Yu gɛt ay blɔd prɛshɔn , we dɛn kin kɔl "haypa prɛshɔn"? I go mɔs bi se yu dɔn ɔlrɛdi de tek wan, tu, ɔ sɔntɛm ivin mɔ mɛrɛsin dɛn we yu dɔktɔ tɛl yu fɔ tek. Bɔt pan ɔl we yu de pan tritmɛnt, yu stil de fil lɛk se i nɔ izi fɔ kɔntrol yu blɔd prɛshɔn ? If na so i bi, di tin we kin mek i apin nɔ kin bi wetin yu kin tink se go apin. Tide, wi want fɔ tɔk bɔt wan patikyula mɛrɛsin we kin mek pɔsin gɛt ay blɔd prɛshɔn we at fɔ mɛn, we nɔ de tek mɛrɛsin: Hyperaldosteronism. Pan ɔl we di nem go tan lɛk se i kɔmpleks, lɛ wi sheb am to simpul wɔd dɛn.
Wetin na Hyperaldosteronism?
Fɔ tɔk am simpul wan, di haypa aldosteronism kin apin we yu adrenal gland dɛn de mek bɔku bɔku ɔmon we dɛn kɔl "aldosterone."
Yu kin de wɔnda: wetin na dɛn adrenal gland ya , ɛn wetin na aldosterone?
Imajin tu smɔl gland dɛn, we shep lɛk smɔl kap, we sidɔm rayt ɔp yu kidni dɛn . Dis na yu adrenal gland dɛn. Dɛn na impɔtant pat pan yu ɛndokrin sistɛm . Dɛn smɔl smɔl gland dɛn ya kin mek bɔku ɔmon dɛn we rili impɔtant fɔ mek yu bɔdi de du tin dɛn ɛvride .
Wan patikyula ɔmon we dɛn gland ya kin mek na aldosterone . Di men wok we i de du na fɔ mek yu blɔd prɛshɔn fayn bay we i de balans di sɔdiɔm ɛn potashɔm we de na yu blɔd. Yu kin tink bɔt dis ɔmon lɛk trafik polisman we de dayrɛkt di we aw trafik de flɔ na rod we pipul dɛn kin pas.
So, insay hayparaldosteronism, tu mכch aldosteron de prodyuz. dis kin mek di sodium lεvεl na yu bכdi de go כp we di potashכm lεvεl de dכn. Di las tin we kin kɔmɔt frɔm am na ay blɔd prɛshɔn (we blɔd prɛshɔn kin bɔku) ɛn haypokalemia (we blɔd potashɔm nɔ bɔku) .
Tu men kayn dɛn de
Dɔktɔ dɛn kin sheb dis sik to tu kayn tin bay di ɔndalayn kɔz.
1. Praymari Hyperaldosteronism: dεn kכl am bak "Conn's syndrome," dis kin apin we di εshyu de dayrekt insay di adrenal gland dεm, we de mek dεn ova prodyuz aldosterone.
2. Sεkכnd Hyperaldosteronism: Insay dis kes, di adrenal gland dεm de hεlty. bifo dat, dεn de mek dεn prodyuz εksyכs aldostεron fכ ansa wan prכblεm we kכmכt כdasay na di bכdi.
Udat dɛn kin afɛkt mɔ?
Dis sik kin mɔs si pan pipul dɛm wae ol bitwin 30 ɛn 50. Risach dɔn sho bak se i kin bɔku smɔl pan uman dɛm pas man dɛm.
stכdi dεm sho se 5% to 10% pan כl di pipul dεm we gεt haypatεnshכn kin gεt praymar haypa aldosteronism. Mɔ impɔtant, masta sabi pipul dɛn biliv se pan di wan dɛn we gɛt aypatɛnshɔn we nɔ de tek mɛrɛsin , di pasɛnt kin rich 25%.
Wetin na di sayn dɛm we de sho se yu gɛt dis sik?
