Ɛnibɔdi na yu famili, sɔntɛm na grani ɔ granpa, dɔn gɛt Alzaima sik? We dat apin, i rili nɔmal fɔ gɛt smɔl fred na yu maynd, "O, a go gɛt dis sik bak?" Na da tɛm de dis APOE jin tɛst kin kam na di spotlayt. Yu tink se i go rili tɔk bɔt wi tumara bambay? Lɛ wi tɔk bɔt ɔltin simpul wan ɛn klia wan.
Wetin na dis APOE jin tɛst?
Fɔ tɔk am simpul wan, di APOE jin tɛst na jenɛtik tɛst we de luk di jɛnɛtik tayp fɔ wan jin we dɛn kɔl apolipoprotein E. If yu gɛt sɔm difrɛn we dɛn fɔ dis jin, yu kin gɛt smɔl risk fɔ gɛt Alzaima sik pas ɔda wan dɛn .
Bɔt di tin we impɔtant pas ɔl na dis. Jɔs bikɔs yu gɛt ay risk nɔr min se yu go mɔs sik. Imajin se dak dak klawd de na di skay. Dat min se chans de fɔ mek ren kam, bɔt i nɔ min se ren go mɔs kam. Na so i bi. Nɔto jɔs wi jin dɛn nɔmɔ kin afɛkt wi wɛlbɔdi biznɛs, bɔt bɔku ɔda tin dɛn kin afɛkt wi, lɛk wetin wi de it, if wi de du ɛksɛsayz, ɛn di we aw wi de liv wi layf.
So, i rili impɔtant fɔ tɔk to yu dɔktɔ fɔ ɔndastand di rizɔlt fɔ dis tɛst.
Okay, so wetin na dis APOE jin?
di jin APOE de tεl wi bכdi in sεl dεm fכ mek wan spεshal protin we dεn kכl apolipoprotein E. Dis protin de du wan rili imכtant wok. I kin kam togɛda wit di fat (lipid) we de na wi bɔdi ɛn kɛr tin dɛn lɛk kɔlɔstrel go usay dɛn nid fɔ de na di blɔd, lɛk taksi. Wi kin kɔl dis lipoprotein.
tri men vεryכnt dεm, כ alεl dεm de fכ di APOE jin insay wi bכdi.
| Jin vεryכnt (Allele) . | Tɔk bɔt |
|---|---|
| APOE-e2 (APOE2) ɛn di ɔda wan dɛn. | Jɛnɛral wan na wan rare variety. |
| APOE-e3 (APOE3) ɛn di ɔda wan dɛn. | Di kayn we we bɔku pipul dɛn kin gɛt. |
| APOE-e4 (APOE4) ɛn di ɔda wan dɛn. | De variant wae gɛt fɔ du wit di risk fɔ gɛt Alzheimer’s disease. |
Wi ɔl gɛt tu kɔpi fɔ dis jin, wan frɔm wi mama ɛn wan frɔm wi papa. so yu kin gεt kכmbaynshכn fכ eni tu pan dεn tri vεryכnt ya (e.g. e3/e3, e3/e4, e2/e4).
Uswan pan dɛn jin ya gɛt fɔ du wit di sik we dɛn kɔl Alzaima?
Fɔs, dɛn nɔ dɔn fɛn no jin yet we de mek pɔsin gɛt Alzaima sik dairekt wan . Bɔt risach dɔn sho se if yu gɛt ivin wan kɔpi fɔ di APOE-e4 jin we de chenj, dat kin mek yu gɛt Alzaima.
- APOE-e4: Pipul dεm we gεt wan כ tu kכpi fכ dis jin vεryכnt gεt inkrεs risk fכ gεt let-onset Alzheimer’s disease, we de divεlכp afta dεn ol 65 ia.
- APOE-e2: Dis na likl gud nyus. Dis jin we de chenj kin gi sɔm prɔtɛkshɔn agens di sik we dɛn kɔl Alzaima. Ivin if pɔsin we gɛt dis jin rili gɛt di sik, i kin apin leta pas pɔsin we gɛt APOE-e4.
Di impɔtant tin na, jɔs bikɔs yu gɛt di APOE-e4 jin, yu nɔ go ebul fɔ tɔk fɔ tru se yu go gɛt Alzaima. Ɛn, yu nɔr kin se pɔrsin wae nɔr gɛt da jin de nɔr go gɛt Alzaima. Dis na jɔs wan tin we kin mek pɔsin gɛt prɔblɛm.
Aw yu kin du dis tɛst? Udat de du am?
Dis nɔto tɛst we dɛn fos yu fɔ tek. Na sɔntin we yu kin du bay yu yon fridɔm. If yu famili dɔn gɛt Alzaima sik, yu go want fɔ no bɔt dis. If na so i bi, yu kin tɔk to yu dɔktɔ ɛn no mɔ bɔt dis.
Di tɛst rili simpul:
1. Fɔ gɛt DNA sɛmpul: Dɔktɔ go gɛt DNA sɛmpul frɔm yu. Yu kin du dis bay we yu tek smɔl blɔd ɔ yu kin swab insay yu mɔt ɔ yu chɛst wit smɔl swab.
