fɔ lɔng tɛm we nɔ kɔmɔn.

Wetin mek akromegali kin kam? Wetin na di tin dɛn we kin mek i apin?

di men rizin fכ dis na wan sכm gland we di sayz lεk pis na di bכs pat na wi bren. Wi kɔl am di Pituitary Gland . di mכst kכmכn kכz fכ Acromegaly na wan tכmכro we nכ de kεnsar (benign) na dis gland. Dɛn kɔl dis tumbu Pituitary Adenoma . dis tכmכro de mek di pituitary gland wok εn i de mek tu mכch gכt כmon (GH).

dis GH כmon we pasmak de kכmכt na wi bכdi εn i de gi signal fכ di liva fכ mek כda כmon we dεn kכl IGF-1 (Insulin-like Growth Factor-1) . Na da IGF-1 ɔmon de mek wi bon ɛn ɔda ɔgan dɛn nɔ gro fayn. I kin afɛkt bak di we aw wi bɔdi de kɔntrol shuga ɛn fat, ɛn dis kin mek wi gɛt ɔda sik dɛn mɔ ɛn mɔ.

Na sכm tεm, dis kכndyushכn kin kכz bak bay tכmכro dεm we de divεlכp na כda pat dεm na di pankrias, liva, כ bren. Risach dɔn sho se sɔm tin dɛn we de mek pɔsin gɛt jɛnɛtiks kin ɛp bak.

Wetin na di sayn dɛm wae de sho se yu gɛt akromegali?

Bɔku tɛm, dɛn sayn ya kin apin smɔl smɔl, so i kin tek sɔm tɛm fɔ lɛ yu notis di difrɛns.

Aw fɔ no bɔt dis sik?

E fayn fɔ no dis sik kwik kwik wan. We yu go to dɔktɔ bikɔs ɔf dɛn sik ya, i go aks yu kwɛstyɔn dɛn lɛk:

• Us chenj dɛn yu si?
• Ustɛm yu fɔs notis dɛn chenj ya?
• Aw yu de fil naw?

Dɔn, dɛn kin du bɔku tɛst dɛn fɔ no if pɔsin gɛt di sik.

Men tɛst dɛn

• Blɔd tɛst: Dɛn kin du blɔd tɛst fɔ si if yu IGF-1 ɔmon lɛvɛl go ɔp fɔ yu ej.
• Glucose Tolerance Test: Na ya, dɛn kin gi yu drink we gɛt shuga ɛn dɛn kin mɛzhɔ yu blɔd shuga ɛn GH ɔmon lɛvɛl fɔ tu awa. Nɔmal wan, di GH lɛvɛl fɔ drɔp afta yu dɔn drink shuga. If dɛn nɔ du dat, ɛn kɔntinyu fɔ de ay, na sayn fɔ akromegali.

Ɔda tɛst dɛn

• MRI ɔ CT skan: Dɛn skan ya kin ɛp fɔ no if pɔsin gɛt pituitary tumor.
• X-ray tɛst: Chɛk fɔ si if di bon dɛn tik.
• Echocardiogram: Na ɔltra saund tɛst fɔ di at fɔ si if di at dɔn afɛkt.
• Kolonoskopi: Chɛk di wɛlbɔdi na di kɔlon.
• Stɔdi fɔ Slip: Si if yu gɛt Slip Apnea.

Wetin na di tritmɛnt dɛn?

Yu dɔktɔ go disayd di tritmɛnt plan we go fayn fɔ yu bay yu ej, wɛlbɔdi prɔblɛm, ɛn aw yu sik bad. Tri men tritmɛnt dɛn de we yu kin du.

1. Ɔpreshɔn:

Bɔku tɛm, di fɔs tritmɛnt na ɔpreshɔn fɔ pul di pituitary tumor. Dis impɔtant mɔ if di tɔŋ de prɛs di nɛv dɛn we de afɛkt di we aw pɔsin de si. Di dɔktɔ we de du di ɔpreshɔn kin pul di tumbu tru wan smɔl say we dɛn kɔt am tru di nos ɔ insay di ɔpa lip. Di sayn dɛm kin bigin fɔ bɛtɛ insay sɔm dez afta dɛn dɔn du di ɔpreshɔn.

2. Mɛrɛsin:

If ɛni pat pan di tumbu we lɛf afta dɛn dɔn du di ɔpreshɔn ɔ if yu nid mɔ ɛp fɔ kɔntrol di ɔmon lɛvɛl, yu dɔktɔ go gi yu mɛrɛsin. Dɛn mɛrɛsin ya kin mek yu GH lɛvɛl ɔ blok di ifɛkt dɛn we i gɛt pan di bɔdi.

• Somatostatin analכg dεm (e.g. lanreotide, כktrεotid) .
• di antagonist dεm fכ di gכt hכmon rεsεpכta dεm (e.g. pegvisomant) .
• Dopamin agonist dεm (e.g. kabεrgolin) .

3. Rɛdieshɔn Tɛrapi:

If sɔm pat dɛn stil de na di tɔŋ we lɛf afta dɛn dɔn ɔpreshɔn am ɛn tek mɛrɛsin, ɔ if dɛn nid fɔ ridyus di GH lɛvɛl mɔ, dɛn kin yuz raytin tɛrapi. dis de stכp di tכmכro fכ gro εn i de ridyus GH prodakshכn. di mכdan tεknik dεm lεk stεriכtaktik rεdyכsכjεri kin gi hכy dכz rεdyushכn to di tכmכro we nכ de damej di hεlty tisu.

Kɔmplikɛshɔn dɛn we kin apin if dɛn nɔ trit am

Akromegali kin kam wit siriɔs wɛl bɔdi prɔblɛm if dɛn nɔ trit am fayn, so nɔr ignore dis kɔndishɔn.

• Di sik we de ambɔg di at ɛn di blɔd
• Shuga
• Di ay blɔd prɛshɔn
• Atraytis (Ɔstiɔ-arayt) .
• Di sik we dɛn kɔl Carpal Tunnel Syndrome
• Slip Apnea we yu kin gɛt
• I nɔ de si fayn igen
• Di risk fɔ gɛt kansa na di kɔlon de go ɔp
• Spinal nεv kכmprεshכn