Yu blɔd prɛshɔn stil nɔ de ɔnda kɔntrol pan ɔl we yu de tek mɛrɛsin? Di kɔz kin bi Hyperaldosteronism!

Yu gɛt ay blɔd prɛshɔn , ɔ “ prɛshɔn ” lɛk aw wi ɔl no am? Sɔntɛm yu de tek wan, tu, ɔ ivin mɔ mɛrɛsin dɛn we yu dɔktɔ gi yu. Bɔt yu tink se i nɔ kin izi fɔ yu fɔ kɔntrol yu blɔd prɛshɔn ivin afta yu dɔn tek bɔku mɛrɛsin? If na so i bi, di rizin fɔ dis nɔ kin bi sɔntin we ɔlman kin tink bɔt. Tide wi go tɔk bɔt wan spɛshal mɛrɛsin we kin mek pɔsin gɛt ay blɔd prɛshɔn we mɛrɛsin nɔ kin izi fɔ kɔntrol. Dat na di sik we dɛn kɔl Hyperaldosteronism. Pan ɔl we di nem kɔmplikt smɔl, lɛ wi ɔndastand am simpul wan.

Wetin na Hyperaldosteronism?

Fɔ tɔk am simpul wan, Hyperaldosteronism na we di adrenal gland dɛn na wi bɔdi de mek tumɔs pan di ɔmon "Aldosterone".

Naw yu go mɔs de tink, wetin na dɛn adrenal gland ya ? Wetin na dis aldosterone ɔmon?

Imajin, ɔp di tu kidni dɛn na wi bɔdi, tu smɔl smɔl gland dɛn de, lɛk tu smɔl kap dɛn. Na dat wi kin kɔl di adrenal gland dɛn. dis na wan rili imכtant pat pan wi εndokrin sistεm. Dɛn tu smɔl gland ya de mek difrɛn kayn ɔmon dɛn we rili impɔtant fɔ di tin dɛn we wi bɔdi de du ɛvride .

Wan spɛshal ɔmon we dɛn gland ya kin mek na in dɛn kɔl aldosterone . Di men wok we dis ɔmon de du na fɔ mek wi blɔd prɛshɔn fayn . I de du dis bay we i de kɔntrol di lɛvɛl we di sɔdiɔm ɛn potashɔm de na wi blɔd. Dis ɔmon de wok na wi bɔdi lɛk trafik polisman we de kɔntrol trafik na rod.

So, insay di kes fɔ Hyperaldosteronism, wetin kin apin na dat dis aldosterone ɔmon de prodyuz pasmak. Dɔn di sɔdiɔm we de na wi bɔdi kin bɔku ɛn di potashɔm kin go dɔŋ. Di ɛnd rizulyt fɔ dis na di ay blɔd prɛshɔn (Hypertension) ɛn di lɔw potassium lɛvɛl na di blɔd (Hypokalemia) .

Tu men kayn dis de.

Dɔktɔ dɛn kin sheb dis sik to tu men kayn, i kin dipen pan di tin we kin mek i sik.

1. Praymari Hayparaldosterɔnism: .Dɛn kin kɔl dis bak "Conn's syndrome." Dis kin bi bikɔs ɔf prɔblɛm we de na di adrenal gland dɛnsɛf, we kin mek dɛn mek tumɔs pan di ɔmon we dɛn kɔl aldosterone. Di tin we kin mek i apin de insay di gland insɛf.

2. Sεkכnd Hyperaldosteronism: Na ya nכ prכblεm de wit di adrenal gland dεm. bכt biכs fכ wan prכblεm כdasay na di bכdi, di adrenal gland dεm de stimulate fכ ansa εn prodyuz mכr aldosterone.

Udat dɛn kin gɛt dis sik pas ɔlman?

Dis sik kin afɛkt pipul dɛm wae ol bitwin 30 ɛn 50. Risach dɔn sho bak se dis sik kin kam smɔl pan uman dɛm pas man dɛm.

Sɔm stɔdi dɛn sho se bitwin 5% ɛn 10% pan di pipul dɛn we gɛt ay blɔd prɛshɔn kin gɛt praymari hayparaldosteronism. Masta sabi pipul dɛn biliv se lɛk 25% pan di pipul dɛn we gɛt ay blɔd prɛshɔn we nɔ de tek mɛrɛsin kin gɛt dis sik.

Wetin na di sayn dɛm fɔ dis?

Sɔmtɛm, if de sik nɔr kin so, nɔr kin gɛt ɛni sayn fɔ de atɔl. Bɔt bɔku pipul dɛn kin gɛt dis sik.