2. Fɔ sɛn to di lɛbɔraytri: Dɛn kin sɛn dis sampul to spɛshal lɛbɔtri fɔ mek dɛn tɛst am.
3. Fɔ gi di rizɔlt: Di lab de tɛst yu DNA ɛn sɛn di rizɔlt bak to yu dɔktɔ.
4. Tɔk bɔt di rizɔlt: Dɔn, yu dɔktɔ ɔ pɔsin we de advays yu bɔt yu jɛnɛtiks go tɔk to yu ɛn ɛksplen wetin dɛn rizɔlt ya min.
Naw, sɔm kɔntri dɛn de we dɛn kin du tɛst fɔ no if pɔsin gɛt jɛnɛtiks na os. Bɔt ilɛksɛf yu gɛt rizɔlt frɔm wan, i stil impɔtant fɔ tɔk to yu famili dɔktɔ fɔ ɔndastand di rayt tin dɛn.
Wetin wi lan frɔm di tin dɛn we kin apin?
di tεst rizulεt de tεl yu us vεryכnt (alεl) fכ di APOE jin yu gεt.
Wetin APOE4 pɔsitiv min?
"APOE4 positif" min se yu gεt at le wan kכpi fכ di APOE-e4 jin na yu DNA.
Wetin na de risk fɔ gɛt Alzaima if yu gɛt APOE4?
bitwin 15% εn 25% pan di pipul dεm na di wכl gεt wan kכpi fכ di APOE-e4 jin. Bitwin 2% ɛn 5% gɛt ɔl tu di kɔpi dɛn. If yu gɛt ivin wan kɔpi, dat kin mek yu gɛt Alzaima.
Bɔt, a de ripit, dis nɔto tɛst we de kɔnfɔm se sik de. I jɔs de tɛl yu bɔt di prɔblɛm.
| Rizɔlt | Wetin di dɔktɔ go advays |
|---|---|
| Yu gɛt di APOE-e4 jin (high risk) . | Yu dɔktɔ go advays yu fɔ fala wɛlbɔdi layf. |
| Yu nɔ gɛt di APOE-e4 jin (lɔ risk) . | Pan ɔl we di prɔblɛm nɔ bɔku, i stil rili impɔtant fɔ mek yu kɔntinyu fɔ liv fayn layf. |
If di rizɔlt sho se di risk bɔku, yu dɔktɔ kin tɛl yu fɔ du tin dɛn lɛk:
- Ɛksesaiz ɔltɛm: Du ɛksɛsayz we de mek yu swet fɔ at le sɔm dez insay di wik.
- Gɛt gud slip: Slip fɔ at le 7-8 awa insay di de.
- Fɔ bi soshal: spɛn tɛm wit yu padi ɛn fambul dɛm, tek pat pan soshal aktiviti dɛm.
- Chalenj di bren: Tin dɛm lɛk fɔ sɔlv pazl, fɔ rid buk, fɔ lan nyu langwej ɔ myuzik inschrumɛnt.
We wi no dɛn tin ya we kin apin kin afɛkt di maynd?
Yɛs, na fɔ tru. We wi lan di rizɔlt fɔ wan jenɛtik tɛst lɛk dis, i kin afɛkt wi bɔku we dɛn. Yu kin fil fred, wɔri, ɔ vɛks. Sɔntɛnde, di tin dɛn we kin apin nɔ kin gi yu di klia ansa we yu bin de op fɔ.
Nɔ strɛs wit dis kɔmpleks infɔmeshɔn nɔmɔ. Tɔk opin wan wit yu dɔktɔ bɔt dis. I go ɛp yu fɔ ɔndastand di tin we de apin ɛn plan fɔ du di nɛks tin we yu fɔ du.
Mɛmba se, ilɛk wetin na yu jin, bɔku tin dɛn de we yu kin du fɔ mek yu nɔ gɛt Alzaima sik. Di bɛst advays fɔ dis na fɔ tɔk to yu dɔktɔ.
Mɛsej we dɛn kin kɛr go na os
- Di APOE jin tɛst de ɔlrɛdi tɛl yu bɔt yu risk fɔ gɛt Alzaima, bɔt i nɔr de tɔk klia wan se yu go gɛt di sik.
- we yu gεt di APOE-e4 jin i kin mek di risk bכku. di APOE-e2 jin kin gi sכm protεkshכn.
- Jɔs bikɔs yu gɛt di APOE-e4 jin nɔ min se yu go gɛt Alzaima. Ɛn i nɔ min se pɔsin we nɔ gɛt di jin nɔ go gɛt am.
- Di tɛst rizɔlt kin afɛkt yu maynd, so ɔltɛm tɔk bɔt di rizɔlt wit yu dɔktɔ .
- I nɔ mata wetin yu jin, fɔ liv fayn layf (gud it, ɛksesaiz, fɔ mek yu bren wok) kin ɛp fɔ ridyus yu risk fɔ gɛt sik.
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