Sɔmtɛm, if de sik nɔr kin fayn, yu nɔr kin gɛt ɛni sayn atɔl. Bɔt, bɔku pipul dɛn kin sho sayn dɛn.
Di sayn we kin apin mɔs na aypatɛnshɔn , mɔ we i kɔntinyu fɔ tranga pan ɔl we dɛn de yuz bɔku blɔd prɛshɔn mɛrɛsin.
Ɔda sayn dɛm kin kam bikɔs ɔf di kɔmbaynshɔn fɔ ay blɔd prɛshɔn ɛn lɔw potashɔm (haypokalemia). Lɛ wi brok dɛn tin ya klia wan.
| Mek | Di Simptom dɛn we kin apin |
|---|---|
| Di sayn dɛm we kin kam bikɔs ɔf di Ay Blɔd Prɛshɔn |
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| Di simptom dɛm we kin kam bikɔs ɔf di Low Potassium |
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Mɛmba se yu nɔ nid fɔ gɛt ɔl dɛn sik ya. Sɔm pipul dɛn kin gɛt wan ɔ tu nɔmɔ.
Wetin mek Hyperaldosteronism kin apin?
As wi bin dɔn tɔk, di tin dɛn we kin mek pɔsin gɛt dis sik kin difrɛn bay di tu kayn tin dɛn.
Di tin dɛn we kin mek pɔsin gɛt Praymari Hyperaldosteronism
Na ya, di prɔblɛm kin kɔmɔt na di adrenal gland insɛf.
- di mכst kכmכn kכz: כltεm na tכmכro we nכ de kεnsar (adrenal adenoma) na di adrenal gland. Dis nɔto kansa, so nid nɔ de fɔ mek pɔsin ala. Dis tumbu kin jɔs mek tumɔs aldosterone.
- Ɔda tin dɛn we nɔ kin apin so ɔltɛm:
- wan adrenal gland de big (yunilatarכl adrenal haypaplasia).
- di prodyushכn fכ aldostεron bay wan kεnsar tכmכro (adrenocortical carcinoma) - dis kin rili rare.
- Wan jεnεtik kכndishכn (familial hayparaldosteronism).
Di tin dɛn we kin mek pɔsin gɛt Sɛkɔndari Hyperaldosteronism
Na ya, di adrenal gland dɛn gɛt wɛlbɔdi, bɔt ɔda tin de mek dɛn wok. Di men rizin na we di blɔd nɔ de go na di kidni dɛn .
Fɔ ɔndastand dis, i go fayn fɔ no bɔt di wɔndaful sistɛm we di bɔdi gɛt fɔ mek di blɔd prɛshɔn kɔntrol: di Renin-Angiotensin-Aldosterone System .
Tink bɔt am lɛk chen riakshɔn:
1. We yu blɔd prɛshɔn go dɔŋ ɔ di sodium lɛvɛl na yu blɔd smɔl, yu kidni dɛn kin no am.
2. afta dat di kidni dεm de rilis wan εnzym we dεn kכl "renin" insay di bכdi.
3. rεnin de akt pan wan protin we di liva de mek we dεn kכl "angiotensinogen," we de kכnvכlt am to "angiotensin I."
4. Neks, dis Angiotensin I de chenj to “Angiotensin II.”
5. te go, na dis Angiotensin II de mek yu blɔd prɛshɔn go ɔp bay we i de kɔnstrikt yu blɔd vesel dɛn ɛn mek yu adrenal gland dɛn prodyuz aldosterone.
If yu gɛt sɛkɔndari Hyperaldosteronism, wan ɔndalayn mɛdikal kɔndishɔn de ridyus di blɔd we de flɔ to yu kidni. So, yu kidni dɛn kin mistek tink se yu bɔdi in blɔd prɛshɔn tu smɔl. Fɔ ansa dis, yu kidni dɛn kin mek yu chenj chenj fɔ aks fɔ ɛp. Dis kin mek di ɔmon we dɛn kɔl aldosterone kin kɔmɔt pasmak, pan ɔl we yu bɔdi nɔ rili nid am.
di kכndishכn dεm we de ridyus di bכdi fכ fכlכ to di kidni dεm εn trigεr sεkכnd Hyperaldosteronism inklud:
- di at dεm we de gi bכdi to di kidni dεm we de sכmtεm sכmtεm sכmtεm (Obstructive renal artery disease).