Di men ɛn kɔmɔn sayn we dɛn kin si pan dis sik na ay blɔd prɛshɔn (Hypertension) , mɔ di ay blɔd prɛshɔn we at fɔ kɔntrol ivin we dɛn yuz bɔku mɛrɛsin dɛn.

Ɔda sayn dɛm kin kam wit tu tin dɛm: ay blɔd prɛshɔn ɛn lɔw blɔd potassium lɛvɛl (Hypokalemia). Lɛ wi separet dɛn sayn ya klia wan.

Wetin mek dis kɔndishɔn fɔ Hyperaldosteronism kin apin?

As wi bin dɔn tɔk, di rizin dɛn fɔ dis kin difrɛn akɔdin to di tu men kayn dɛn.

Di tin dɛn we kin mek pɔsin gɛt Praymari Hyperaldosteronism

Di prɔblɛm we de ya de na di adrenal gland insɛf.

• di mכst kכmכn kכz: bכku tεm, dis kin kכz fכ wan tכmכro we nכ de kεnsar (adrenal adenoma) we de divεlכp na di adrenal gland. Dis nɔto kansa, so natin nɔ de fɔ wɔri bɔt. Dis tumbu de mek tumɔs pan di ɔmon we dɛn kɔl aldosterone.
• Ɔda tin dɛn we nɔ kin apin so ɔltɛm:
• כnli wan adrenal gland de big (yunilatarכl adrenal haypaplasia).
• Aldosterone prodakshכn bay wan kεnsar tכmכro (adrenocortical carcinoma) (dis kin rili rare).
• wan jεnεtik kכndishכn we de pas dכn tru jεnereshכn (Familial hyperaldosteronism).

Di tin dɛn we kin mek pɔsin gɛt Sɛkɔndari Hyperaldosteronism

Na ya di adrenal gland dɛn gɛt wɛlbɔdi. Bɔt dɛn kin mek dɛn want fɔ du sɔntin fɔ ɔda rizin. Di men rizin na di blɔd we nɔ de go na di kidni dɛn .

Fɔ ɔndastand dis, wi nid fɔ no smɔl bɔt wan rili intrestin sistɛm na wi bɔdi we de kɔntrol blɔd prɛshɔn. Dɛn kɔl am di Renin-Angiotensin-Aldosterone System .

Tink bɔt dis as chen riakshɔn:

1. We wi blɔd prɛshɔn go dɔŋ ɔ wi blɔd sodium lɛvɛl go dɔŋ, wi kidni dɛn kin no am.

2. afta dat di kidni dεm de rilis wan εnzym we dεn kכl "renin" insay di bכdi.

3. dis renin de kכnvכlt wan protin we dεn kכl "Angiotensinogen", we di liva de mek, to "Angiotensin I".

4. Neks, dis angiotensin I de bi “Angiotensin II”.

5. fכ tεm, na dis angiotensin II de inkrεs di bכdi prεshכn bay we i de kכnstrikt di bכdi vεsul dεm εn mek di adrenal gland dεm fכ prodyuz aldosterone.

naw, insay sεkכnd hayparaldosteronism, wetin de apin na dat bikoz fכ sכm mεdikal kכndishכn, di bכdi we de go na di kidni dεm de dכn. Dɔn di kidni dɛn kin mistek tink se di prɛshɔn na di bɔdi nɔ bɔku. So, di kidni dεm de kכl fכ εp εn dat chen riakshכn de stat. Dis kin mek dɛn prodyuz mɔ pan di ɔmon we dɛn kɔl aldosterone, we rili nɔ nid fɔ du am.

di kכndishכn dεm we de ridyus di bכdi saplai to di kidni dεm εn mek sεkכnd hayparaldosteronism:

• Obstruktiv rεnal atεri sik.
• Di tin dɛn we kin mek wata gɛda na di bɔdi, lɛk we at nɔ de wok fayn.
• Sirosis na di liva.
• Nephrotic syndrome, we na wan sik we de na di kidni.

Aw dɔktɔ kin no bɔt dis sik?

We yu tɛl yu dɔktɔ bɔt yu sik, mɔ di ay blɔd prɛshɔn we mɛrɛsin nɔ de kɔntrol, i kin sɔprayz se yu gɛt dis sik. Dɔn, dɛn kin ɔda fɔ du bɔku tɛst fɔ kɔnfirm dis.

