Sɔntɛnde yu kin fil lɛk se yu wek ɛn fil fayn na mɔnin, bɔt as di de de go, yu kin fil lɛk se yu nɔ gɛt ɛni trɛnk? I tan lɛk se yu mɔsul dɛn wik so yu nɔ ebul fɔ du natin, mɔ yu yay dɛn ebi, ɛn i nɔ kin izi fɔ yu fɔ tɔk ɔ swɛla it? If yu dɔn gɛt dɛn kayn ɛkspiriɛns ya, i rili impɔtant fɔ mek yu no bɔt di sik we wi de tɔk bɔt tide we dɛn kɔl ‘Myasthenia Gravis’. Pan ɔl we yu nɔ no dis smɔl, we yu ɔndastand am simpul wan, yu go ebul fɔ fɛn ansa to bɔku kwɛstyɔn dɛn.
Fɔ tɔk am simpul wan, wetin na Myasthenia Gravis?
Myasthenia gravis, ɔ MG fɔ shɔt, na wan sik we pɔsin kin gɛt we i de fɛt insɛf . Fɔ tɔk am simpul wan, na we wi bɔdi in yon difens sistɛm, we na di imyun sistɛm, mistek atak sɔm pat dɛn na wi yon bɔdi. insay MG, di imyun sistεm de atak di kכnεkshכn bitwin wi nεv dεm εn mכsul dεm.
Dis kin mek di mɔsul dɛn we de kɔnɛkt to wi bon dɛn ɛn mek wi wik smɔl smɔl. Dis kin afɛkt mɔ:
- Fɔ di mɔsul dɛn na yu yay, yu fes, yu nɛk, yu an, ɛn yu leg.
Dis wikɛd tin kin mek i nɔ izi fɔ yu fɔ du tin dɛn lɛk:
- Muv yu yay rawnd, blink.
- Kip yu yay opin.
- Ɛksprɛs difrɛn filin dɛn wit yu fes.
- Chew it, swɛla, ɛn tɔk.
- Rayt yu an, es yu tin dɛn ɔp.
- Klaym wan flayt stej, grap frɔm wan chia.
De tin wae yu kin du pasmak ɛn impɔtant pas ɔl na dis sik na dat, dɛn mɔsul ya kin wik wae yu de du tin, bɔt dɛn kin kam bak to layf afta yu dɔn rɛst fɔ shɔt tɛm.
Dis na wan sik we nɔ de mɛn. Dis min se no wan saiz-fit-ɔl mɛrɛsin nɔ de. Bɔt nɔr wɔri, wit di tritmɛnt dɛm wae de tide wae de woke fayn fayn wan, ɛnibɔdi kin ebul fɔ kɔntrol in sik dɛm ɛn liv wɛl bɔdi layf.
Yu tink se men kayn myasthenia gravis de?
Yɛs, sɔm men kayn tin dɛn de fɔ dis sik. Lɛ wi si wetin dɛn bi.
| Di kayn sik (Type) . | Smɔl Ɛksplen |
|---|---|
| Autoimyun Mayasthenia we de mek pɔsin gɛt sik | Dis na di kayn we we pipul dɛn kin gɛt mɔ. Na sɔm antibodi dɛm we di bɔdi in imyun sistɛm de mek. Di rayt rizin nɔ klia. |
| Nyu bɔn pikin dɛn we dɛn kɔl Myasthenia | wan tεmporari kכndishכn we di pikin de gεt antibodi dεm frכm mama we gεt MG we i bεlε. We dɛn bɔn di pikin, i kin kray wik ɛn i nɔ kin izi fɔ mek i sok. Dɛn sayn ya kin dɔn afta lɛk tri mɔnt so. |
| Mayasthenia we dɛn bɔn wit | Dis nɔto ɔtoimyun kɔndishɔn. Na wan sik we nɔ kin apin so ɔltɛm we pɔsin chenj in jɛnɛtiks. |
di mכst kכmכn כtoimyun myasthenia gravis kכndishכn dεm dεn divayd am bak to tu men tכp dεm.
Ocular Myasthenia we gɛt di sik
Dis na kכndyushכn we na di mכsul dεm we de muv di yay εn di aylid dεm nכmכ kin wik. Dis kin mek yu yaylid dɛn drɔp ɔ mek i nɔ izi fɔ mek yu yay opin. Sɔm pipul dɛn kin si bak tu tɛm. Dis wik wik na di yay kin bi di fɔs sayn fɔ MG. Na lɛk af pan pipul dɛm wae gɛt dis sik go dɔn gɛt jɛnɛral vishɔn.
Jɛnɛralayz Mayasthenia
Insay dis kɔndishɔn, apat frɔm di mɔsul dɛm na di yay, di mɔsul dɛm na di fes, nɛk, an, leg, ɛn trot kin wik bak. Dis kin mek i nɔ izi fɔ tɔk, swɛla it, es yu an ɔp ɔp yu ed, grap frɔm usay yu sidɔm, waka lɔng, ɛn klaym stej.