- Kɔndishɔn dɛm we wata kin gɛda na di bɔdi, lɛk we at nɔ de wok fayn.
- Sirosis na di liva.
- Nephrotic syndrome, na wan kayn sik we de mek pɔsin gɛt sik na in kidni.
Aw dɔktɔ kin no bɔt dis sik?
We yu tɔk to yu dɔktɔ bɔt yu sik dɛn—espɛshali if yu tɔk se yu ay blɔd prɛshɔn nɔ de du di standad mɛrɛsin dɛn—dɛn kin tink se dis sik. Dɔn yu dɔktɔ go ɔda fɔ du sɔm tɛst fɔ no if yu gɛt di sik.
1. Blɔd Tɛst:
- Insay wan rutin ilɛktrɔlayt blɔd panɛl, di sɔdiɔm lɛvɛl we go ɔp smɔl (Hypernatremia) ɛn di potashɔm lɛvɛl we smɔl (Hypokalemia) kin mek pipul dɛn sɔprayz.
- Neks, tu spɛshal blɔd tɛst dɛn de we dɛn kin yuz spɛshal fɔ no dis sik: di Plasma Renin Concentration (PRC) ɔ Plasma Renin Activity (PRA) tɛst.
- if yu gεt praymar Hyperaldosteronism, yu renin lεvεl (PRC εn PRA) go tipikli lכw pas nכmal.
- if yu gεt sεkכnd Hyperaldosteronism, yu renin lεvεl go hכy pas nכmal.
2. Aldosterone Suprεshכn Tεst:
- insay dis tεst, dεn de gi yu inkrεs amoun fכ sכdiכm (sכlt) fכ wan spεshal tεm, we yu de it כ bay we dεn de gi yu intravenכs (IV) salin drip.
- fכ fala dis, dεn kin kכlekt yu urine ova 24 awa fכ mכsu di lεvεl fכ aldosterone we de de.
- pan hεlty pכsin, we di sכdiכm inkrεs de mek di bכdi nכmal fכ ridyus di aldosterone prodakshכn. Bɔt pan pɔsin we gɛt Hyperaldosteronism, dis nɔ kin apin.
3. Imej Tɛst dɛn:
- If blɔd tɛst kɔnfirm se yu gɛt praymari Hyperaldosteronism, yu dɔktɔ kin ɔda fɔ mek dɛn du CT skan (Computed Tomography scan) fɔ no di ɔndalayn kɔz, lɛk fɔ chɛk fɔ adrenal gland tumor.
Wetin na di tritmɛnt dɛn we de?
Di tritmɛnt plan dɛn kin dipen ɔl pan di ɔndalayn kɔz. Bɔt di men tin we yu want fɔ du na fɔ kɔntrol yu blɔd prɛshɔn fayn fayn wan.
- Fɔ praymari Hyperaldosteronism we wan tumor kin mek:
Bɔku tɛm dɔktɔ dɛn kin se dɛn fɔ du ɔpreshɔn fɔ pul di tumbu ɛn di gland we gɛt di sik . Afta dɛn dɔn du di ɔpreshɔn, bɔku sik pipul dɛn kin si se dɛn blɔd prɛshɔn ɛn potashɔm lɛvɛl kin kam bak to nɔmal. Sɔm pipul dɛn kin stil nid fɔ kɔntinyu fɔ tek blɔd prɛshɔn mɛrɛsin afta dɛn dɔn du di ɔpreshɔn.
