Yu bin no se yu bɔdi gɛt big "ami" we de protɛkt yu frɔm sik? Wi kin kɔl dis di imyun sistɛm. Dis ami in wok na fɔ mek wi gɛt wɛlbɔdi bay we dɛn de fɛt ɛnimi dɛn lɛk jem, vayrɔs, ɛn kansa sɛl dɛn we de kɔmɔt na do. Bɔt sɔntɛnde, dis ami kin nid smɔl ɛp. Ɔ di ami in trɛnk nɔ go du, ɔ di ami bigin fɔ wok we dɛn nɔ ebul fɔ kɔntrol. Na da tɛm de wan spɛshal klas ɔf drɔgs we dɛn kɔl `(Immunomodulators)` kin ɛp wi.
Fɔ tɔk am simpul wan, wetin na dɛn Immunomodulators ya?
Immunomodulator na wan kayn mεdikal we de "modify" כ "modify" di aktiviti fכ yu imyun sistεm. Tink bɔt yu imyun sistɛm lɛk di vɔlyum kɔntrol na redio. Insay sɔm sik dɛn, dis volyum kin tu smɔl, we min se di imyun sistɛm wik. Insay ɔda sik dɛn, dis volyum tu bɔku, we min se di imyun sistɛm de wok pasmak.
So wetin `(Immunomodulators)` de du na fɔ ajɔst dis volyum as nid de. Dat min se if di imyuniti nɔ bɔku, dɛn mɛrɛsin ya kin mek i bɔku , ɛn if di imyuniti bɔku pasmak, dɛn kin ridyus am ɛn kɔntrol am . Dis na wan rili patikyula wok.
Dɛn mɛrɛsin ya kin wok mɔ pan tu we dɛn:
As wi bin dɔn tɔk, tu men we dɛn de we dɛn drɔgs ya kin wok. If yu ɔndastand dis, dat go ɛp yu fɔ ɔndastand dis mɛrɛsin mɔ.
| Du | Wetin dis de du? (Wetin i de du) |
|---|---|
| Boosting di Imyun Rispɔns | Insay sɔm sik stet dɛm, mɔ kansa, kansa sɛl dɛm kin rili sabi fɔ ayd frɔm wi imyun sistɛm. Wetin dɛn drɔgs ya de du na fɔ gi wi "ami" di trɛnk ɛn trenin we i nid fɔ fɛn ɛn pwɛl dɛn ɛnimi ya we ayd. |
| Fɔ stɔp di Imyun Rispɔns | Wi kin kɔl dɛn mɛrɛsin ya spɛshal wan Immunosuppressants.Dɛn tin ya nid fɔ pipul dɛm wae gɛt ɔtoimyun sik dɛm. Insay dɛn sik ya, wi yon imyun sistɛm kin mistek atak wi yon wɛlbɔdi sɛl dɛn. Dɔn bak, we dɛn transplant ɔgan, dɛn mɛrɛsin ya kin ɛp di bɔdi fɔ mek i nɔ rijek di nyu ɔgan. |
Wetin na di men kɔndishɔn dɛn we dɛn kin yuz imyunomodulator fɔ?
Dɛn kin yuz dis kayn mɛrɛsin fɔ mɛn difrɛn sik dɛn. Sɔm pan dɛn na:
- Joyn ɛn kɔnɛktiv tisu sik dɛm: Dis na di men kategori fɔ ɔtoimyun sik dɛm. fכ egzampl, pan sik dεm lεk `(Rheumatoid Arthritis)` (joint inflammation), `(Lupus)`, `(Psoriatic Arthritis)`, `(Ankylosing Spondylitis)`, dεn mεdisin dεm ya de εp fכ kכntrכl di bכdi in atak pan in כwn jכint, skin, εn כda tin dεm.