Aw dis sik kin rili bigin? Wetin kin apin insay wi bɔdi?
Fɔ ɔndastand dis, lɛ wi tek wan smɔl ɛgzampul. Imajin se di rilayshɔn bitwin wi nerv ɛn mɔsul dɛn tan lɛk di wan we de bitwin pitcha ɛn pɔsin we de kech na kriket mats.
1. di bowla (nerve): di nerve na di wan we de sεnd di mεsej to di mכsul fכ "kכntrakt".
2. di bכl (Acetylcholine): dis mεsej de sεnd tru wan kεmikכl (nyurotransmitta) we dεn kכl ‘acetylcholine’. Dis na wi 'bol'.
3. Di filda in glɔv (risɛptɔ): Spɛshal ples de na di pal fɔ kech dis ‘bɔl’. Wi kin kɔl dɛn ‘rɛsɛptɔ’. Dis na lɛk di filda in ‘glɔv’.
nכmal wan, di ‘bכl’ (asetilkolin) we dεn sεnd frכm di nεv de mach wit di ‘glכv’ (rεsεpכta) na di mכsul. Na da tɛm de di mɔsul kin gɛt di signal fɔ kɔntrakt. Dis kin apin kwik kwik wan, ɛn nɔbɔdi nɔ kin ambɔg am.
Bɔt sɔmtin difrɛn kin apin na pɔsin in bɔdi we gɛt myasthenia gravis.
di imyun sistεm we dεn de mek de mek di rכng antibodi dεm εn de blכk כ pwεl di rεsεpכta dεm na di mכsul. Dɔn, pan ɔl we di nerv de sɛn di bɔl, no glɔv nɔ de fɔ kech am. So, di mכsul nכ de gεt di rayt signal, so i de wik. We yu wok tranga wan, di mɔsul kin wik mɔ bikɔs i nɔ kin ebul fɔ kech di bɔl. We yu rɛst, yu kin yuz di glɔv bak smɔl, so i kin kam bak to layf. Yu ɔndastand?
Wetin na di men sayn dɛm fɔ myasthenia gravis?
Di simptom dɛm fɔ MG kin bigin wantɛm wantɛm. Dɛn kin difrɛn bak pan aw dɛn kin tranga frɔm wan de to ɔda de ɛn wan wan tɛm. Bɔku pipul dɛn kin fil se dɛn strɔng we di de bigin ɛn dɛn kin fil wik we di de dɔn.
| Di sayn we de sho se di sik de | Fɔ ɛksplen |
|---|---|
| Aylid we de drɔp (Ptosis) . | Aylid dɛn we de drɔp na wan ɔ ɔl tu di yay dɛn. Dis na de sik wae kin kam fɔs. |
| Blɔr ɔ dɛbul vishɔn | We di mɔsul dɛn we de muv di yay wik, dat kin mek yu si tu tɛm. |
| I nɔ kin izi fɔ tɔk, fɔ swɛla, ɔ fɔ it | Tin dɛn lɛk we yu vɔys chenj we yu de tɔk, i nɔ kin izi fɔ swɛla, it we kin stɔp, ɛn i kin at fɔ it. |
| Wiknɛs na di an, leg, ɛn nɛk | An kin taya izi wan we yu de du tin lɛk fɔ es yu ia, fɔ kɔm yu ia, fɔ brus yu tit. I nɔ izi fɔ waka, i nɔ izi fɔ ol ed ɔp stret. |
| Chenj we yu de chenj yu fes | If yu nɔ sho di sem fes we yu de smayl, i kin mek yu luk lɛk se yu de "fɔs fɔ smayl." |
| I nɔ kin izi fɔ yu fɔ blo | Dis na tin we rili denja ɛn we kin apin kwik kwik wan. If yu gɛt shɔt briz bikɔs di mɔsul dɛn we de blo wik, yu fɔ go wantɛm wantɛm na di Imejɛnsi Dipatmɛnt (ETU) na ɔspitul. Dɛn kɔl dis ‘Myasthenic Crisis’. |
Aw di dɔktɔ kin no dis sik klia wan?
If yu gɛt dɛn sik ya, yu dɔktɔ go aks yu fɔs bɔt yu mɛdikal istri ɛn du yu bɔdi ɛgzam. Dɔn dɛn kin ɔda fɔ du sɔm tɛst fɔ no if dɛn no di sik:
- Blɔd tɛst: Dɛn go chɛk yu blɔd fɔ di abnɔmal antibodi dɛm we wi bin dɔn tɔk bɔt bifo tɛm (`acetylcholine receptor antibodies` ɔ `MuSK antibodies`). Na lɛk 85% pan di pipul dɛm we gɛt MG gɛt dɛn antibodi ya na dɛn blɔd.
