Yu no bɔt di sik we dɛn kɔl Cowden Syndrome? Lɛ wi tɔk bɔt am simpul wan!

Yu dɔn notis smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl. Ɔ sɔntɛm yu dɔn yɛri se sɔmbɔdi na yu famili dɔn gɛt kansa we i rili yɔŋ. Sɔntɛnde, wan kayn jenɛtik kɔndishɔn we nɔ kin bɔku biɛn dɛn tin ya. Wan pan dɛn kayn tin ya na di sik we dɛn kɔl Cowden Syndrome. Wi go tɔk bɔt dis smɔl mɔ tide?

Wetin na di sik we dɛn kɔl Cowden Syndrome?

Fɔ tɔk am simpul wan, di sik we dɛn kɔl Cowden syndrome na wan sik we nɔ kin apin so ɔltɛm we kin pas tru wi jin dɛn. Pipul dεm wae gεt dis kכndyushכn kin gεt bכku bכku wan wae nכ de kכnsa, lεk tכmכro. Bɔt dɛn kin gɛt sɔm kayn kansa smɔl.

Aw kɔmɔn tin dis?

Nɔto fɔ tru. Dis sik we dɛn kɔl Cowden Syndrome, nɔ kin apin so ɔltɛm . Di wan dɛn we sabi bɔt mɛrɛsin se i kin afɛkt lɛk wan pan ɛvri tu ɔndrɛd tawzin pipul dɛn. Bɔt sɔntɛnde, pipul dɛn nɔ kin no bɔt in sayn dɛn, so dɛn nɔ kin no bɔt am.

So yu tink se Cowden Syndrome na kansa?

Nɔ, di sik we dɛn kɔl Cowden syndrome nɔto kansa. Bɔt pipul dɛn we gɛt dis sik kin gɛt sɔm kayn kansa , ɛn dɛn kin gɛt bak we dɛn yɔŋ pas aw dɛn kin gɛt am (we kin bigin kwik kwik wan) . ‘Early-onset’ min se di sik kin kam pan pɔsin we yɔŋ pas aw i kin bi. Fɔ ɛgzampul, uman we gɛt Cowden syndrome kin gɛt bɔdi kansa bifo i ol 40. Dɛn nɔ kin si bɔdi kansa bifo i ol 60. Ɔda kayn kansa de we kin gɛt fɔ du wit dis sik:

• Kansa we de na di εndometrial (kansa we de na di uterin) .
• Tayroyd kansa (especially di kayn we dεn kכl `follicular thyroid cancer`) .
• Kansa we de na di kɔlɔrɛkt
• Kidni kansa
• Melanoma, we na wan kansa we de na di skin

Wetin na di difrɛns bitwin Cowden Syndrome ɛn PTEN hamartoma tumor syndrome?

Dis na dip tɔpik smɔl, bɔt a go kip am simpul. `PTEN hamartoma tumor syndrome (PHTS)` na wan grup we de inhεrit simptom dεm we de kכz fכ chenj (mכtεshכn) na di `PTEN` jin. lεk wan pan fכ pipul dεm we gεt Cowden syndrome dεn fכnshכn fכ gεt dis mכtεshכn na di `PTEN` jin.

Bɔt bikɔs di sayn dɛm fɔ dɛn tu tin ya rili fiba, if yu gɛt Cowden syndrome ɔr wan kayn sik, yu dɔktɔ go trit yu lɛk se yu gɛt PHTS. Dis na bikɔs fɔ chɛk fɔ kansa kwik ɛn ɔltɛm impɔtant pan ɔl tu.

Wetin na di sayn dɛm wae de sho se yu gɛt Cowden Syndrome?

Bɔrku tɛm, di sayn dɛm fɔ dis sik kin bigin fɔ apia na di bɔdi wae dɔn pas 20 ia. Sɔm pipul dɛn kin jɔs no se dɛn gɛt Cowden syndrome we dɛn go to dɔktɔ, bikɔs ɔf di lumps we dɛn kɔl hamartomas ɔ bikɔs ɔf kansa we kin kam we dɛn yɔŋ.

Hamartomas (dεn kin kɔl am ‘ha-ma-to-mas’) na di mכst kכmכn εn prominεnt fכm fכ Cowden syndrome. Dɛn na tin dɛn we nɔ gɛt kansa, we tan lɛk tumor. Dɛn kin divɛlɔp ɛnisay na di bɔdi, insay ɛn na do. Dɛn kin de mɔ na di nɛk, fes, ɛn skel.