- Fɔ ɔda kɔz ɛn sɛkɔndari Hyperaldosteronism:
Insay dɛn kayn tin ya, di tritmɛnt kin gɛt fɔ du wit mɛrɛsin . pan tap dat, if na sεkכnd kכndyushכn, fכ adrεs di כndalayn sik (εgz., at fεil) implεnt.
Di mɛrɛsin dɛn we dɛn kin gi yu na:
- Spironolaktכn (Aldaktכn®) .
- Eplerenɔn (Inspra®) we dɛn kɔl .
- Amilorid (Midamor®) we dɛn kɔl .
Duya notis se if yu yuz mɛrɛsin fɔ lɔng tɛm we de blok di aldosterone aktiviti, lɛk Spironolactone, i kin mek man dɛn gɛt sayd ɛfɛkt, lɛk we dɛn nɔ ebul fɔ tinap fayn ɔ we dɛn bɔdi kin big (Gynecomastia). If yu gɛt ɛni prɔblɛm ɔ sayd ɛfɛkt, nɔ ɛva shem fɔ tɔk to yu dɔktɔ bɔt am.
Wetin na di lukin-grɔn ɛn di prɔblɛm dɛn we kin apin?
Yu prɔgnosis, ɔ aw yu go si tin fɔ lɔng tɛm, dipen mɔ pan di ɔndalayn kɔz.
if dεn no di praymar Hyperaldosteronism εli εn trit am kכrekt wan, di risכlt dεm kin tipikul fayn fayn wan. fכ sεkכnd Hyperaldosteronism, di autkam dipכnt pan aw dεn kin mεnεj di כndalayn mεdikal kכndishכn fayn fayn wan.
Di big big prɔblɛm dɛn we kin kam wit dis sik kin kɔmɔt frɔm di ay blɔd prɛshɔn we kin de fɔ lɔng tɛm, we dɛn nɔ kin kɔntrol, we kin mek i gɛt siriɔs prɔblɛm wit di at ɛn di blɔd.
| Big Big Kɔmplikɛshɔn dɛn we kin apin |
|---|
| Atrial fibrillation (di at bit we nɔ de bit ɔltɛm) . |
| di lεft vεntrikulכr haypatrכfi (di at in men chεmba de big) . |
| At atak |
| Strok |
Fɔ dis rizin, i rili impɔtant fɔ kɔntrol yu blɔd prɛshɔn strikt wan.
Yu tink se dɛn kin ebul fɔ avɔyd dis sik?
Bɔrku tɛm, dɛn nɔ kin ebul fɔ stɔp dis sik bikɔs bɔku tɛm i kin kɔmɔt na di intanɛnt bɔdi prɔses dɛm. Bɔt di gud nyus na dat, we dɛn dɔn no, di fayn tritmɛnt kin mek dɛn nɔ gɛt siriɔs prɔblɛm dɛn we go de fɔ lɔng tɛm.
Mɛsej we dɛn kin kɛr go na os
- If i stil at fɔ kɔntrol yu blɔd prɛshɔn pan ɔl we yu de tek bɔku mɛrɛsin dɛn, mek shɔ se yu tɔk to yu dɔktɔ .
- hayperaldosteronism na wan kכndyushכn we de kכz we di כmon aldosterone de prodyuz pasmak.
- I kin bi praymari (we kɔmɔt na di gland) ɔ sɛkɔndari (we kin kam wit ɔda mɛrɛsin).
- Dɛn kin no am kɔrɛkt wan tru spɛshal blɔd tɛst ɛn imej.
- Dɛn kin trit am fayn fayn wan tru ɔpreshɔn ɔ mɛrɛsin, i go dipen pan di tin we mek i apin.
- De tin wae impɔtant pas ɔl fɔ no na dat dis na sik wae dɛn kin trit; if yu gɛt sɔntin we de mɔna yu, go to dɔktɔ kwik kwik wan.
Hyperaldosteronism, aldosterone, adrenal glands, Conn’s syndrome, ay blɔd prɛshɔn, ay blɔd prɛshɔn, prɛshɔn, potashɔm, sɔdiɔm, kidni, ɔmon
