Wan strenj prɔtin we de na yu blɔd? Lɛ wi tɔk bɔt MGUS (Monoclonal Gammopathy of Undetermined Significance)!

Yu go mɔs dɔn go to dɔktɔ, ɔ ivin jɔs fɔ mek dɛn du sɔm blɔd wok, ɛn dɛn dɔn tɛl yu bɔt wan sik we gɛt wan strenj nem we yu nɔ ɛva yɛri bɔt bifo. MGUS (we sɔm pipul dɛn kin kɔl bak M-Gas) na wan pan dɛn kɔndishɔn dɛn de, na kɔndishɔn we kin mek yu fil fred smɔl we yu yɛri di nem, bɔt i nɔ klia wetin i bi. So tide, lɛ wi tɔk bɔt MGUS (Monoclonal Gammopathy of Undetermined Significance) insay wan simpul we we yu go ɔndastand.

Wetin na MGUS (Monoclonal Gammopathy of Undetermined Sigifikans)?

Fɔ tɔk am simpul wan, MGUS na wan sik we de afɛkt wan spɛshal kayn sɛl we dɛn kɔl plasma sɛl, we na pat pan wi blɔd ɛn we de na di bon mɛro. Naw yu go de wɔnda wetin na dɛn plasma sɛl dɛn ya. Dɛn plasma sɛl ya na rili impɔtant pat dɛn na wi bɔdi in imyun sistɛm. Dɛn men wok na fɔ mek prɔtin dɛn we dɛn kɔl antibodies we de ɛp wi bɔdi fɔ protɛkt insɛf frɔm sik.

bכt pan pכsin we gεt MGUS, dεn plasma sεl dεm ya de chenj sכmtεm, εn insted fכ di rial antibodi dεm we dεn fכ mek, dεn de prodyuz difrεn, abnכmal tכp protin we dεn kכl "M protin dεm." dis M protin dεm nכ de rili du nכtin fכ wi bכdi. Bɔrku tɛm, dɛn M protin ya nɔr kin kɔz bɔrku harm, ɛn bɔrku pipul dɛm wae gɛt MGUS nɔr kin gɛt ɛni simptom. Bɔku tɛm, dɔktɔ kin no dis sik bay chans we dɛn du blɔd tɛst ɔ urine tɛst fɔ ɔda rizin.

Bɔt nɔto ɔltɛm, MGUS kin bi mɔ siriɔs ɛn divɛlɔp to blɔd kansa ɔ ɔda siriɔs blɔd disɔda. Na dat mek dɔktɔ dɛn, we dɛn no se yu gɛt MGUS, kin du blɔd ɛn urine tɛst ɛvri 6 mɔnt ɔ wan tɛm insay di ia fɔ si if i de tɔn to sɔntin we siriɔs.

Udat dis tin kin afɛkt mɔ?

Pan ɔl we ɛnibɔdi kin gɛt dis sik we dɛn kɔl MGUS, sɔm pipul dɛn kin gɛt am mɔ.

• Pipul wae dɔn pas 50 ia kin gɛt MGUS. Dis risk kin go ɔp smɔl as yu de ol. Pɔsin wae dɔn pas 50 ia gɛt 3% to 5% chans fɔ gɛt dis sik. If yu luk pan pipul dɛm wae dɔn pas 75 ia, dis na lɛk 5%.
• MGUS de mɔ pan blak pipul dɛn .
• Man dɛn kin gɛt MGUS pas uman dɛn.
• Pipul dɛn we dɔn gɛt histri fɔ gɛt peshɛnt ɔ insekt sayd kin de pan denja bak.