Ɔda sayn dɛn de we kin sho se yu gɛt dis sik:

• Fɔ gɛt ed we big pas aw i fɔ bi (macrocephaly) .
• Smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl.
• Klir bכmp dεm we lεk blista na di sכl dεm na di fut dεm, di an dεm, εn di bak dεm na di an dεm (acral keratosis).
• di tin dεm we de gro lεk wכt na di tכng, di gכm, bak pat pan di trot, εn di tכnsil dεm (`oral papillomatosis`).

Bɔt i impɔtant fɔ mɛmba dis: Jɔs bikɔs yu gɛt sɔm pan dɛn sik ya nɔ min se yu gɛt Cowden syndrome. Dɔktɔ dɛn kin sɔprayz se yu gɛt dis sik if yu gɛt wan kɔmbayn pan dɛn patikyula sayn ya .

Wetin kin mek pɔsin gɛt Cowden Syndrome?

Cowden syndrome kin kam bikɔs ɔf sɔm jɛnɛtik muteshon dɛm wae yu kin gɛt. Fɔ tɔk am simpul wan, di jin dɛn de kɔntrol aw di sɛl dɛn na wi bɔdi de gro, sheb, ɛn day. insay Cowden syndrome, bikoz fכ difεkt na dεn jin dεm ya, abnכmal sεl dεm de gro aut כf kכntrol εn de de we dεn fכ de. afta dat, dεn sεl dεm ya kin kכlכp tכgeda fכ mek tכmכro dεm we nכ de kεnsar we dεn kכl hamartomas.

Sayɛnsman dɛn stil de du risach bɔt di chenj dɛn we de apin na di jɛnɛtiks we de mek pɔsin gɛt dis kansa, we na di jin dɛn we gɛt fɔ du wit di sik we dɛn kɔl Cowden syndrome. sכm pipul dεm we gεt Cowden syndrome nכ gεt mכtεshכn na di `PTEN` jin. pan sכm nכmba pan pipul dεm, dεn fכn mכtεshכn insay כda jin dεm, lεk `PIK3CA/AKT1`, `SDHB-D`, `KLLN` εn `SEC23B`. So, di wan dɛn we de stɔdi bɔt mɛrɛsin de kɔntinyu fɔ luk insay dis.

Aw dis kin pas fɔ lɔng lɔng tɛm?

Pipul dεm we gεt Cowden syndrome kin gεt di kכndyushכn insay wan ``autosomal dominant pattern.'' Dis min se yu kin gεt nכmal jin frכm wan pan yu bayolojikal mama εn papa εn wan mutated jin frכm di כda mama εn papa. dis min se εvri pikin gεt 50% chans fכ gεt di mutated jin.

Wetin na di tin dɛm wae kin mek pɔrsin gɛt Cowden Syndrome?

Di wangren big tin we dɛn dɔn no te naw na di famili istri . Dis min se if pɔrsin na yu famili gɛt Cowden syndrome, yu kin gɛt bɔrku chans fɔ gɛt am bak.

Wetin na de prɔblɛm wae kin kam wit dis sik?

If yu gɛt Cowden syndrome, yu kin gɛt sɔm kayn kansa. Dɔn bak, yu kin gɛt kansa we yu yɔŋ , ɔr pas wan kayn kansa insay yu layf.I kin apin difrɛn tɛm, so i impɔtant fɔ tɔk to yu dɔktɔ bɔt ustɛm ɛn aw ɔltɛm yu fɔ gɛt kansa skrinin.

Aw dɔktɔ dɛn kin no se pɔsin gɛt Cowden Syndrome?

Cowden syndrome na wan kɔmpleks sik wae gɛt bɔrku sayn dɛm ɛn sɔm kayn tin dɛm wae gɛt fɔ du wit am. Ivin if yu gɛt wan ɔr mɔr pan dɛn sik ya, i nɔr min se yu gɛt Cowden syndrome.