- Imej skan: Dɛn kin du CT ɔ MRI skan fɔ chɛk fɔ si if prɔblɛm ɔ tumbu (taymoma) de na yu taymus gland.
- Ilektromayografi (EMG): Dis na sɔm spɛshal tɛst we de luk fɔ ɛni abnɔmal tin na di we aw ilɛktrik signal dɛn de transmit bitwin di nɛv ɛn mɔsul dɛn.
Bay di rizɔlt fɔ dɛn tɛst ya, yu dɔktɔ go no di stej fɔ yu sik ɛn tɛl yu di tritmɛnt plan we fit yu pas ɔl.
Wetin na di tritmɛnt dɛm fɔ dis?
Fɔs, MG na wan sik we dɛn kin trit. Pan ɔl we no mɛrɛsin nɔ de, bɔku fayn tritmɛnt dɛn de tide we go ɛp yu fɔ kɔntrol yu sik dɛn ɛn liv nɔmal, aktif layf.
Bɔku we dɛn de fɔ trit pɔsin:
- Di mɛrɛsin dɛn we dɛn kin yuz:
- dכg dεm lεk `cholinesterase inhibitors` de impruv di transmishכn fכ signal bitwin nεv dεm εn mכsul dεm, we de mek di mכsul dεm trεnk go כp.
- di imyun supεrshכn dεm lεk kכtikostεroyd, de ridyus di prodakshכn fכ dεn abnכmal antibodi dεm de.
- Mɔnoklɔnal antibodi dɛn:Dis na spɛshal prɔtin dɛn we dɛn kin gi insay di bɛlɛ. Dɛn kin kɔntrol aw di imyun sistɛm de wok.
- Plasma exchange (Plasmapheresis): Dis min fɔ kɔnɛkt yu to wan spɛshal mashin we de pul di plasma pat pan yu blɔd we gɛt antibodi dɛn we de ambɔg yu ɛn put wɛlbɔdi plasma ɔ sɔlvushɔn insay.
- IV immunoglobulin (IVIG): Na infuzכn fכ antibodi dεm frכm hεlty dona dεm we dεn kin put insay di bכdi. Dis kin ɛp fɔ stɔp di imyun sistɛm.
- כpεrayshכn: fכ sכm pipul dεm, spεshal wan dεm we gεt taymus tכmכro, dεn kin כpεrayshכn kכl di gland (a `thymectomy`). Dis kin rili kɔntrol di sayn dɛm.
Yu dɔktɔ go pik di tritmɛnt we go fayn fɔ yu sik.
Wetin wi kin du fɔ wisɛf we wi de liv wit di sayn dɛm?
Wae yu de gɛt tritmɛnt, fɔ mek smɔl chenj na yu layf kin mek i izi fɔ liv wit dis sik.
- Ɛksesaiz: Aks yu dɔktɔ ɛn du layt ɛksesaiz we fit yu . Dis go mek yu mɔsul dɛn strɔng, mek yu maynd rilaks, ɛn gi yu trɛnk.
- Nɔ wam: If yu wam pasmak, dat kin mek di sik wɔs. So nɔ go na do na di hot san insay di de. We yu fil se yu wam, put klos we yu sok insay kol wata na yu nɛk ɛn yu fɔrɛst.
- Gud it: It balans it we gɛt bɔku prɔtin ɛn kabɔhaydrɛt fɔ mek yu gɛt trɛnk.
- Plan yu wok: Du di wok dɛn we yu nid fɔ tray tranga wan we yu gɛt mɔ trɛnk, we min se na mɔnin.
- I impɔtant fɔ rɛst: Tek shɔt briŋ ɔl di de. Gɛt sɔm slip. Lisin to yu bɔdi. Nɔ fos yusɛf fɔ wok we yu fil se yu taya.
Mɛsej we dɛn kin kɛr go na os
- Myasthenia gravis (MG) na wan sik we wi yon imyun sistɛm nɔ de wok fayn, bɔt wi kin trit am fayn fayn wan .
- If yu gɛt sɔm sayn dɛn lɛk we yu aylid de drɔp, yu nɔ de si fayn, i nɔ izi fɔ tɔk ɔ swɛla, ɔ yu taya we nɔ kɔmɔn we de go ɔp ɔl di de, go to dɔktɔ we yu nɔ de te.
- If yu gɛt ɛni prɔblɛm fɔ blo, go na ɔspitul in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm, bikɔs i kin bi mɛdikal imejensi (myasthenic crisis) .
- If yu gɛt di rayt tritmɛnt, fala yu dɔktɔ in advays, ɛn mek simpul chenj na dɛn layf, bɔku pipul dɛn we gɛt MG kin liv ful ɛn aktif layf . No nid fɔ fred.
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