Aw MGUS de afɛkt mi bɔdi?

as wi bin dכn tכk bכt, MGUS de kכz fכ yu bon mכro we de prodyuz abnכmal plasma sεl dεm. Tink bɔt am lɛk se pɔsin we gɛt wɛlbɔdi in plasma sɛl dɛn tan lɛk sojaman dɛn we dɛn dɔn tren. Dɛn kin mek wɛpɔn dɛn we dɛn kɔl antibodies we spɛshal fɔ ɛni jem. Dɛn antibodi ya de ɛp wi fɔ no ɛn fɛt di jem dɛm we de kam insay wi bɔdi, we de protɛkt wi frɔm sik.

bכt insay MGUS, dεn plasma sεl dεm ya go "kray" sכmtεm εn dεn de mek M protin dεm. dis M protin dεm de kכmכt na wi bכdi εn de travul כlsay na wi bכdi. Sɔntɛnde dɛn abnɔmal M protin ya kin gɛda na wi blɔd ɛn urine ɛn dɛn kin pwɛl yu kidni, at, ɛn nerv dɛn. Nɔto dat nɔmɔ, bɔt we tumɔs M protin dɛn de na yu blɔd, di ebul we yu bɔdi ebul fɔ fɛt di jem dɛn kin ridyus bak. Dis min se yu kin sik izi wan.

MGUS na kansa?

Na wan kweshon we plenti pipul de aks. Nɔ, MGUS nɔto kansa insɛf. Bɔt na sik we kin mek i tɔn to kansa. In ɔda wɔd, dɛn kin tink bɔt MGUS as "pri-kansa" kɔndishɔn we de bifo kansa.

Risach dɔn sho se lɛk 20% pan di pipul dɛn we gɛt MGUS go gɛt wan blɔd kansa we dɛn kɔl multiple myeloma . Dis min se nɔto ɔlman we gɛt MGUS go gɛt kansa, bɔt lɛk wan pan ɛvri fayv pipul dɛn kin gɛt kansa.

Apat frɔm dat, sɔm pipul dɛn we gɛt MGUS kin gɛt ɔda kayn blɔd kansa ɔ siriɔs sik dɛn we gɛt fɔ du wit blɔd. Fɔ ɛgzampul:

• Amyloidosis we dɛn kɔl am
• Waldenstrom makroglobulinemia
• Kronik limfosaytik lukimiya (CLL) .

Impɔtant: Nɔto ɔlman we gɛt MGUS go gɛt kansa. Bɔt i impɔtant fɔ mek yu de chɛk yu dɔktɔ ɔltɛm bikɔs i gɛt prɔblɛm.

Wetin na di sayn dɛm fɔ MGUS?

As wi bin dɔn tɔk, bɔku tɛm MGUS nɔ kin kɔz ɛni patikyula sayn. Dat na wan pan di big prɔblɛm dɛn wit am. Bɔt, na smɔl tɛm nɔmɔ, sɔm pipul dɛn kin gɛt sɔm kayn sik. If dɛn du dat, dɛn kin gɛt tin dɛn lɛk:

• Wan tin we kin mek pɔsin fil lɛk se i de swɛt na di an ɛn fut dɛn.
• Fɔ fil se yu wik ɛn yu nɔ gɛt layf .
• Fɔ fil se yu nɔr de fil fayn ɔr yu nɔr de fil fayn na sɔm say dɛm.

Dɛn sayn ya kin bi sayn fɔ bɔrku ɔda kayn sik, so nɔr tink se yu gɛt MGUS jɔs bikɔs yu gɛt wan ɔr tu pan dɛn tin ya. Bɔt if yu gɛt di sik dɛn we nɔ de chenj, i go fayn fɔ mek yu go to dɔktɔ.

Wetin kin mek pɔsin gɛt MGUS?

infakt, dכkta dεm stil nכ no bכku bכku wan wetin mek di plasma sεl dεm na wi bon mכro de chenj εn bigin fכ mek M protin dεm. Na dat di "Undetermined Significance" pat pan di sik in nem se.

Bɔt sɔm tin dɛn de we dɛn kin tink se kin mek pɔsin gɛt dis sik:

• Jɛnɛtik chenj: Sɔm chenj na wi jin kin mek dis apin.
• Fɔ gɛt sik dɛn we pɔsin kin gɛt we i de fɛt insɛf:Dis min se pipul dɛm we gɛt sik dɛm we di bɔdi in yon imyun sistɛm de atak di bɔdi in yon sɛl dɛm (lɛk rεumatoid atraytis) kin gɛt MGUS.
• Tritmɛnt fɔ ɔtoimyun sik dɛm: Sɔm mɛrɛsin dɛm wae dɛn kin tek fɔ dɛn sik ya kin gɛt ɛfɛkt bak.
• We yu gɛt bɔku bɔku raytin.
• Fɔ gɛt peshɛnt sayd ɛn insɛktisayd.