1. Blɔd tɛst:

• If wan rutin ilɛktrɔlayt blɔd panɛl sho se di sɔdiɔm lɛvɛl dɔn go ɔp smɔl (Hypernatremia) ɛn di potashɔm lɛvɛl smɔl (Hypokalemia) , di saspek kin bɔku.
• Neks, tu patikyula blɔd tɛst dɛn de we dɛn kin yuz fɔ no dis sik: Plasma Renin Concentration (PRC) ɔ Plasma Renin Activity (PRA) .
• If yu gɛt Primary Hyperaldosteronism, yu renin lɛvɛl (PRC ɛn PRA) go smɔl pas aw i nɔmal.
• if yu gεt sεkכnd hayparaldosteronism, yu renin lεvεl go hכy pas nכmal.

2. Aldosterone Suprεshכn Tεst:

• Dis tɛst involv fɔ gi yu ɛkstra sɔdiɔm (sɔl) fɔ sɔm tɛm. I kin bi sɔlv we yu tek wit yu mɔt ɔ salin sɔlvushɔn we yu gi insay vein.
• Dɔn, dɛn kin gɛda yu urine fɔ 24 awa ɛn dɛn kin mɛzhɔ di aldosterone we de insay da urine de.
• pan pɔsin we gɛt wɛlbɔdi, if yu it bɔku sodium, dat kin mek di bɔdi nɔ gɛt aldosterone. Bɔt pan pɔsin we gɛt hyperaldosteronism, dis nɔ kin apin.

3. Imej Tɛst dɛn:

• If blɔd tɛst kɔnfirm se yu gɛt praymari hayparaldosteronism, yu dɔktɔ go ɔda fɔ du tɛst lɛk CT skan (Computed Tomography scan) fɔ no di kɔz. dis kin chεk fכ tכmכro na di adrenal gland.

Wetin na di tritmɛnt dɛm fɔ dis?

Di tritmɛnt dipen pan wetin mek di sik de. Bɔt di men tin we yu want fɔ du na fɔ kɔntrol yu blɔd prɛshɔn.

• fכ praymar hayparaldosteronism we tכmכro kכz:

Bɔku tɛm, dɔktɔ dɛn kin se dɛn fɔ du ɔpreshɔn fɔ pul di tumbu ɛn di gland we gɛt fɔ du wit am.. Bɔrku pipul dɛn blɔd prɛshɔn ɛn potashɔm lɛvɛl kin kam bak to nɔmal afta dis ɔpreshɔn. Bɔt sɔm pipul dɛn kin kɔntinyu fɔ gɛt ay blɔd prɛshɔn afta dɛn dɔn du dɛn ɔpreshɔn, ɛn dɛn go nid fɔ kɔntinyu fɔ tek mɛrɛsin.

• Fɔ ɔda kɔz ɛn sɛkɔndari hayparaldosteronism:

Insay dɛn kayn tin ya, di tritmɛnt na wit mɛrɛsin . Dɔn bak, if na sɛkɔndari kɔndishɔn, i impɔtant fɔ trit di sik we de ɔnda am (e.g. at sik).

Sɔm pan di mɛrɛsin dɛn we dɛn kin yuz mɔ fɔ dis na:

• Spironolaktכn (Spironolaktכn – Aldaktכn®) .
• Eplerenɔn (Eplerenɔn – Inspra®) .
• Amilɔrayd (Amilɔrayd – Midamɔr®) .

Wetin go apin afta dɛn dɔn trit am? Ɛn wetin na di prɔblɛm dɛn we kin apin?

di prכgnosis fכ dis kכndyushכn, dat na di fכs stet, dipכnt pan di kכz.

Praymari hayparaldosteronism kin rili fayn if dɛn no am kwik ɛn trit am di rayt we . insay sεkכnd hayparaldosteronism, di autkam dipכnt pan if dεn kin kכntro di כndalayn kכndishכn.

Di men kɔmplikeshɔn dɛm wae kin apun pan dis kɔndishɔn na wae dɛn nɔr kin kɔntrol aw pɔrsin gɛt ay blɔd prɛshɔn fɔ lɔng tɛm. Dis na siriɔs prɔblɛm dɛn we gɛt fɔ du wit di at ɛn di blɔd sistɛm.

So, i rili impɔtant fɔ kɔntrol di blɔd prɛshɔn fayn fayn wan.

Yu tink se dɛn go ebul fɔ mek dis tin nɔ apin?

Bɔrku tɛm, natin nɔr de wae wi kin du fɔ mek dis sik nɔr kam. Na bikɔs di chenj dɛn we kin apin insay wi bɔdi kin mek i apin. Bɔt di bɛst tin na dat, wans dɛn dɔn no se i gɛt am, dɛn kin trit am ɛn avɔyd kɔmplikeshɔn dɛn.

Hyperaldosteronism, aldosterone, adrenal glands, Conn’s syndrome, ay blɔd prɛshɔn, ay blɔd prɛshɔn, prɛshɔn, potashɔm, sɔdiɔm, kidni, ɔmon