- digεstiv sistεm sik dεm: Insay sik dεm lεk ``Crohn's Disease'' εn ``Ulcerative Colitis'', dεn kin yuz dεn ya fכ kכntrכl di imyun prכsεs we dεn nכ want we de apin na di intestines.
- Skin sik dɛm: Insay sik dɛm lɛk psoriasis, di imyun sistɛm de kɔntrol aw di skin sɛl dɛm de gro kwik kwik wan.
- di sik dεm na di nεv sεstem: dεn drog dεm ya de εp fכ kכntrכl di damej we di nεv sεstem de pwεl pan sik dεm lεk ``Multiple Sclerosis``.
- Kansa: Insay sɔm kayn kansa, dɛn kin yuz dɛn tin ya fɔ mek di imyun sistɛm pwɛl di kansa sɛl dɛn. Dis na pat pan wan tritmɛnt we dɛn kɔl ``Immunotherapy.''
Wetin na di men kayn imyunomodulator dɛm?
Dɛn drɔgs ya nɔto ɔl di sem kayn. Dɔktɔ dɛn kin gi difrɛn kayn ``Immunomodulators`` dipen pan di kayn sik.
Kɔtikosterɔyd dɛn
Dis na di mɛrɛsin wae dɛn kin yuse pasmak wae bɔrku pipul dɛn no. wan egzampl na `(Prednisone).` dεn ya de wok bay we dεn de ridyus di aktvכti fכ di imyun sistεm kwik kwik wan εn kכntro di swεla εn inflameshn na di bכdi.
DMARDs (Drɔg dɛn we de chenj di sik) .
As di nem sho, dis na mɛrɛsin wae de ɛp fɔ chenj di kayn sik. Ɛspɛshali pan sik dɛn lɛk at at sik, dɛn mɛrɛsin ya kin ɛp fɔ mek dɛn nɔ gɛt ɔ kɔntrol di damej we de pan di jɔyn dɛn we di sik kin mek, pas fɔ jɔs ridyus di pen. `(Methotrexate)` na wan drɔg we bɔku pipul dɛn sabi na dis klas.
Bayolojikal tin dɛn
Dis na nyu, mɔ advans klas fɔ drɔgs pas DMARD. Dɛn mek dɛn wit prɔtin dɛn we dɛn pul frɔm di sɛl dɛn we gɛt layf na lɛbɔtri.
Fɔ tɔk am simpul wan, pan ɔl we ol drɔgs dɛn de wok lɛk ‘kapɛt bɔm’ ɛn afɛkt di ɔl imyun sistɛm, bayolojikal dɛn tan lɛk ‘smat bɔm’. dat min se dεn de go dayrekt to εn tכk to wan spεsifi k sεl כ kεmikכl nכmכ (lεk `(TNF)`, `(Interleukin)`) we de mek di sik.
Dis kin ridyus di sayd ɛfɛkt dɛm ɛn mek yu gɛt mɔ sakrifays.
Immunotherapy fɔ Kansa
Dis na wan kayn tritmɛnt we rili spɛshal. Wetin kin apin ya nɔto dat di imyun sistɛm kin ridyus, bɔt na dat i kin bɔku. dכg dεm lεk ``Checkpoint Inhibitors`` de stכp di "signal" dεm we di kεnsar sεl dεm de yuz fכ ayd frכm wi imyun sεl dεm (``(T-sεl)``), εn εp di T-sεl dεm fכ no εn pwεl di kεnsar sεl dεm.
Aw dɛn kin gi dis mɛrɛsin to di bɔdi?
Di we aw dɛn de gi yu dis mɛrɛsin kin difrɛn difrɛn wan bay aw yu de mɛn yu ɛn di kayn mɛrɛsin.
- Tru wan vein (By IV): Lεk salin, dεn de gi am dairekt insay di bכdi tru wan kanula.
- Bay Injɛkshɔn: Dɛn kin injekt am ɔnda di skin ɔ insay wan mɔsul.