Fɔ no if yu gɛt Cowden syndrome, dɔktɔ dɛn kin kɔmpia yu sik to di tin dɛn we dɔktɔ dɛn we spɛshal pan inhɛrit kansa sindrom dɔn mek. Insay dis prɔses, dɛn kin mach yu kɔndishɔn wit di men krayteria ɛn smɔl krayteria . Dɛn kin no se yu gɛt Cowden syndrome if yu gɛt wan patikyula kɔmbaynshɔn fɔ dɛn krayteria ya.

Dɔktɔ dɛn kin sɔprayz se yu gɛt Cowden syndrome if:

• apat frכm `macrocephaly` (big ed), tri men krayteria de .
• Fɔ gɛt wan men krayteria ɔ tri smɔl krayteria .
• Fɔ gɛt 4 smɔl smɔl tin dɛn we yu fɔ du .
• Wan pan yu fambul gɛt Cowden syndrome ɔr wan sik we gɛt fɔ du wit am lɛk Bannayan-Riley-Ruvalcaba syndrome (BRRS).

Krayteria fɔ di Cowden Syndrome

Na sɔm pan di men ɛn smɔl tin dɛn we dɔktɔ dɛn kin tink bɔt:

Di men tin dɛn we yu fɔ du:

• Brɔst kansa
• Kansa we de na di ɛndometrial
• Fɔlikul tayroyd kansa
• fכ gεt bכku hamartomas na di gεstrointestinal (GI) trakt
• Makrosεfali - (di ed sεkכnfεnshכn pas wan sכm valyu) .
• di prεsεns fכ dak spat dεm (pigmented macules) na di glans penis
• we dεn tek wan pat pan di skin εn egzamin (bayopsi), i de sho sayn dεm fכ wan `trichilemmoma'.
• fכ gεt bכku tik skin (palmoplantar keratosis) na di an εn fut
• fכ gεt bכku tin dεm we de gro lεk wכt (`papillomatosis`) insay di mכt (oral mucosal) .
• Bɔku bɔku bɔmp dɛn we tan lɛk wɔt (`papules`) na di skin na di fes (`cutaneous facial`) .

Smɔl krayteria dɛn:

• Kansa na di kɔlon
• εsophageal glycogenic acanthosis (dis na wan spεsifi k kכndyushכn we de apin na di εsophagus) .
• Ɔtizm spɛktrum disɔda
• Disabiliti fɔ lan
• Papillary tayroyd kansa
• Tayrɔyd prɔblɛm (e.g. goiters, adenomas) .
• Kidni kansa
• Fεt tכmכro dεm (`Lipomas`) .
• fכ gεt wan singl `hamartoma` na di dijestiv sistεm
• fεt dεposit dεm na di tεstikul dεm (`Tεstikul lipomatosis`) .

If yu dɔktɔ tink se yu kin gɛt Cowden syndrome, i go aks bɔt yu famili histri ɛn i kin ɔda bak fɔ mek dɛn du yu jenɛtik tɛst fɔ si if yu gɛt jɛnɛtik muteshon.

Wetin yu fɔ du if yu tink se yu gɛt dis sik?

If yu gɛt dɛn sik ya, i impɔtant fɔ go to pɔsin we sabi bɔt di jenɛtiks fɔ advays . Dɔn dɛn kin disayd if yu nid fɔ du tin lɛk PTEN jin tɛst. Dɛn kin rifer yu bak to pɔsin we de advays yu bɔt yu jɛnɛtiks . Di jenɛtik kɔlnɔ kin ɛp yu fɔ ɔndastand aw jɛnɛtik kɔndishɔn lɛk PTEN muteshon kin afɛkt yu. Dɛn kin ɛksplen bak di rizɔlt fɔ di jenɛtik tɛst ɛn us kansa skrinin yu kin nid if yu gɛt PTEN hamartoma tumor syndrome (PHTS). Bikɔs Cowden syndrome na wan sik wae nɔr kin bɔrku, e fayn fɔ fɛn wan tim ɔr sɛnta wae spɛshal pan PHTS ɛn Cowden syndrome.

Aw dɔktɔ dɛn kin trit di sik we dɛn kɔl Cowden Syndrome?

Cowden syndrome na wan sik wae gɛt fɔ du wit difrɛn kayn sik dɛm, lɛk wae yu gɛt prɔblɛm wit yu skin ɛn kansa. Bɔrku tɛm, pipul dɛn kin no se dɛn gɛt Cowden syndrome wae dɛn de trit dɛn fɔ ɔda sik wae gɛt fɔ du wit de syndrome.