Dis na di risk factor dɛm wae dɛn dɔn no naw, bɔt ivin pɔrsin wae nɔr gɛt ɛni wan pan dɛn kin gɛt MGUS.

Aw dɔktɔ dɛn kin no se yu gɛt MGUS?

Bɔku tɛm, na chans dɛn kin fɛn MGUS. Dɔktɔ go chɛk yu blɔd ɛn yu urine fɔ si if yu gɛt M prɔtin. Apat frɔm dat, dɛn go luk pan sɔm ɔda tin dɛn fɔ no di risk fɔ mek MGUS bi kansa ɔ ɔda siriɔs blɔd dizayd. Dɛn tin ya we kin mek pɔsin gɛt prɔblɛm na:

• di amount of M protin na yu bכdi: di hכy amoun fכ M protin, na di hכy risk.
• di kayn M protin we de insay yu bכdi: difrεn kayn M protin dεm de bak. Sɔm kayn dɛn kin denja smɔl pas ɔda wan dɛn.
• di amoun fכ fri layt chen (FLC) dεm na yu bכdi: FLC na wan kayn protin we di plasma sεl dεm de mek bak. FLC tεst dεm de luk fכ abnכmal kכnsantreshכn fכ dεn wan ya.

Risach sho se pɔrsin wae gɛt ɔl tri pan dɛn risk factor ya gɛt 58% chans fɔ gɛt lukimiya insay 20 ia. Semweso, pɔrsin wae nɔr gɛt ɛni wan pan dɛn risk factor ya gɛt 5% chans fɔ gɛt lukimiya insay 20 ia. So dɛn tɛst ya kin ɛp yu dɔktɔ fɔ ɔndastand yu risk lɛvɛl.

Aw dɛn kin trit MGUS?

Di gud nyus na dat, bɔrku pipul dɛm wae gɛt MGUS nɔr nid ɛni tritmɛnt. Bikɔs, lɛk aw wi bin dɔn tɔk, bɔrku pipul nɔr kin gɛt ɛni prɔblɛm wit am ɛn nɔr kin gɛt ɛni sayn.

Bɔt bikɔs MGUS kin tɔn to kansa, yu dɔktɔ go chɛk di lɛvɛl we di M protin de na yu blɔd ɛn yu urine ɛvri 6 mɔnt ɔ wan tɛm insay di ia. Dɛn kɔl dis "watchful waiting." Lɛk sɛntinɛl, di dɔktɔ de wach fɔ si if ɛnitin chenj.

Sɔntɛnde, pipul dɛm wae gɛt MGUS kin gɛt bɔrku risk fɔ lɛ dɛn bon ɔ fɔ brok. If yu de pan denja, yu dɔktɔ kin gi yu mɛrɛsin fɔ mek yu bon dɛn strɔng ɛn ɔda tin dɛn fɔ mek yu bon dɛn bɔku.

Yu tink se dɛn kin ebul fɔ stɔp MGUS?

Bɔt i sɔri fɔ no se, nɔto so. Wi nɔ go ebul fɔ stɔp dis kɔndishɔn we dɛn kɔl MGUS. biכs i de kכz fכ sכm chenj dεm na wi jin dεm (jin mכtεshכn), tru we dεn de fכm abnכmal plasma sεl dεm, εn dεn sεl dεm de bigin fכ prodyuz M protin dεm. Dɛn jɛnɛtik chenj ya na tin dɛn we wi nɔ go ebul fɔ kɔntrol.

Wetin kin apin if yu gɛt MGUS? Wetin wi fɔ ɛkspɛkt?