- Yu kin tek am wit yu mɔt: Dɛn kin tek am wit yu mɔt as tablɛt ɔ kapsul.
- As krim pan di skin (Topically): Dɛn kin put am pan di skin surface as krim fɔ sik dɛn na di skin.
Lɛ wi no bak bɔt di bad tin dɛn we kin apin to wi ɛn di bad tin dɛn we kin apin to wi.
Pan ɔl we dɛn mɛrɛsin ya rili yusful, dɛn kin gɛt sɔm sayd ɛfɛkt ɛn risk bikɔs dɛn kin afɛkt di imyun sistɛm. Yu dɔktɔ go tich yu bɔt dɛn tin ya.
| Di kayn risk we pɔsin kin gɛt | Tin dɛn we yu fɔ wach bɔt |
|---|---|
| Kɔmɔn sayd ɛfɛkt dɛn | Yu kin taya, yu kin slip, yu kin nɔs, yu bɛlɛ kin pwɛl, ɛn yu skin kin gɛt rɔsh. Bɔku tɛm, dɛn tin ya kin stɔp as tɛm de go. |
| Speshal risk dεm (we dεn imyun suprεs) . | di "difεns fכs" dεm na yu bכdi wik, so yu kin gεt infεkshכn mכr.. Ivin kol ɔ flu we nɔ gɛt bɛtɛ flu kin bi siriɔs. So, yu fɔ tek kia ɔf tin dɛn lɛk fɔ avɔyd ples dɛn we pipul dɛn kin bɔku ɛn fɔ was yu an ɔltɛm. If yu gɛt sɔm sayn dɛm lɛk fiva, kɔf, ɔr prɔblɛm fɔ blo, go to dɔktɔ wantɛm wantɛm. |
| Speshal risk dεm (we yu de bכst di imyuniti) . | Sɔntɛnde di imyun sistɛm kin ɔva stimulate ɛn bigin fɔ atak di wɛlbɔdi tisu. Dis kin mek tin dɛn lɛk ɔmon prɔblɛm, skin prɔblɛm, ɛn dayarɛa. |
Ilɛk wetin apin, yu dɔktɔ no gud gud wan bɔt dɛn bad tin ya. Na dat mek i go de chɛk yu ɔltɛm, du di blɔd tɛst dɛn we i nid, ɛn ajɔst di doz fɔ yu mɛrɛsin fɔ kia fɔ yu fayn fayn wan. Ɔl wetin yu fɔ du na fɔ tɛl yu dɔktɔ bɔt ɛni chenj ɔ diskɔmfɔt we yu fil.
Mɛsej we dɛn kin kɛr go na os
- Immunomodulators na wan rili pawaful ɛn spɛshal klas ɔf drɔgs we de chenj di wok we yu imyun sistɛm de du as nid de.
- Dɛn kin yuz dɛn tin ya fɔ mek di bɔdi gɛt mɔ pawa (insay sik dɛn lɛk kansa) ɔ fɔ ridyus am (insay ɔtoimyun sik dɛn).
- Dɛn tin ya nɔ tan lɛk di mɛrɛsin dɛn we dɛn kin yuz fɔ mɛn pen ɔltɛm. Dɛn mɛrɛsin ya kin afɛkt di men tin we kin mek pɔsin gɛt sik.
- Tek spɛshal kia fɔ protɛkt yusɛf frɔm infɛkshɔn we yu de tek dɛn mɛrɛsin ya.
- Nɔ shem fɔ tɛl yu dɔktɔ bɔt ɛni sayd ɛfɛkt ɔ nyu sayn we yu gɛt.
- Na bikɔs ɔf dɛn mɛrɛsin ya, bɔku sik dɛn we dɛn bin de tink se i nɔ izi fɔ mɛn, naw dɛn dɔn ebul fɔ kɔntrol dɛn fayn fayn wan. So, i rili impɔtant fɔ fala di advays we dɔktɔ gi yu kɔrɛkt wan.
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