Bɔt i impɔtant fɔ mek pipul dɛn we gɛt Cowden syndrome, bɔt we nɔ gɛt kansa naw , fɔ gɛt kansa skrinin ɔltɛm, kwik kwik wan . Na sɔm ɛgzampul dɛn ya:

• Fɔ brɔst kansa: Dɛn kin du mammogram ɛvri ia we i ol 30. Dɛn kin advays bak fɔ du magnɛtik rɛsɔnans imej (MRI) skan fɔ di wan dɛn we gɛt dense brɔst.
• Fɔ tayroyd kansa: Dɛn kin du tayroyd ɔltrasɔund ɛvri ia we yu ol 7. Bɔt if yu gɛt sɔm sayn dɛm (e.g., tayroyd nodul, i nɔ kin izi fɔ swɛla), yu kin nid fɔ mek dɛn du dɛn tɛst ya bifo tɛm.

Semweso, yu dɔktɔ kin se bak fɔ chɛk fɔ ɔda kayn kansa (e.g., uterin, kidni, kɔlon kansa) ɔltɛm, i go dipen pan yu wan wan sityueshɔn.

Wetin yu fɔ ɛkspɛkt we yu de liv wit dis sik?

If yu gɛt Cowden syndrome, yu jenɛtik kɔlnɔ go ɛp yu fɔ ɔndastand di rizɔlt fɔ yu jenɛtik tɛst. If yu jenɛtik tɛst sho se yu gɛt PTEN hamartoma tumor syndrome (PHTS), dɛn go ɛksplen bak us kansa tɛst yu nid. Yu kin gɛt yɔŋ ej pas di avrej pɔsin .Yu kin gɛt fɔ bigin fɔ du dɛn kansa tɛst ya. Bɔt if yu de du dɛn tɛst ya ɔltɛm, yu kin gɛt kansa bifo yu ivin gɛt sɔm sayn dɛn.

Wetin na de layf wae pipul dɛm wae gɛt Cowden Syndrome kin liv?

De layf wae yu de liv wit Cowden syndrome de dipen pan yu wan wan sikɔstɛms. Fɔ ɛgzampul, if dɛn no se yu gɛt bɔdi kansa we yu yɔŋ ɛn i dɔn skata, yu layf kin shɔt pas pɔsin we dɛn bin no se gɛt di kansa kwik kwik wan ɛn we dɛn bin dɔn trit am. Bɔt fɔ gɛt di kansa skrinin we dɛn kin se kin ɛp yu fɔ mek kansa nɔ kam, ɔ at ɔl fɔ kech am kwik kwik wan we dɛn kin trit am.

Aw a kin kia fɔ misɛf? / Aw yu de tek kia ɔf yusɛf?

If yu gɛt Cowden syndrome, i impɔtant fɔ gɛt kansa skrinin ɔltɛm we go ebul fɔ no kansa bifo yu gɛt di sayn dɛm. Aks yu dɔktɔ if ɛni patikyula sayn de we yu fɔ wach fɔ we kin bi kansa. If yu gɛt Cowden syndrome, aks yu jenɛtik kɔlnɔ if ɔda pipul dɛn na yu famili fɔ gɛt jenɛtik tɛst bak.

A fɔ go to dɔktɔ? / Yu fɔ go to dɔktɔ?

Yɛs, na fɔ tru. Cowden syndrome, mɔ if dɛn no se yu gɛt ``germline PTEN mutation`` ɔ ``PTEN hamartoma tumor syndrome (PHTS),`` gɛt fɔ du wit bɔku kayn kansa. Yu mɛdikal tim go wach gud gud wan fɔ yu ɔl yu wɛlbɔdi ɛn di rizɔlt fɔ di kansa tɛst ɔltɛm.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ? / Us kwɛstyɔn dɛn yu fɔ aks yu dɔktɔ?

I fayn fɔ aks kwɛstyɔn dɛn lɛk dis we yu go si yu dɔktɔ:

• "A don get wan kain kansa bikos of dis kondishon. I posibul fo mi fo get oda kain kansa?"
• "Jɛnɛtik tɛst sho se a gɛt wan mutated `PTEN` jin. Dɛn fɔ tɛst di ɔda pipul dɛn na mi famili fɔ dis jin?"
• "Dis kondishon fit afekt di pikin dem we a get fo di fyuja?"
• "A gɛt Cowden syndrome, bɔt a nɔ gɛt di `PTEN` mutation. So us ɔda jenɛtik mutation kin mek dis?"
• "Jɛnɛtik tɛst sho se a gɛt wan mutated jin we de mek a gɛt Cowden syndrome. Dat go rili mek a gɛt kansa?"