In jɛnɛral, bɔrku pipul dɛm wae gɛt MGUS kin liv nɔrmal layf wae nɔr gɛt ɛni simptom. Na smɔl pipul dɛn nɔmɔ kin gɛt di blɔd kansa ɔ ɔda blɔd sik dɛn we wi bin dɔn tɔk bɔt.

If yu blɔd ɛn urine tɛst sho se yu gɛt M protin, yu go nid fɔ du blɔd ɛn urine tɛst bak ɛvri 6 to 12 mɔnt. Dis na fɔ ɛp yu dɔktɔ dɛn fɔ wach yu sik fɔ si if i de wɔs. Dis kin tan lɛk se yu de mɔna yu smɔl, bɔt i rili impɔtant fɔ mek yu sef.

Aw a kin kia fɔ misɛf?

Pan ɔl we wi nɔ no di rayt tin we kin mek pɔsin gɛt MGUS, wi dɔn tɔk bɔt wan link bitwin ɔtoimyun sik dɛn, aw dɛn kin trit dɛn, di ay levul fɔ redyushɔn, ɛn peshɛnt sayd. I kin pasmak bak pan pipul dɛm wae dɔn pas 50 ia.

• If yu de wɔri se yu kin gɛt MGUS, tɔk to yu dɔktɔ bɔt di tin dɛn we kin mek yu gɛt dis sik ɛn tɔk bɔt aw fɔ du tɛst if nid de.
• If yu dɔn gɛt MGUS, fala yu dɔktɔ in instrɔkshɔn dɛn ɛksaktɔli. Gɛt tɛst di rayt tɛm.
• If yu gɛt ɛni nyu sayn, lɛk we yu nɔ de fil fayn, yu wik, ɛn yu nɔ de fil fayn we wi bin dɔn tɔk bɔt, tɛl yu dɔktɔ wantɛm wantɛm.

MGUS na wan kɔndishɔn we ivin mɛdikal sayɛns nɔ ɔndastand gud gud wan yet. As di nem sho, bɔku tin dɛn stil de we wi nɔ no bɔt am. Fɔ ɛgzampul, e nɔr kin rili klia aw sɔm pipul dɛm wae gɛt dis sik kin gɛt blɔd kansa ɔr siriɔs blɔd sik wae ɔda pipul dɛm nɔr kin gɛt.

Bɔt dɔktɔ dɛn de pul dɛn sikrit dɛn ya smɔl smɔl. If yu gɛt MGUS, dɔktɔ dɛn kin tɔk naw to sɔm mak aw yu go gɛt siriɔs sik. I impɔtant fɔ tɔk to yu dɔktɔ bɔt ɛni risk factor wae kin put yu pan risk fɔ gɛt MGUS. Bay da infɔmeshɔn de, yu kin disayd if i fayn fɔ mek dɛn tɛst yu fɔ di sik.

Fɔ dɔn, tin dɛn we wi fɔ mɛmba

Nɔ frayd we yu yɛri di nem MGUS (Monoclonal Gammopathy of Undetermined Significance). Di tin we impɔtant pas ɔl na fɔ no bɔt dis.

• MGUS nɔto kansa, bɔt na wan sik we kin mek pɔsin gɛt kansa.
• Bɔrku pipul nɔr kin gɛt dis sik ɛn nɔr nid tritmɛnt.
• Di tin we impɔtant pas ɔl na fɔ de chɛk-ap ɔltɛm ɔltɛm .
• If nyu sayn dɛn de sho, tɛl yu dɔktɔ wantɛm wantɛm.
• Tɔk opin wan wit yu dɔktɔ bɔt ɛni kwɛstyɔn ɔ tin we de mɔna yu. Dɛn de de fɔ ɛp yu.

A op se dis infɔmeshɔn dɔn ɛp yu fɔ ɔndastand mɔ bɔt MGUS. Mɛmba se nɔto yu wan de, yu dɔktɔ dɛn ɛn di wan dɛn we yu lɛk de wit yu.

` MGUS, Monoclonal Gammopathy of Undetermined Significance, M protin, Plasma sel dεm, Bon mכro, Blכd kεnsar, Blכd sik dεm, Multiple Myeloma