Cowden syndrome na wan sik wae nɔr kin bɔrku, wae kin kam wit am, wae nɔr kin izi fɔ no. I bεst fɔ go to jεnεtiks fכ no fכ sכri if yu gεt PTEN hamartoma tumor syndrome (PHTS). Dɔn yu dɔktɔ dɛn kin plan fɔ gɛt tritmɛnt plan we go mek yu gɛt di sik. Sɔntɛnde, if di jenɛtik tɛst nɔ fɛn di PTEN muteshon, yu kin nid fɔ du sɔm difrɛn tɛst fɔ pul ɔda kɔndishɔn dɛn. Di pɔsin we de advays yu bɔt yu jɛnɛtiks go gayd yu fɔ no wetin fɔ du nɛks.

E kin bi wan tin wae de mek yu frayd fɔ no se sɔmtin nɔr de na yu bɔdi, bɔt yu nɔr no wetin i bi ɔr wetin fɔ du bɔt am. If yu kam fɔ no se yu gɛt Cowden syndrome, yu go gɛt fɔ liv wit di no se yu kin gɛt difrɛn kayn kansa fɔ di res ɔf yu layf. Pan ɔl we yu no se tɛst dɛn de we kin mek pɔsin no bɔt kansa bifo di sayn dɛn we de sho se i gɛt kansa, di tin we yu de tink bɔt kin rili mek yu fred. If yu gɛt dis sik, yu mɛdikal tim go de wach yu wɛlbɔdi ɛn tɛst rizɔlt ɔltɛm. Dɛn go tek akshɔn kwik kwik wan fɔ trit di kansa bifo i skata. So, i impɔtant fɔ gɛt maynd, fala yu dɔktɔ in advays, ɛn go de chɛk yu ɔltɛm.

Fɔ sɔm ɔltin (Tek-Home Message)

Okay, so lɛ wi luk sɔm pan di impɔtant tin dɛn we yu nid fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt:

• Cowden Syndrome na wan jεnεtik kכndyushכn we nכ kin kכmכt na di bכdi we nכ gεt kansa (hamartomas), εn i kin mek yu gεt sכm kayn kεnsar (especially brεst, tayroyd, εn uterin kεnsar).
• Dis nɔto dairekt kansa, bɔt i rili impɔtant fɔ mek dɛn de chɛk yu ɔltɛm bikɔs ɔf di risk fɔ gɛt kansa .
• Di sayn dɛn we pɔsin kin gɛt kin difrɛn. di men wan dεm na big ed (macrocephaly) εn spεshal lumps dεm na di skin εn mכt. Dɛn sayn ya nɔmɔ nɔr kin sho se di sik de, ɛn dɛn kin no di sik bay di mɛrɛsin krayteria.
• dis kכndyushכn kin bכku tεm wit chenj dεm na di jin `PTEN`. Jεnεtik tεst εn jεnεtik kכnsεl rili impɔtant pan dis.
• Di tritmɛnt na fɔ no bɔt kansa kwik kwik wan ɛn fɔ trit am . So, mek di tɛst dɛn (mamogram, ɔltra saund, ɛn ɔda tin dɛn) we yu dɔktɔ tɛl yu fɔ du di rayt tɛm.
• If yu gɛt ɛni dawt bɔt dis sik, ɔr if pɔrsin na yu famili gɛt dɛn kayn sik ya, nɔr shem fɔ go to dɔktɔ ɛn aks fɔ advays. I rili impɔtant fɔ mek dɛn no ɛn tek akshɔn kwik kwik wan.

Mɛmba se fɔ liv wit dis sik kin tranga, bɔt if di dɔktɔ de kia fɔ yu ɛn sɔpɔt yu fayn fayn wan, yu kin ebul fɔ kɔntrol am. Nɔto yu wan de.

` Cowden Syndrome, Jɛnɛtik Sik, Kansa Risk, PTEN Jin, Skin Lump, Ɛmatoma, Hɛridit sik, Kansa Tɛst